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Aza-stilbenes as potent and selective c-RAF inhibitors
Compound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed. The synthesis of several novel aza-stilbene derivatives was carried out. The compounds were tested for their c-RA...
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Published in: | Bioorganic & medicinal chemistry letters 2006-10, Vol.16 (20), p.5378-5383 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Compound
27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.
The synthesis of several novel aza-stilbene derivatives was carried out. The compounds were tested for their c-RAF enzyme inhibition. Compound
27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2006.07.063 |