Incidence of primary dengue virus infections in Southern Vietnamese children and reactivity against other flaviviruses

To study the incidence of asymptomatic primary dengue infections among children and reactivity against other flaviviruses. A total of 216 children, who had no dengue-specific IgG antibodies during a serosurvey in 2003 were re-examined 23 months later to determine if seroconversion had occurred. Deng...

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Bibliographic Details
Published in:Tropical medicine & international health 2007-12, Vol.12 (12), p.1553-1557
Main Authors: Thai, Khoa T.D, Nga, Tran Thi Thanh, Van Nam, Nguyen, Phuong, Hoang Lan, Giao, Phan Trong, Hung, Le Quoc, Binh, Tran Quang, van Doornum, Gerard J.J, de Vries, Peter J
Format: Article
Language:English
Subjects:
analyse d’immunofluorescence
Antibodies, Viral - blood
Arboviroses
Biological and medical sciences
Child
Children & youth
Cross-Sectional Studies
dengue
Dengue - epidemiology
Dengue - immunology
Dengue fevers
Dengue virus
ensayo de inmunofluorescencia
Enzyme-Linked Immunosorbent Assay
Epidemiology
estudios seroepidemiológicos
Female
Flavivirus
Flavivirus Infections - immunology
General aspects
Human viral diseases
Humans
immunofluorescence assay
Incidence
incidencia
Infectious diseases
Japanese encephalitis virus
Male
Medical sciences
seroepidemiologic studies
serological surveys
Tropical diseases
Tropical viral diseases
Vietnam
Vietnam - epidemiology
Viral diseases
Viruses
études séroépidémiologiques
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Summary:To study the incidence of asymptomatic primary dengue infections among children and reactivity against other flaviviruses. A total of 216 children, who had no dengue-specific IgG antibodies during a serosurvey in 2003 were re-examined 23 months later to determine if seroconversion had occurred. Dengue-specific IgG was demonstrated with enzyme-linked immunosorbent assay (ELISA) and reactivity patterns against other flaviviruses were assessed by using immunofluorescence assay (IFA). Sixty-six children had seroconverted for dengue virus-specific IgG; the true annual incidence of primary dengue was thus 17.3% (95% CI: 13.8-21.4). Japanese Encephalitis virus (JEV)-specific IgG antibodies were detected by IFA among three (4.6%) samples that showed seroconversion in the dengue ELISA, because of cross-reactivity. Our findings highlight the high incidence of dengue among Vietnamese children; JEV infections are rare. The true annual incidence of dengue can be estimated with a single cross-sectional seroprevalence survey.
ISSN:1360-2276
1365-3156
DOI:10.1111/j.1365-3156.2007.01964.x