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Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer
Individual classes of human endogenous retrovirus (HERV) genes and proteins are expressed in cancer, but expression of more than one type of HERV is rare. We report here the expression of multiple HERV genes and proteins in ovarian cell lines and tissues. Expression of HERV‐K env mRNA was greater in...
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| Published in: | International journal of cancer 2007-01, Vol.120 (1), p.81-90 |
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| container_title | International journal of cancer |
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| creator | Wang‐Johanning, Feng Liu, Jinsong Rycaj, Kiera Huang, Miao Tsai, Kate Rosen, Daniel G. Chen, Dung‐Tsa Lu, Danielle W. Barnhart, Kirstin F. Johanning, Gary L. |
| description | Individual classes of human endogenous retrovirus (HERV) genes and proteins are expressed in cancer, but expression of more than one type of HERV is rare. We report here the expression of multiple HERV genes and proteins in ovarian cell lines and tissues. Expression of HERV‐K env mRNA was greater in ovarian epithelial tumors than in normal ovarian tissues (N = 254). The expression of this protein on the surface and in the cytoplasm of ovarian cancer cells was confirmed using anti‐HERV‐K specific antibody by flow cytometric analysis. The frequency of expression of HERV‐K env protein in multitissue microarrays (N = 641) was determined by immunohistochemistry and a significant correlation with tumor histotype was found. A significantly increased expression of HERV‐K was observed in tumors with low malignant potential and low grade, relative to expression in normal ovarian tissues. The increase in expression of HERV‐K env protein took place in a stepwise fashion in serous papillary adenocarcinoma. Interestingly, we found that other classes of HERV env mRNAs, including ERV3 and HERV‐E, are expressed in the same ovarian cancer tissues that expressed HERV‐K. Furthermore, anti‐HERV antibodies including anti‐ERV3 (30%), anti‐HERV‐E (40%) and anti‐HERV‐K (55%) were detected in patients with ovarian cancer, but not in normal female controls. HERV env proteins are frequently transcribed and translated in ovarian epithelial tumors, and multiple HERV families are detectable in ovarian cancer. HERV env proteins, and especially those expressed on the cell surface, may serve as novel tumor targets for detection, diagnosis and immunotherapy of ovarian cancer. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.22256 |
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We report here the expression of multiple HERV genes and proteins in ovarian cell lines and tissues. Expression of HERV‐K env mRNA was greater in ovarian epithelial tumors than in normal ovarian tissues (N = 254). The expression of this protein on the surface and in the cytoplasm of ovarian cancer cells was confirmed using anti‐HERV‐K specific antibody by flow cytometric analysis. The frequency of expression of HERV‐K env protein in multitissue microarrays (N = 641) was determined by immunohistochemistry and a significant correlation with tumor histotype was found. A significantly increased expression of HERV‐K was observed in tumors with low malignant potential and low grade, relative to expression in normal ovarian tissues. The increase in expression of HERV‐K env protein took place in a stepwise fashion in serous papillary adenocarcinoma. Interestingly, we found that other classes of HERV env mRNAs, including ERV3 and HERV‐E, are expressed in the same ovarian cancer tissues that expressed HERV‐K. Furthermore, anti‐HERV antibodies including anti‐ERV3 (30%), anti‐HERV‐E (40%) and anti‐HERV‐K (55%) were detected in patients with ovarian cancer, but not in normal female controls. HERV env proteins are frequently transcribed and translated in ovarian epithelial tumors, and multiple HERV families are detectable in ovarian cancer. HERV env proteins, and especially those expressed on the cell surface, may serve as novel tumor targets for detection, diagnosis and immunotherapy of ovarian cancer. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.22256</identifier><identifier>PMID: 17013901</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma, Clear Cell - metabolism ; Adenocarcinoma, Clear Cell - virology ; Adenocarcinoma, Mucinous - metabolism ; Adenocarcinoma, Mucinous - virology ; Adult ; Aged ; Aged, 80 and over ; Amino Acid Sequence ; anti‐HERV antibodies ; Base Sequence ; Biological and medical sciences ; Carcinoma, Endometrioid - metabolism ; Carcinoma, Endometrioid - virology ; Case-Control Studies ; Cystadenocarcinoma, Serous - metabolism ; Cystadenocarcinoma, Serous - virology ; Endogenous Retroviruses - genetics ; Endogenous Retroviruses - immunology ; Endogenous Retroviruses - metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Female genital diseases ; Flow Cytometry ; Fluorescent Antibody Technique ; Gene Products, env - genetics ; Gene Products, env - metabolism ; Gene Products, env - physiology ; Gynecology. Andrology. Obstetrics ; Human endogenous retrovirus ; human endogenous retroviruses ; Humans ; Immunoenzyme Techniques ; Medical sciences ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Middle Aged ; Molecular Sequence Data ; ovarian cancer ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - virology ; Ovary - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; surface envelope proteins ; Tissue Array Analysis ; Tumor Cells, Cultured ; tumor targets ; Tumors</subject><ispartof>International journal of cancer, 2007-01, Vol.120 (1), p.81-90</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4856-a9f1f16d75d49c6b19b92e9aa32c539f3daccb929906bda15a65421ea47de38c3</citedby><cites>FETCH-LOGICAL-c4856-a9f1f16d75d49c6b19b92e9aa32c539f3daccb929906bda15a65421ea47de38c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.22256$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.22256$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18361052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17013901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang‐Johanning, Feng</creatorcontrib><creatorcontrib>Liu, Jinsong</creatorcontrib><creatorcontrib>Rycaj, Kiera</creatorcontrib><creatorcontrib>Huang, Miao</creatorcontrib><creatorcontrib>Tsai, Kate</creatorcontrib><creatorcontrib>Rosen, Daniel G.</creatorcontrib><creatorcontrib>Chen, Dung‐Tsa</creatorcontrib><creatorcontrib>Lu, Danielle W.</creatorcontrib><creatorcontrib>Barnhart, Kirstin F.</creatorcontrib><creatorcontrib>Johanning, Gary L.</creatorcontrib><title>Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Individual classes of human endogenous retrovirus (HERV) genes and proteins are expressed in cancer, but expression of more than one type of HERV is rare. We report here the expression of multiple HERV genes and proteins in ovarian cell lines and tissues. Expression of HERV‐K env mRNA was greater in ovarian epithelial tumors than in normal ovarian tissues (N = 254). The expression of this protein on the surface and in the cytoplasm of ovarian cancer cells was confirmed using anti‐HERV‐K specific antibody by flow cytometric analysis. The frequency of expression of HERV‐K env protein in multitissue microarrays (N = 641) was determined by immunohistochemistry and a significant correlation with tumor histotype was found. A significantly increased expression of HERV‐K was observed in tumors with low malignant potential and low grade, relative to expression in normal ovarian tissues. The increase in expression of HERV‐K env protein took place in a stepwise fashion in serous papillary adenocarcinoma. Interestingly, we found that other classes of HERV env mRNAs, including ERV3 and HERV‐E, are expressed in the same ovarian cancer tissues that expressed HERV‐K. Furthermore, anti‐HERV antibodies including anti‐ERV3 (30%), anti‐HERV‐E (40%) and anti‐HERV‐K (55%) were detected in patients with ovarian cancer, but not in normal female controls. HERV env proteins are frequently transcribed and translated in ovarian epithelial tumors, and multiple HERV families are detectable in ovarian cancer. HERV env proteins, and especially those expressed on the cell surface, may serve as novel tumor targets for detection, diagnosis and immunotherapy of ovarian cancer. © 2006 Wiley‐Liss, Inc.</description><subject>Adenocarcinoma, Clear Cell - metabolism</subject><subject>Adenocarcinoma, Clear Cell - virology</subject><subject>Adenocarcinoma, Mucinous - metabolism</subject><subject>Adenocarcinoma, Mucinous - virology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acid Sequence</subject><subject>anti‐HERV antibodies</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Endometrioid - metabolism</subject><subject>Carcinoma, Endometrioid - virology</subject><subject>Case-Control Studies</subject><subject>Cystadenocarcinoma, Serous - metabolism</subject><subject>Cystadenocarcinoma, Serous - virology</subject><subject>Endogenous Retroviruses - genetics</subject><subject>Endogenous Retroviruses - immunology</subject><subject>Endogenous Retroviruses - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Flow Cytometry</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene Products, env - genetics</subject><subject>Gene Products, env - metabolism</subject><subject>Gene Products, env - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human endogenous retrovirus</subject><subject>human endogenous retroviruses</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Medical sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>ovarian cancer</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - virology</subject><subject>Ovary - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>surface envelope proteins</subject><subject>Tissue Array Analysis</subject><subject>Tumor Cells, Cultured</subject><subject>tumor targets</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKxDAUhoMoznhZ-ALSjYKLak7SpM1ShvGG4Ea3ljQ91Qy9mbSjvr3RDrgSVwk5X_7_8BFyBPQcKGUXdmXOGWNCbpE5UJXGlIHYJvMwo3EKXM7InvcrSgEETXbJDFIKXFGYk-flR-_Qe9u1UVdFzVgPtq8xeh0b3UbYlt0Ltt3oI4eD69bWhasfXaUNhuka667HqHfdgLb1kQ0ha-1s-Gp0a9AdkJ1K1x4PN-c-ebpaPi5u4vuH69vF5X1skkzIWKsKKpBlKspEGVmAKhRDpTVnRnBV8VIbE56UorIoNQgtRcIAdZKWyDPD98nplBtWeRvRD3ljvcG61i2G7XOZcaGyVP0LMioSSCUL4NkEGtd577DKe2cb7T5zoPm39TxYz3-sB_Z4EzoWDZa_5EZzAE42gPZG15ULcqz_5TIugYrv0ouJe7c1fv7dmN_eLabqL-DLmkc</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Wang‐Johanning, Feng</creator><creator>Liu, Jinsong</creator><creator>Rycaj, Kiera</creator><creator>Huang, Miao</creator><creator>Tsai, Kate</creator><creator>Rosen, Daniel G.</creator><creator>Chen, Dung‐Tsa</creator><creator>Lu, Danielle W.</creator><creator>Barnhart, Kirstin F.</creator><creator>Johanning, Gary L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer</title><author>Wang‐Johanning, Feng ; Liu, Jinsong ; Rycaj, Kiera ; Huang, Miao ; Tsai, Kate ; Rosen, Daniel G. ; Chen, Dung‐Tsa ; Lu, Danielle W. ; Barnhart, Kirstin F. ; Johanning, Gary L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4856-a9f1f16d75d49c6b19b92e9aa32c539f3daccb929906bda15a65421ea47de38c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma, Clear Cell - metabolism</topic><topic>Adenocarcinoma, Clear Cell - virology</topic><topic>Adenocarcinoma, Mucinous - metabolism</topic><topic>Adenocarcinoma, Mucinous - virology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino Acid Sequence</topic><topic>anti‐HERV antibodies</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Endometrioid - metabolism</topic><topic>Carcinoma, Endometrioid - virology</topic><topic>Case-Control Studies</topic><topic>Cystadenocarcinoma, Serous - metabolism</topic><topic>Cystadenocarcinoma, Serous - virology</topic><topic>Endogenous Retroviruses - genetics</topic><topic>Endogenous Retroviruses - immunology</topic><topic>Endogenous Retroviruses - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Flow Cytometry</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene Products, env - genetics</topic><topic>Gene Products, env - metabolism</topic><topic>Gene Products, env - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human endogenous retrovirus</topic><topic>human endogenous retroviruses</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Medical sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>ovarian cancer</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - virology</topic><topic>Ovary - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>surface envelope proteins</topic><topic>Tissue Array Analysis</topic><topic>Tumor Cells, Cultured</topic><topic>tumor targets</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang‐Johanning, Feng</creatorcontrib><creatorcontrib>Liu, Jinsong</creatorcontrib><creatorcontrib>Rycaj, Kiera</creatorcontrib><creatorcontrib>Huang, Miao</creatorcontrib><creatorcontrib>Tsai, Kate</creatorcontrib><creatorcontrib>Rosen, Daniel G.</creatorcontrib><creatorcontrib>Chen, Dung‐Tsa</creatorcontrib><creatorcontrib>Lu, Danielle W.</creatorcontrib><creatorcontrib>Barnhart, Kirstin F.</creatorcontrib><creatorcontrib>Johanning, Gary L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang‐Johanning, Feng</au><au>Liu, Jinsong</au><au>Rycaj, Kiera</au><au>Huang, Miao</au><au>Tsai, Kate</au><au>Rosen, Daniel G.</au><au>Chen, Dung‐Tsa</au><au>Lu, Danielle W.</au><au>Barnhart, Kirstin F.</au><au>Johanning, Gary L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>120</volume><issue>1</issue><spage>81</spage><epage>90</epage><pages>81-90</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><notes>Fax: +512‐332‐5218.</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Individual classes of human endogenous retrovirus (HERV) genes and proteins are expressed in cancer, but expression of more than one type of HERV is rare. We report here the expression of multiple HERV genes and proteins in ovarian cell lines and tissues. Expression of HERV‐K env mRNA was greater in ovarian epithelial tumors than in normal ovarian tissues (N = 254). The expression of this protein on the surface and in the cytoplasm of ovarian cancer cells was confirmed using anti‐HERV‐K specific antibody by flow cytometric analysis. The frequency of expression of HERV‐K env protein in multitissue microarrays (N = 641) was determined by immunohistochemistry and a significant correlation with tumor histotype was found. A significantly increased expression of HERV‐K was observed in tumors with low malignant potential and low grade, relative to expression in normal ovarian tissues. The increase in expression of HERV‐K env protein took place in a stepwise fashion in serous papillary adenocarcinoma. Interestingly, we found that other classes of HERV env mRNAs, including ERV3 and HERV‐E, are expressed in the same ovarian cancer tissues that expressed HERV‐K. Furthermore, anti‐HERV antibodies including anti‐ERV3 (30%), anti‐HERV‐E (40%) and anti‐HERV‐K (55%) were detected in patients with ovarian cancer, but not in normal female controls. HERV env proteins are frequently transcribed and translated in ovarian epithelial tumors, and multiple HERV families are detectable in ovarian cancer. HERV env proteins, and especially those expressed on the cell surface, may serve as novel tumor targets for detection, diagnosis and immunotherapy of ovarian cancer. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17013901</pmid><doi>10.1002/ijc.22256</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma, Clear Cell - metabolism Adenocarcinoma, Clear Cell - virology Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - virology Adult Aged Aged, 80 and over Amino Acid Sequence anti‐HERV antibodies Base Sequence Biological and medical sciences Carcinoma, Endometrioid - metabolism Carcinoma, Endometrioid - virology Case-Control Studies Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - virology Endogenous Retroviruses - genetics Endogenous Retroviruses - immunology Endogenous Retroviruses - metabolism Enzyme-Linked Immunosorbent Assay Female Female genital diseases Flow Cytometry Fluorescent Antibody Technique Gene Products, env - genetics Gene Products, env - metabolism Gene Products, env - physiology Gynecology. Andrology. Obstetrics Human endogenous retrovirus human endogenous retroviruses Humans Immunoenzyme Techniques Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Molecular Sequence Data ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - virology Ovary - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism surface envelope proteins Tissue Array Analysis Tumor Cells, Cultured tumor targets Tumors |
| title | Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer |
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