Pituitary desensitization for eight weeks after the administration of two distinct gonadotrophin-releasing hormone agonists

The objective was to evaluate the duration of pituitary desensitization after the administration of 3.5 mg of triptorelin (T) and leuprolin (L) depot preparations in patients with endometriosis. Two groups of 30 patients received, on 21st day of the cycle, 3.75 mg i.m. of triptorelin (T group), and...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2006-05, Vol.126 (1), p.77-80
Main Authors: Matteo, Maria, Caroppo, Ettore, Gliozheni, Orion, Carone, Domenico, Schonauer, Luca Maria, Vizziello, Giovanni, Greco, Pantaleo, D’Amato, Giuseppe
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Delayed-Action Preparations - pharmacology
Endometriosis - drug therapy
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
GnRH analogues
Gonadotropin-Releasing Hormone - agonists
Gonadotropin-Releasing Hormone - pharmacology
Gynecology. Andrology. Obstetrics
Humans
Leuprolide - pharmacology
Leuprolin
Luteinizing Hormone - blood
Medical sciences
Ovulation Inhibition - blood
Ovulation Inhibition - drug effects
Pituitary desensitization
Pituitary Gland - metabolism
Triptorelin
Triptorelin Pamoate - pharmacology
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Summary:The objective was to evaluate the duration of pituitary desensitization after the administration of 3.5 mg of triptorelin (T) and leuprolin (L) depot preparations in patients with endometriosis. Two groups of 30 patients received, on 21st day of the cycle, 3.75 mg i.m. of triptorelin (T group), and of leuprolin acetate (L group). From the first to the eighth week following gonadotrophin-releasing hormone agonists (GnRH-a) administration both groups underwent pelvic ultrasound and serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) evaluation. Statistical analysis was performed using the ANOVA test and the median test. A p-value < 0.05 was considered significant. Pituitary suppression was achieved from two to six and from two to seven weeks after the administration of 3.75 mg of leuprolin and triptorelin, respectively. FSH and LH serum levels were significantly higher in the L group than in the T group after the fourth week. Leuprolin and triptorelin depots (3.75 mg) promote satisfactory ovarian suppression lasting for six and seven weeks, respectively, after administration, with significantly different ambient levels of endogenous LH.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2005.09.018