Brazilian phytopharmaceuticals - evaluation against hospital bacteria

Pharmaceutical companies have demonstrated renewed interest in investigating higher plants as sources for new lead structures and also for the development of standardized phytotherapeutic agents of proven efficacy, safety and quality. This work analysed three commercial phytopharmaceuticals against...

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Bibliographic Details
Published in:Phytotherapy research 2005-06, Vol.19 (6), p.519-525
Main Authors: Machado, T. de B, Leal, I.C.R, Kuster, R.M, Amaral, A.C.F, Kokis, V, Silva, M.G. de, Santos, K.R.N. dos
Format: Article
Language:English
Subjects:
2-oxopopulifolic acid
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antibiotic multi-resistance
Aristolochia
Biological and medical sciences
Brazil
Cross Infection - microbiology
Cross Infection - prevention & control
General pharmacology
Humans
isoliquiritigenin
Medical sciences
Medicine, Traditional
Methicillin Resistance
Microbial Sensitivity Tests
Myroxylon
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytopharmaceuticals
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus spp
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Summary:Pharmaceutical companies have demonstrated renewed interest in investigating higher plants as sources for new lead structures and also for the development of standardized phytotherapeutic agents of proven efficacy, safety and quality. This work analysed three commercial phytopharmaceuticals against multi‐resistant bacteria of medical importance, including methicillin‐resistant Staphylococcus aureus isolates from the Brazilian endemic clone. From the phytopharmaceuticals assayed, plants from the products ‘Astmoflora®’ and ‘Kókolos®’ were considered active, while plants from ‘Uva do Mato®’ were not active in the tested concentrations, which ranged from 62.5 to 500 µg/mL. Among fractions of Aristolochia cymbifera and Myroxylon balsamum, the hexane extracts showed the best results against Staphylococcus spp. and Pseudomonas aeruginosa. These fractions showed growth inhibition of all methicillin‐sensitive and ‐resistant Staphylococcus aureus strains and the majority of the Pseudomonas aeruginosa strains at a concentration of 500 µg/mL. Bioassay‐guided fractionation of hexane extracts of Aristolochia cymbifera and Myroxylon balsamum led to the identification of the diterpene 2‐oxo‐populifolic acid and of the chalcone isoliquiritigenin, respectively, as antimicrobial compounds. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1696