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Acute zonal occult outer retinopathy in a patient with graft-versus-host disease
To investigate the mechanism of bilateral central vision loss in a patient with graft-versus-host disease. Observational case report. A 43-year-old man with graft-versus-host disease developed acute painless progressive central vision loss, first in the left eye and then in the right. The patient un...
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| Published in: | American journal of ophthalmology 2004-12, Vol.138 (6), p.1058-1060 |
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| Main Authors: | , , , , |
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| container_end_page | 1060 |
| container_issue | 6 |
| container_start_page | 1058 |
| container_title | American journal of ophthalmology |
| container_volume | 138 |
| creator | Cheung, Marsha C. Nune, George C. Hwang, David G. Sutter, Erich E. Duncan, Jacque L. |
| description | To investigate the mechanism of bilateral central vision loss in a patient with graft-versus-host disease.
Observational case report.
A 43-year-old man with graft-versus-host disease developed acute painless progressive central vision loss, first in the left eye and then in the right. The patient underwent slit-lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, visual field testing, full-field electroretinography, multifocal electroretinography, and testing for paraneoplastic antibodies.
Fundus examination and fluorescein angiography were unremarkable. Goldmann perimetry revealed enlarged blind spots with central scotomas bilaterally. An electroretinogram testing showed asymmetric retinal dysfunction, consistent with acute zonal occult outer retinopathy. No paraneoplastic autoantibodies were detected. The patient continued to have asymmetric progressive vision loss that stabilized over the next 6 months.
Graft-versus-host disease should be included in the autoimmune conditions associated with AZOOR. |
| doi_str_mv | 10.1016/j.ajo.2004.06.042 |
| format | article |
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Observational case report.
A 43-year-old man with graft-versus-host disease developed acute painless progressive central vision loss, first in the left eye and then in the right. The patient underwent slit-lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, visual field testing, full-field electroretinography, multifocal electroretinography, and testing for paraneoplastic antibodies.
Fundus examination and fluorescein angiography were unremarkable. Goldmann perimetry revealed enlarged blind spots with central scotomas bilaterally. An electroretinogram testing showed asymmetric retinal dysfunction, consistent with acute zonal occult outer retinopathy. No paraneoplastic autoantibodies were detected. The patient continued to have asymmetric progressive vision loss that stabilized over the next 6 months.
Graft-versus-host disease should be included in the autoimmune conditions associated with AZOOR.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2004.06.042</identifier><identifier>PMID: 15629309</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Adult ; Autoimmune diseases ; Biological and medical sciences ; Bone marrow ; Disease ; Electroretinography ; Eyes & eyesight ; Fluorescein Angiography ; Graft vs Host Disease - complications ; Graft vs Host Disease - diagnosis ; Humans ; Male ; Medical sciences ; Ophthalmology ; Ophthalmoscopy ; Retinal Diseases - diagnosis ; Retinal Diseases - etiology ; Retinopathies ; Transplants & implants ; Vision Disorders - diagnosis ; Vision Disorders - etiology ; Visual Acuity ; Visual Field Tests ; Visual Fields</subject><ispartof>American journal of ophthalmology, 2004-12, Vol.138 (6), p.1058-1060</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-e6b1bc859558ae751233381a166120df59b4eb4aae5b99c05c9e25714baf7373</citedby><cites>FETCH-LOGICAL-c409t-e6b1bc859558ae751233381a166120df59b4eb4aae5b99c05c9e25714baf7373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16412273$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15629309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheung, Marsha C.</creatorcontrib><creatorcontrib>Nune, George C.</creatorcontrib><creatorcontrib>Hwang, David G.</creatorcontrib><creatorcontrib>Sutter, Erich E.</creatorcontrib><creatorcontrib>Duncan, Jacque L.</creatorcontrib><title>Acute zonal occult outer retinopathy in a patient with graft-versus-host disease</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To investigate the mechanism of bilateral central vision loss in a patient with graft-versus-host disease.
Observational case report.
A 43-year-old man with graft-versus-host disease developed acute painless progressive central vision loss, first in the left eye and then in the right. The patient underwent slit-lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, visual field testing, full-field electroretinography, multifocal electroretinography, and testing for paraneoplastic antibodies.
Fundus examination and fluorescein angiography were unremarkable. Goldmann perimetry revealed enlarged blind spots with central scotomas bilaterally. An electroretinogram testing showed asymmetric retinal dysfunction, consistent with acute zonal occult outer retinopathy. No paraneoplastic autoantibodies were detected. The patient continued to have asymmetric progressive vision loss that stabilized over the next 6 months.
Graft-versus-host disease should be included in the autoimmune conditions associated with AZOOR.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Disease</subject><subject>Electroretinography</subject><subject>Eyes & eyesight</subject><subject>Fluorescein Angiography</subject><subject>Graft vs Host Disease - complications</subject><subject>Graft vs Host Disease - diagnosis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Ophthalmoscopy</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Diseases - etiology</subject><subject>Retinopathies</subject><subject>Transplants & implants</subject><subject>Vision Disorders - diagnosis</subject><subject>Vision Disorders - etiology</subject><subject>Visual Acuity</subject><subject>Visual Field Tests</subject><subject>Visual Fields</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kE1r3DAQhkVJaLZpf0AuRRCSm11J1odFTiEkbSDQHnIXsjzOynitrSRvSX99texCIIeeJA3PzLx6ELqgpKaEym9jbcdQM0J4TWRNOPuAVrRVuqKtpidoRQhhlW40P0OfUhrLUyquPqIzKiTTDdEr9OvWLRnw3zDbCQfnlinjUCoRR8h-Dlub16_Yz9jicvUwZ_zH5zV-iXbI1Q5iWlK1Dinj3iewCT6j08FOCb4cz3P0_HD_fPejevr5_fHu9qlynOhcgexo51qhhWgtKEFZ0zQttVRKykg_CN1x6Li1IDqtHRFOAxOK8s4OqlHNObo-jN3G8HuBlM3GJwfTZGcISzJSMcaFaAp4-Q4cwxLLb5Mpi1rBCSO8UPRAuRhSijCYbfQbG18NJWbv2oymuDZ714ZIU1yXnq_HyUu3gf6t4yi3AFdHwCZnpyHa2fn0xklOGVP7iDcHDoqvnYdokiumHfQ-gsumD_4_Mf4BAAybIA</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Cheung, Marsha C.</creator><creator>Nune, George C.</creator><creator>Hwang, David G.</creator><creator>Sutter, Erich E.</creator><creator>Duncan, Jacque L.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Acute zonal occult outer retinopathy in a patient with graft-versus-host disease</title><author>Cheung, Marsha C. ; Nune, George C. ; Hwang, David G. ; Sutter, Erich E. ; Duncan, Jacque L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-e6b1bc859558ae751233381a166120df59b4eb4aae5b99c05c9e25714baf7373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Autoimmune diseases</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Disease</topic><topic>Electroretinography</topic><topic>Eyes & eyesight</topic><topic>Fluorescein Angiography</topic><topic>Graft vs Host Disease - complications</topic><topic>Graft vs Host Disease - diagnosis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Ophthalmoscopy</topic><topic>Retinal Diseases - diagnosis</topic><topic>Retinal Diseases - etiology</topic><topic>Retinopathies</topic><topic>Transplants & implants</topic><topic>Vision Disorders - diagnosis</topic><topic>Vision Disorders - etiology</topic><topic>Visual Acuity</topic><topic>Visual Field Tests</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheung, Marsha C.</creatorcontrib><creatorcontrib>Nune, George C.</creatorcontrib><creatorcontrib>Hwang, David G.</creatorcontrib><creatorcontrib>Sutter, Erich E.</creatorcontrib><creatorcontrib>Duncan, Jacque L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheung, Marsha C.</au><au>Nune, George C.</au><au>Hwang, David G.</au><au>Sutter, Erich E.</au><au>Duncan, Jacque L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute zonal occult outer retinopathy in a patient with graft-versus-host disease</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>138</volume><issue>6</issue><spage>1058</spage><epage>1060</epage><pages>1058-1060</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><notes>ObjectType-Case Study-3</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-4</notes><notes>content type line 23</notes><notes>ObjectType-Report-2</notes><abstract>To investigate the mechanism of bilateral central vision loss in a patient with graft-versus-host disease.
Observational case report.
A 43-year-old man with graft-versus-host disease developed acute painless progressive central vision loss, first in the left eye and then in the right. The patient underwent slit-lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, visual field testing, full-field electroretinography, multifocal electroretinography, and testing for paraneoplastic antibodies.
Fundus examination and fluorescein angiography were unremarkable. Goldmann perimetry revealed enlarged blind spots with central scotomas bilaterally. An electroretinogram testing showed asymmetric retinal dysfunction, consistent with acute zonal occult outer retinopathy. No paraneoplastic autoantibodies were detected. The patient continued to have asymmetric progressive vision loss that stabilized over the next 6 months.
Graft-versus-host disease should be included in the autoimmune conditions associated with AZOOR.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15629309</pmid><doi>10.1016/j.ajo.2004.06.042</doi><tpages>3</tpages></addata></record> |
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| subjects | Acute Disease Adult Autoimmune diseases Biological and medical sciences Bone marrow Disease Electroretinography Eyes & eyesight Fluorescein Angiography Graft vs Host Disease - complications Graft vs Host Disease - diagnosis Humans Male Medical sciences Ophthalmology Ophthalmoscopy Retinal Diseases - diagnosis Retinal Diseases - etiology Retinopathies Transplants & implants Vision Disorders - diagnosis Vision Disorders - etiology Visual Acuity Visual Field Tests Visual Fields |
| title | Acute zonal occult outer retinopathy in a patient with graft-versus-host disease |
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