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Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques
Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques John R. Davies, James H. F. Rudd, Peter L. Weissberg, Jagat Narula High risk, vulnerable atherosclerotic plaques are characterized by high numbers of inflammatory cells and proteins. Consequently, there is an urgent need fo...
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| Published in: | Journal of the American College of Cardiology 2006-04, Vol.47 (8), p.C57-C68 |
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| creator | Davies, John R. Rudd, James H.F. Weissberg, Peter L. Narula, Jagat |
| description | Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques
John R. Davies, James H. F. Rudd, Peter L. Weissberg, Jagat Narula
High risk, vulnerable atherosclerotic plaques are characterized by high numbers of inflammatory cells and proteins. Consequently, there is an urgent need for imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Nuclear tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. But the identification of inflamed lesions within the coronary circulation remains problematic, owing to the small plaque size and lack of a suitable nuclear tracer.
Imaging of atheromatous plaques has traditionally centered on assessing the degree of luminal stenosis. More recently it has become clear that the vulnerable atherosclerotic plaques responsible for the majority of life-threatening syndromes are characterized by high numbers of inflammatory cells and proteins. This has highlighted the urgent need for suitable imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Positron emission tomography and single-photon emission computed tomography imaging hold promise in this regard. Tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. The identification of inflamed lesions within the coronary circulation, however, remains elusive owing to small plaque size, cardiac and respiratory motion, and lack of a suitable specific nuclear tracer. |
| doi_str_mv | 10.1016/j.jacc.2005.11.049 |
| format | article |
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John R. Davies, James H. F. Rudd, Peter L. Weissberg, Jagat Narula
High risk, vulnerable atherosclerotic plaques are characterized by high numbers of inflammatory cells and proteins. Consequently, there is an urgent need for imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Nuclear tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. But the identification of inflamed lesions within the coronary circulation remains problematic, owing to the small plaque size and lack of a suitable nuclear tracer.
Imaging of atheromatous plaques has traditionally centered on assessing the degree of luminal stenosis. More recently it has become clear that the vulnerable atherosclerotic plaques responsible for the majority of life-threatening syndromes are characterized by high numbers of inflammatory cells and proteins. This has highlighted the urgent need for suitable imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Positron emission tomography and single-photon emission computed tomography imaging hold promise in this regard. Tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. The identification of inflamed lesions within the coronary circulation, however, remains elusive owing to small plaque size, cardiac and respiratory motion, and lack of a suitable specific nuclear tracer.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2005.11.049</identifier><identifier>PMID: 16631511</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Apoptosis ; Atherosclerosis ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - immunology ; Atherosclerosis - pathology ; Cardiology ; Cholesterol ; Enzymes ; Fluorodeoxyglucose F18 ; Foam Cells ; Heart attacks ; Humans ; Inflammation ; Lipids ; Lipoproteins ; Macrophages ; Matrix Metalloproteinases ; Medical imaging ; Monocytes ; Phagocytosis ; Plasma ; Positron-Emission Tomography ; Proteins ; Radiopharmaceuticals ; Tomography</subject><ispartof>Journal of the American College of Cardiology, 2006-04, Vol.47 (8), p.C57-C68</ispartof><rights>2006 American College of Cardiology Foundation</rights><rights>Copyright Elsevier Limited Apr 18, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-fef0bdf156d17c8e9c078f0a6c459dcfc5a021d02db1d78e9074d2b7ba7811a83</citedby><cites>FETCH-LOGICAL-c490t-fef0bdf156d17c8e9c078f0a6c459dcfc5a021d02db1d78e9074d2b7ba7811a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16631511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davies, John R.</creatorcontrib><creatorcontrib>Rudd, James H.F.</creatorcontrib><creatorcontrib>Weissberg, Peter L.</creatorcontrib><creatorcontrib>Narula, Jagat</creatorcontrib><title>Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques
John R. Davies, James H. F. Rudd, Peter L. Weissberg, Jagat Narula
High risk, vulnerable atherosclerotic plaques are characterized by high numbers of inflammatory cells and proteins. Consequently, there is an urgent need for imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Nuclear tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. But the identification of inflamed lesions within the coronary circulation remains problematic, owing to the small plaque size and lack of a suitable nuclear tracer.
Imaging of atheromatous plaques has traditionally centered on assessing the degree of luminal stenosis. More recently it has become clear that the vulnerable atherosclerotic plaques responsible for the majority of life-threatening syndromes are characterized by high numbers of inflammatory cells and proteins. This has highlighted the urgent need for suitable imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Positron emission tomography and single-photon emission computed tomography imaging hold promise in this regard. Tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. The identification of inflamed lesions within the coronary circulation, however, remains elusive owing to small plaque size, cardiac and respiratory motion, and lack of a suitable specific nuclear tracer.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - immunology</subject><subject>Atherosclerosis - pathology</subject><subject>Cardiology</subject><subject>Cholesterol</subject><subject>Enzymes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Foam Cells</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Macrophages</subject><subject>Matrix Metalloproteinases</subject><subject>Medical imaging</subject><subject>Monocytes</subject><subject>Phagocytosis</subject><subject>Plasma</subject><subject>Positron-Emission Tomography</subject><subject>Proteins</subject><subject>Radiopharmaceuticals</subject><subject>Tomography</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kE2L1EAQhhtR3HH1D3iQgOAtsSpJfwS8yPo1MLCLqNem0129dsjH2p0s7L-3xxkQPHgqinrqreJh7CVChYDi7VANxtqqBuAVYgVt94jtkHNVNryTj9kOZMNLhE5esGcpDQAgFHZP2QUK0SBH3LHDV-PCMm92DI6K_WRuw3xb-CUW608qPtBKds3zYvHFfvajmSbzpw9z8WMbZ4qmH6m4Gc2vjdJz9sSbMdGLc71k3z99_Hb1pTxcf95fvT-Utu1gLT156J1HLhxKq6izIJUHI2zLO2e95QZqdFC7Hp3Mc5Ctq3vZG6kQjWou2ZtT7l1cjndXPYVkaRzNTMuWtJBK8aapM_j6H3BYtjjn3zRyEG3bKCkyVZ8oG5eUInl9F8Nk4oNG0EfTetBH0_poWiPqbDovvTpHb_1E7u_KWW0G3p0AyibuA0WdbKDZkgsxS9VuCf_L_w3JJI7C</recordid><startdate>20060418</startdate><enddate>20060418</enddate><creator>Davies, John R.</creator><creator>Rudd, James H.F.</creator><creator>Weissberg, Peter L.</creator><creator>Narula, Jagat</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20060418</creationdate><title>Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques</title><author>Davies, John R. ; Rudd, James H.F. ; Weissberg, Peter L. ; Narula, Jagat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-fef0bdf156d17c8e9c078f0a6c459dcfc5a021d02db1d78e9074d2b7ba7811a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - immunology</topic><topic>Atherosclerosis - pathology</topic><topic>Cardiology</topic><topic>Cholesterol</topic><topic>Enzymes</topic><topic>Fluorodeoxyglucose F18</topic><topic>Foam Cells</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Macrophages</topic><topic>Matrix Metalloproteinases</topic><topic>Medical imaging</topic><topic>Monocytes</topic><topic>Phagocytosis</topic><topic>Plasma</topic><topic>Positron-Emission Tomography</topic><topic>Proteins</topic><topic>Radiopharmaceuticals</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davies, John R.</creatorcontrib><creatorcontrib>Rudd, James H.F.</creatorcontrib><creatorcontrib>Weissberg, Peter L.</creatorcontrib><creatorcontrib>Narula, Jagat</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davies, John R.</au><au>Rudd, James H.F.</au><au>Weissberg, Peter L.</au><au>Narula, Jagat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2006-04-18</date><risdate>2006</risdate><volume>47</volume><issue>8</issue><spage>C57</spage><epage>C68</epage><pages>C57-C68</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques
John R. Davies, James H. F. Rudd, Peter L. Weissberg, Jagat Narula
High risk, vulnerable atherosclerotic plaques are characterized by high numbers of inflammatory cells and proteins. Consequently, there is an urgent need for imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Nuclear tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. But the identification of inflamed lesions within the coronary circulation remains problematic, owing to the small plaque size and lack of a suitable nuclear tracer.
Imaging of atheromatous plaques has traditionally centered on assessing the degree of luminal stenosis. More recently it has become clear that the vulnerable atherosclerotic plaques responsible for the majority of life-threatening syndromes are characterized by high numbers of inflammatory cells and proteins. This has highlighted the urgent need for suitable imaging techniques that can identify and quantify levels of inflammation within atheromatous lesions. Positron emission tomography and single-photon emission computed tomography imaging hold promise in this regard. Tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. The identification of inflamed lesions within the coronary circulation, however, remains elusive owing to small plaque size, cardiac and respiratory motion, and lack of a suitable specific nuclear tracer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16631511</pmid><doi>10.1016/j.jacc.2005.11.049</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis Atherosclerosis Atherosclerosis - diagnostic imaging Atherosclerosis - immunology Atherosclerosis - pathology Cardiology Cholesterol Enzymes Fluorodeoxyglucose F18 Foam Cells Heart attacks Humans Inflammation Lipids Lipoproteins Macrophages Matrix Metalloproteinases Medical imaging Monocytes Phagocytosis Plasma Positron-Emission Tomography Proteins Radiopharmaceuticals Tomography |
| title | Radionuclide Imaging for the Detection of Inflammation in Vulnerable Plaques |
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