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Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal Injury
Background and Objectives We introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin. Study Design/Materials and Methods Two prototype devices emitting a...
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| Published in: | Lasers in surgery and medicine 2004-06, Vol.34 (5), p.426-438 |
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| Main Authors: | , , , , |
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| cites | cdi_FETCH-LOGICAL-c4918-39872925c201e1244dc8346317b4fdf0312511da92e0621de780a3c6b9fb0dfd3 |
| container_end_page | 438 |
| container_issue | 5 |
| container_start_page | 426 |
| container_title | Lasers in surgery and medicine |
| container_volume | 34 |
| creator | Manstein, Dieter Herron, G. Scott Sink, R. Kehl Tanner, Heather Anderson, R. Rox |
| description | Background and Objectives
We introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin.
Study Design/Materials and Methods
Two prototype devices emitting at 1.5 μm wavelength provided a pattern of micro‐exposures with variable MTZ density. Effects of different MTZ densities were tested on the forearms of 15 subjects. Clinical effects and histology were assessed up to 3 months after exposure. Treatment of photoaged skin on the periorbital area in an additional 30 subjects receiving four treatments over a period of 2–3 weeks was also tested. Tissue shrinkage and clinical effects were assessed up to 3 months after treatment.
Results
Pattern densities with spacing of 250 μm or more were well tolerated. Typical MTZ had a diameter of 100 μm and penetrated 300 μm into the skin. Reepithelialization was complete within 1 day. Clinical effects were assessed over a 3‐month period. Histology at 3 months revealed enhanced undulating rete ridges and increased mucin deposition within the superficial dermis. Periorbital treatments were well tolerated with minimal erythema and edema. Linear shrinkage of 2.1% was measured 3 months after the last treatment. The wrinkle score improved 18% (P |
| doi_str_mv | 10.1002/lsm.20048 |
| format | article |
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We introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin.
Study Design/Materials and Methods
Two prototype devices emitting at 1.5 μm wavelength provided a pattern of micro‐exposures with variable MTZ density. Effects of different MTZ densities were tested on the forearms of 15 subjects. Clinical effects and histology were assessed up to 3 months after exposure. Treatment of photoaged skin on the periorbital area in an additional 30 subjects receiving four treatments over a period of 2–3 weeks was also tested. Tissue shrinkage and clinical effects were assessed up to 3 months after treatment.
Results
Pattern densities with spacing of 250 μm or more were well tolerated. Typical MTZ had a diameter of 100 μm and penetrated 300 μm into the skin. Reepithelialization was complete within 1 day. Clinical effects were assessed over a 3‐month period. Histology at 3 months revealed enhanced undulating rete ridges and increased mucin deposition within the superficial dermis. Periorbital treatments were well tolerated with minimal erythema and edema. Linear shrinkage of 2.1% was measured 3 months after the last treatment. The wrinkle score improved 18% (P<0.001) 3 months after the last treatment.
Conclusions
FP is a new concept for skin restoration treatment. Safety and efficacy were demonstrated with a prototype device. Further clinical studies are necessary to refine the optimum parameters and to explore further dermatological applications. Lasers Surg. Med. 34:426–438, 2004. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.20048</identifier><identifier>PMID: 15216537</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Face ; Female ; Forearm ; fractional ; Humans ; laser ; Laser Therapy ; Male ; Middle Aged ; MTZ ; non-ablative ; photoaging ; photothermolysis ; rejuvenation ; remodeling ; resurfacing ; Skin - pathology ; Skin Aging ; wrinkles</subject><ispartof>Lasers in surgery and medicine, 2004-06, Vol.34 (5), p.426-438</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>Copyright 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4918-39872925c201e1244dc8346317b4fdf0312511da92e0621de780a3c6b9fb0dfd3</citedby><cites>FETCH-LOGICAL-c4918-39872925c201e1244dc8346317b4fdf0312511da92e0621de780a3c6b9fb0dfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.20048$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.20048$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15216537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manstein, Dieter</creatorcontrib><creatorcontrib>Herron, G. Scott</creatorcontrib><creatorcontrib>Sink, R. Kehl</creatorcontrib><creatorcontrib>Tanner, Heather</creatorcontrib><creatorcontrib>Anderson, R. Rox</creatorcontrib><title>Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal Injury</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objectives
We introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin.
Study Design/Materials and Methods
Two prototype devices emitting at 1.5 μm wavelength provided a pattern of micro‐exposures with variable MTZ density. Effects of different MTZ densities were tested on the forearms of 15 subjects. Clinical effects and histology were assessed up to 3 months after exposure. Treatment of photoaged skin on the periorbital area in an additional 30 subjects receiving four treatments over a period of 2–3 weeks was also tested. Tissue shrinkage and clinical effects were assessed up to 3 months after treatment.
Results
Pattern densities with spacing of 250 μm or more were well tolerated. Typical MTZ had a diameter of 100 μm and penetrated 300 μm into the skin. Reepithelialization was complete within 1 day. Clinical effects were assessed over a 3‐month period. Histology at 3 months revealed enhanced undulating rete ridges and increased mucin deposition within the superficial dermis. Periorbital treatments were well tolerated with minimal erythema and edema. Linear shrinkage of 2.1% was measured 3 months after the last treatment. The wrinkle score improved 18% (P<0.001) 3 months after the last treatment.
Conclusions
FP is a new concept for skin restoration treatment. Safety and efficacy were demonstrated with a prototype device. Further clinical studies are necessary to refine the optimum parameters and to explore further dermatological applications. Lasers Surg. Med. 34:426–438, 2004. © 2004 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Face</subject><subject>Female</subject><subject>Forearm</subject><subject>fractional</subject><subject>Humans</subject><subject>laser</subject><subject>Laser Therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MTZ</subject><subject>non-ablative</subject><subject>photoaging</subject><subject>photothermolysis</subject><subject>rejuvenation</subject><subject>remodeling</subject><subject>resurfacing</subject><subject>Skin - pathology</subject><subject>Skin Aging</subject><subject>wrinkles</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkcFu1DAURS0EokNhwQ8gr5BYpH22E8dmV0W0U3VaKmjVpeVxHOqSxMF2VObvSZoBVojN81uce2T7IvSWwBEBoMdt7I4oQC6eoRUByTNJgDxHKyDTLkDSA_QqxgcAYBTKl-iAFJTwgpUrNJwGbZLzvW7x9b1PPt3b0Pl2F138iE_wlX3Ele-NHRJufMDVmHRv_RjxF9v52rau_4Zv4zwvnQk-Gj84g691Sjb0EfsG38zGSX_eP4xh9xq9aHQb7Zv9eYhuTz_dVOts8_nsvDrZZCaXRGRMipJKWhgKxBKa57URLOeMlNu8qRtghBaE1FpSC5yS2pYCNDN8K5st1E3NDtH7xTsE_2O0ManORWPbdrm-4pznopDwX5CUTIAQM_hhAednxmAbNQTX6bBTBNTcg5p6UE89TOy7vXTcdrb-S-4_fgKOF-DRtXb3b5PafL38rcyWhIvJ_vyT0OG74iUrC3V3dabW7G7NeHWhNuwXgMihQA</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Manstein, Dieter</creator><creator>Herron, G. Scott</creator><creator>Sink, R. Kehl</creator><creator>Tanner, Heather</creator><creator>Anderson, R. Rox</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal Injury</title><author>Manstein, Dieter ; Herron, G. Scott ; Sink, R. Kehl ; Tanner, Heather ; Anderson, R. Rox</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4918-39872925c201e1244dc8346317b4fdf0312511da92e0621de780a3c6b9fb0dfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Face</topic><topic>Female</topic><topic>Forearm</topic><topic>fractional</topic><topic>Humans</topic><topic>laser</topic><topic>Laser Therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MTZ</topic><topic>non-ablative</topic><topic>photoaging</topic><topic>photothermolysis</topic><topic>rejuvenation</topic><topic>remodeling</topic><topic>resurfacing</topic><topic>Skin - pathology</topic><topic>Skin Aging</topic><topic>wrinkles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manstein, Dieter</creatorcontrib><creatorcontrib>Herron, G. Scott</creatorcontrib><creatorcontrib>Sink, R. Kehl</creatorcontrib><creatorcontrib>Tanner, Heather</creatorcontrib><creatorcontrib>Anderson, R. Rox</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manstein, Dieter</au><au>Herron, G. Scott</au><au>Sink, R. Kehl</au><au>Tanner, Heather</au><au>Anderson, R. Rox</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal Injury</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>2004-06</date><risdate>2004</risdate><volume>34</volume><issue>5</issue><spage>426</spage><epage>438</epage><pages>426-438</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><notes>ArticleID:LSM20048</notes><notes>All of the authors have disclosed potential financial conflict of interests with this study.</notes><notes>ark:/67375/WNG-H3WH36CK-L</notes><notes>istex:091547B455CAF10E428B799B4CF42E52380F2457</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-News-3</notes><abstract>Background and Objectives
We introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin.
Study Design/Materials and Methods
Two prototype devices emitting at 1.5 μm wavelength provided a pattern of micro‐exposures with variable MTZ density. Effects of different MTZ densities were tested on the forearms of 15 subjects. Clinical effects and histology were assessed up to 3 months after exposure. Treatment of photoaged skin on the periorbital area in an additional 30 subjects receiving four treatments over a period of 2–3 weeks was also tested. Tissue shrinkage and clinical effects were assessed up to 3 months after treatment.
Results
Pattern densities with spacing of 250 μm or more were well tolerated. Typical MTZ had a diameter of 100 μm and penetrated 300 μm into the skin. Reepithelialization was complete within 1 day. Clinical effects were assessed over a 3‐month period. Histology at 3 months revealed enhanced undulating rete ridges and increased mucin deposition within the superficial dermis. Periorbital treatments were well tolerated with minimal erythema and edema. Linear shrinkage of 2.1% was measured 3 months after the last treatment. The wrinkle score improved 18% (P<0.001) 3 months after the last treatment.
Conclusions
FP is a new concept for skin restoration treatment. Safety and efficacy were demonstrated with a prototype device. Further clinical studies are necessary to refine the optimum parameters and to explore further dermatological applications. Lasers Surg. Med. 34:426–438, 2004. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15216537</pmid><doi>10.1002/lsm.20048</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0196-8092 |
| ispartof | Lasers in surgery and medicine, 2004-06, Vol.34 (5), p.426-438 |
| issn | 0196-8092 1096-9101 |
| language | eng |
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| source | Wiley |
| subjects | Adult Aged Face Female Forearm fractional Humans laser Laser Therapy Male Middle Aged MTZ non-ablative photoaging photothermolysis rejuvenation remodeling resurfacing Skin - pathology Skin Aging wrinkles |
| title | Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal Injury |
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