Cortical and subcortical brain effects of Transcranial Magnetic Stimulation (TMS)-induced movement: An interleaved TMS/functional magnetic resonance imaging study

To date, interleaved transcranial magnetic stimulation and functional magnetic resonance imaging (TMS/fMRI) studies of motor activation have not recorded whole brain patterns. We hypothesized that TMS would activate known motor circuitry with some additional regions plus some areas dropping out. We...

Full description

Saved in:
Bibliographic Details
Published in:Biological psychiatry (1969) 2005-04, Vol.57 (7), p.752-760
Main Authors: Denslow, Stewart, Lomarev, Mikhail, George, Mark S., Bohning, Daryl E.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
BOLD
Brain - anatomy & histology
Brain - blood supply
Brain - physiology
Brain - radiation effects
Brain Mapping
Electric Stimulation - methods
Female
fMRI
Functional Laterality
Humans
Image Processing, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Male
Medical sciences
motor circuits
motor cortex
Movement - radiation effects
Nerve Net - blood supply
Nerve Net - physiology
Nerve Net - radiation effects
Nervous system
Oxygen - blood
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reaction Time - radiation effects
Time Factors
Transcranial Magnetic Stimulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To date, interleaved transcranial magnetic stimulation and functional magnetic resonance imaging (TMS/fMRI) studies of motor activation have not recorded whole brain patterns. We hypothesized that TMS would activate known motor circuitry with some additional regions plus some areas dropping out. We used interleaved TMS/fMRI (11 subjects, three scans each) to elucidate whole brain activation patterns from 1-Hz TMS over left primary motor cortex. Both TMS (110% motor threshold) and volitional movement of the same muscles excited by TMS caused blood oxygen level–dependent (BOLD) patterns encompassing known motor circuitry. Additional activation was observed bilaterally in superior temporal auditory areas. Decreases in BOLD signal with unexpected posttask “rebounds” were observed for both tasks in the right motor area, right superior parietal lobe, and in occipital regions. Paired t test of parametric contrast maps failed to detect significant differences between TMS- and volition-induced effects. Differences were detectable, however, in primary data time-intensity profiles. Using this interleaved TMS/fMRI technique, TMS over primary motor cortex produces a whole brain pattern of BOLD activation similar to known motor circuitry, without detectable differences from mimicked volitional movement. Some differences may exist between time courses of BOLD intensity during TMS circuit activation and volitional circuit activation.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2004.12.017