Nuclear Localization of Flavonoid Enzymes in Arabidopsis

Flavonoids represent one of the oldest, largest, and most diverse families of plant secondary metabolites. These compounds serve a wide range of functions in plants, from pigmentation and UV protection to the regulation of hormone transport. Flavonoids also have interesting pharmacological activitie...

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Bibliographic Details
Published in:The Journal of biological chemistry 2005-06, Vol.280 (25), p.23735-23740
Main Authors: Saslowsky, David E., Warek, Ujwala, Winkel, Brenda S.J.
Format: Article
Language:English
Subjects:
Arabidopsis - enzymology
Cell Nucleus - enzymology
Flavonoids - biosynthesis
Green Fluorescent Proteins - metabolism
Microscopy, Immunoelectron
Models, Molecular
Plant Roots - enzymology
Plants, Genetically Modified - enzymology
Recombinant Fusion Proteins - metabolism
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Summary:Flavonoids represent one of the oldest, largest, and most diverse families of plant secondary metabolites. These compounds serve a wide range of functions in plants, from pigmentation and UV protection to the regulation of hormone transport. Flavonoids also have interesting pharmacological activities in animals that are increasingly being characterized in terms of effects on specific proteins or other macromolecules. Although flavonoids are found in many different locations both inside and outside the cell, biosynthesis has long been believed to take place exclusively in the cytoplasm. Recent reports from a number of different plant species have documented the presence of flavonoids in nuclei, raising the possibility of novel mechanisms of action for these compounds. Here we present evidence that not only flavonoids, but also at least two of the biosynthetic enzymes, are located in the nucleus in several cell types in Arabidopsis. This is the first indication that differential targeting of the biosynthetic machinery may be used to regulate the deposition of plant secondary products at diverse sites of action within the cell.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M413506200