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Sex Differences in the Heritability of Alcohol Problems
Genetic factors may have a role in defining more coherent clinical phenotypes and subtypes in the DSM-V. Research has demonstrated that there are gender differences in the patterns of alcohol consumption, specific symptom endorsement, withdrawal effects, and rates of alcohol use disorders (AUD). We...
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| Published in: | The American journal on addictions 2008-07, Vol.17 (4), p.319-327 |
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| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c6070-b88bfbc725dfe83b8125c07d19f7ed2907797cf2e0c99f5b9f2eb9f2f753ccc93 |
| container_end_page | 327 |
| container_issue | 4 |
| container_start_page | 319 |
| container_title | The American journal on addictions |
| container_volume | 17 |
| creator | Hardie, Thomas L. Moss, Howard B. Lynch, Kevin Gerard |
| description | Genetic factors may have a role in defining more coherent clinical phenotypes and subtypes in the DSM-V. Research has demonstrated that there are gender differences in the patterns of alcohol consumption, specific symptom endorsement, withdrawal effects, and rates of alcohol use disorders (AUD). We examined the sex-specific heritability of diagnostic symptoms for alcohol-related problems in a community-based sample of twin pairs (males: n = 519; females: n = 613) using a biometrical analytic strategy to estimate the genetic and environmental components of AUD symptoms. Five of the seven symptoms of alcohol problems demonstrated sex-differences in heritability. Three of the seven symptoms examined had significant heritability in female twins only: "increased risk of injury or harm," "emotional problems related to drinking," and "the desire to drink." In males, a different pattern was observed, with four of the seven examined symptoms demonstrating heritability: "Increased chance of injury or harm," "spending more time using alcohol or getting over its effects," "using larger amounts for longer periods of time than intended," and "the need to use more alcohol to get the same effect." These data suggest that alcohol problems in females and males may be etiologically distinct, and that diagnostic criteria and therapeutics might be enhanced if these sex differences were taken into consideration. |
| doi_str_mv | 10.1080/10550490802139010 |
| format | article |
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Research has demonstrated that there are gender differences in the patterns of alcohol consumption, specific symptom endorsement, withdrawal effects, and rates of alcohol use disorders (AUD). We examined the sex-specific heritability of diagnostic symptoms for alcohol-related problems in a community-based sample of twin pairs (males: n = 519; females: n = 613) using a biometrical analytic strategy to estimate the genetic and environmental components of AUD symptoms. Five of the seven symptoms of alcohol problems demonstrated sex-differences in heritability. Three of the seven symptoms examined had significant heritability in female twins only: "increased risk of injury or harm," "emotional problems related to drinking," and "the desire to drink." In males, a different pattern was observed, with four of the seven examined symptoms demonstrating heritability: "Increased chance of injury or harm," "spending more time using alcohol or getting over its effects," "using larger amounts for longer periods of time than intended," and "the need to use more alcohol to get the same effect." 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Research has demonstrated that there are gender differences in the patterns of alcohol consumption, specific symptom endorsement, withdrawal effects, and rates of alcohol use disorders (AUD). We examined the sex-specific heritability of diagnostic symptoms for alcohol-related problems in a community-based sample of twin pairs (males: n = 519; females: n = 613) using a biometrical analytic strategy to estimate the genetic and environmental components of AUD symptoms. Five of the seven symptoms of alcohol problems demonstrated sex-differences in heritability. Three of the seven symptoms examined had significant heritability in female twins only: "increased risk of injury or harm," "emotional problems related to drinking," and "the desire to drink." In males, a different pattern was observed, with four of the seven examined symptoms demonstrating heritability: "Increased chance of injury or harm," "spending more time using alcohol or getting over its effects," "using larger amounts for longer periods of time than intended," and "the need to use more alcohol to get the same effect." These data suggest that alcohol problems in females and males may be etiologically distinct, and that diagnostic criteria and therapeutics might be enhanced if these sex differences were taken into consideration.</description><subject>Adult</subject><subject>Alcohol consumption</subject><subject>Alcohol-Related Disorders - epidemiology</subject><subject>Alcohol-Related Disorders - genetics</subject><subject>Alcoholism - epidemiology</subject><subject>Alcoholism - genetics</subject><subject>Diseases in Twins - epidemiology</subject><subject>Diseases in Twins - genetics</subject><subject>Female</subject><subject>Gender differences</subject><subject>Genetic factors</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Heritability</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sex Ratio</subject><subject>Social Environment</subject><subject>Twin studies</subject><subject>United States</subject><issn>1055-0496</issn><issn>1521-0391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqFkUtPGzEUhS1EBZTyA9igWbGb9tqDX2IV8W5pi9RWLK0Z51oxeMbBngjy73GUqF0gFS_uPZK_cyQfE3JI4TMFBV8ocA4nukhGGw0Utsge5YzW0Gi6XXS5rwsgdsnHnB-gHKXFDtmlSlCmlNoj8he-VOfeOUw4WMyVH6pxhtU1Jj-2nQ9-XFbRVZNg4yyG6i7FLmCfP5EPrg0ZDzZ7n_y5vPh9dl3f_ry6OZvc1laAhLpTqnOdlYxPHaqmU5RxC3JKtZM4ZRqk1NI6hmC1drzTRa6Gk7yx1upmnxyvc-cpPi0wj6b32WII7YBxkQ2XTAoh2LsgA6G0pqKAdA3aFHNO6Mw8-b5NS0PBrGo1b2otnqNN-KLrcfrPsemxAGINPPuAy_cTzeTr5JzCKrleG30e8eWvsU2PRshGcnP_48p8VyDuTy7vzLfCn274wcXUtzNswzizbULzEBdpKH_xn3e8Avcboc0</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Hardie, Thomas L.</creator><creator>Moss, Howard B.</creator><creator>Lynch, Kevin Gerard</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7QJ</scope></search><sort><creationdate>200807</creationdate><title>Sex Differences in the Heritability of Alcohol Problems</title><author>Hardie, Thomas L. ; 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In males, a different pattern was observed, with four of the seven examined symptoms demonstrating heritability: "Increased chance of injury or harm," "spending more time using alcohol or getting over its effects," "using larger amounts for longer periods of time than intended," and "the need to use more alcohol to get the same effect." These data suggest that alcohol problems in females and males may be etiologically distinct, and that diagnostic criteria and therapeutics might be enhanced if these sex differences were taken into consideration.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>18612888</pmid><doi>10.1080/10550490802139010</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal on addictions, 2008-07, Vol.17 (4), p.319-327 |
| issn | 1055-0496 1521-0391 |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Wiley; SPORTDiscus with Full Text |
| subjects | Adult Alcohol consumption Alcohol-Related Disorders - epidemiology Alcohol-Related Disorders - genetics Alcoholism - epidemiology Alcoholism - genetics Diseases in Twins - epidemiology Diseases in Twins - genetics Female Gender differences Genetic factors Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Heritability Humans Male Middle Aged Risk Factors Sex Ratio Social Environment Twin studies United States |
| title | Sex Differences in the Heritability of Alcohol Problems |
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