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Pemphigus: Analysis of 1209 cases
Background Pemphigus is a rare and chronic life‐threatening disease. The clinical picture varies in reports from different regions of the world. Objective To define the clinical forms of pemphigus in a large cohort of patients. Methods Prospective analysis of 1209 patients diagnosed and followed...
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| Published in: | International journal of dermatology 2005-06, Vol.44 (6), p.470-476 |
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| container_end_page | 476 |
| container_issue | 6 |
| container_start_page | 470 |
| container_title | International journal of dermatology |
| container_volume | 44 |
| creator | Chams‐Davatchi, Cheyda Valikhani, Mahin Daneshpazhooh, Maryam Esmaili, Nafiseh Balighi, Kamran Hallaji, Zahra Barzegari, Massoume Akhiani, Maryam Ghodsi, Zahra Mortazavi, Hosein Naraghi, Zahra |
| description | Background Pemphigus is a rare and chronic life‐threatening disease. The clinical picture varies in reports from different regions of the world.
Objective To define the clinical forms of pemphigus in a large cohort of patients.
Methods Prospective analysis of 1209 patients diagnosed and followed at the Pemphigus Research Unit, Tehran University for Medical Sciences, from 1984 to 2003.
Results The mean age at onset was 42 years with a female to male ratio of 1.5/1. The most frequent form was pemphigus vulgaris. In pemphigus vulgaris, patients’ mucous membrane involvement alone was observed in 18%, skin involvement alone in 12%, and both in 70%. Pemphigus foliaceus was observed in 7% of the patients. Most complications were iatrogenic.
Conclusion In Iran, pemphigus vulgaris is the most frequent form of pemphigus. Females are more prone to the disease. The incidence of pemphigus in Tehran is approximately 1.6 per 100 000/year, and in Iran 1.0 per 100 000/year. The age of onset was lower than classically reported. Death occurred in 6.2% of the patients. In pemphigus vulgaris, the mucosal and skin form together had a worse prognosis than the other clinical forms. |
| doi_str_mv | 10.1111/j.1365-4632.2004.02501.x |
| format | article |
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Objective To define the clinical forms of pemphigus in a large cohort of patients.
Methods Prospective analysis of 1209 patients diagnosed and followed at the Pemphigus Research Unit, Tehran University for Medical Sciences, from 1984 to 2003.
Results The mean age at onset was 42 years with a female to male ratio of 1.5/1. The most frequent form was pemphigus vulgaris. In pemphigus vulgaris, patients’ mucous membrane involvement alone was observed in 18%, skin involvement alone in 12%, and both in 70%. Pemphigus foliaceus was observed in 7% of the patients. Most complications were iatrogenic.
Conclusion In Iran, pemphigus vulgaris is the most frequent form of pemphigus. Females are more prone to the disease. The incidence of pemphigus in Tehran is approximately 1.6 per 100 000/year, and in Iran 1.0 per 100 000/year. The age of onset was lower than classically reported. Death occurred in 6.2% of the patients. In pemphigus vulgaris, the mucosal and skin form together had a worse prognosis than the other clinical forms.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4632.2004.02501.x</identifier><identifier>PMID: 15941433</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adrenal Cortex Hormones - therapeutic use ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Azathioprine - therapeutic use ; Biological and medical sciences ; Bullous diseases of the skin ; Child, Preschool ; Dermatology ; Female ; Fluorescent Antibody Technique ; Humans ; Immunosuppressive Agents - therapeutic use ; Iran - epidemiology ; Male ; Medical sciences ; Middle Aged ; Pemphigus - complications ; Pemphigus - diagnosis ; Pemphigus - drug therapy ; Pemphigus - epidemiology ; Prospective Studies ; Sex Distribution</subject><ispartof>International journal of dermatology, 2005-06, Vol.44 (6), p.470-476</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Jun 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4901-8436905e66847009f05a777aa39ae8d87f0916a32f32abd420a764b4e03021a63</citedby><cites>FETCH-LOGICAL-c4901-8436905e66847009f05a777aa39ae8d87f0916a32f32abd420a764b4e03021a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-4632.2004.02501.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-4632.2004.02501.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16837873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15941433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chams‐Davatchi, Cheyda</creatorcontrib><creatorcontrib>Valikhani, Mahin</creatorcontrib><creatorcontrib>Daneshpazhooh, Maryam</creatorcontrib><creatorcontrib>Esmaili, Nafiseh</creatorcontrib><creatorcontrib>Balighi, Kamran</creatorcontrib><creatorcontrib>Hallaji, Zahra</creatorcontrib><creatorcontrib>Barzegari, Massoume</creatorcontrib><creatorcontrib>Akhiani, Maryam</creatorcontrib><creatorcontrib>Ghodsi, Zahra</creatorcontrib><creatorcontrib>Mortazavi, Hosein</creatorcontrib><creatorcontrib>Naraghi, Zahra</creatorcontrib><title>Pemphigus: Analysis of 1209 cases</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background Pemphigus is a rare and chronic life‐threatening disease. The clinical picture varies in reports from different regions of the world.
Objective To define the clinical forms of pemphigus in a large cohort of patients.
Methods Prospective analysis of 1209 patients diagnosed and followed at the Pemphigus Research Unit, Tehran University for Medical Sciences, from 1984 to 2003.
Results The mean age at onset was 42 years with a female to male ratio of 1.5/1. The most frequent form was pemphigus vulgaris. In pemphigus vulgaris, patients’ mucous membrane involvement alone was observed in 18%, skin involvement alone in 12%, and both in 70%. Pemphigus foliaceus was observed in 7% of the patients. Most complications were iatrogenic.
Conclusion In Iran, pemphigus vulgaris is the most frequent form of pemphigus. Females are more prone to the disease. The incidence of pemphigus in Tehran is approximately 1.6 per 100 000/year, and in Iran 1.0 per 100 000/year. The age of onset was lower than classically reported. Death occurred in 6.2% of the patients. In pemphigus vulgaris, the mucosal and skin form together had a worse prognosis than the other clinical forms.</description><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Azathioprine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bullous diseases of the skin</subject><subject>Child, Preschool</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pemphigus - complications</subject><subject>Pemphigus - diagnosis</subject><subject>Pemphigus - drug therapy</subject><subject>Pemphigus - epidemiology</subject><subject>Prospective Studies</subject><subject>Sex Distribution</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkF1LwzAUhoMobk7_glRB71rPSdJ8CF6M-c1AL_Q6ZF2qLe06G4vbv7d1xYFX5iY55DnvOTyEBAgRtucij5CJOOSC0YgC8AhoDBitdsjw92OXDAEQQw2xHpAD7_O2ZBT5PhlgrDlyxobk5NmVy_fsrfGXwXhhi7XPfFClAVLQQWK984dkL7WFd0f9PSKvtzcvk_tw-nT3MBlPw4RrwFBxJtpRTgjFJYBOIbZSSmuZtk7NlUxBo7CMpoza2ZxTsFLwGXfAgKIVbETON7nLuvponP80ZeYTVxR24arGGyE1AouhBU__gHnV1O3u3lBKleSoO0htoKSuvK9dapZ1Vtp6bRBM59DkplNlOlWmc2h-HJpV23rc5zez0s23jb20FjjrAesTW6S1XSSZ33JCMalkx11tuK-scOt_L2AeHq-7F_sGHUGHLQ</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Chams‐Davatchi, Cheyda</creator><creator>Valikhani, Mahin</creator><creator>Daneshpazhooh, Maryam</creator><creator>Esmaili, Nafiseh</creator><creator>Balighi, Kamran</creator><creator>Hallaji, Zahra</creator><creator>Barzegari, Massoume</creator><creator>Akhiani, Maryam</creator><creator>Ghodsi, Zahra</creator><creator>Mortazavi, Hosein</creator><creator>Naraghi, Zahra</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Pemphigus: Analysis of 1209 cases</title><author>Chams‐Davatchi, Cheyda ; Valikhani, Mahin ; Daneshpazhooh, Maryam ; Esmaili, Nafiseh ; Balighi, Kamran ; Hallaji, Zahra ; Barzegari, Massoume ; Akhiani, Maryam ; Ghodsi, Zahra ; Mortazavi, Hosein ; Naraghi, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4901-8436905e66847009f05a777aa39ae8d87f0916a32f32abd420a764b4e03021a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Azathioprine - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bullous diseases of the skin</topic><topic>Child, Preschool</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pemphigus - complications</topic><topic>Pemphigus - diagnosis</topic><topic>Pemphigus - drug therapy</topic><topic>Pemphigus - epidemiology</topic><topic>Prospective Studies</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chams‐Davatchi, Cheyda</creatorcontrib><creatorcontrib>Valikhani, Mahin</creatorcontrib><creatorcontrib>Daneshpazhooh, Maryam</creatorcontrib><creatorcontrib>Esmaili, Nafiseh</creatorcontrib><creatorcontrib>Balighi, Kamran</creatorcontrib><creatorcontrib>Hallaji, Zahra</creatorcontrib><creatorcontrib>Barzegari, Massoume</creatorcontrib><creatorcontrib>Akhiani, Maryam</creatorcontrib><creatorcontrib>Ghodsi, Zahra</creatorcontrib><creatorcontrib>Mortazavi, Hosein</creatorcontrib><creatorcontrib>Naraghi, Zahra</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chams‐Davatchi, Cheyda</au><au>Valikhani, Mahin</au><au>Daneshpazhooh, Maryam</au><au>Esmaili, Nafiseh</au><au>Balighi, Kamran</au><au>Hallaji, Zahra</au><au>Barzegari, Massoume</au><au>Akhiani, Maryam</au><au>Ghodsi, Zahra</au><au>Mortazavi, Hosein</au><au>Naraghi, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pemphigus: Analysis of 1209 cases</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2005-06</date><risdate>2005</risdate><volume>44</volume><issue>6</issue><spage>470</spage><epage>476</epage><pages>470-476</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><notes>The authors had no funding source for this work.</notes><notes>The authors have no conflict of interest to disclose</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background Pemphigus is a rare and chronic life‐threatening disease. The clinical picture varies in reports from different regions of the world.
Objective To define the clinical forms of pemphigus in a large cohort of patients.
Methods Prospective analysis of 1209 patients diagnosed and followed at the Pemphigus Research Unit, Tehran University for Medical Sciences, from 1984 to 2003.
Results The mean age at onset was 42 years with a female to male ratio of 1.5/1. The most frequent form was pemphigus vulgaris. In pemphigus vulgaris, patients’ mucous membrane involvement alone was observed in 18%, skin involvement alone in 12%, and both in 70%. Pemphigus foliaceus was observed in 7% of the patients. Most complications were iatrogenic.
Conclusion In Iran, pemphigus vulgaris is the most frequent form of pemphigus. Females are more prone to the disease. The incidence of pemphigus in Tehran is approximately 1.6 per 100 000/year, and in Iran 1.0 per 100 000/year. The age of onset was lower than classically reported. Death occurred in 6.2% of the patients. In pemphigus vulgaris, the mucosal and skin form together had a worse prognosis than the other clinical forms.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15941433</pmid><doi>10.1111/j.1365-4632.2004.02501.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of dermatology, 2005-06, Vol.44 (6), p.470-476 |
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| subjects | Adolescent Adrenal Cortex Hormones - therapeutic use Adult Age of Onset Aged Aged, 80 and over Azathioprine - therapeutic use Biological and medical sciences Bullous diseases of the skin Child, Preschool Dermatology Female Fluorescent Antibody Technique Humans Immunosuppressive Agents - therapeutic use Iran - epidemiology Male Medical sciences Middle Aged Pemphigus - complications Pemphigus - diagnosis Pemphigus - drug therapy Pemphigus - epidemiology Prospective Studies Sex Distribution |
| title | Pemphigus: Analysis of 1209 cases |
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