Neurons and glia: team players in axon guidance

In the developing nervous system, growth cones follow specific trajectories to reach their target area and ultimately connect with their correct postsynaptic partners. This review focuses on studies in both Drosophila and vertebrates to highlight that mutual interactions between neurons and glia are...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2004-11, Vol.27 (11), p.655-661
Main Authors: Chotard, Carole, Salecker, Iris
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Biological and medical sciences
Drosophila
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Humans
Insects
Isolated neuron and nerve. Neuroglia
Nerve Net - growth & development
Nervous system
Neuroglia - physiology
Neurons
Neurons - physiology
Vertebrata
Vertebrates
Vertebrates: nervous system and sense organs
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Summary:In the developing nervous system, growth cones follow specific trajectories to reach their target area and ultimately connect with their correct postsynaptic partners. This review focuses on studies in both Drosophila and vertebrates to highlight that mutual interactions between neurons and glia are essential in forming specific neuronal connections. Glia signal to neurons to direct pathfinding and targeting of axons, as well as to stabilize and refine axonal branches within the target area. Equally, neurons provide crucial information to glia, supporting their migration and correct positioning.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2004.09.001