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Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon
Diabetes is a major cause of morbidity and mortality in both industrialized and developing countries. In Africa, there are little data on the prevalence and immunological features of patients with autoimmune endocrine diseases. The present hospital-based study was carried out to evaluate disease-ass...
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| Published in: | Clinical Immunology 2006-02, Vol.118 (2), p.229-232 |
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| creator | Hawa, M.I. Picardi, A. Costanza, F. D'Avola, D. Beretta Anguissola, G. Guglielmi, C. Mottini, G. Fezeu, L. Mbanya, J.C. Leslie, R.D.G. Pozzilli, P. |
| description | Diabetes is a major cause of morbidity and mortality in both industrialized and developing countries. In Africa, there are little data on the prevalence and immunological features of patients with autoimmune endocrine diseases.
The present hospital-based study was carried out to evaluate disease-associated autoantibodies in both type 1 diabetes and thyrotoxicosis attending the Central Hospital of Yaoundee in Cameroon.
Samples were collected from a total of 101 subjects, 47 of whom clinically had established type 1 diabetes (mean age 30.1 years ± 7.6, mean disease duration 3.3 years), 18 had thyrotoxicosis (mean age 32.7 years ± 7.6, mean disease duration 6.3 years ± 2.8) and 36 normal subjects (mean age 26 years ± 4.5). All subjects were tested for diabetes-associated glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2) autoantibodies using antigen-specific radioimmunoassay as well as thyroiditis-associated thyroglobulin (Tg) and thyroid peroxidase (TPO) autoantibodies using commercially available kits.
Of 47 patients with type 1 diabetes, 16 (34%) had GAD autoantibodies (Abs), 3 (6.4%) had IA2 Abs, and 2 (4.3%) had TPO Abs. Of 18 patients with thyrotoxicosis 4 (22.2%) had GAD Abs, 5 (27.8%) showed IA2 Abs, while 8 patients (44.4%) were TPO Abs positive. No patients in either group had Tg Abs. Among normal subjects, 2 (5.6%) showed GAD Abs, and one of these was also IA2 Abs positive, but none had thyroid autoantibodies.
Adult-onset type 1 diabetic patients some years post-diagnosis from central Africa show GAD, IA2 or TPO Abs; and surprisingly, patients with thyrotoxicosis had a similar frequency of diabetes-associated autoantibodies. We conclude that, despite a different genetic and environmental background to European populations, islet cell autoimmunity is common in autoimmune endocrine patients in central Africa. |
| doi_str_mv | 10.1016/j.clim.2005.09.016 |
| format | article |
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The present hospital-based study was carried out to evaluate disease-associated autoantibodies in both type 1 diabetes and thyrotoxicosis attending the Central Hospital of Yaoundee in Cameroon.
Samples were collected from a total of 101 subjects, 47 of whom clinically had established type 1 diabetes (mean age 30.1 years ± 7.6, mean disease duration 3.3 years), 18 had thyrotoxicosis (mean age 32.7 years ± 7.6, mean disease duration 6.3 years ± 2.8) and 36 normal subjects (mean age 26 years ± 4.5). All subjects were tested for diabetes-associated glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2) autoantibodies using antigen-specific radioimmunoassay as well as thyroiditis-associated thyroglobulin (Tg) and thyroid peroxidase (TPO) autoantibodies using commercially available kits.
Of 47 patients with type 1 diabetes, 16 (34%) had GAD autoantibodies (Abs), 3 (6.4%) had IA2 Abs, and 2 (4.3%) had TPO Abs. Of 18 patients with thyrotoxicosis 4 (22.2%) had GAD Abs, 5 (27.8%) showed IA2 Abs, while 8 patients (44.4%) were TPO Abs positive. No patients in either group had Tg Abs. Among normal subjects, 2 (5.6%) showed GAD Abs, and one of these was also IA2 Abs positive, but none had thyroid autoantibodies.
Adult-onset type 1 diabetic patients some years post-diagnosis from central Africa show GAD, IA2 or TPO Abs; and surprisingly, patients with thyrotoxicosis had a similar frequency of diabetes-associated autoantibodies. We conclude that, despite a different genetic and environmental background to European populations, islet cell autoimmunity is common in autoimmune endocrine patients in central Africa.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.clim.2005.09.016</identifier><identifier>PMID: 16298164</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Autoantibodies - blood ; Autoantigens - immunology ; Autoimmune thyroid disease ; Autoimmunity ; Biological and medical sciences ; Cameroon - epidemiology ; Diabetes Mellitus - blood ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; GAD antibodies ; Glutamate Decarboxylase - immunology ; Humans ; IA2 antibodies ; Immunopathology ; Iodide Peroxidase - immunology ; Iron-Binding Proteins - immunology ; Male ; Medical sciences ; Polyendocrinopathies, Autoimmune - blood ; Polyendocrinopathies, Autoimmune - epidemiology ; Polyendocrinopathies, Autoimmune - immunology ; Thyroglobulin - immunology ; Thyroid Gland - immunology ; Thyrotoxicosis - blood ; Thyrotoxicosis - immunology ; TPO antibodies ; Type 1 diabetes</subject><ispartof>Clinical Immunology, 2006-02, Vol.118 (2), p.229-232</ispartof><rights>2005</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-720c8aea6cbb289caf7afb7ee3ac3a6b80e185e589e115be0d33ad6d01b75a5b3</citedby><cites>FETCH-LOGICAL-c415t-720c8aea6cbb289caf7afb7ee3ac3a6b80e185e589e115be0d33ad6d01b75a5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17568125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16298164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawa, M.I.</creatorcontrib><creatorcontrib>Picardi, A.</creatorcontrib><creatorcontrib>Costanza, F.</creatorcontrib><creatorcontrib>D'Avola, D.</creatorcontrib><creatorcontrib>Beretta Anguissola, G.</creatorcontrib><creatorcontrib>Guglielmi, C.</creatorcontrib><creatorcontrib>Mottini, G.</creatorcontrib><creatorcontrib>Fezeu, L.</creatorcontrib><creatorcontrib>Mbanya, J.C.</creatorcontrib><creatorcontrib>Leslie, R.D.G.</creatorcontrib><creatorcontrib>Pozzilli, P.</creatorcontrib><title>Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon</title><title>Clinical Immunology</title><addtitle>Clin Immunol</addtitle><description>Diabetes is a major cause of morbidity and mortality in both industrialized and developing countries. In Africa, there are little data on the prevalence and immunological features of patients with autoimmune endocrine diseases.
The present hospital-based study was carried out to evaluate disease-associated autoantibodies in both type 1 diabetes and thyrotoxicosis attending the Central Hospital of Yaoundee in Cameroon.
Samples were collected from a total of 101 subjects, 47 of whom clinically had established type 1 diabetes (mean age 30.1 years ± 7.6, mean disease duration 3.3 years), 18 had thyrotoxicosis (mean age 32.7 years ± 7.6, mean disease duration 6.3 years ± 2.8) and 36 normal subjects (mean age 26 years ± 4.5). All subjects were tested for diabetes-associated glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2) autoantibodies using antigen-specific radioimmunoassay as well as thyroiditis-associated thyroglobulin (Tg) and thyroid peroxidase (TPO) autoantibodies using commercially available kits.
Of 47 patients with type 1 diabetes, 16 (34%) had GAD autoantibodies (Abs), 3 (6.4%) had IA2 Abs, and 2 (4.3%) had TPO Abs. Of 18 patients with thyrotoxicosis 4 (22.2%) had GAD Abs, 5 (27.8%) showed IA2 Abs, while 8 patients (44.4%) were TPO Abs positive. No patients in either group had Tg Abs. Among normal subjects, 2 (5.6%) showed GAD Abs, and one of these was also IA2 Abs positive, but none had thyroid autoantibodies.
Adult-onset type 1 diabetic patients some years post-diagnosis from central Africa show GAD, IA2 or TPO Abs; and surprisingly, patients with thyrotoxicosis had a similar frequency of diabetes-associated autoantibodies. We conclude that, despite a different genetic and environmental background to European populations, islet cell autoimmunity is common in autoimmune endocrine patients in central Africa.</description><subject>Adult</subject><subject>Autoantibodies - blood</subject><subject>Autoantigens - immunology</subject><subject>Autoimmune thyroid disease</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Cameroon - epidemiology</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>GAD antibodies</subject><subject>Glutamate Decarboxylase - immunology</subject><subject>Humans</subject><subject>IA2 antibodies</subject><subject>Immunopathology</subject><subject>Iodide Peroxidase - immunology</subject><subject>Iron-Binding Proteins - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polyendocrinopathies, Autoimmune - blood</subject><subject>Polyendocrinopathies, Autoimmune - epidemiology</subject><subject>Polyendocrinopathies, Autoimmune - immunology</subject><subject>Thyroglobulin - immunology</subject><subject>Thyroid Gland - immunology</subject><subject>Thyrotoxicosis - blood</subject><subject>Thyrotoxicosis - immunology</subject><subject>TPO antibodies</subject><subject>Type 1 diabetes</subject><issn>1521-6616</issn><issn>1521-7035</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkcFuFDEMhqMKREvhBXpAudDbDklmk5mRuKAVpZUqcYFz5CQeNauZZEkyoH17st2ReoOTf9mfLds_ITecNZxx9Wnf2MnPjWBMNmxoauqCXHEp-KZjrXy1aqW4uiRvc96zCgqh3pBLrsTQc7W9ItNdwl8LBnukcaTOg8GCmUJwtDwdU_SOwlIihOJNdL6WfKAHKB5DyfSPL0_PdT_PS0CKwUWbfFXOZ4SMdExxpjuYMcUY3pHXI0wZ36_xmvy8-_pjd795_P7tYfflcWO3XJZNJ5jtAUFZY0Q_WBg7GE2H2IJtQZmeIe8lyn5AzqVB5toWnHKMm06CNO01uT3PPaRYj8tFzz5bnCYIGJesVae2Uvb8vyDvOBOtaisozqBNMeeEoz4kP0M6as70yQy91ycz9MkMzQZdU7Xpwzp9MTO6l5b1-xX4uAKQLUxjgmB9fuE6qXouZOU-nzmsT_vtMelsqwEWnU9oi3bR_2uPv5ITqtA</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Hawa, M.I.</creator><creator>Picardi, A.</creator><creator>Costanza, F.</creator><creator>D'Avola, D.</creator><creator>Beretta Anguissola, G.</creator><creator>Guglielmi, C.</creator><creator>Mottini, G.</creator><creator>Fezeu, L.</creator><creator>Mbanya, J.C.</creator><creator>Leslie, R.D.G.</creator><creator>Pozzilli, P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon</title><author>Hawa, M.I. ; Picardi, A. ; Costanza, F. ; D'Avola, D. ; Beretta Anguissola, G. ; Guglielmi, C. ; Mottini, G. ; Fezeu, L. ; Mbanya, J.C. ; Leslie, R.D.G. ; Pozzilli, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-720c8aea6cbb289caf7afb7ee3ac3a6b80e185e589e115be0d33ad6d01b75a5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Autoantibodies - blood</topic><topic>Autoantigens - immunology</topic><topic>Autoimmune thyroid disease</topic><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Cameroon - epidemiology</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes Mellitus - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>GAD antibodies</topic><topic>Glutamate Decarboxylase - immunology</topic><topic>Humans</topic><topic>IA2 antibodies</topic><topic>Immunopathology</topic><topic>Iodide Peroxidase - immunology</topic><topic>Iron-Binding Proteins - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polyendocrinopathies, Autoimmune - blood</topic><topic>Polyendocrinopathies, Autoimmune - epidemiology</topic><topic>Polyendocrinopathies, Autoimmune - immunology</topic><topic>Thyroglobulin - immunology</topic><topic>Thyroid Gland - immunology</topic><topic>Thyrotoxicosis - blood</topic><topic>Thyrotoxicosis - immunology</topic><topic>TPO antibodies</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawa, M.I.</creatorcontrib><creatorcontrib>Picardi, A.</creatorcontrib><creatorcontrib>Costanza, F.</creatorcontrib><creatorcontrib>D'Avola, D.</creatorcontrib><creatorcontrib>Beretta Anguissola, G.</creatorcontrib><creatorcontrib>Guglielmi, C.</creatorcontrib><creatorcontrib>Mottini, G.</creatorcontrib><creatorcontrib>Fezeu, L.</creatorcontrib><creatorcontrib>Mbanya, J.C.</creatorcontrib><creatorcontrib>Leslie, R.D.G.</creatorcontrib><creatorcontrib>Pozzilli, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawa, M.I.</au><au>Picardi, A.</au><au>Costanza, F.</au><au>D'Avola, D.</au><au>Beretta Anguissola, G.</au><au>Guglielmi, C.</au><au>Mottini, G.</au><au>Fezeu, L.</au><au>Mbanya, J.C.</au><au>Leslie, R.D.G.</au><au>Pozzilli, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon</atitle><jtitle>Clinical Immunology</jtitle><addtitle>Clin Immunol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>118</volume><issue>2</issue><spage>229</spage><epage>232</epage><pages>229-232</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><eissn>1365-2567</eissn><coden>CLIIFY</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Diabetes is a major cause of morbidity and mortality in both industrialized and developing countries. In Africa, there are little data on the prevalence and immunological features of patients with autoimmune endocrine diseases.
The present hospital-based study was carried out to evaluate disease-associated autoantibodies in both type 1 diabetes and thyrotoxicosis attending the Central Hospital of Yaoundee in Cameroon.
Samples were collected from a total of 101 subjects, 47 of whom clinically had established type 1 diabetes (mean age 30.1 years ± 7.6, mean disease duration 3.3 years), 18 had thyrotoxicosis (mean age 32.7 years ± 7.6, mean disease duration 6.3 years ± 2.8) and 36 normal subjects (mean age 26 years ± 4.5). All subjects were tested for diabetes-associated glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2) autoantibodies using antigen-specific radioimmunoassay as well as thyroiditis-associated thyroglobulin (Tg) and thyroid peroxidase (TPO) autoantibodies using commercially available kits.
Of 47 patients with type 1 diabetes, 16 (34%) had GAD autoantibodies (Abs), 3 (6.4%) had IA2 Abs, and 2 (4.3%) had TPO Abs. Of 18 patients with thyrotoxicosis 4 (22.2%) had GAD Abs, 5 (27.8%) showed IA2 Abs, while 8 patients (44.4%) were TPO Abs positive. No patients in either group had Tg Abs. Among normal subjects, 2 (5.6%) showed GAD Abs, and one of these was also IA2 Abs positive, but none had thyroid autoantibodies.
Adult-onset type 1 diabetic patients some years post-diagnosis from central Africa show GAD, IA2 or TPO Abs; and surprisingly, patients with thyrotoxicosis had a similar frequency of diabetes-associated autoantibodies. We conclude that, despite a different genetic and environmental background to European populations, islet cell autoimmunity is common in autoimmune endocrine patients in central Africa.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>16298164</pmid><doi>10.1016/j.clim.2005.09.016</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical Immunology, 2006-02, Vol.118 (2), p.229-232 |
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| subjects | Adult Autoantibodies - blood Autoantigens - immunology Autoimmune thyroid disease Autoimmunity Biological and medical sciences Cameroon - epidemiology Diabetes Mellitus - blood Diabetes Mellitus - epidemiology Diabetes Mellitus - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology GAD antibodies Glutamate Decarboxylase - immunology Humans IA2 antibodies Immunopathology Iodide Peroxidase - immunology Iron-Binding Proteins - immunology Male Medical sciences Polyendocrinopathies, Autoimmune - blood Polyendocrinopathies, Autoimmune - epidemiology Polyendocrinopathies, Autoimmune - immunology Thyroglobulin - immunology Thyroid Gland - immunology Thyrotoxicosis - blood Thyrotoxicosis - immunology TPO antibodies Type 1 diabetes |
| title | Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon |
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