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Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors
Mercaptoacetamides were designed and synthesized as HDAC inhibitors. A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some c...
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| Published in: | Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (5), p.1389-1392 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c450t-dbaf1c11a1c419e36620f09be99ca7f43f0929ae87ebb4d34aa6bf5fc2f456073 |
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| cites | cdi_FETCH-LOGICAL-c450t-dbaf1c11a1c419e36620f09be99ca7f43f0929ae87ebb4d34aa6bf5fc2f456073 |
| container_end_page | 1392 |
| container_issue | 5 |
| container_start_page | 1389 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 15 |
| creator | Chen, Bin Petukhov, Pavel A. Jung, Mira Velena, Alfredo Eliseeva, Elena Dritschilo, Anatoly Kozikowski, Alan P. |
| description | Mercaptoacetamides were designed and synthesized as HDAC inhibitors.
A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA. |
| doi_str_mv | 10.1016/j.bmcl.2005.01.006 |
| format | article |
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A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2005.01.006</identifier><identifier>PMID: 15713393</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acetamides - chemistry ; Acetamides - pharmacology ; Antineoplastic agents ; Binding Sites ; Biological and medical sciences ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; General aspects ; HDAC ; Histone deacetylase inhibitor ; Histone Deacetylase Inhibitors ; Medical sciences ; Mercaptoacetamide ; Models, Molecular ; Molecular Conformation ; Pharmacology. Drug treatments ; Structure-Activity Relationship ; Sulfhydryl Compounds - chemistry ; Sulfhydryl Compounds - pharmacology</subject><ispartof>Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (5), p.1389-1392</ispartof><rights>2005 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-dbaf1c11a1c419e36620f09be99ca7f43f0929ae87ebb4d34aa6bf5fc2f456073</citedby><cites>FETCH-LOGICAL-c450t-dbaf1c11a1c419e36620f09be99ca7f43f0929ae87ebb4d34aa6bf5fc2f456073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16558284$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15713393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Bin</creatorcontrib><creatorcontrib>Petukhov, Pavel A.</creatorcontrib><creatorcontrib>Jung, Mira</creatorcontrib><creatorcontrib>Velena, Alfredo</creatorcontrib><creatorcontrib>Eliseeva, Elena</creatorcontrib><creatorcontrib>Dritschilo, Anatoly</creatorcontrib><creatorcontrib>Kozikowski, Alan P.</creatorcontrib><title>Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Mercaptoacetamides were designed and synthesized as HDAC inhibitors.
A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.</description><subject>Acetamides - chemistry</subject><subject>Acetamides - pharmacology</subject><subject>Antineoplastic agents</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>General aspects</subject><subject>HDAC</subject><subject>Histone deacetylase inhibitor</subject><subject>Histone Deacetylase Inhibitors</subject><subject>Medical sciences</subject><subject>Mercaptoacetamide</subject><subject>Models, Molecular</subject><subject>Molecular Conformation</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Structure-Activity Relationship</topic><topic>Sulfhydryl Compounds - chemistry</topic><topic>Sulfhydryl Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Bin</creatorcontrib><creatorcontrib>Petukhov, Pavel A.</creatorcontrib><creatorcontrib>Jung, Mira</creatorcontrib><creatorcontrib>Velena, Alfredo</creatorcontrib><creatorcontrib>Eliseeva, Elena</creatorcontrib><creatorcontrib>Dritschilo, Anatoly</creatorcontrib><creatorcontrib>Kozikowski, Alan P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Bin</au><au>Petukhov, Pavel A.</au><au>Jung, Mira</au><au>Velena, Alfredo</au><au>Eliseeva, Elena</au><au>Dritschilo, Anatoly</au><au>Kozikowski, Alan P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>15</volume><issue>5</issue><spage>1389</spage><epage>1392</epage><pages>1389-1392</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Mercaptoacetamides were designed and synthesized as HDAC inhibitors.
A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15713393</pmid><doi>10.1016/j.bmcl.2005.01.006</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (5), p.1389-1392 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Acetamides - chemistry Acetamides - pharmacology Antineoplastic agents Binding Sites Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects HDAC Histone deacetylase inhibitor Histone Deacetylase Inhibitors Medical sciences Mercaptoacetamide Models, Molecular Molecular Conformation Pharmacology. Drug treatments Structure-Activity Relationship Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - pharmacology |
| title | Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors |
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