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Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state
Simultaneous profiling analysis of urinary amino acids (AAs) and carboxylic acids (CAs) was combined with retention index (I) analysis for graphic recognition of abnormal metabolic state. The temperature-programmed I values of the AA and CA standards measured as ethoxycarbonyl (EOC)/methoxime (MO)/t...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-07, Vol.821 (1), p.94-104 |
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| cites | cdi_FETCH-LOGICAL-c366t-70383b662f732984e1a54666f6ab55d54f6c28fa4e5af72bf76a6e11387693b03 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | PAIK, Man-Jeong LEE, Hong-Jin KIM, Kyoung-Rae |
| description | Simultaneous profiling analysis of urinary amino acids (AAs) and carboxylic acids (CAs) was combined with retention index (I) analysis for graphic recognition of abnormal metabolic state. The temperature-programmed I values of the AA and CA standards measured as ethoxycarbonyl (EOC)/methoxime (MO)/tert-butyldimethylsilyl (TBDMS) derivatives were used as the reference I values. Urine samples were subjected to the sequential EOC, MO and TBDMS reactions for the analysis by gas chromatography (GC) and GC-mass spectrometry. The complex GC profiles were then transformed into their respective I patterns in bar graphic forms by plotting the normalized peak area ratios (%) of the identified AAs and CAs against their reference I values as the identification numbers. When the present method was applied to infant urine specimens from normal controls and patients with inherited metabolic diseases such as phenylketonuria, maple syrup urine disease, methylmalonic aciduria or isovaleric aciduria, each I pattern of bar graph more distinctly displayed quantitative abundances of urinary AAs and CAs in qualitative I scale, thus allowing graphic discrimination between normal and abnormal states. |
| doi_str_mv | 10.1016/j.jchromb.2005.04.011 |
| format | article |
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The temperature-programmed I values of the AA and CA standards measured as ethoxycarbonyl (EOC)/methoxime (MO)/tert-butyldimethylsilyl (TBDMS) derivatives were used as the reference I values. Urine samples were subjected to the sequential EOC, MO and TBDMS reactions for the analysis by gas chromatography (GC) and GC-mass spectrometry. The complex GC profiles were then transformed into their respective I patterns in bar graphic forms by plotting the normalized peak area ratios (%) of the identified AAs and CAs against their reference I values as the identification numbers. When the present method was applied to infant urine specimens from normal controls and patients with inherited metabolic diseases such as phenylketonuria, maple syrup urine disease, methylmalonic aciduria or isovaleric aciduria, each I pattern of bar graph more distinctly displayed quantitative abundances of urinary AAs and CAs in qualitative I scale, thus allowing graphic discrimination between normal and abnormal states.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2005.04.011</identifier><identifier>PMID: 15894518</identifier><language>eng</language><publisher>Amsterdam: Elsevier Science</publisher><subject>Acetamides ; Amino Acids - urine ; Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Carboxylic Acids - urine ; Child ; Child, Preschool ; Chromatography, Gas - methods ; Fluoroacetates ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Humans ; Hydroxylamines - chemistry ; Infant ; Maple Syrup Urine Disease - urine ; Medical sciences ; Metabolism, Inborn Errors - urine ; Methylmalonic Acid - urine ; Organosilicon Compounds - chemistry ; Pentanoic Acids - urine ; Pharmacology. Drug treatments ; Phenylketonurias - urine ; Trifluoroacetic Acid - chemistry</subject><ispartof>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>Simultaneous profiling analysis of urinary amino acids (AAs) and carboxylic acids (CAs) was combined with retention index (I) analysis for graphic recognition of abnormal metabolic state. The temperature-programmed I values of the AA and CA standards measured as ethoxycarbonyl (EOC)/methoxime (MO)/tert-butyldimethylsilyl (TBDMS) derivatives were used as the reference I values. Urine samples were subjected to the sequential EOC, MO and TBDMS reactions for the analysis by gas chromatography (GC) and GC-mass spectrometry. The complex GC profiles were then transformed into their respective I patterns in bar graphic forms by plotting the normalized peak area ratios (%) of the identified AAs and CAs against their reference I values as the identification numbers. When the present method was applied to infant urine specimens from normal controls and patients with inherited metabolic diseases such as phenylketonuria, maple syrup urine disease, methylmalonic aciduria or isovaleric aciduria, each I pattern of bar graph more distinctly displayed quantitative abundances of urinary AAs and CAs in qualitative I scale, thus allowing graphic discrimination between normal and abnormal states.</description><subject>Acetamides</subject><subject>Amino Acids - urine</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Carboxylic Acids - urine</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, Gas - methods</subject><subject>Fluoroacetates</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hydroxylamines - chemistry</subject><subject>Infant</subject><subject>Maple Syrup Urine Disease - urine</subject><subject>Medical sciences</subject><subject>Metabolism, Inborn Errors - urine</subject><subject>Methylmalonic Acid - urine</subject><subject>Organosilicon Compounds - chemistry</subject><subject>Pentanoic Acids - urine</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylketonurias - urine</subject><subject>Trifluoroacetic Acid - chemistry</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpFkE1P3DAQhq2qqFDan9DKl3JLsOPPPSIEtBJSDxSJmzVxbPAqsRc7kVjx52vYSJxmNH7mteZB6AclLSVUnm_brX3KaerbjhDREt4SSj-hE6oVa5iSD59rLxRpSMe6Y_S1lC0hVBHFvqBjKvSGC6pP0OtdmJZxhujSUnB2s4tzSBGHOLgXDBHGfQkFJ4-XHCLkPYYpxITBhqHU9wFbyH162Y_BrkOfMn7MsHuqk-xseozhPbJmQB9TnmDEZYbZfUNHHsbivq_1FN1fX_27_N3c_r35c3lx21gm5dwowjTrpey8Yt1Gc0dBcCmll9ALMQjupe20B-4EeNX1XkmQjlKmldywnrBTdHbI3eX0vLgymykU68bxcLWRSldUqgqKA2hzKiU7b3Y5TPVoQ4l5s262ZrVu3qwbwk21Xvd-rh8s_eSGj61VcwV-rQAUC6PPEG0oH5zUnLANZ_8B43-Pog</recordid><startdate>20050705</startdate><enddate>20050705</enddate><creator>PAIK, Man-Jeong</creator><creator>LEE, Hong-Jin</creator><creator>KIM, Kyoung-Rae</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050705</creationdate><title>Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state</title><author>PAIK, Man-Jeong ; LEE, Hong-Jin ; KIM, Kyoung-Rae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-70383b662f732984e1a54666f6ab55d54f6c28fa4e5af72bf76a6e11387693b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetamides</topic><topic>Amino Acids - urine</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Carboxylic Acids - urine</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, Gas - methods</topic><topic>Fluoroacetates</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hydroxylamines - chemistry</topic><topic>Infant</topic><topic>Maple Syrup Urine Disease - urine</topic><topic>Medical sciences</topic><topic>Metabolism, Inborn Errors - urine</topic><topic>Methylmalonic Acid - urine</topic><topic>Organosilicon Compounds - chemistry</topic><topic>Pentanoic Acids - urine</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylketonurias - urine</topic><topic>Trifluoroacetic Acid - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAIK, Man-Jeong</creatorcontrib><creatorcontrib>LEE, Hong-Jin</creatorcontrib><creatorcontrib>KIM, Kyoung-Rae</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2005-07-05</date><risdate>2005</risdate><volume>821</volume><issue>1</issue><spage>94</spage><epage>104</epage><pages>94-104</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>Simultaneous profiling analysis of urinary amino acids (AAs) and carboxylic acids (CAs) was combined with retention index (I) analysis for graphic recognition of abnormal metabolic state. The temperature-programmed I values of the AA and CA standards measured as ethoxycarbonyl (EOC)/methoxime (MO)/tert-butyldimethylsilyl (TBDMS) derivatives were used as the reference I values. Urine samples were subjected to the sequential EOC, MO and TBDMS reactions for the analysis by gas chromatography (GC) and GC-mass spectrometry. The complex GC profiles were then transformed into their respective I patterns in bar graphic forms by plotting the normalized peak area ratios (%) of the identified AAs and CAs against their reference I values as the identification numbers. When the present method was applied to infant urine specimens from normal controls and patients with inherited metabolic diseases such as phenylketonuria, maple syrup urine disease, methylmalonic aciduria or isovaleric aciduria, each I pattern of bar graph more distinctly displayed quantitative abundances of urinary AAs and CAs in qualitative I scale, thus allowing graphic discrimination between normal and abnormal states.</abstract><cop>Amsterdam</cop><pub>Elsevier Science</pub><pmid>15894518</pmid><doi>10.1016/j.jchromb.2005.04.011</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-07, Vol.821 (1), p.94-104 |
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| language | eng |
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| source | Elsevier |
| subjects | Acetamides Amino Acids - urine Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Carboxylic Acids - urine Child Child, Preschool Chromatography, Gas - methods Fluoroacetates Fundamental and applied biological sciences. Psychology General pharmacology Humans Hydroxylamines - chemistry Infant Maple Syrup Urine Disease - urine Medical sciences Metabolism, Inborn Errors - urine Methylmalonic Acid - urine Organosilicon Compounds - chemistry Pentanoic Acids - urine Pharmacology. Drug treatments Phenylketonurias - urine Trifluoroacetic Acid - chemistry |
| title | Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state |
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