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Synthesis and properties of 2′- O,4′- C-methyleneoxymethylene bridged nucleic acid
A novel bridged nucleic acid (BNA) analogue, 2′- O,4′- C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNA COC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNA COC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stabi...
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| Published in: | Bioorganic & medicinal chemistry 2006-02, Vol.14 (4), p.1029-1038 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c478t-599d77e129ede8da53acda102f4b288ae7f1672b97b52d64b2c827d29019d3893 |
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| cites | cdi_FETCH-LOGICAL-c478t-599d77e129ede8da53acda102f4b288ae7f1672b97b52d64b2c827d29019d3893 |
| container_end_page | 1038 |
| container_issue | 4 |
| container_start_page | 1029 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 14 |
| creator | Hari, Yoshiyuki Obika, Satoshi Ohnishi, Ryo Eguchi, Ken Osaki, Tomohisa Ohishi, Hirofumi Imanishi, Takeshi |
| description | A novel bridged nucleic acid (BNA) analogue, 2′-
O,4′-
C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNA
COC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNA
COC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase. |
| doi_str_mv | 10.1016/j.bmc.2005.09.020 |
| format | article |
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O,4′-
C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNA
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C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNA
COC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNA
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O,4′-
C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNA
COC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNA
COC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16213732</pmid><doi>10.1016/j.bmc.2005.09.020</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2006-02, Vol.14 (4), p.1029-1038 |
| issn | 0968-0896 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67616870 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Biological and medical sciences Bridged nucleic acids Conformation Crystallography, X-Ray Heterocyclic Compounds - chemistry Medical sciences Miscellaneous Molecular Structure Nucleic Acid Denaturation Nucleic Acids - chemical synthesis Nucleic Acids - chemistry Nucleic Acids - metabolism Nucleosides Oligonucleotides Pharmacology. Drug treatments Phosphodiesterase I - metabolism Snakes Temperature |
| title | Synthesis and properties of 2′- O,4′- C-methyleneoxymethylene bridged nucleic acid |
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