Neurotrophin expression in the hippocampus and cerebellum is affected by chronic placental insufficiency in the late gestational ovine fetus

Our aim was to determine the effects of chronic placental insufficiency (CPI) during late gestation on the expression of neurotrophic factors and their receptors in the hippocampus and cerebellum in the near-term fetus. Structural alterations were also assessed in these brain regions. CPI was induce...

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Bibliographic Details
Published in:Brain research. Developmental brain research 2004-11, Vol.153 (2), p.243-250
Main Authors: Duncan, Jhodie R., Cock, Megan L., Harding, Richard, Rees, Sandra M.
Format: Article
Language:English
Subjects:
Animals
BDNF
Brain damage
Brain-Derived Neurotrophic Factor - biosynthesis
Cerebellum - cytology
Cerebellum - embryology
Cerebellum - metabolism
Female
Fetus - metabolism
Hippocampus - cytology
Hippocampus - embryology
Hippocampus - metabolism
Hypoxia
Immunohistochemistry
Intrauterine growth restriction
Nerve Growth Factors - biosynthesis
Neurotrophin 3 - biosynthesis
Placental Insufficiency - metabolism
Pregnancy
Purkinje Cells - metabolism
Receptor, trkB - biosynthesis
Sheep
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Summary:Our aim was to determine the effects of chronic placental insufficiency (CPI) during late gestation on the expression of neurotrophic factors and their receptors in the hippocampus and cerebellum in the near-term fetus. Structural alterations were also assessed in these brain regions. CPI was induced in eight fetal sheep by umbilicoplacental embolization (UPE) from 120 to 140 days of gestation (term ∼147d) such that fetal arterial O 2 saturation (SaO 2) was maintained at ∼50% of pre-UPE values. Five non-UPE fetuses served as controls. UPE resulted in fetal hypoxemia, hypoglycaemia, and growth restriction. In hippocampi from UPE fetuses, there were reductions in the optical density (OD) of the immunoreactivity (IR) of brain-derived neurotrophic factor (BDNF) protein within the mossy fibre collaterals of the polymorphic layer and in stratum lucidum ( p
ISSN:0165-3806
DOI:10.1016/j.devbrainres.2004.09.004