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Assessing medication effects in the MTA study using neuropsychological outcomes
Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods:...
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| Published in: | Journal of child psychology and psychiatry 2006-05, Vol.47 (5), p.446-456 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c6129-e485af0c816544bde4bcea94d263f0f2bc96719a4ca9ba8ef7d1619911e654673 |
| container_end_page | 456 |
| container_issue | 5 |
| container_start_page | 446 |
| container_title | Journal of child psychology and psychiatry |
| container_volume | 47 |
| creator | Epstein, Jeffery N. Keith Conners, C. Hervey, Aaron S. Tonev, Simon T. Eugene Arnold, L. Abikoff, Howard B. Elliott, Glen Greenhill, Laurence L. Hechtman, Lily Hoagwood, Kimberly Hinshaw, Stephen P. Hoza, Betsy Jensen, Peter S. March, John S. Newcorn, Jeffrey H. Pelham, William E. Severe, Joanne B. Swanson, James M. Wells, Karen Vitiello, Benedetto Wigal, Timothy |
| description | Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures.
Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners’ Continuous Performance Test (CPT) at the 24‐month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex‐Gaussian distributional model (i.e., mu, sigma, and tau).
Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex‐Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability.
Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD. |
| doi_str_mv | 10.1111/j.1469-7610.2005.01469.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67936231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ericid>EJ950486</ericid><sourcerecordid>1305207691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6129-e485af0c816544bde4bcea94d263f0f2bc96719a4ca9ba8ef7d1619911e654673</originalsourceid><addsrcrecordid>eNqNkV9v0zAUxS0EYmXwDRCKkOAtxXZsJ35Bqqox2ALrwxASL5bj3GwuaVzsRLTfHqepOomX4Rf_ub9zdH0PQgnBcxLXh_WcMCHTXMQHijGf4_E-3z1Bs1PhKZphTEkqRYbP0IsQ1hhjkfHiOTojQuRE0mKGbhYhQAi2u0s2UFuje-u6BJoGTB8S2yX9PSRfbxdJ6Id6nwwHsoPBu23Ym3vXursoahM39MZtILxEzxrdBnh13M_R908Xt8vPaXlz-WW5KFMjCJUpsILrBpuCCM5YVQOrDGjJaiqyBje0MnLsUDOjZaULaPKaCCIlIRAFIs_O0fvJd-vd7wFCrzY2GGhb3YEbghK5zATNyKMgz0kcWcEfBYlkjBOeRfDtP-DaDb6Lv1U0yzGWnNIIFRNkvAvBQ6O23m603yuC1ZihWqsxKjVGpcYM1SFDtYvSN0f_oYqZPAiPoUXg3RHQIc6-8bozNjxwBaWCFCJyrycOvDWn8sWV5Jgdyh-n8h_bwv6_-1NXy9VqPEaDdDKwoYfdyUD7X3H8Wc7Vj2-XavWzvC5FSdV19hcz8M87</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>237009522</pqid></control><display><type>article</type><title>Assessing medication effects in the MTA study using neuropsychological outcomes</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Wiley</source><source>ERIC</source><creator>Epstein, Jeffery N. ; Keith Conners, C. ; Hervey, Aaron S. ; Tonev, Simon T. ; Eugene Arnold, L. ; Abikoff, Howard B. ; Elliott, Glen ; Greenhill, Laurence L. ; Hechtman, Lily ; Hoagwood, Kimberly ; Hinshaw, Stephen P. ; Hoza, Betsy ; Jensen, Peter S. ; March, John S. ; Newcorn, Jeffrey H. ; Pelham, William E. ; Severe, Joanne B. ; Swanson, James M. ; Wells, Karen ; Vitiello, Benedetto ; Wigal, Timothy</creator><creatorcontrib>Epstein, Jeffery N. ; Keith Conners, C. ; Hervey, Aaron S. ; Tonev, Simon T. ; Eugene Arnold, L. ; Abikoff, Howard B. ; Elliott, Glen ; Greenhill, Laurence L. ; Hechtman, Lily ; Hoagwood, Kimberly ; Hinshaw, Stephen P. ; Hoza, Betsy ; Jensen, Peter S. ; March, John S. ; Newcorn, Jeffrey H. ; Pelham, William E. ; Severe, Joanne B. ; Swanson, James M. ; Wells, Karen ; Vitiello, Benedetto ; Wigal, Timothy ; MTA Cooperative Study Group ; the MTA Cooperative Study Group</creatorcontrib><description>Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures.
Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners’ Continuous Performance Test (CPT) at the 24‐month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex‐Gaussian distributional model (i.e., mu, sigma, and tau).
Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex‐Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability.
Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.</description><identifier>ISSN: 0021-9630</identifier><identifier>EISSN: 1469-7610</identifier><identifier>DOI: 10.1111/j.1469-7610.2005.01469.x</identifier><identifier>PMID: 16671928</identifier><identifier>CODEN: JPPDAI</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ADHD/ADD ; Amphetamine - pharmacology ; Analysis of Variance ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Attention Deficit Disorder with Hyperactivity - psychology ; Attention Deficit Disorder with Hyperactivity - therapy ; Attention Deficit Hyperactivity Disorder ; Biological and medical sciences ; Central Nervous System Stimulants - pharmacology ; Child ; Child Behavior - drug effects ; Child Behavior - psychology ; Child psychology ; Children ; Clinical outcomes ; Combined Modality Therapy - methods ; Combined Modality Therapy - psychology ; Combined Modality Therapy - statistics & numerical data ; Continuous Performance Test ; Data Interpretation, Statistical ; Dextroamphetamine - pharmacology ; distributions ; Drug Therapy ; Effectiveness ; Evaluation Methods ; Female ; Follow-Up Studies ; go/no-go test ; Humans ; Hyperactivity ; Medical sciences ; Methylphenidate - pharmacology ; Neurological Impairments ; Neurological Organization ; Neuropharmacology ; Neuropsychological functioning ; Neuropsychological Tests - statistics & numerical data ; Neuropsychology ; Normal Distribution ; Outcomes of Treatment ; Pemoline - pharmacology ; Performance Tests ; pharmacology ; Pharmacology. Drug treatments ; Prescription drugs ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Reaction Time ; Reaction Time - drug effects ; Reaction times ; Response time ; Stimulants ; Task Performance and Analysis ; Time Factors ; Treatment Outcome</subject><ispartof>Journal of child psychology and psychiatry, 2006-05, Vol.47 (5), p.446-456</ispartof><rights>2007 INIST-CNRS</rights><rights>2005 Association for Child Psychology and Psychiatry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6129-e485af0c816544bde4bcea94d263f0f2bc96719a4ca9ba8ef7d1619911e654673</citedby><cites>FETCH-LOGICAL-c6129-e485af0c816544bde4bcea94d263f0f2bc96719a4ca9ba8ef7d1619911e654673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1469-7610.2005.01469.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1469-7610.2005.01469.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,31034,31035,50923,51032</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ950486$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18226186$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16671928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Epstein, Jeffery N.</creatorcontrib><creatorcontrib>Keith Conners, C.</creatorcontrib><creatorcontrib>Hervey, Aaron S.</creatorcontrib><creatorcontrib>Tonev, Simon T.</creatorcontrib><creatorcontrib>Eugene Arnold, L.</creatorcontrib><creatorcontrib>Abikoff, Howard B.</creatorcontrib><creatorcontrib>Elliott, Glen</creatorcontrib><creatorcontrib>Greenhill, Laurence L.</creatorcontrib><creatorcontrib>Hechtman, Lily</creatorcontrib><creatorcontrib>Hoagwood, Kimberly</creatorcontrib><creatorcontrib>Hinshaw, Stephen P.</creatorcontrib><creatorcontrib>Hoza, Betsy</creatorcontrib><creatorcontrib>Jensen, Peter S.</creatorcontrib><creatorcontrib>March, John S.</creatorcontrib><creatorcontrib>Newcorn, Jeffrey H.</creatorcontrib><creatorcontrib>Pelham, William E.</creatorcontrib><creatorcontrib>Severe, Joanne B.</creatorcontrib><creatorcontrib>Swanson, James M.</creatorcontrib><creatorcontrib>Wells, Karen</creatorcontrib><creatorcontrib>Vitiello, Benedetto</creatorcontrib><creatorcontrib>Wigal, Timothy</creatorcontrib><creatorcontrib>MTA Cooperative Study Group</creatorcontrib><creatorcontrib>the MTA Cooperative Study Group</creatorcontrib><title>Assessing medication effects in the MTA study using neuropsychological outcomes</title><title>Journal of child psychology and psychiatry</title><addtitle>J Child Psychol Psychiatry</addtitle><description>Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures.
Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners’ Continuous Performance Test (CPT) at the 24‐month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex‐Gaussian distributional model (i.e., mu, sigma, and tau).
Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex‐Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability.
Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.</description><subject>ADHD/ADD</subject><subject>Amphetamine - pharmacology</subject><subject>Analysis of Variance</subject><subject>Attention Deficit Disorder with Hyperactivity - drug therapy</subject><subject>Attention Deficit Disorder with Hyperactivity - psychology</subject><subject>Attention Deficit Disorder with Hyperactivity - therapy</subject><subject>Attention Deficit Hyperactivity Disorder</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Child</subject><subject>Child Behavior - drug effects</subject><subject>Child Behavior - psychology</subject><subject>Child psychology</subject><subject>Children</subject><subject>Clinical outcomes</subject><subject>Combined Modality Therapy - methods</subject><subject>Combined Modality Therapy - psychology</subject><subject>Combined Modality Therapy - statistics & numerical data</subject><subject>Continuous Performance Test</subject><subject>Data Interpretation, Statistical</subject><subject>Dextroamphetamine - pharmacology</subject><subject>distributions</subject><subject>Drug Therapy</subject><subject>Effectiveness</subject><subject>Evaluation Methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>go/no-go test</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Medical sciences</subject><subject>Methylphenidate - pharmacology</subject><subject>Neurological Impairments</subject><subject>Neurological Organization</subject><subject>Neuropharmacology</subject><subject>Neuropsychological functioning</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Neuropsychology</subject><subject>Normal Distribution</subject><subject>Outcomes of Treatment</subject><subject>Pemoline - pharmacology</subject><subject>Performance Tests</subject><subject>pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prescription drugs</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Reaction Time</subject><subject>Reaction Time - drug effects</subject><subject>Reaction times</subject><subject>Response time</subject><subject>Stimulants</subject><subject>Task Performance and Analysis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0021-9630</issn><issn>1469-7610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>7SW</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkV9v0zAUxS0EYmXwDRCKkOAtxXZsJ35Bqqox2ALrwxASL5bj3GwuaVzsRLTfHqepOomX4Rf_ub9zdH0PQgnBcxLXh_WcMCHTXMQHijGf4_E-3z1Bs1PhKZphTEkqRYbP0IsQ1hhjkfHiOTojQuRE0mKGbhYhQAi2u0s2UFuje-u6BJoGTB8S2yX9PSRfbxdJ6Id6nwwHsoPBu23Ym3vXursoahM39MZtILxEzxrdBnh13M_R908Xt8vPaXlz-WW5KFMjCJUpsILrBpuCCM5YVQOrDGjJaiqyBje0MnLsUDOjZaULaPKaCCIlIRAFIs_O0fvJd-vd7wFCrzY2GGhb3YEbghK5zATNyKMgz0kcWcEfBYlkjBOeRfDtP-DaDb6Lv1U0yzGWnNIIFRNkvAvBQ6O23m603yuC1ZihWqsxKjVGpcYM1SFDtYvSN0f_oYqZPAiPoUXg3RHQIc6-8bozNjxwBaWCFCJyrycOvDWn8sWV5Jgdyh-n8h_bwv6_-1NXy9VqPEaDdDKwoYfdyUD7X3H8Wc7Vj2-XavWzvC5FSdV19hcz8M87</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Epstein, Jeffery N.</creator><creator>Keith Conners, C.</creator><creator>Hervey, Aaron S.</creator><creator>Tonev, Simon T.</creator><creator>Eugene Arnold, L.</creator><creator>Abikoff, Howard B.</creator><creator>Elliott, Glen</creator><creator>Greenhill, Laurence L.</creator><creator>Hechtman, Lily</creator><creator>Hoagwood, Kimberly</creator><creator>Hinshaw, Stephen P.</creator><creator>Hoza, Betsy</creator><creator>Jensen, Peter S.</creator><creator>March, John S.</creator><creator>Newcorn, Jeffrey H.</creator><creator>Pelham, William E.</creator><creator>Severe, Joanne B.</creator><creator>Swanson, James M.</creator><creator>Wells, Karen</creator><creator>Vitiello, Benedetto</creator><creator>Wigal, Timothy</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Blackwell</general><scope>BSCLL</scope><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Assessing medication effects in the MTA study using neuropsychological outcomes</title><author>Epstein, Jeffery N. ; Keith Conners, C. ; Hervey, Aaron S. ; Tonev, Simon T. ; Eugene Arnold, L. ; Abikoff, Howard B. ; Elliott, Glen ; Greenhill, Laurence L. ; Hechtman, Lily ; Hoagwood, Kimberly ; Hinshaw, Stephen P. ; Hoza, Betsy ; Jensen, Peter S. ; March, John S. ; Newcorn, Jeffrey H. ; Pelham, William E. ; Severe, Joanne B. ; Swanson, James M. ; Wells, Karen ; Vitiello, Benedetto ; Wigal, Timothy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6129-e485af0c816544bde4bcea94d263f0f2bc96719a4ca9ba8ef7d1619911e654673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ADHD/ADD</topic><topic>Amphetamine - pharmacology</topic><topic>Analysis of Variance</topic><topic>Attention Deficit Disorder with Hyperactivity - drug therapy</topic><topic>Attention Deficit Disorder with Hyperactivity - psychology</topic><topic>Attention Deficit Disorder with Hyperactivity - therapy</topic><topic>Attention Deficit Hyperactivity Disorder</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Child</topic><topic>Child Behavior - drug effects</topic><topic>Child Behavior - psychology</topic><topic>Child psychology</topic><topic>Children</topic><topic>Clinical outcomes</topic><topic>Combined Modality Therapy - methods</topic><topic>Combined Modality Therapy - psychology</topic><topic>Combined Modality Therapy - statistics & numerical data</topic><topic>Continuous Performance Test</topic><topic>Data Interpretation, Statistical</topic><topic>Dextroamphetamine - pharmacology</topic><topic>distributions</topic><topic>Drug Therapy</topic><topic>Effectiveness</topic><topic>Evaluation Methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>go/no-go test</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Medical sciences</topic><topic>Methylphenidate - pharmacology</topic><topic>Neurological Impairments</topic><topic>Neurological Organization</topic><topic>Neuropharmacology</topic><topic>Neuropsychological functioning</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Neuropsychology</topic><topic>Normal Distribution</topic><topic>Outcomes of Treatment</topic><topic>Pemoline - pharmacology</topic><topic>Performance Tests</topic><topic>pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prescription drugs</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Reaction Time</topic><topic>Reaction Time - drug effects</topic><topic>Reaction times</topic><topic>Response time</topic><topic>Stimulants</topic><topic>Task Performance and Analysis</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Epstein, Jeffery N.</creatorcontrib><creatorcontrib>Keith Conners, C.</creatorcontrib><creatorcontrib>Hervey, Aaron S.</creatorcontrib><creatorcontrib>Tonev, Simon T.</creatorcontrib><creatorcontrib>Eugene Arnold, L.</creatorcontrib><creatorcontrib>Abikoff, Howard B.</creatorcontrib><creatorcontrib>Elliott, Glen</creatorcontrib><creatorcontrib>Greenhill, Laurence L.</creatorcontrib><creatorcontrib>Hechtman, Lily</creatorcontrib><creatorcontrib>Hoagwood, Kimberly</creatorcontrib><creatorcontrib>Hinshaw, Stephen P.</creatorcontrib><creatorcontrib>Hoza, Betsy</creatorcontrib><creatorcontrib>Jensen, Peter S.</creatorcontrib><creatorcontrib>March, John S.</creatorcontrib><creatorcontrib>Newcorn, Jeffrey H.</creatorcontrib><creatorcontrib>Pelham, William E.</creatorcontrib><creatorcontrib>Severe, Joanne B.</creatorcontrib><creatorcontrib>Swanson, James M.</creatorcontrib><creatorcontrib>Wells, Karen</creatorcontrib><creatorcontrib>Vitiello, Benedetto</creatorcontrib><creatorcontrib>Wigal, Timothy</creatorcontrib><creatorcontrib>MTA Cooperative Study Group</creatorcontrib><creatorcontrib>the MTA Cooperative Study Group</creatorcontrib><collection>Istex</collection><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of child psychology and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Epstein, Jeffery N.</au><au>Keith Conners, C.</au><au>Hervey, Aaron S.</au><au>Tonev, Simon T.</au><au>Eugene Arnold, L.</au><au>Abikoff, Howard B.</au><au>Elliott, Glen</au><au>Greenhill, Laurence L.</au><au>Hechtman, Lily</au><au>Hoagwood, Kimberly</au><au>Hinshaw, Stephen P.</au><au>Hoza, Betsy</au><au>Jensen, Peter S.</au><au>March, John S.</au><au>Newcorn, Jeffrey H.</au><au>Pelham, William E.</au><au>Severe, Joanne B.</au><au>Swanson, James M.</au><au>Wells, Karen</au><au>Vitiello, Benedetto</au><au>Wigal, Timothy</au><aucorp>MTA Cooperative Study Group</aucorp><aucorp>the MTA Cooperative Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ950486</ericid><atitle>Assessing medication effects in the MTA study using neuropsychological outcomes</atitle><jtitle>Journal of child psychology and psychiatry</jtitle><addtitle>J Child Psychol Psychiatry</addtitle><date>2006-05</date><risdate>2006</risdate><volume>47</volume><issue>5</issue><spage>446</spage><epage>456</epage><pages>446-456</pages><issn>0021-9630</issn><eissn>1469-7610</eissn><coden>JPPDAI</coden><notes>ark:/67375/WNG-PZLKL6L2-K</notes><notes>istex:0F418469E9F515BC1A2E1BABEA16F15F4CF5D2FF</notes><notes>ArticleID:JCPP1469</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures.
Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners’ Continuous Performance Test (CPT) at the 24‐month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex‐Gaussian distributional model (i.e., mu, sigma, and tau).
Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex‐Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability.
Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16671928</pmid><doi>10.1111/j.1469-7610.2005.01469.x</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9630 |
| ispartof | Journal of child psychology and psychiatry, 2006-05, Vol.47 (5), p.446-456 |
| issn | 0021-9630 1469-7610 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67936231 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Wiley; ERIC |
| subjects | ADHD/ADD Amphetamine - pharmacology Analysis of Variance Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - psychology Attention Deficit Disorder with Hyperactivity - therapy Attention Deficit Hyperactivity Disorder Biological and medical sciences Central Nervous System Stimulants - pharmacology Child Child Behavior - drug effects Child Behavior - psychology Child psychology Children Clinical outcomes Combined Modality Therapy - methods Combined Modality Therapy - psychology Combined Modality Therapy - statistics & numerical data Continuous Performance Test Data Interpretation, Statistical Dextroamphetamine - pharmacology distributions Drug Therapy Effectiveness Evaluation Methods Female Follow-Up Studies go/no-go test Humans Hyperactivity Medical sciences Methylphenidate - pharmacology Neurological Impairments Neurological Organization Neuropharmacology Neuropsychological functioning Neuropsychological Tests - statistics & numerical data Neuropsychology Normal Distribution Outcomes of Treatment Pemoline - pharmacology Performance Tests pharmacology Pharmacology. Drug treatments Prescription drugs Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Reaction Time Reaction Time - drug effects Reaction times Response time Stimulants Task Performance and Analysis Time Factors Treatment Outcome |
| title | Assessing medication effects in the MTA study using neuropsychological outcomes |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T01%3A55%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessing%20medication%20effects%20in%20the%20MTA%20study%20using%20neuropsychological%20outcomes&rft.jtitle=Journal%20of%20child%20psychology%20and%20psychiatry&rft.au=Epstein,%20Jeffery%20N.&rft.aucorp=MTA%20Cooperative%20Study%20Group&rft.date=2006-05&rft.volume=47&rft.issue=5&rft.spage=446&rft.epage=456&rft.pages=446-456&rft.issn=0021-9630&rft.eissn=1469-7610&rft.coden=JPPDAI&rft_id=info:doi/10.1111/j.1469-7610.2005.01469.x&rft_dat=%3Cproquest_cross%3E1305207691%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c6129-e485af0c816544bde4bcea94d263f0f2bc96719a4ca9ba8ef7d1619911e654673%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=237009522&rft_id=info:pmid/16671928&rft_ericid=EJ950486&rfr_iscdi=true |