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An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population
Conventional understanding of CD4 T cell development is that the MHC class II molecules on cortical thymic epithelial cell are necessary for positive selection, as demonstrated in mouse models. Clinical data, however, show that hematopoietic stem cells reconstitute CD4 T cells in patients devoid of...
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| Published in: | Immunity (Cambridge, Mass.) Mass.), 2005-10, Vol.23 (4), p.375-386 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c434t-61e5752c512209b90637028e3654a4bd3df5544390388304664e7e9066c2219e3 |
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| cites | cdi_FETCH-LOGICAL-c434t-61e5752c512209b90637028e3654a4bd3df5544390388304664e7e9066c2219e3 |
| container_end_page | 386 |
| container_issue | 4 |
| container_start_page | 375 |
| container_title | Immunity (Cambridge, Mass.) |
| container_volume | 23 |
| creator | Li, Wei Kim, Moon-Gyo Gourley, Tania S. McCarthy, Brian P. Sant’Angelo, Derek B. Chang, Cheong-Hee |
| description | Conventional understanding of CD4 T cell development is that the MHC class II molecules on cortical thymic epithelial cell are necessary for positive selection, as demonstrated in mouse models. Clinical data, however, show that hematopoietic stem cells reconstitute CD4 T cells in patients devoid of MHC class II. Additionally, CD4 T cells generated from human stem cells in immunocompromised mice were restricted to human, but not mouse, MHC class II. These studies suggest an alternative pathway for CD4 T cell development that does not normally exist in mice. MHC class II is expressed on developing human thymocytes, indicating a possible role of MHC II on thymocytes for CD4 T cell generation. Therefore, we created mice in which MHC class II is expressed only on T lineage cells. Remarkably, the CD4 compartment in such mice is efficiently reconstituted with unique specificity, demonstrating a novel thymocyte-driven pathway of CD4 T cell selection. |
| doi_str_mv | 10.1016/j.immuni.2005.09.002 |
| format | article |
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Clinical data, however, show that hematopoietic stem cells reconstitute CD4 T cells in patients devoid of MHC class II. Additionally, CD4 T cells generated from human stem cells in immunocompromised mice were restricted to human, but not mouse, MHC class II. These studies suggest an alternative pathway for CD4 T cell development that does not normally exist in mice. MHC class II is expressed on developing human thymocytes, indicating a possible role of MHC II on thymocytes for CD4 T cell generation. Therefore, we created mice in which MHC class II is expressed only on T lineage cells. 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Kim, Moon-Gyo ; Gourley, Tania S. ; McCarthy, Brian P. ; Sant’Angelo, Derek B. ; Chang, Cheong-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-61e5752c512209b90637028e3654a4bd3df5544390388304664e7e9066c2219e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antigens, Differentiation, T-Lymphocyte - immunology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>Cell growth</topic><topic>Cell Proliferation</topic><topic>Epithelial Cells - immunology</topic><topic>Genes, MHC Class II - immunology</topic><topic>Humans</topic><topic>Ligands</topic><topic>Lymphocytes</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Peptides</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Signal Transduction - immunology</topic><topic>Spleen</topic><topic>T cell receptors</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - immunology</topic><topic>Transgenic animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Kim, Moon-Gyo</creatorcontrib><creatorcontrib>Gourley, Tania S.</creatorcontrib><creatorcontrib>McCarthy, Brian P.</creatorcontrib><creatorcontrib>Sant’Angelo, Derek B.</creatorcontrib><creatorcontrib>Chang, Cheong-Hee</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Wei</au><au>Kim, Moon-Gyo</au><au>Gourley, Tania S.</au><au>McCarthy, Brian P.</au><au>Sant’Angelo, Derek B.</au><au>Chang, Cheong-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>23</volume><issue>4</issue><spage>375</spage><epage>386</epage><pages>375-386</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Conventional understanding of CD4 T cell development is that the MHC class II molecules on cortical thymic epithelial cell are necessary for positive selection, as demonstrated in mouse models. 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| ispartof | Immunity (Cambridge, Mass.), 2005-10, Vol.23 (4), p.375-386 |
| issn | 1074-7613 1097-4180 |
| language | eng |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Animals Antigens, Differentiation, T-Lymphocyte - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell growth Cell Proliferation Epithelial Cells - immunology Genes, MHC Class II - immunology Humans Ligands Lymphocytes Mice Mice, Transgenic Peptides Receptors, Antigen, T-Cell - immunology Signal Transduction - immunology Spleen T cell receptors T-Lymphocyte Subsets - immunology Thymus Gland - cytology Thymus Gland - immunology Transgenic animals |
| title | An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population |
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