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Hybrid tumour ‘oncocytoma‐chromophobe renal cell carcinoma’ of the kidney: a report of seven sporadic cases
OBJECTIVES To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt‐Hogg‐Dube syndrome...
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| Published in: | BJU international 2009-05, Vol.103 (10), p.1381-1384 |
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| creator | Delongchamps, Nicolas B. Galmiche, Louise Eiss, David Rouach, Yannick Vogt, Benoit Timsit, Marc‐Olivier Vieillefond, Annick Méjean, Arnaud |
| description | OBJECTIVES
To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt‐Hogg‐Dube syndrome.
PATIENTS AND METHODS
We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007. We report the clinical, radiological and pathological characteristics of the seven cases of HT.
RESULTS
The mean (range) age of the patients was 56 (41–68) year. None of the seven patients had any suspicion of RO, based on computed tomography (CT). Two patients had a history of kidney cancer. Five patients had partial and two a radical nephrectomy. The mean (range) maximum tumour diameter was 5.5 (1.8–9) cm. Two tumours were pT1a, two were pT1b and three were pT2. Pathological analysis showed RO‐like and CRCC‐like cells intermixed (six patients) or distinct (one). After a median (range) follow‐up of 20 (8–25) months, none of the patients had any evidence of disease recurrence.
CONCLUSIONS
In a large series of patients with sporadic RO and CRCC, 10% of the tumours had hybrid morphological features, as described in oncocytosis and Birt‐Hogg‐Dube syndrome. We were unable to identify any specific clinical characteristic. Most importantly, none of these HT showed any of the radiological characteristics of RO. |
| doi_str_mv | 10.1111/j.1464-410X.2008.08263.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67253403</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67253403</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3973-6c8d38fb578ef2673970defc7974abeb2f3bba321aea6570708ebda395801a5f3</originalsourceid><addsrcrecordid>eNqNkM1O3DAUha2KqlDaV0DewG6CfxI7QeqioLZQIXVTpO4s27nWZEjiwU6A7HiELtvX40nqMANs64V9ffyd66uDEKYko2kdrzKai3yRU_IrY4SUGSmZ4Nn9G7T38rDzXJNK7KL3Ma4ISYIo3qFdWtEizyu5h27OJxOaGg9j58eAHx_--N56Ow2-048Pv-0y-M6vl94ADtDrFlto06aDbfon5C_2Dg9LwNdN3cN0gnUC1z4Msx7hFnoc01XXjU22CPEDeut0G-Hj9txHV1-__Dw7X1z--HZx9vlyYXkl-ULYsualM4UswTEhk0hqcFZWMtcGDHPcGM0Z1aBFIYkkJZha86ooCdWF4_voaNN3HfzNCHFQXRPn6XUPfoxKSFbwnPAElhvQBh9jAKfWoel0mBQlao5brdScpJpTVXPc6iludZ-sB9s_RtNB_Wrc5puAwy2go9WtC7q3TXzhGM1ZIRhJ3KcNd9e0MP33AOr0-9Vc8X-FPKBL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67253403</pqid></control><display><type>article</type><title>Hybrid tumour ‘oncocytoma‐chromophobe renal cell carcinoma’ of the kidney: a report of seven sporadic cases</title><source>Wiley</source><creator>Delongchamps, Nicolas B. ; Galmiche, Louise ; Eiss, David ; Rouach, Yannick ; Vogt, Benoit ; Timsit, Marc‐Olivier ; Vieillefond, Annick ; Méjean, Arnaud</creator><creatorcontrib>Delongchamps, Nicolas B. ; Galmiche, Louise ; Eiss, David ; Rouach, Yannick ; Vogt, Benoit ; Timsit, Marc‐Olivier ; Vieillefond, Annick ; Méjean, Arnaud</creatorcontrib><description>OBJECTIVES
To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt‐Hogg‐Dube syndrome.
PATIENTS AND METHODS
We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007. We report the clinical, radiological and pathological characteristics of the seven cases of HT.
RESULTS
The mean (range) age of the patients was 56 (41–68) year. None of the seven patients had any suspicion of RO, based on computed tomography (CT). Two patients had a history of kidney cancer. Five patients had partial and two a radical nephrectomy. The mean (range) maximum tumour diameter was 5.5 (1.8–9) cm. Two tumours were pT1a, two were pT1b and three were pT2. Pathological analysis showed RO‐like and CRCC‐like cells intermixed (six patients) or distinct (one). After a median (range) follow‐up of 20 (8–25) months, none of the patients had any evidence of disease recurrence.
CONCLUSIONS
In a large series of patients with sporadic RO and CRCC, 10% of the tumours had hybrid morphological features, as described in oncocytosis and Birt‐Hogg‐Dube syndrome. We were unable to identify any specific clinical characteristic. Most importantly, none of these HT showed any of the radiological characteristics of RO.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2008.08263.x</identifier><identifier>PMID: 19154497</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenoma, Oxyphilic - genetics ; Adenoma, Oxyphilic - pathology ; Adenoma, Oxyphilic - surgery ; Adult ; Aged ; Biological and medical sciences ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; chromophobe carcinoma ; Female ; Genetic Predisposition to Disease ; Humans ; hybrid tumours ; kidney ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Nephrectomy - methods ; Nephrology. Urinary tract diseases ; oncocytoma ; Prognosis ; Tomography, X-Ray Computed</subject><ispartof>BJU international, 2009-05, Vol.103 (10), p.1381-1384</ispartof><rights>2009 THE AUTHORS. JOURNAL COMPILATION © 2009 BJU INTERNATIONAL</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3973-6c8d38fb578ef2673970defc7974abeb2f3bba321aea6570708ebda395801a5f3</citedby><cites>FETCH-LOGICAL-c3973-6c8d38fb578ef2673970defc7974abeb2f3bba321aea6570708ebda395801a5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2008.08263.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2008.08263.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21425620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19154497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delongchamps, Nicolas B.</creatorcontrib><creatorcontrib>Galmiche, Louise</creatorcontrib><creatorcontrib>Eiss, David</creatorcontrib><creatorcontrib>Rouach, Yannick</creatorcontrib><creatorcontrib>Vogt, Benoit</creatorcontrib><creatorcontrib>Timsit, Marc‐Olivier</creatorcontrib><creatorcontrib>Vieillefond, Annick</creatorcontrib><creatorcontrib>Méjean, Arnaud</creatorcontrib><title>Hybrid tumour ‘oncocytoma‐chromophobe renal cell carcinoma’ of the kidney: a report of seven sporadic cases</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>OBJECTIVES
To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt‐Hogg‐Dube syndrome.
PATIENTS AND METHODS
We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007. We report the clinical, radiological and pathological characteristics of the seven cases of HT.
RESULTS
The mean (range) age of the patients was 56 (41–68) year. None of the seven patients had any suspicion of RO, based on computed tomography (CT). Two patients had a history of kidney cancer. Five patients had partial and two a radical nephrectomy. The mean (range) maximum tumour diameter was 5.5 (1.8–9) cm. Two tumours were pT1a, two were pT1b and three were pT2. Pathological analysis showed RO‐like and CRCC‐like cells intermixed (six patients) or distinct (one). After a median (range) follow‐up of 20 (8–25) months, none of the patients had any evidence of disease recurrence.
CONCLUSIONS
In a large series of patients with sporadic RO and CRCC, 10% of the tumours had hybrid morphological features, as described in oncocytosis and Birt‐Hogg‐Dube syndrome. We were unable to identify any specific clinical characteristic. Most importantly, none of these HT showed any of the radiological characteristics of RO.</description><subject>Adenoma, Oxyphilic - genetics</subject><subject>Adenoma, Oxyphilic - pathology</subject><subject>Adenoma, Oxyphilic - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>chromophobe carcinoma</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>hybrid tumours</subject><subject>kidney</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nephrectomy - methods</subject><subject>Nephrology. Urinary tract diseases</subject><subject>oncocytoma</subject><subject>Prognosis</subject><subject>Tomography, X-Ray Computed</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkM1O3DAUha2KqlDaV0DewG6CfxI7QeqioLZQIXVTpO4s27nWZEjiwU6A7HiELtvX40nqMANs64V9ffyd66uDEKYko2kdrzKai3yRU_IrY4SUGSmZ4Nn9G7T38rDzXJNK7KL3Ma4ISYIo3qFdWtEizyu5h27OJxOaGg9j58eAHx_--N56Ow2-048Pv-0y-M6vl94ADtDrFlto06aDbfon5C_2Dg9LwNdN3cN0gnUC1z4Msx7hFnoc01XXjU22CPEDeut0G-Hj9txHV1-__Dw7X1z--HZx9vlyYXkl-ULYsualM4UswTEhk0hqcFZWMtcGDHPcGM0Z1aBFIYkkJZha86ooCdWF4_voaNN3HfzNCHFQXRPn6XUPfoxKSFbwnPAElhvQBh9jAKfWoel0mBQlao5brdScpJpTVXPc6iludZ-sB9s_RtNB_Wrc5puAwy2go9WtC7q3TXzhGM1ZIRhJ3KcNd9e0MP33AOr0-9Vc8X-FPKBL</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Delongchamps, Nicolas B.</creator><creator>Galmiche, Louise</creator><creator>Eiss, David</creator><creator>Rouach, Yannick</creator><creator>Vogt, Benoit</creator><creator>Timsit, Marc‐Olivier</creator><creator>Vieillefond, Annick</creator><creator>Méjean, Arnaud</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200905</creationdate><title>Hybrid tumour ‘oncocytoma‐chromophobe renal cell carcinoma’ of the kidney: a report of seven sporadic cases</title><author>Delongchamps, Nicolas B. ; Galmiche, Louise ; Eiss, David ; Rouach, Yannick ; Vogt, Benoit ; Timsit, Marc‐Olivier ; Vieillefond, Annick ; Méjean, Arnaud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3973-6c8d38fb578ef2673970defc7974abeb2f3bba321aea6570708ebda395801a5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenoma, Oxyphilic - genetics</topic><topic>Adenoma, Oxyphilic - pathology</topic><topic>Adenoma, Oxyphilic - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>chromophobe carcinoma</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>hybrid tumours</topic><topic>kidney</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nephrectomy - methods</topic><topic>Nephrology. Urinary tract diseases</topic><topic>oncocytoma</topic><topic>Prognosis</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delongchamps, Nicolas B.</creatorcontrib><creatorcontrib>Galmiche, Louise</creatorcontrib><creatorcontrib>Eiss, David</creatorcontrib><creatorcontrib>Rouach, Yannick</creatorcontrib><creatorcontrib>Vogt, Benoit</creatorcontrib><creatorcontrib>Timsit, Marc‐Olivier</creatorcontrib><creatorcontrib>Vieillefond, Annick</creatorcontrib><creatorcontrib>Méjean, Arnaud</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delongchamps, Nicolas B.</au><au>Galmiche, Louise</au><au>Eiss, David</au><au>Rouach, Yannick</au><au>Vogt, Benoit</au><au>Timsit, Marc‐Olivier</au><au>Vieillefond, Annick</au><au>Méjean, Arnaud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hybrid tumour ‘oncocytoma‐chromophobe renal cell carcinoma’ of the kidney: a report of seven sporadic cases</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2009-05</date><risdate>2009</risdate><volume>103</volume><issue>10</issue><spage>1381</spage><epage>1384</epage><pages>1381-1384</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>OBJECTIVES
To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt‐Hogg‐Dube syndrome.
PATIENTS AND METHODS
We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007. We report the clinical, radiological and pathological characteristics of the seven cases of HT.
RESULTS
The mean (range) age of the patients was 56 (41–68) year. None of the seven patients had any suspicion of RO, based on computed tomography (CT). Two patients had a history of kidney cancer. Five patients had partial and two a radical nephrectomy. The mean (range) maximum tumour diameter was 5.5 (1.8–9) cm. Two tumours were pT1a, two were pT1b and three were pT2. Pathological analysis showed RO‐like and CRCC‐like cells intermixed (six patients) or distinct (one). After a median (range) follow‐up of 20 (8–25) months, none of the patients had any evidence of disease recurrence.
CONCLUSIONS
In a large series of patients with sporadic RO and CRCC, 10% of the tumours had hybrid morphological features, as described in oncocytosis and Birt‐Hogg‐Dube syndrome. We were unable to identify any specific clinical characteristic. Most importantly, none of these HT showed any of the radiological characteristics of RO.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19154497</pmid><doi>10.1111/j.1464-410X.2008.08263.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenoma, Oxyphilic - genetics Adenoma, Oxyphilic - pathology Adenoma, Oxyphilic - surgery Adult Aged Biological and medical sciences Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery chromophobe carcinoma Female Genetic Predisposition to Disease Humans hybrid tumours kidney Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidney Neoplasms - surgery Male Medical sciences Middle Aged Neoplasm Staging Nephrectomy - methods Nephrology. Urinary tract diseases oncocytoma Prognosis Tomography, X-Ray Computed |
| title | Hybrid tumour ‘oncocytoma‐chromophobe renal cell carcinoma’ of the kidney: a report of seven sporadic cases |
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