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Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles
In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20 wt% poly ( dl-lactic- co-glycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out...
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| Published in: | Biomaterials 2006-10, Vol.27 (28), p.4941-4947 |
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| cites | cdi_FETCH-LOGICAL-c492t-f391c6deed851089616f773c3aedf7044e5c35c5128876d50a0c08091750e9383 |
| container_end_page | 4947 |
| container_issue | 28 |
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| creator | Link, Dennis P. van den Dolder, Juliette Jurgens, Wouter J.F.M. Wolke, Joop G.C. Jansen, John A. |
| description | In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20
wt% poly (
dl-lactic-
co-glycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out test) and morphologically (Scanning Electron Microscopy (SEM) and histology). The results of the push-out test showed that after 2 weeks the shear strength of the implants was 0.44±0.44
MPa (average±sd), which increased to 1.34±1.05
MPa at 4 weeks and finally resulted in 2.60±2.78
MPa at 8 weeks. SEM examination showed a fracture plane at the bone–cement interface at 2 weeks, while the 4- and 8-week specimens created a fracture plane into the CaP/PLGA composites, indicating an increased strength of the bone–cement interface. Histological evaluation revealed that the two weeks implantation period resulted in minimal bone ingrowth, while at 4 weeks of implantation the peripheral PLGA microparticles were degraded and replaced by deposition of newly formed bone. Finally, after 8 weeks of implantation the degradation of the PLGA microparticles was almost completed, which was observed by the bone ingrowth throughout the CaP/PLGA composites.
On basis of our results, we conclude that the shear strength of the bone–cement interface increased over time due to bone ingrowth into the CaP/PLGA composites. Although the bone–cement contact could be optimized with an injectable CaP cement to enhance bone ingrowth, still the mechanical properties of the composites after 8 weeks of implantation are insufficient for load-bearing purposes. |
| doi_str_mv | 10.1016/j.biomaterials.2006.05.022 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68090467</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0142961206004649</els_id><sourcerecordid>19445201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-f391c6deed851089616f773c3aedf7044e5c35c5128876d50a0c08091750e9383</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EapfSv4AsDtwSxo4_Ym5VC22lreAAZ8t1JlqvkjjYSVH_PV7tSnArJ8vyM35n5iHkA4OaAVOf9vVjiKNbMAU35JoDqBpkDZy_IhvW6raSBuRrsgEmeGUU4-fkbc57KHcQ_IycM6WlUUZsiHtAv3NT8G6g-OSG1S0hTjT2NIzz4KYFO1refFhHOu9inncll3occVpomHxMc0zuQP0Oy45-395e0TH4FGeXluAHzO_Im760iZen84L8_Prlx_Vdtf12e399ta28MHyp-sYwrzrErpUM2tK16rVufOOw6zUIgdI30kvG21arToIDDy0YpiWgadrmgnw8_jun-GvFvNgxZI9DGQLjmq0qMAilXwS54Voyo14EmRFCcmAF_HwEy9w5J-ztnMLo0rNlYA_K7N7-q8welFmQtigrxe9PKevjiN3f0pOjAtwcASzbewqYbPYBJ49dSOgX28XwPzl_AANFryc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19445201</pqid></control><display><type>article</type><title>Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles</title><source>ScienceDirect Freedom Collection</source><creator>Link, Dennis P. ; van den Dolder, Juliette ; Jurgens, Wouter J.F.M. ; Wolke, Joop G.C. ; Jansen, John A.</creator><creatorcontrib>Link, Dennis P. ; van den Dolder, Juliette ; Jurgens, Wouter J.F.M. ; Wolke, Joop G.C. ; Jansen, John A.</creatorcontrib><description>In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20
wt% poly (
dl-lactic-
co-glycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out test) and morphologically (Scanning Electron Microscopy (SEM) and histology). The results of the push-out test showed that after 2 weeks the shear strength of the implants was 0.44±0.44
MPa (average±sd), which increased to 1.34±1.05
MPa at 4 weeks and finally resulted in 2.60±2.78
MPa at 8 weeks. SEM examination showed a fracture plane at the bone–cement interface at 2 weeks, while the 4- and 8-week specimens created a fracture plane into the CaP/PLGA composites, indicating an increased strength of the bone–cement interface. Histological evaluation revealed that the two weeks implantation period resulted in minimal bone ingrowth, while at 4 weeks of implantation the peripheral PLGA microparticles were degraded and replaced by deposition of newly formed bone. Finally, after 8 weeks of implantation the degradation of the PLGA microparticles was almost completed, which was observed by the bone ingrowth throughout the CaP/PLGA composites.
On basis of our results, we conclude that the shear strength of the bone–cement interface increased over time due to bone ingrowth into the CaP/PLGA composites. Although the bone–cement contact could be optimized with an injectable CaP cement to enhance bone ingrowth, still the mechanical properties of the composites after 8 weeks of implantation are insufficient for load-bearing purposes.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2006.05.022</identifier><identifier>PMID: 16759694</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Absorbable Implants - standards ; Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - standards ; Bone Cements - chemistry ; Bone Cements - pharmacology ; Bone ingrowth ; Calcium Phosphates - chemistry ; Calcium Phosphates - pharmacology ; Injectable CaP/PLGA cement ; Lactic Acid - chemistry ; Materials Testing ; Mechanical properties ; Microscopy, Electron, Scanning ; Osteogenesis - drug effects ; Particle Size ; Polyglycolic Acid - chemistry ; Polymers - chemistry ; Rats ; Rats, Wistar ; Skull - drug effects ; Skull - pathology ; Skull - ultrastructure ; Stress, Mechanical ; Time Factors</subject><ispartof>Biomaterials, 2006-10, Vol.27 (28), p.4941-4947</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-f391c6deed851089616f773c3aedf7044e5c35c5128876d50a0c08091750e9383</citedby><cites>FETCH-LOGICAL-c492t-f391c6deed851089616f773c3aedf7044e5c35c5128876d50a0c08091750e9383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16759694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Link, Dennis P.</creatorcontrib><creatorcontrib>van den Dolder, Juliette</creatorcontrib><creatorcontrib>Jurgens, Wouter J.F.M.</creatorcontrib><creatorcontrib>Wolke, Joop G.C.</creatorcontrib><creatorcontrib>Jansen, John A.</creatorcontrib><title>Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20
wt% poly (
dl-lactic-
co-glycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out test) and morphologically (Scanning Electron Microscopy (SEM) and histology). The results of the push-out test showed that after 2 weeks the shear strength of the implants was 0.44±0.44
MPa (average±sd), which increased to 1.34±1.05
MPa at 4 weeks and finally resulted in 2.60±2.78
MPa at 8 weeks. SEM examination showed a fracture plane at the bone–cement interface at 2 weeks, while the 4- and 8-week specimens created a fracture plane into the CaP/PLGA composites, indicating an increased strength of the bone–cement interface. Histological evaluation revealed that the two weeks implantation period resulted in minimal bone ingrowth, while at 4 weeks of implantation the peripheral PLGA microparticles were degraded and replaced by deposition of newly formed bone. Finally, after 8 weeks of implantation the degradation of the PLGA microparticles was almost completed, which was observed by the bone ingrowth throughout the CaP/PLGA composites.
On basis of our results, we conclude that the shear strength of the bone–cement interface increased over time due to bone ingrowth into the CaP/PLGA composites. Although the bone–cement contact could be optimized with an injectable CaP cement to enhance bone ingrowth, still the mechanical properties of the composites after 8 weeks of implantation are insufficient for load-bearing purposes.</description><subject>Absorbable Implants - standards</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - standards</subject><subject>Bone Cements - chemistry</subject><subject>Bone Cements - pharmacology</subject><subject>Bone ingrowth</subject><subject>Calcium Phosphates - chemistry</subject><subject>Calcium Phosphates - pharmacology</subject><subject>Injectable CaP/PLGA cement</subject><subject>Lactic Acid - chemistry</subject><subject>Materials Testing</subject><subject>Mechanical properties</subject><subject>Microscopy, Electron, Scanning</subject><subject>Osteogenesis - drug effects</subject><subject>Particle Size</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Polymers - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Skull - drug effects</subject><subject>Skull - pathology</subject><subject>Skull - ultrastructure</subject><subject>Stress, Mechanical</subject><subject>Time Factors</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkU1v1DAQhi0EapfSv4AsDtwSxo4_Ym5VC22lreAAZ8t1JlqvkjjYSVH_PV7tSnArJ8vyM35n5iHkA4OaAVOf9vVjiKNbMAU35JoDqBpkDZy_IhvW6raSBuRrsgEmeGUU4-fkbc57KHcQ_IycM6WlUUZsiHtAv3NT8G6g-OSG1S0hTjT2NIzz4KYFO1refFhHOu9inncll3occVpomHxMc0zuQP0Oy45-395e0TH4FGeXluAHzO_Im760iZen84L8_Prlx_Vdtf12e399ta28MHyp-sYwrzrErpUM2tK16rVufOOw6zUIgdI30kvG21arToIDDy0YpiWgadrmgnw8_jun-GvFvNgxZI9DGQLjmq0qMAilXwS54Voyo14EmRFCcmAF_HwEy9w5J-ztnMLo0rNlYA_K7N7-q8welFmQtigrxe9PKevjiN3f0pOjAtwcASzbewqYbPYBJ49dSOgX28XwPzl_AANFryc</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Link, Dennis P.</creator><creator>van den Dolder, Juliette</creator><creator>Jurgens, Wouter J.F.M.</creator><creator>Wolke, Joop G.C.</creator><creator>Jansen, John A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles</title><author>Link, Dennis P. ; van den Dolder, Juliette ; Jurgens, Wouter J.F.M. ; Wolke, Joop G.C. ; Jansen, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-f391c6deed851089616f773c3aedf7044e5c35c5128876d50a0c08091750e9383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorbable Implants - standards</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - standards</topic><topic>Bone Cements - chemistry</topic><topic>Bone Cements - pharmacology</topic><topic>Bone ingrowth</topic><topic>Calcium Phosphates - chemistry</topic><topic>Calcium Phosphates - pharmacology</topic><topic>Injectable CaP/PLGA cement</topic><topic>Lactic Acid - chemistry</topic><topic>Materials Testing</topic><topic>Mechanical properties</topic><topic>Microscopy, Electron, Scanning</topic><topic>Osteogenesis - drug effects</topic><topic>Particle Size</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Polymers - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Skull - drug effects</topic><topic>Skull - pathology</topic><topic>Skull - ultrastructure</topic><topic>Stress, Mechanical</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Link, Dennis P.</creatorcontrib><creatorcontrib>van den Dolder, Juliette</creatorcontrib><creatorcontrib>Jurgens, Wouter J.F.M.</creatorcontrib><creatorcontrib>Wolke, Joop G.C.</creatorcontrib><creatorcontrib>Jansen, John A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Link, Dennis P.</au><au>van den Dolder, Juliette</au><au>Jurgens, Wouter J.F.M.</au><au>Wolke, Joop G.C.</au><au>Jansen, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>27</volume><issue>28</issue><spage>4941</spage><epage>4947</epage><pages>4941-4947</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20
wt% poly (
dl-lactic-
co-glycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out test) and morphologically (Scanning Electron Microscopy (SEM) and histology). The results of the push-out test showed that after 2 weeks the shear strength of the implants was 0.44±0.44
MPa (average±sd), which increased to 1.34±1.05
MPa at 4 weeks and finally resulted in 2.60±2.78
MPa at 8 weeks. SEM examination showed a fracture plane at the bone–cement interface at 2 weeks, while the 4- and 8-week specimens created a fracture plane into the CaP/PLGA composites, indicating an increased strength of the bone–cement interface. Histological evaluation revealed that the two weeks implantation period resulted in minimal bone ingrowth, while at 4 weeks of implantation the peripheral PLGA microparticles were degraded and replaced by deposition of newly formed bone. Finally, after 8 weeks of implantation the degradation of the PLGA microparticles was almost completed, which was observed by the bone ingrowth throughout the CaP/PLGA composites.
On basis of our results, we conclude that the shear strength of the bone–cement interface increased over time due to bone ingrowth into the CaP/PLGA composites. Although the bone–cement contact could be optimized with an injectable CaP cement to enhance bone ingrowth, still the mechanical properties of the composites after 8 weeks of implantation are insufficient for load-bearing purposes.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>16759694</pmid><doi>10.1016/j.biomaterials.2006.05.022</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2006-10, Vol.27 (28), p.4941-4947 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Absorbable Implants - standards Animals Biocompatible Materials - chemistry Biocompatible Materials - standards Bone Cements - chemistry Bone Cements - pharmacology Bone ingrowth Calcium Phosphates - chemistry Calcium Phosphates - pharmacology Injectable CaP/PLGA cement Lactic Acid - chemistry Materials Testing Mechanical properties Microscopy, Electron, Scanning Osteogenesis - drug effects Particle Size Polyglycolic Acid - chemistry Polymers - chemistry Rats Rats, Wistar Skull - drug effects Skull - pathology Skull - ultrastructure Stress, Mechanical Time Factors |
| title | Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles |
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