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Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/poly(lactic acid) nanoparticles
Poly(lactic acid) (PLA) was successfully grafted to both ends of Pluronic F127 block copolymers (PEO–PPO–PEO) to obtain amphiphilic PLA–F127–PLA block copolymers. The block composition and structure of PLA–F127–PLA block copolymers were studied by nuclear magnetic resonance (NMR), gel permeation chr...
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| Published in: | Journal of controlled release 2005-03, Vol.103 (1), p.73-82 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c490t-3d4b0e4e2ae975143ba75da9eb5799463657035bb73ccc103134e9cec712e16d3 |
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| cites | cdi_FETCH-LOGICAL-c490t-3d4b0e4e2ae975143ba75da9eb5799463657035bb73ccc103134e9cec712e16d3 |
| container_end_page | 82 |
| container_issue | 1 |
| container_start_page | 73 |
| container_title | Journal of controlled release |
| container_volume | 103 |
| creator | Xiong, X.Y. Tam, K.C. Gan, L.H. |
| description | Poly(lactic acid) (PLA) was successfully grafted to both ends of Pluronic F127 block copolymers (PEO–PPO–PEO) to obtain amphiphilic PLA–F127–PLA block copolymers. The block composition and structure of PLA–F127–PLA block copolymers were studied by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), differential scanning calorimetric (DSC) and wide angle X-ray diffraction (WXRD) techniques. Data from DSC and WXRD measurements indicated that
T
g and
T
m of PLA blocks in PLA–F127–PLA block polymers are lower than those of PLA homopolymer. Furthermore,
T
m and crystallinity of PLA blocks decrease with decreasing PLA block length in PLA–F127–PLA block copolymers. The release behaviors of both hydrophobic 9-(methylaminomethyl)anthracene (MAMA) and hydrophilic procaine hydrochloride (PrHy) model drugs from PLA–F127–PLA nanoparticles with vesicular structure in PBS solution at 37 °C were examined by UV spectroscopy. The release kinetics of both MAMA and PrHy model drugs from PLA–F127–PLA nanoparticles exhibit burst release characteristics, which are believed to be controlled by concentration gradient resulting from the slow hydrolytic degradation of PLA segments. |
| doi_str_mv | 10.1016/j.jconrel.2004.11.018 |
| format | article |
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T
g and
T
m of PLA blocks in PLA–F127–PLA block polymers are lower than those of PLA homopolymer. Furthermore,
T
m and crystallinity of PLA blocks decrease with decreasing PLA block length in PLA–F127–PLA block copolymers. The release behaviors of both hydrophobic 9-(methylaminomethyl)anthracene (MAMA) and hydrophilic procaine hydrochloride (PrHy) model drugs from PLA–F127–PLA nanoparticles with vesicular structure in PBS solution at 37 °C were examined by UV spectroscopy. The release kinetics of both MAMA and PrHy model drugs from PLA–F127–PLA nanoparticles exhibit burst release characteristics, which are believed to be controlled by concentration gradient resulting from the slow hydrolytic degradation of PLA segments.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2004.11.018</identifier><identifier>PMID: 15710501</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biocompatible ; Biodegradable ; Biological and medical sciences ; Drug delivery ; General pharmacology ; Hydrophobic and Hydrophilic Interactions ; Lactic Acid - pharmacokinetics ; Medical sciences ; Models, Chemical ; Nanostructures ; Pharmaceutical Preparations - metabolism ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; PLA–F127–PLA nanoparticles ; Poloxamer - pharmacokinetics ; Polyesters ; Polymers - pharmacokinetics ; Vesicles</subject><ispartof>Journal of controlled release, 2005-03, Vol.103 (1), p.73-82</ispartof><rights>2004 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-3d4b0e4e2ae975143ba75da9eb5799463657035bb73ccc103134e9cec712e16d3</citedby><cites>FETCH-LOGICAL-c490t-3d4b0e4e2ae975143ba75da9eb5799463657035bb73ccc103134e9cec712e16d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16552059$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15710501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiong, X.Y.</creatorcontrib><creatorcontrib>Tam, K.C.</creatorcontrib><creatorcontrib>Gan, L.H.</creatorcontrib><title>Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/poly(lactic acid) nanoparticles</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Poly(lactic acid) (PLA) was successfully grafted to both ends of Pluronic F127 block copolymers (PEO–PPO–PEO) to obtain amphiphilic PLA–F127–PLA block copolymers. The block composition and structure of PLA–F127–PLA block copolymers were studied by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), differential scanning calorimetric (DSC) and wide angle X-ray diffraction (WXRD) techniques. Data from DSC and WXRD measurements indicated that
T
g and
T
m of PLA blocks in PLA–F127–PLA block polymers are lower than those of PLA homopolymer. Furthermore,
T
m and crystallinity of PLA blocks decrease with decreasing PLA block length in PLA–F127–PLA block copolymers. The release behaviors of both hydrophobic 9-(methylaminomethyl)anthracene (MAMA) and hydrophilic procaine hydrochloride (PrHy) model drugs from PLA–F127–PLA nanoparticles with vesicular structure in PBS solution at 37 °C were examined by UV spectroscopy. The release kinetics of both MAMA and PrHy model drugs from PLA–F127–PLA nanoparticles exhibit burst release characteristics, which are believed to be controlled by concentration gradient resulting from the slow hydrolytic degradation of PLA segments.</description><subject>Biocompatible</subject><subject>Biodegradable</subject><subject>Biological and medical sciences</subject><subject>Drug delivery</subject><subject>General pharmacology</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Lactic Acid - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Models, Chemical</subject><subject>Nanostructures</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>PLA–F127–PLA nanoparticles</subject><subject>Poloxamer - pharmacokinetics</subject><subject>Polyesters</subject><subject>Polymers - pharmacokinetics</subject><subject>Vesicles</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkUGP1CAUxxujccfVj6DpRaOHdnkFynDamI2rJpuYGD0TCq8uI4UKrcl8e5lMzR73RB78_u8Bv6p6DaQFAv3VoT2YGBL6tiOEtQAtgf2Tagd7QRsmJX9a7Qq3b2jP5UX1IucDIYRTJp5XF8AFEE5gV4Xv6FFnrH-7gIszuY5jfX-0Kc73cXCm1sH-r50v9RQt-tqm9VeuxxSnevZriqGc3EInruboj--9Nsspapz9UAcd4qxT2fCYX1bPRu0zvtrWy-rn7acfN1-au2-fv958vGsMk2RpqGUDQYadRik4MDpowa2WOHAhJevLmwShfBgENcYAoUAZSoNGQIfQW3pZvTv3nVP8s2Je1OSyQe91wLhm1QtGuz0Rj4IgeFf6kwLyM2hSzDnhqObkJp2OCog6GVEHtRlRJyMKQBUjJfdmG7AOE9qH1KagAG83QGej_Zh0MC4_cD3nHeGycNdnDsu__XWYVDYOg0HrEppF2egeuco_od2svg</recordid><startdate>20050302</startdate><enddate>20050302</enddate><creator>Xiong, X.Y.</creator><creator>Tam, K.C.</creator><creator>Gan, L.H.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050302</creationdate><title>Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/poly(lactic acid) nanoparticles</title><author>Xiong, X.Y. ; Tam, K.C. ; Gan, L.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-3d4b0e4e2ae975143ba75da9eb5799463657035bb73ccc103134e9cec712e16d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biocompatible</topic><topic>Biodegradable</topic><topic>Biological and medical sciences</topic><topic>Drug delivery</topic><topic>General pharmacology</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Lactic Acid - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Models, Chemical</topic><topic>Nanostructures</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>PLA–F127–PLA nanoparticles</topic><topic>Poloxamer - pharmacokinetics</topic><topic>Polyesters</topic><topic>Polymers - pharmacokinetics</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiong, X.Y.</creatorcontrib><creatorcontrib>Tam, K.C.</creatorcontrib><creatorcontrib>Gan, L.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiong, X.Y.</au><au>Tam, K.C.</au><au>Gan, L.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/poly(lactic acid) nanoparticles</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2005-03-02</date><risdate>2005</risdate><volume>103</volume><issue>1</issue><spage>73</spage><epage>82</epage><pages>73-82</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Poly(lactic acid) (PLA) was successfully grafted to both ends of Pluronic F127 block copolymers (PEO–PPO–PEO) to obtain amphiphilic PLA–F127–PLA block copolymers. The block composition and structure of PLA–F127–PLA block copolymers were studied by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), differential scanning calorimetric (DSC) and wide angle X-ray diffraction (WXRD) techniques. Data from DSC and WXRD measurements indicated that
T
g and
T
m of PLA blocks in PLA–F127–PLA block polymers are lower than those of PLA homopolymer. Furthermore,
T
m and crystallinity of PLA blocks decrease with decreasing PLA block length in PLA–F127–PLA block copolymers. The release behaviors of both hydrophobic 9-(methylaminomethyl)anthracene (MAMA) and hydrophilic procaine hydrochloride (PrHy) model drugs from PLA–F127–PLA nanoparticles with vesicular structure in PBS solution at 37 °C were examined by UV spectroscopy. The release kinetics of both MAMA and PrHy model drugs from PLA–F127–PLA nanoparticles exhibit burst release characteristics, which are believed to be controlled by concentration gradient resulting from the slow hydrolytic degradation of PLA segments.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15710501</pmid><doi>10.1016/j.jconrel.2004.11.018</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2005-03, Vol.103 (1), p.73-82 |
| issn | 0168-3659 1873-4995 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Biocompatible Biodegradable Biological and medical sciences Drug delivery General pharmacology Hydrophobic and Hydrophilic Interactions Lactic Acid - pharmacokinetics Medical sciences Models, Chemical Nanostructures Pharmaceutical Preparations - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLA–F127–PLA nanoparticles Poloxamer - pharmacokinetics Polyesters Polymers - pharmacokinetics Vesicles |
| title | Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/poly(lactic acid) nanoparticles |
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