Biophysical dissection of membrane proteins

The first atomic-resolution structure of a membrane protein was solved in 1985. Twenty-four years and more than 180 unique structures later, what have we have learned? An examination of the atomic details of several diverse membrane proteins reveals some remarkable biophysical features and suggests...

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Bibliographic Details
Published in:Nature 2009-05, Vol.459 (7245), p.344-346
Main Author: White, Stephen H
Format: Article
Language:English
Subjects:
Amino Acid Motifs
Animals
Bacteriorhodopsin
Biophysics
Dissection
E coli
Humans
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
Membrane proteins
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Membranes
Physiological aspects
Protein Structure, Secondary
Proteins
R&D
Research & development
Signal Transduction
Structure
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Summary:The first atomic-resolution structure of a membrane protein was solved in 1985. Twenty-four years and more than 180 unique structures later, what have we have learned? An examination of the atomic details of several diverse membrane proteins reveals some remarkable biophysical features and suggests that we can expect to achieve much more in the decades to come.
ISSN:0028-0836
1476-4687
1476-4679
DOI:10.1038/nature08142