Modulating Angiogenesis: More vs Less

The concept of manipulation of the vascular bed to either increase or decrease the number of blood vessels has attracted considerable interest. This review focuses on angiogenesis as a therapeutic target, particularly in the context of cancer and arthritis, as well as on promoting angiogenesis in ca...

Full description

Saved in:
Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2004-08, Vol.292 (8), p.972-977
Main Authors: Sivakumar, Branavan, Harry, Lorraine E, Paleolog, Ewa M
Format: Article
Language:English
Subjects:
Angiogenesis Inducing Agents - therapeutic use
Angiogenesis Inhibitors - therapeutic use
Arthritis, Rheumatoid - drug therapy
Biological and medical sciences
Blood vessels
Cardiovascular disease
Cardiovascular Diseases - drug therapy
Clinical trials
Fractures
Fractures, Bone - drug therapy
General aspects
Humans
Medical sciences
Neoplasms - blood supply
Neoplasms - drug therapy
Neovascularization, Pathologic - drug therapy
Neovascularization, Physiologic - drug effects
Rheumatoid arthritis
Synovial Membrane - blood supply
Tumors
Vascular Endothelial Growth Factors
Wound Healing - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The concept of manipulation of the vascular bed to either increase or decrease the number of blood vessels has attracted considerable interest. This review focuses on angiogenesis as a therapeutic target, particularly in the context of cancer and arthritis, as well as on promoting angiogenesis in cardiovascular disease and the healing of bone fractures. Although once touted almost as a panacea for treatment of tumors, as well as other diseases associated with angiogenesis, such as diabetic retinopathy or rheumatoid arthritis, it is now clear that such enthusiasm was somewhat premature. Similarly, some clinical trials of therapeutic angiogenesis for the management of cardiovascular disease have been disappointing. Nevertheless, this exciting field of research holds promise for more targeted therapies.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.292.8.972