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Expression of the RET proto-oncogene in human Embryos
The patterns of RET proto‐oncogene expression in mouse, rat, and chicken and the anomalies observed in targeted RET mutants suggest that RET plays a major role in development of mouse enteric nervous system and in kidney organogenesis. Here, we report on in situ hybridization studies describing the...
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| Published in: | American journal of medical genetics 1998-12, Vol.80 (5), p.481-486 |
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| container_title | American journal of medical genetics |
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| creator | Attié-Bitach, Tania Abitbol, Marc Gérard, Marion Delezoide, Anne-Lise Augé, Joelle Pelet, Anna Amiel, Jeanne Pachnis, Vassilis Munnich, Arnold Lyonnet, Stanislas Vekemans, Michel |
| description | The patterns of RET proto‐oncogene expression in mouse, rat, and chicken and the anomalies observed in targeted RET mutants suggest that RET plays a major role in development of mouse enteric nervous system and in kidney organogenesis. Here, we report on in situ hybridization studies describing the pattern of RET proto‐oncogene expression during early development of human embryos between 23 and 42 days. We show that the RET gene is expressed in the developing kidney (nephric duct, mesonephric tubules, and ureteric bud), the presumptive enteric neuroblasts of the developing enteric nervous system, cranial ganglia (VII+VIII, IX, and X) and in the presumptive motor neurons of the spinal cord. Yet, despite the high level of RET gene expression in the kidney and in the motor neurons of the developing central nervous system in human embryos, only rare cases with renal agenesis have been reported in Hirschsprung disease patients, and no clinical evidence of spinal cord involvement has been shown in patients carrying RET germline mutations (i.e., multiple endocrine neoplasia syndromes and Hirschsprung disease). Am. J. Med. Genet. 80:481–486, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8628(19981228)80:5<481::AID-AJMG8>3.0.CO;2-6 |
| format | article |
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Here, we report on in situ hybridization studies describing the pattern of RET proto‐oncogene expression during early development of human embryos between 23 and 42 days. We show that the RET gene is expressed in the developing kidney (nephric duct, mesonephric tubules, and ureteric bud), the presumptive enteric neuroblasts of the developing enteric nervous system, cranial ganglia (VII+VIII, IX, and X) and in the presumptive motor neurons of the spinal cord. Yet, despite the high level of RET gene expression in the kidney and in the motor neurons of the developing central nervous system in human embryos, only rare cases with renal agenesis have been reported in Hirschsprung disease patients, and no clinical evidence of spinal cord involvement has been shown in patients carrying RET germline mutations (i.e., multiple endocrine neoplasia syndromes and Hirschsprung disease). Am. J. Med. Genet. 80:481–486, 1998. © 1998 Wiley‐Liss, Inc.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/(SICI)1096-8628(19981228)80:5<481::AID-AJMG8>3.0.CO;2-6</identifier><identifier>PMID: 9880212</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Biological and medical sciences ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Central Nervous System - embryology ; Central Nervous System - metabolism ; Drosophila Proteins ; Embryo, Mammalian - metabolism ; Enteric Nervous System - embryology ; Enteric Nervous System - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Hirschsprung disease ; human embryos ; Humans ; In Situ Hybridization ; Kidney - embryology ; Kidney - metabolism ; Molecular and cellular biology ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins c-ret ; Receptor Protein-Tyrosine Kinases - genetics ; RET proto-oncogene</subject><ispartof>American journal of medical genetics, 1998-12, Vol.80 (5), p.481-486</ispartof><rights>Copyright © 1998 Wiley‐Liss, Inc.</rights><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-8628%2819981228%2980%3A5%3C481%3A%3AAID-AJMG8%3E3.0.CO%3B2-6$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-8628%2819981228%2980%3A5%3C481%3A%3AAID-AJMG8%3E3.0.CO%3B2-6$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1611291$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9880212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attié-Bitach, Tania</creatorcontrib><creatorcontrib>Abitbol, Marc</creatorcontrib><creatorcontrib>Gérard, Marion</creatorcontrib><creatorcontrib>Delezoide, Anne-Lise</creatorcontrib><creatorcontrib>Augé, Joelle</creatorcontrib><creatorcontrib>Pelet, Anna</creatorcontrib><creatorcontrib>Amiel, Jeanne</creatorcontrib><creatorcontrib>Pachnis, Vassilis</creatorcontrib><creatorcontrib>Munnich, Arnold</creatorcontrib><creatorcontrib>Lyonnet, Stanislas</creatorcontrib><creatorcontrib>Vekemans, Michel</creatorcontrib><title>Expression of the RET proto-oncogene in human Embryos</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>The patterns of RET proto‐oncogene expression in mouse, rat, and chicken and the anomalies observed in targeted RET mutants suggest that RET plays a major role in development of mouse enteric nervous system and in kidney organogenesis. Here, we report on in situ hybridization studies describing the pattern of RET proto‐oncogene expression during early development of human embryos between 23 and 42 days. We show that the RET gene is expressed in the developing kidney (nephric duct, mesonephric tubules, and ureteric bud), the presumptive enteric neuroblasts of the developing enteric nervous system, cranial ganglia (VII+VIII, IX, and X) and in the presumptive motor neurons of the spinal cord. Yet, despite the high level of RET gene expression in the kidney and in the motor neurons of the developing central nervous system in human embryos, only rare cases with renal agenesis have been reported in Hirschsprung disease patients, and no clinical evidence of spinal cord involvement has been shown in patients carrying RET germline mutations (i.e., multiple endocrine neoplasia syndromes and Hirschsprung disease). Am. J. Med. Genet. 80:481–486, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Central Nervous System - embryology</subject><subject>Central Nervous System - metabolism</subject><subject>Drosophila Proteins</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Enteric Nervous System - embryology</subject><subject>Enteric Nervous System - metabolism</subject><subject>Fundamental and applied biological sciences. 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J. Med. Genet</addtitle><date>1998-12-28</date><risdate>1998</risdate><volume>80</volume><issue>5</issue><spage>481</spage><epage>486</epage><pages>481-486</pages><issn>0148-7299</issn><eissn>1096-8628</eissn><coden>AJMGDA</coden><notes>The Projet Hospitalier de Recherche Clinique - No. PHRC AOA 94060</notes><notes>IMAGE</notes><notes>ArticleID:AJMG8</notes><notes>ark:/67375/WNG-VHHH5MGX-S</notes><notes>The Association Française contre les Myopathies (AFM)</notes><notes>The Caisse Nationale des Assurances Maladies (CANAM)</notes><notes>istex:E76FFBBA0E85BFE5639FE9AC5E9F41C746ACFCCE</notes><notes>The Association pour la Recherche contre le Cancer (ARC)</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The patterns of RET proto‐oncogene expression in mouse, rat, and chicken and the anomalies observed in targeted RET mutants suggest that RET plays a major role in development of mouse enteric nervous system and in kidney organogenesis. Here, we report on in situ hybridization studies describing the pattern of RET proto‐oncogene expression during early development of human embryos between 23 and 42 days. We show that the RET gene is expressed in the developing kidney (nephric duct, mesonephric tubules, and ureteric bud), the presumptive enteric neuroblasts of the developing enteric nervous system, cranial ganglia (VII+VIII, IX, and X) and in the presumptive motor neurons of the spinal cord. Yet, despite the high level of RET gene expression in the kidney and in the motor neurons of the developing central nervous system in human embryos, only rare cases with renal agenesis have been reported in Hirschsprung disease patients, and no clinical evidence of spinal cord involvement has been shown in patients carrying RET germline mutations (i.e., multiple endocrine neoplasia syndromes and Hirschsprung disease). Am. J. Med. 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| ispartof | American journal of medical genetics, 1998-12, Vol.80 (5), p.481-486 |
| issn | 0148-7299 1096-8628 |
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| source | Wiley-Blackwell Journals |
| subjects | Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Central Nervous System - embryology Central Nervous System - metabolism Drosophila Proteins Embryo, Mammalian - metabolism Enteric Nervous System - embryology Enteric Nervous System - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Hirschsprung disease human embryos Humans In Situ Hybridization Kidney - embryology Kidney - metabolism Molecular and cellular biology Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases - genetics RET proto-oncogene |
| title | Expression of the RET proto-oncogene in human Embryos |
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