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Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors
The nicotinic cholinergic system influences cognition, anxiety, locomotion, and addiction by acting upon nicotinic acetylcholine receptors (nAChRs). To date, there are 12 known neuronal mammalian nAChR subunits leading to a rich pharmacological diversity that is difficult to attribute to specific su...
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| Published in: | Neuroscience 2004, Vol.129 (3), p.575-582 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c406t-9879e24bf7c9364ded10532b3156bbbdadbfeecebdeea8653b8b3fc35b4147783 |
| container_end_page | 582 |
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| container_title | Neuroscience |
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| creator | Marubio, L.M. Paylor, R. |
| description | The nicotinic cholinergic system influences cognition, anxiety, locomotion, and addiction by acting upon nicotinic acetylcholine receptors (nAChRs). To date, there are 12 known neuronal mammalian nAChR subunits leading to a rich pharmacological diversity that is difficult to attribute to specific subunits. We generated α7-β2 nAChR double mutant mice by breeding to investigate the effect of a minimal number of nAChRs in the CNS. These mice have been used to determine the role these receptor subunits play in a variety of behaviors. A battery of behavioral tests was used to determine the effect of the mutation in anxiety, locomotor activity, startle response, pre-pulse inhibition, motor coordination and learning and memory. Mice lacking both the α7 and the β2 nAChR subunits displayed impaired learning and memory performance in a passive avoidance test and showed enhanced motor performance on the rotarod. |
| doi_str_mv | 10.1016/j.neuroscience.2004.09.003 |
| format | article |
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Mice lacking both the α7 and the β2 nAChR subunits displayed impaired learning and memory performance in a passive avoidance test and showed enhanced motor performance on the rotarod.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Avoidance Learning - physiology</subject><subject>behavior</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Brain - cytology</subject><subject>cholinergic</subject><subject>Exploratory Behavior - physiology</subject><subject>Fundamental and applied biological sciences. 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| fulltext | fulltext |
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| ispartof | Neuroscience, 2004, Vol.129 (3), p.575-582 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Analysis of Variance Animals Avoidance Learning - physiology behavior Behavior, Animal Biological and medical sciences Brain - cytology cholinergic Exploratory Behavior - physiology Fundamental and applied biological sciences. Psychology Inhibition (Psychology) locomotor activity Male Mice Mice, Knockout Motor Activity - genetics motor coordination Neurons - metabolism nicotinic passive avoidance Protein Subunits - deficiency Protein Subunits - genetics Psychomotor Performance - physiology Receptors, Nicotinic - deficiency Receptors, Nicotinic - genetics Receptors, Nicotinic - physiology Reflex, Acoustic - physiology Vertebrates: nervous system and sense organs |
| title | Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors |
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