Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level

Residence at high altitude modifies thremoregulatory responses to cold stress upon return to lower altitude. These changes are difficult to explain since several stresses related to high altitude may interact, including hypoxia, cold, solar radiation, and physical exertion. We hypothesized that adap...

Full description

Saved in:
Bibliographic Details
Published in:Aviation, space, and environmental medicine space, and environmental medicine, 2006-12, Vol.77 (12), p.1230-1235
Main Authors: Launay, Jean-Claude, Besnard, Yves, Guinet-Lebreton, Angélique, Savourey, Gustave
Format: Article
Language:English
Subjects:
Acclimatization - physiology
Adult
Altitude
Atmosphere Exposure Chambers
Atmospheric Pressure
Body Temperature Regulation - physiology
Cold Temperature
Humans
Hypoxia - physiopathology
Male
Skin Temperature - physiology
Space life sciences
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 1235
container_issue 12
container_start_page 1230
container_title Aviation, space, and environmental medicine
container_volume 77
creator Launay, Jean-Claude
Besnard, Yves
Guinet-Lebreton, Angélique
Savourey, Gustave
description Residence at high altitude modifies thremoregulatory responses to cold stress upon return to lower altitude. These changes are difficult to explain since several stresses related to high altitude may interact, including hypoxia, cold, solar radiation, and physical exertion. We hypothesized that adaptation to hypoxia without cold exposure would produce at least part of the observed changes. Five men underwent acclimation to intermittent hypoxia (AIH) in a hypobaric chamber (8 h daily for 4 d, and 6 h on the last day, 4500 to 6000 m) at 24 degrees C. Cold stress responses were tested during a whole-body standard cold air test (1 degrees C, 2 h at rest at sea level) both before and after AIH. Increased reticulocyte counts and percentages confirmed acclimation to hypoxia after AIH. Changes in thermoregulation during the cold test included lower mean skin temperature after 60-80 min (18.8 +/- 0.7 degrees C vs. 19.4 +/- 0.7 degrees C); higher mean metabolic heat production (127 +/- 8 W x m(-2) vs. 118 +/- 6 W x m(-2)); and lower heat debt (7.7 +/- 1.3 kJ x kg(-1) vs. 10.3 +/- 1.2 kJ x kg(-1)), without significant change in rectal temperature. Time to onset for continuous shivering decreased after AIH (12 +/- 5 min vs. 21 +/- 6.3 min), and shivering activity occurred at higher mean skin but not rectal temperatures. AIH in comfortable ambient temperature leads to a normothermic-insulative-metabolic general cold adaptation. We conclude that AIH modifies the thermoregulatory responses to cold at sea level without cold exposure leading to a cross-adaptation.
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68264976</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68264976</sourcerecordid><originalsourceid>FETCH-LOGICAL-p209t-cd2eba5184afdd84d1d403f0a519453506bc39b282df9d097d2e9125f4f53eb43</originalsourceid><addsrcrecordid>eNo1kE1LxDAQhoMo7rr6FyQnb4V8tslxWfyCBS_uuaTJBCNpU5tU3H9v0d3T-_DyzMDMBVpTLXglhFCXaE2IllUta7ZCNzl_EkK4YOQarWhDFddUrdFha20MvSkhDbgkHIYCUx9KgaHgj-OYOjMF-0c_weA-ueADZDxBHtOQF1qGbIoOm4IzGBzhG-ItuvImZrg75QYdnh7fdy_V_u35dbfdVyMjulTWMeiMpEoY75wSjjpBuCdLpYXkktSd5bpjijmvHdHN4mvKpBdecugE36CH_73jlL5myKXtQ7YQoxkgzbmtFauFbupFvD-Jc9eDa8dpuXk6tudH8F_ZmVwU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68264976</pqid></control><display><type>article</type><title>Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level</title><source>IngentaConnect Journals</source><creator>Launay, Jean-Claude ; Besnard, Yves ; Guinet-Lebreton, Angélique ; Savourey, Gustave</creator><creatorcontrib>Launay, Jean-Claude ; Besnard, Yves ; Guinet-Lebreton, Angélique ; Savourey, Gustave</creatorcontrib><description>Residence at high altitude modifies thremoregulatory responses to cold stress upon return to lower altitude. These changes are difficult to explain since several stresses related to high altitude may interact, including hypoxia, cold, solar radiation, and physical exertion. We hypothesized that adaptation to hypoxia without cold exposure would produce at least part of the observed changes. Five men underwent acclimation to intermittent hypoxia (AIH) in a hypobaric chamber (8 h daily for 4 d, and 6 h on the last day, 4500 to 6000 m) at 24 degrees C. Cold stress responses were tested during a whole-body standard cold air test (1 degrees C, 2 h at rest at sea level) both before and after AIH. Increased reticulocyte counts and percentages confirmed acclimation to hypoxia after AIH. Changes in thermoregulation during the cold test included lower mean skin temperature after 60-80 min (18.8 +/- 0.7 degrees C vs. 19.4 +/- 0.7 degrees C); higher mean metabolic heat production (127 +/- 8 W x m(-2) vs. 118 +/- 6 W x m(-2)); and lower heat debt (7.7 +/- 1.3 kJ x kg(-1) vs. 10.3 +/- 1.2 kJ x kg(-1)), without significant change in rectal temperature. Time to onset for continuous shivering decreased after AIH (12 +/- 5 min vs. 21 +/- 6.3 min), and shivering activity occurred at higher mean skin but not rectal temperatures. AIH in comfortable ambient temperature leads to a normothermic-insulative-metabolic general cold adaptation. We conclude that AIH modifies the thermoregulatory responses to cold at sea level without cold exposure leading to a cross-adaptation.</description><identifier>ISSN: 0095-6562</identifier><identifier>EISSN: 1943-4448</identifier><identifier>PMID: 17183918</identifier><language>eng</language><publisher>United States</publisher><subject>Acclimatization - physiology ; Adult ; Altitude ; Atmosphere Exposure Chambers ; Atmospheric Pressure ; Body Temperature Regulation - physiology ; Cold Temperature ; Humans ; Hypoxia - physiopathology ; Male ; Skin Temperature - physiology ; Space life sciences</subject><ispartof>Aviation, space, and environmental medicine, 2006-12, Vol.77 (12), p.1230-1235</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17183918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Launay, Jean-Claude</creatorcontrib><creatorcontrib>Besnard, Yves</creatorcontrib><creatorcontrib>Guinet-Lebreton, Angélique</creatorcontrib><creatorcontrib>Savourey, Gustave</creatorcontrib><title>Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level</title><title>Aviation, space, and environmental medicine</title><addtitle>Aviat Space Environ Med</addtitle><description>Residence at high altitude modifies thremoregulatory responses to cold stress upon return to lower altitude. These changes are difficult to explain since several stresses related to high altitude may interact, including hypoxia, cold, solar radiation, and physical exertion. We hypothesized that adaptation to hypoxia without cold exposure would produce at least part of the observed changes. Five men underwent acclimation to intermittent hypoxia (AIH) in a hypobaric chamber (8 h daily for 4 d, and 6 h on the last day, 4500 to 6000 m) at 24 degrees C. Cold stress responses were tested during a whole-body standard cold air test (1 degrees C, 2 h at rest at sea level) both before and after AIH. Increased reticulocyte counts and percentages confirmed acclimation to hypoxia after AIH. Changes in thermoregulation during the cold test included lower mean skin temperature after 60-80 min (18.8 +/- 0.7 degrees C vs. 19.4 +/- 0.7 degrees C); higher mean metabolic heat production (127 +/- 8 W x m(-2) vs. 118 +/- 6 W x m(-2)); and lower heat debt (7.7 +/- 1.3 kJ x kg(-1) vs. 10.3 +/- 1.2 kJ x kg(-1)), without significant change in rectal temperature. Time to onset for continuous shivering decreased after AIH (12 +/- 5 min vs. 21 +/- 6.3 min), and shivering activity occurred at higher mean skin but not rectal temperatures. AIH in comfortable ambient temperature leads to a normothermic-insulative-metabolic general cold adaptation. We conclude that AIH modifies the thermoregulatory responses to cold at sea level without cold exposure leading to a cross-adaptation.</description><subject>Acclimatization - physiology</subject><subject>Adult</subject><subject>Altitude</subject><subject>Atmosphere Exposure Chambers</subject><subject>Atmospheric Pressure</subject><subject>Body Temperature Regulation - physiology</subject><subject>Cold Temperature</subject><subject>Humans</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Skin Temperature - physiology</subject><subject>Space life sciences</subject><issn>0095-6562</issn><issn>1943-4448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNo1kE1LxDAQhoMo7rr6FyQnb4V8tslxWfyCBS_uuaTJBCNpU5tU3H9v0d3T-_DyzMDMBVpTLXglhFCXaE2IllUta7ZCNzl_EkK4YOQarWhDFddUrdFha20MvSkhDbgkHIYCUx9KgaHgj-OYOjMF-0c_weA-ueADZDxBHtOQF1qGbIoOm4IzGBzhG-ItuvImZrg75QYdnh7fdy_V_u35dbfdVyMjulTWMeiMpEoY75wSjjpBuCdLpYXkktSd5bpjijmvHdHN4mvKpBdecugE36CH_73jlL5myKXtQ7YQoxkgzbmtFauFbupFvD-Jc9eDa8dpuXk6tudH8F_ZmVwU</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Launay, Jean-Claude</creator><creator>Besnard, Yves</creator><creator>Guinet-Lebreton, Angélique</creator><creator>Savourey, Gustave</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level</title><author>Launay, Jean-Claude ; Besnard, Yves ; Guinet-Lebreton, Angélique ; Savourey, Gustave</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-cd2eba5184afdd84d1d403f0a519453506bc39b282df9d097d2e9125f4f53eb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acclimatization - physiology</topic><topic>Adult</topic><topic>Altitude</topic><topic>Atmosphere Exposure Chambers</topic><topic>Atmospheric Pressure</topic><topic>Body Temperature Regulation - physiology</topic><topic>Cold Temperature</topic><topic>Humans</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Skin Temperature - physiology</topic><topic>Space life sciences</topic><toplevel>online_resources</toplevel><creatorcontrib>Launay, Jean-Claude</creatorcontrib><creatorcontrib>Besnard, Yves</creatorcontrib><creatorcontrib>Guinet-Lebreton, Angélique</creatorcontrib><creatorcontrib>Savourey, Gustave</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Aviation, space, and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Launay, Jean-Claude</au><au>Besnard, Yves</au><au>Guinet-Lebreton, Angélique</au><au>Savourey, Gustave</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level</atitle><jtitle>Aviation, space, and environmental medicine</jtitle><addtitle>Aviat Space Environ Med</addtitle><date>2006-12</date><risdate>2006</risdate><volume>77</volume><issue>12</issue><spage>1230</spage><epage>1235</epage><pages>1230-1235</pages><issn>0095-6562</issn><eissn>1943-4448</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Residence at high altitude modifies thremoregulatory responses to cold stress upon return to lower altitude. These changes are difficult to explain since several stresses related to high altitude may interact, including hypoxia, cold, solar radiation, and physical exertion. We hypothesized that adaptation to hypoxia without cold exposure would produce at least part of the observed changes. Five men underwent acclimation to intermittent hypoxia (AIH) in a hypobaric chamber (8 h daily for 4 d, and 6 h on the last day, 4500 to 6000 m) at 24 degrees C. Cold stress responses were tested during a whole-body standard cold air test (1 degrees C, 2 h at rest at sea level) both before and after AIH. Increased reticulocyte counts and percentages confirmed acclimation to hypoxia after AIH. Changes in thermoregulation during the cold test included lower mean skin temperature after 60-80 min (18.8 +/- 0.7 degrees C vs. 19.4 +/- 0.7 degrees C); higher mean metabolic heat production (127 +/- 8 W x m(-2) vs. 118 +/- 6 W x m(-2)); and lower heat debt (7.7 +/- 1.3 kJ x kg(-1) vs. 10.3 +/- 1.2 kJ x kg(-1)), without significant change in rectal temperature. Time to onset for continuous shivering decreased after AIH (12 +/- 5 min vs. 21 +/- 6.3 min), and shivering activity occurred at higher mean skin but not rectal temperatures. AIH in comfortable ambient temperature leads to a normothermic-insulative-metabolic general cold adaptation. We conclude that AIH modifies the thermoregulatory responses to cold at sea level without cold exposure leading to a cross-adaptation.</abstract><cop>United States</cop><pmid>17183918</pmid><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0095-6562
ispartof Aviation, space, and environmental medicine, 2006-12, Vol.77 (12), p.1230-1235
issn 0095-6562
1943-4448
language eng
recordid cdi_proquest_miscellaneous_68264976
source IngentaConnect Journals
subjects Acclimatization - physiology
Adult
Altitude
Atmosphere Exposure Chambers
Atmospheric Pressure
Body Temperature Regulation - physiology
Cold Temperature
Humans
Hypoxia - physiopathology
Male
Skin Temperature - physiology
Space life sciences
title Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T20%3A28%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acclimation%20to%20intermittent%20hypobaric%20hypoxia%20modifies%20responses%20to%20cold%20at%20sea%20level&rft.jtitle=Aviation,%20space,%20and%20environmental%20medicine&rft.au=Launay,%20Jean-Claude&rft.date=2006-12&rft.volume=77&rft.issue=12&rft.spage=1230&rft.epage=1235&rft.pages=1230-1235&rft.issn=0095-6562&rft.eissn=1943-4448&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68264976%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p209t-cd2eba5184afdd84d1d403f0a519453506bc39b282df9d097d2e9125f4f53eb43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=68264976&rft_id=info:pmid/17183918&rfr_iscdi=true