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Effect of Long-term Hormone Replacement Therapy on Coronary Endothelial Function in Postmenopausal Women
To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function. Women undergoing coronary physiology studies for chest pain at the Mayo Cl...
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Published in: | Mayo Clinic proceedings 2004-12, Vol.79 (12), p.1514-1520 |
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container_title | Mayo Clinic proceedings |
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creator | Halligan, Sean C. Murtagh, Blaithnead Lennon, Ryan J. Pumper, Geralyn M. Mathew, Verghese Higano, Stuart T. Lerman, Amir |
description | To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function.
Women undergoing coronary physiology studies for chest pain at the Mayo Clinic in Rochester, Minn, between December 1992 and April 2002 underwent assessment of coronary endothelium-independent and -dependent function with intracoronary administration of adenosine and acetylcholine, respectively. The coronary diameters, coronary blood flows, and coronary velocity reserves were measured.
A total of 270 women (89 premenopausal and 181 postmenopausal) participated in the study. Endothelium-dependent coronary blood flow change (baseline to peak flow) in response to acetylcholine (10
−6, 10
−5, and 10
−4 mol/L) was lower in postmenopausal women compared with premenopausal women (39.7% vs 72.9%,
P=.03). There was no significant difference between the postmenopausal women receiving and not receiving HRT with regard to percent change in coronary diameter (-21.8% vs -13.9%,
P=.15), percent change in coronary blood flow (37.3% vs 42.7%,
P=.74), or coronary velocity reserve (2.7 vs 2.7,
P=.82).
This study shows that the postmenopausal state is associated with a greater abnormality in coronary endothelial function at the level of the microcirculation. Moreover, HRT status was not associated with an improvement in coronary endothelial function in postmenopausal women. |
doi_str_mv | 10.4065/79.12.1514 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67185222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0025619611618569</els_id><sourcerecordid>755459681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-fa230efc66533a3b64c4fb0662f36fae6d5846ac35da184ce346e58765cb3bf33</originalsourceid><addsrcrecordid>eNpt0U1r3DAQBmARWpJN2kt-QBGF5hDwVt-2j2XZJIWFlpLSo5DlUVbBllzJLuTfV2EXAiEnIebRaPQKoUtK1oIo-bVu15StqaTiBK1oK1glpVDv0IoQJitFW3WGznN-JITUbStO0RmVspWcyxXab50DO-Po8C6Gh2qGNOK7mMYYAP-CaTAWRggzvt9DMtMTjgFvYorBpCe8DX2c9zB4M-CbJdjZl6oP-GfMczkUJ7PkUvoTy-YDeu_MkOHjcb1Av2-295u7avfj9vvm266yQtK5coZxAs4qVeYzvFPCCtcRpZjjyhlQvWyEMpbL3tBGWOBCgWxqJW3HO8f5Bbo69J1S_LtAnvXos4VhMAHikrWqaSMZYwV-fgUf45JCmU0zqholGyYKuj4gm2LOCZyekh_L2zUl-jl8XbeaMv0cfsGfjh2XboT-hR7TLuDLEZhszeCSCdbnF6c4a0RTFycODkpQ_zwkna2HYKH3qXyW7qN_6_7_DLmdUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216865824</pqid></control><display><type>article</type><title>Effect of Long-term Hormone Replacement Therapy on Coronary Endothelial Function in Postmenopausal Women</title><source>ScienceDirect Journals</source><creator>Halligan, Sean C. ; Murtagh, Blaithnead ; Lennon, Ryan J. ; Pumper, Geralyn M. ; Mathew, Verghese ; Higano, Stuart T. ; Lerman, Amir</creator><creatorcontrib>Halligan, Sean C. ; Murtagh, Blaithnead ; Lennon, Ryan J. ; Pumper, Geralyn M. ; Mathew, Verghese ; Higano, Stuart T. ; Lerman, Amir</creatorcontrib><description>To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function.
Women undergoing coronary physiology studies for chest pain at the Mayo Clinic in Rochester, Minn, between December 1992 and April 2002 underwent assessment of coronary endothelium-independent and -dependent function with intracoronary administration of adenosine and acetylcholine, respectively. The coronary diameters, coronary blood flows, and coronary velocity reserves were measured.
A total of 270 women (89 premenopausal and 181 postmenopausal) participated in the study. Endothelium-dependent coronary blood flow change (baseline to peak flow) in response to acetylcholine (10
−6, 10
−5, and 10
−4 mol/L) was lower in postmenopausal women compared with premenopausal women (39.7% vs 72.9%,
P=.03). There was no significant difference between the postmenopausal women receiving and not receiving HRT with regard to percent change in coronary diameter (-21.8% vs -13.9%,
P=.15), percent change in coronary blood flow (37.3% vs 42.7%,
P=.74), or coronary velocity reserve (2.7 vs 2.7,
P=.82).
This study shows that the postmenopausal state is associated with a greater abnormality in coronary endothelial function at the level of the microcirculation. Moreover, HRT status was not associated with an improvement in coronary endothelial function in postmenopausal women.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.4065/79.12.1514</identifier><identifier>PMID: 15595335</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>Rochester, MN: Elsevier Inc</publisher><subject>Acetylcholine ; Adenosine ; Adult ; Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Angiography - methods ; Coronary Circulation - drug effects ; Coronary Circulation - physiology ; Coronary heart disease ; Coronary Vessels - drug effects ; Coronary Vessels - physiology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Female ; General aspects ; Heart ; Hormone Replacement Therapy - methods ; Humans ; Long-Term Care ; Medical sciences ; Middle Aged ; Postmenopause - drug effects ; Postmenopause - physiology ; Premenopause - physiology ; Probability ; Prospective Studies ; Reference Values ; Sensitivity and Specificity ; Ultrasonography, Interventional - methods</subject><ispartof>Mayo Clinic proceedings, 2004-12, Vol.79 (12), p.1514-1520</ispartof><rights>2004 Mayo Foundation for Medical Education and Research</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Mayo Foundation for Medical Education and Research Dec 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-fa230efc66533a3b64c4fb0662f36fae6d5846ac35da184ce346e58765cb3bf33</citedby><cites>FETCH-LOGICAL-c451t-fa230efc66533a3b64c4fb0662f36fae6d5846ac35da184ce346e58765cb3bf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0025619611618569$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,786,790,3568,27957,27958,45815</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16328487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15595335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halligan, Sean C.</creatorcontrib><creatorcontrib>Murtagh, Blaithnead</creatorcontrib><creatorcontrib>Lennon, Ryan J.</creatorcontrib><creatorcontrib>Pumper, Geralyn M.</creatorcontrib><creatorcontrib>Mathew, Verghese</creatorcontrib><creatorcontrib>Higano, Stuart T.</creatorcontrib><creatorcontrib>Lerman, Amir</creatorcontrib><title>Effect of Long-term Hormone Replacement Therapy on Coronary Endothelial Function in Postmenopausal Women</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function.
Women undergoing coronary physiology studies for chest pain at the Mayo Clinic in Rochester, Minn, between December 1992 and April 2002 underwent assessment of coronary endothelium-independent and -dependent function with intracoronary administration of adenosine and acetylcholine, respectively. The coronary diameters, coronary blood flows, and coronary velocity reserves were measured.
A total of 270 women (89 premenopausal and 181 postmenopausal) participated in the study. Endothelium-dependent coronary blood flow change (baseline to peak flow) in response to acetylcholine (10
−6, 10
−5, and 10
−4 mol/L) was lower in postmenopausal women compared with premenopausal women (39.7% vs 72.9%,
P=.03). There was no significant difference between the postmenopausal women receiving and not receiving HRT with regard to percent change in coronary diameter (-21.8% vs -13.9%,
P=.15), percent change in coronary blood flow (37.3% vs 42.7%,
P=.74), or coronary velocity reserve (2.7 vs 2.7,
P=.82).
This study shows that the postmenopausal state is associated with a greater abnormality in coronary endothelial function at the level of the microcirculation. Moreover, HRT status was not associated with an improvement in coronary endothelial function in postmenopausal women.</description><subject>Acetylcholine</subject><subject>Adenosine</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary Circulation - physiology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - physiology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>General aspects</subject><subject>Heart</subject><subject>Hormone Replacement Therapy - methods</subject><subject>Humans</subject><subject>Long-Term Care</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postmenopause - drug effects</subject><subject>Postmenopause - physiology</subject><subject>Premenopause - physiology</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography, Interventional - methods</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpt0U1r3DAQBmARWpJN2kt-QBGF5hDwVt-2j2XZJIWFlpLSo5DlUVbBllzJLuTfV2EXAiEnIebRaPQKoUtK1oIo-bVu15StqaTiBK1oK1glpVDv0IoQJitFW3WGznN-JITUbStO0RmVspWcyxXab50DO-Po8C6Gh2qGNOK7mMYYAP-CaTAWRggzvt9DMtMTjgFvYorBpCe8DX2c9zB4M-CbJdjZl6oP-GfMczkUJ7PkUvoTy-YDeu_MkOHjcb1Av2-295u7avfj9vvm266yQtK5coZxAs4qVeYzvFPCCtcRpZjjyhlQvWyEMpbL3tBGWOBCgWxqJW3HO8f5Bbo69J1S_LtAnvXos4VhMAHikrWqaSMZYwV-fgUf45JCmU0zqholGyYKuj4gm2LOCZyekh_L2zUl-jl8XbeaMv0cfsGfjh2XboT-hR7TLuDLEZhszeCSCdbnF6c4a0RTFycODkpQ_zwkna2HYKH3qXyW7qN_6_7_DLmdUA</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Halligan, Sean C.</creator><creator>Murtagh, Blaithnead</creator><creator>Lennon, Ryan J.</creator><creator>Pumper, Geralyn M.</creator><creator>Mathew, Verghese</creator><creator>Higano, Stuart T.</creator><creator>Lerman, Amir</creator><general>Elsevier Inc</general><general>Mayo Medical Ventures</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Effect of Long-term Hormone Replacement Therapy on Coronary Endothelial Function in Postmenopausal Women</title><author>Halligan, Sean C. ; Murtagh, Blaithnead ; Lennon, Ryan J. ; Pumper, Geralyn M. ; Mathew, Verghese ; Higano, Stuart T. ; Lerman, Amir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-fa230efc66533a3b64c4fb0662f36fae6d5846ac35da184ce346e58765cb3bf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetylcholine</topic><topic>Adenosine</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary Circulation - physiology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - physiology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>General aspects</topic><topic>Heart</topic><topic>Hormone Replacement Therapy - methods</topic><topic>Humans</topic><topic>Long-Term Care</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postmenopause - drug effects</topic><topic>Postmenopause - physiology</topic><topic>Premenopause - physiology</topic><topic>Probability</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography, Interventional - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halligan, Sean C.</creatorcontrib><creatorcontrib>Murtagh, Blaithnead</creatorcontrib><creatorcontrib>Lennon, Ryan J.</creatorcontrib><creatorcontrib>Pumper, Geralyn M.</creatorcontrib><creatorcontrib>Mathew, Verghese</creatorcontrib><creatorcontrib>Higano, Stuart T.</creatorcontrib><creatorcontrib>Lerman, Amir</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Journals (ProQuest Database)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halligan, Sean C.</au><au>Murtagh, Blaithnead</au><au>Lennon, Ryan J.</au><au>Pumper, Geralyn M.</au><au>Mathew, Verghese</au><au>Higano, Stuart T.</au><au>Lerman, Amir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Long-term Hormone Replacement Therapy on Coronary Endothelial Function in Postmenopausal Women</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>79</volume><issue>12</issue><spage>1514</spage><epage>1520</epage><pages>1514-1520</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function.
Women undergoing coronary physiology studies for chest pain at the Mayo Clinic in Rochester, Minn, between December 1992 and April 2002 underwent assessment of coronary endothelium-independent and -dependent function with intracoronary administration of adenosine and acetylcholine, respectively. The coronary diameters, coronary blood flows, and coronary velocity reserves were measured.
A total of 270 women (89 premenopausal and 181 postmenopausal) participated in the study. Endothelium-dependent coronary blood flow change (baseline to peak flow) in response to acetylcholine (10
−6, 10
−5, and 10
−4 mol/L) was lower in postmenopausal women compared with premenopausal women (39.7% vs 72.9%,
P=.03). There was no significant difference between the postmenopausal women receiving and not receiving HRT with regard to percent change in coronary diameter (-21.8% vs -13.9%,
P=.15), percent change in coronary blood flow (37.3% vs 42.7%,
P=.74), or coronary velocity reserve (2.7 vs 2.7,
P=.82).
This study shows that the postmenopausal state is associated with a greater abnormality in coronary endothelial function at the level of the microcirculation. Moreover, HRT status was not associated with an improvement in coronary endothelial function in postmenopausal women.</abstract><cop>Rochester, MN</cop><pub>Elsevier Inc</pub><pmid>15595335</pmid><doi>10.4065/79.12.1514</doi><tpages>7</tpages></addata></record> |
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subjects | Acetylcholine Adenosine Adult Aged Biological and medical sciences Cardiology. Vascular system Coronary Angiography - methods Coronary Circulation - drug effects Coronary Circulation - physiology Coronary heart disease Coronary Vessels - drug effects Coronary Vessels - physiology Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female General aspects Heart Hormone Replacement Therapy - methods Humans Long-Term Care Medical sciences Middle Aged Postmenopause - drug effects Postmenopause - physiology Premenopause - physiology Probability Prospective Studies Reference Values Sensitivity and Specificity Ultrasonography, Interventional - methods |
title | Effect of Long-term Hormone Replacement Therapy on Coronary Endothelial Function in Postmenopausal Women |
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