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Circulating Endothelial Progenitor Cells After Kidney Transplantation
Circulating endothelial progenitor cells (EPCs) promote vascular repair and maintain integrity of the endothelial monolayer. Reduced EPCs number has been associated with endothelial dysfunction in various cardiovascular diseases. Cardiovascular disease risk is higher in renal transplant patients (RT...
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| Published in: | American journal of transplantation 2005-09, Vol.5 (9), p.2154-2159 |
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| container_end_page | 2159 |
| container_issue | 9 |
| container_start_page | 2154 |
| container_title | American journal of transplantation |
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| creator | Soler, María José Martínez‐Estrada, Ofelia María Puig‐Marí, Josep Maria Marco‐Feliu, Didac Oliveras, Anna Vila, Joan Mir, Marisa Orfila, Antonia Vilaró, Senén Lloveras, Josep |
| description | Circulating endothelial progenitor cells (EPCs) promote vascular repair and maintain integrity of the endothelial monolayer. Reduced EPCs number has been associated with endothelial dysfunction in various cardiovascular diseases. Cardiovascular disease risk is higher in renal transplant patients (RT) than the general population. We studied EPCs number and proliferation in RT, and examined the association with other cardiovascular risk factors such as reduced glomerular filtration rate (GFR) and LDL cholesterol. EPCs concentration was determined in 94 RT and 39 control subjects (C) by flow cytometry. EPCs proliferation was also studied after 7 days in culture. EPCs concentration was significantly reduced in RT versus C (median 33.5 [5–177] vs. 53 [9–257] EPCs/105 PMN cells, p = 0.006). EPCs proliferation was also reduced in RT versus C (mean ± SD; 372.7 ± 229.3 vs. 539.8 ± 291.3 EPCs × field, p = 0.003). In multiple regression analysis, GFR, HDL, LDL and body weight were independent predictors of EPCs concentration in RT (r2= 0.25, p < 0.001). EPCs number is reduced in RT, particularly in patients with reduced GFR. Moreover, EPCs from RT studied in vitro, showed reduced proliferation, which is a sign of functional impairment. These alterations may be involved in increased cardiovascular risk of RT. |
| doi_str_mv | 10.1111/j.1600-6143.2005.01010.x |
| format | article |
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Reduced EPCs number has been associated with endothelial dysfunction in various cardiovascular diseases. Cardiovascular disease risk is higher in renal transplant patients (RT) than the general population. We studied EPCs number and proliferation in RT, and examined the association with other cardiovascular risk factors such as reduced glomerular filtration rate (GFR) and LDL cholesterol. EPCs concentration was determined in 94 RT and 39 control subjects (C) by flow cytometry. EPCs proliferation was also studied after 7 days in culture. EPCs concentration was significantly reduced in RT versus C (median 33.5 [5–177] vs. 53 [9–257] EPCs/105 PMN cells, p = 0.006). EPCs proliferation was also reduced in RT versus C (mean ± SD; 372.7 ± 229.3 vs. 539.8 ± 291.3 EPCs × field, p = 0.003). In multiple regression analysis, GFR, HDL, LDL and body weight were independent predictors of EPCs concentration in RT (r2= 0.25, p < 0.001). EPCs number is reduced in RT, particularly in patients with reduced GFR. Moreover, EPCs from RT studied in vitro, showed reduced proliferation, which is a sign of functional impairment. These alterations may be involved in increased cardiovascular risk of RT.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2005.01010.x</identifier><identifier>PMID: 16095494</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>AC133 Antigen ; Adult ; Antigens, CD - biosynthesis ; Antigens, CD34 - biosynthesis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Weight ; Cardiology. Vascular system ; Cardiovascular Diseases - pathology ; Cardiovascular risk ; Cardiovascular System - pathology ; Cell Proliferation ; Endothelial Cells - cytology ; endothelial progenitor cells ; Female ; Flow Cytometry ; Glomerular Filtration Rate ; Glycoproteins - biosynthesis ; Humans ; Immunosuppressive Agents - pharmacology ; Immunosuppressive Agents - therapeutic use ; Kidney Failure, Chronic ; Kidney Transplantation ; Leukocyte Common Antigens - biosynthesis ; Linear Models ; Lipoproteins, HDL - metabolism ; Lipoproteins, LDL - metabolism ; Male ; Medical sciences ; Middle Aged ; Neutrophils - metabolism ; Peptides ; Regression Analysis ; Sex Factors ; Stem Cells - cytology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Time Factors</subject><ispartof>American journal of transplantation, 2005-09, Vol.5 (9), p.2154-2159</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4470-cf9a40e9a121450fc99d1ebbcb617623f42f4a06c1bdd1d46bbc1564aa54ecbc3</citedby><cites>FETCH-LOGICAL-c4470-cf9a40e9a121450fc99d1ebbcb617623f42f4a06c1bdd1d46bbc1564aa54ecbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2005.01010.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2005.01010.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17029445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16095494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soler, María José</creatorcontrib><creatorcontrib>Martínez‐Estrada, Ofelia María</creatorcontrib><creatorcontrib>Puig‐Marí, Josep Maria</creatorcontrib><creatorcontrib>Marco‐Feliu, Didac</creatorcontrib><creatorcontrib>Oliveras, Anna</creatorcontrib><creatorcontrib>Vila, Joan</creatorcontrib><creatorcontrib>Mir, Marisa</creatorcontrib><creatorcontrib>Orfila, Antonia</creatorcontrib><creatorcontrib>Vilaró, Senén</creatorcontrib><creatorcontrib>Lloveras, Josep</creatorcontrib><title>Circulating Endothelial Progenitor Cells After Kidney Transplantation</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Circulating endothelial progenitor cells (EPCs) promote vascular repair and maintain integrity of the endothelial monolayer. Reduced EPCs number has been associated with endothelial dysfunction in various cardiovascular diseases. Cardiovascular disease risk is higher in renal transplant patients (RT) than the general population. We studied EPCs number and proliferation in RT, and examined the association with other cardiovascular risk factors such as reduced glomerular filtration rate (GFR) and LDL cholesterol. EPCs concentration was determined in 94 RT and 39 control subjects (C) by flow cytometry. EPCs proliferation was also studied after 7 days in culture. EPCs concentration was significantly reduced in RT versus C (median 33.5 [5–177] vs. 53 [9–257] EPCs/105 PMN cells, p = 0.006). EPCs proliferation was also reduced in RT versus C (mean ± SD; 372.7 ± 229.3 vs. 539.8 ± 291.3 EPCs × field, p = 0.003). In multiple regression analysis, GFR, HDL, LDL and body weight were independent predictors of EPCs concentration in RT (r2= 0.25, p < 0.001). EPCs number is reduced in RT, particularly in patients with reduced GFR. Moreover, EPCs from RT studied in vitro, showed reduced proliferation, which is a sign of functional impairment. These alterations may be involved in increased cardiovascular risk of RT.</description><subject>AC133 Antigen</subject><subject>Adult</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD34 - biosynthesis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Body Weight</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Cardiovascular risk</subject><subject>Cardiovascular System - pathology</subject><subject>Cell Proliferation</subject><subject>Endothelial Cells - cytology</subject><subject>endothelial progenitor cells</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Glomerular Filtration Rate</subject><subject>Glycoproteins - biosynthesis</subject><subject>Humans</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Kidney Failure, Chronic</subject><subject>Kidney Transplantation</subject><subject>Leukocyte Common Antigens - biosynthesis</subject><subject>Linear Models</subject><subject>Lipoproteins, HDL - metabolism</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophils - metabolism</subject><subject>Peptides</subject><subject>Regression Analysis</subject><subject>Sex Factors</subject><subject>Stem Cells - cytology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Time Factors</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkE9PwyAYh4nRuDn9CqYXvbVCS-k4eFia-XeJHuaZUAqThdEJbdy-vdQ18yoceJPf8_K-eQCIEExQOHfrBBEIY4JwlqQQ5glE4Sa7EzA-BqfHOstH4ML7NYSoSKfpORiFgOaY4jGYl9qJzvBW21U0t3XTfkqjuYneXbOSVreNi0ppjI9mqpUuetW1lfto6bj1W8NtGzobewnOFDdeXg3vBHw8zJflU7x4e3wuZ4tYYFzAWCjKMZSUoxThHCpBaY1kVYmKoIKkmcKpwhwSgaq6RjUmIUI5wZznWIpKZBNwe_h365qvTvqWbbQXYT1uZdN5RqZhDKEwgNMDKFzjvZOKbZ3ecLdnCLJeIVuz3g7rTbFeIftVyHah9XqY0VUbWf81Ds4CcDMA3AtuVFAhtP_jCphSjPPA3R-4b23k_t8LsNnLsq-yHyiijNM</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Soler, María José</creator><creator>Martínez‐Estrada, Ofelia María</creator><creator>Puig‐Marí, Josep Maria</creator><creator>Marco‐Feliu, Didac</creator><creator>Oliveras, Anna</creator><creator>Vila, Joan</creator><creator>Mir, Marisa</creator><creator>Orfila, Antonia</creator><creator>Vilaró, Senén</creator><creator>Lloveras, Josep</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Circulating Endothelial Progenitor Cells After Kidney Transplantation</title><author>Soler, María José ; Martínez‐Estrada, Ofelia María ; Puig‐Marí, Josep Maria ; Marco‐Feliu, Didac ; Oliveras, Anna ; Vila, Joan ; Mir, Marisa ; Orfila, Antonia ; Vilaró, Senén ; Lloveras, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4470-cf9a40e9a121450fc99d1ebbcb617623f42f4a06c1bdd1d46bbc1564aa54ecbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>AC133 Antigen</topic><topic>Adult</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD34 - biosynthesis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Body Weight</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Cardiovascular risk</topic><topic>Cardiovascular System - pathology</topic><topic>Cell Proliferation</topic><topic>Endothelial Cells - cytology</topic><topic>endothelial progenitor cells</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Glomerular Filtration Rate</topic><topic>Glycoproteins - biosynthesis</topic><topic>Humans</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Kidney Failure, Chronic</topic><topic>Kidney Transplantation</topic><topic>Leukocyte Common Antigens - biosynthesis</topic><topic>Linear Models</topic><topic>Lipoproteins, HDL - metabolism</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophils - metabolism</topic><topic>Peptides</topic><topic>Regression Analysis</topic><topic>Sex Factors</topic><topic>Stem Cells - cytology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soler, María José</creatorcontrib><creatorcontrib>Martínez‐Estrada, Ofelia María</creatorcontrib><creatorcontrib>Puig‐Marí, Josep Maria</creatorcontrib><creatorcontrib>Marco‐Feliu, Didac</creatorcontrib><creatorcontrib>Oliveras, Anna</creatorcontrib><creatorcontrib>Vila, Joan</creatorcontrib><creatorcontrib>Mir, Marisa</creatorcontrib><creatorcontrib>Orfila, Antonia</creatorcontrib><creatorcontrib>Vilaró, Senén</creatorcontrib><creatorcontrib>Lloveras, Josep</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soler, María José</au><au>Martínez‐Estrada, Ofelia María</au><au>Puig‐Marí, Josep Maria</au><au>Marco‐Feliu, Didac</au><au>Oliveras, Anna</au><au>Vila, Joan</au><au>Mir, Marisa</au><au>Orfila, Antonia</au><au>Vilaró, Senén</au><au>Lloveras, Josep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Endothelial Progenitor Cells After Kidney Transplantation</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2005-09</date><risdate>2005</risdate><volume>5</volume><issue>9</issue><spage>2154</spage><epage>2159</epage><pages>2154-2159</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Circulating endothelial progenitor cells (EPCs) promote vascular repair and maintain integrity of the endothelial monolayer. Reduced EPCs number has been associated with endothelial dysfunction in various cardiovascular diseases. Cardiovascular disease risk is higher in renal transplant patients (RT) than the general population. We studied EPCs number and proliferation in RT, and examined the association with other cardiovascular risk factors such as reduced glomerular filtration rate (GFR) and LDL cholesterol. EPCs concentration was determined in 94 RT and 39 control subjects (C) by flow cytometry. EPCs proliferation was also studied after 7 days in culture. EPCs concentration was significantly reduced in RT versus C (median 33.5 [5–177] vs. 53 [9–257] EPCs/105 PMN cells, p = 0.006). EPCs proliferation was also reduced in RT versus C (mean ± SD; 372.7 ± 229.3 vs. 539.8 ± 291.3 EPCs × field, p = 0.003). In multiple regression analysis, GFR, HDL, LDL and body weight were independent predictors of EPCs concentration in RT (r2= 0.25, p < 0.001). EPCs number is reduced in RT, particularly in patients with reduced GFR. Moreover, EPCs from RT studied in vitro, showed reduced proliferation, which is a sign of functional impairment. These alterations may be involved in increased cardiovascular risk of RT.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>16095494</pmid><doi>10.1111/j.1600-6143.2005.01010.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of transplantation, 2005-09, Vol.5 (9), p.2154-2159 |
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| subjects | AC133 Antigen Adult Antigens, CD - biosynthesis Antigens, CD34 - biosynthesis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Body Weight Cardiology. Vascular system Cardiovascular Diseases - pathology Cardiovascular risk Cardiovascular System - pathology Cell Proliferation Endothelial Cells - cytology endothelial progenitor cells Female Flow Cytometry Glomerular Filtration Rate Glycoproteins - biosynthesis Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Kidney Failure, Chronic Kidney Transplantation Leukocyte Common Antigens - biosynthesis Linear Models Lipoproteins, HDL - metabolism Lipoproteins, LDL - metabolism Male Medical sciences Middle Aged Neutrophils - metabolism Peptides Regression Analysis Sex Factors Stem Cells - cytology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Time Factors |
| title | Circulating Endothelial Progenitor Cells After Kidney Transplantation |
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