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Phase I Enzyme Induction in Girardinichthys viviparus, an Endangered Goodeid Fish, Exposed to Water from Native Localities Enriched with Polychlorinated Biphenyls
The present study examines the induction of mixed-function oxidase (MFO) enzymes, including CYP content CYP1A (EROD) activity and alcohol dehydrogenase activity (ADH), in an endemic Mexican fish species, the black-fin goodeid Girardinichthys viviparus, exposed to the water of two localities, Lake Te...
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| Published in: | Archives of environmental contamination and toxicology 2009-10, Vol.57 (3), p.561-570 |
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| cites | cdi_FETCH-LOGICAL-c519t-eb35f01d5fbd3927d629401208c7a4a9b40837f65844edf2ffb2e21c60775a353 |
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| container_title | Archives of environmental contamination and toxicology |
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| creator | Vega-López, Armando Jiménez-Orozco, F. Alejandro Jiménez-Zamudio, Luís A García-Latorre, Ethel Domínguez-López, M. Lilia |
| description | The present study examines the induction of mixed-function oxidase (MFO) enzymes, including CYP content CYP1A (EROD) activity and alcohol dehydrogenase activity (ADH), in an endemic Mexican fish species, the black-fin goodeid Girardinichthys viviparus, exposed to the water of two localities, Lake Texcoco (LTX) and Lake Zumpango, and to the same matrices enriched in polychlorinated biphenyls (PCBs) to simulate the potential toxic effects of sublethal increases in these xenobiotics. Fishes of both sexes born in the laboratory were exposed for 1, 2, 4, 8, and 16 days. Water from the two types of localities of the black-fin goodeid contains MFO inducers. Of the two, the most contaminated is LTX water, which also contains PCBs. EROD activity was higher in all treatments with female compared with male fish. This suggests greater metabolic compromise in female fish as a response to damage caused by these xenobiotics. In this species, CYP induction displayed two patterns that were not always concurrent with higher CYP1A activity. In the enriched matrix system, biotransformation processes were notably altered. Increased ADH may indicate that this enzyme is involved in the biotransformation of PCBs and their metabolites, particularly in male fish, and provides at least a part of reductive power required by the MFO enzymes; however, specific studies are needed to clarify this point. |
| doi_str_mv | 10.1007/s00244-009-9289-8 |
| format | article |
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Alejandro ; Jiménez-Zamudio, Luís A ; García-Latorre, Ethel ; Domínguez-López, M. Lilia</creator><creatorcontrib>Vega-López, Armando ; Jiménez-Orozco, F. Alejandro ; Jiménez-Zamudio, Luís A ; García-Latorre, Ethel ; Domínguez-López, M. Lilia</creatorcontrib><description>The present study examines the induction of mixed-function oxidase (MFO) enzymes, including CYP content CYP1A (EROD) activity and alcohol dehydrogenase activity (ADH), in an endemic Mexican fish species, the black-fin goodeid Girardinichthys viviparus, exposed to the water of two localities, Lake Texcoco (LTX) and Lake Zumpango, and to the same matrices enriched in polychlorinated biphenyls (PCBs) to simulate the potential toxic effects of sublethal increases in these xenobiotics. Fishes of both sexes born in the laboratory were exposed for 1, 2, 4, 8, and 16 days. Water from the two types of localities of the black-fin goodeid contains MFO inducers. Of the two, the most contaminated is LTX water, which also contains PCBs. EROD activity was higher in all treatments with female compared with male fish. This suggests greater metabolic compromise in female fish as a response to damage caused by these xenobiotics. In this species, CYP induction displayed two patterns that were not always concurrent with higher CYP1A activity. In the enriched matrix system, biotransformation processes were notably altered. Increased ADH may indicate that this enzyme is involved in the biotransformation of PCBs and their metabolites, particularly in male fish, and provides at least a part of reductive power required by the MFO enzymes; however, specific studies are needed to clarify this point.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s00244-009-9289-8</identifier><identifier>PMID: 19198751</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>New York: New York : Springer-Verlag</publisher><subject>Agnatha. Pisces ; Alcohol ; Alcohol Dehydrogenase - biosynthesis ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biochemistry ; Biological and medical sciences ; Biomarkers ; Biomarkers - analysis ; Biotransformation ; Cytochrome ; Cytochrome P-450 CYP1A1 - biosynthesis ; Dehydrogenases ; Earth and Environmental Science ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Endangered & extinct species ; Endangered Species ; Enrichment ; Environment ; Environmental Chemistry ; Environmental Exposure - analysis ; Environmental Health ; Enzyme Induction ; Enzymes ; Exposure ; Female ; Fish ; Fresh Water - analysis ; Freshwater ; Freshwater ecology ; Fundamental and applied biological sciences. Psychology ; General aspects ; Hazardous materials ; Killifishes - metabolism ; Lakes ; Liver - drug effects ; Liver - enzymology ; Male ; Males ; Medical laboratories ; Metabolic Detoxication, Phase I ; Metabolites ; Mexico ; Mixed Function Oxygenases - biosynthesis ; Monitoring/Environmental Analysis ; PCB ; Pollution ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - analysis ; Polychlorinated Biphenyls - pharmacokinetics ; Polychlorinated Biphenyls - toxicity ; Soil Science & Conservation ; Studies ; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - pharmacokinetics ; Water Pollutants, Chemical - toxicity ; Water pollution</subject><ispartof>Archives of environmental contamination and toxicology, 2009-10, Vol.57 (3), p.561-570</ispartof><rights>Springer Science+Business Media, LLC 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-eb35f01d5fbd3927d629401208c7a4a9b40837f65844edf2ffb2e21c60775a353</citedby><cites>FETCH-LOGICAL-c519t-eb35f01d5fbd3927d629401208c7a4a9b40837f65844edf2ffb2e21c60775a353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/209538988/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/209538988?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,786,790,11715,27957,27958,36095,36096,44398,75252</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21981448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19198751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vega-López, Armando</creatorcontrib><creatorcontrib>Jiménez-Orozco, F. Alejandro</creatorcontrib><creatorcontrib>Jiménez-Zamudio, Luís A</creatorcontrib><creatorcontrib>García-Latorre, Ethel</creatorcontrib><creatorcontrib>Domínguez-López, M. Lilia</creatorcontrib><title>Phase I Enzyme Induction in Girardinichthys viviparus, an Endangered Goodeid Fish, Exposed to Water from Native Localities Enriched with Polychlorinated Biphenyls</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><addtitle>Arch Environ Contam Toxicol</addtitle><description>The present study examines the induction of mixed-function oxidase (MFO) enzymes, including CYP content CYP1A (EROD) activity and alcohol dehydrogenase activity (ADH), in an endemic Mexican fish species, the black-fin goodeid Girardinichthys viviparus, exposed to the water of two localities, Lake Texcoco (LTX) and Lake Zumpango, and to the same matrices enriched in polychlorinated biphenyls (PCBs) to simulate the potential toxic effects of sublethal increases in these xenobiotics. Fishes of both sexes born in the laboratory were exposed for 1, 2, 4, 8, and 16 days. Water from the two types of localities of the black-fin goodeid contains MFO inducers. Of the two, the most contaminated is LTX water, which also contains PCBs. EROD activity was higher in all treatments with female compared with male fish. This suggests greater metabolic compromise in female fish as a response to damage caused by these xenobiotics. In this species, CYP induction displayed two patterns that were not always concurrent with higher CYP1A activity. In the enriched matrix system, biotransformation processes were notably altered. Increased ADH may indicate that this enzyme is involved in the biotransformation of PCBs and their metabolites, particularly in male fish, and provides at least a part of reductive power required by the MFO enzymes; however, specific studies are needed to clarify this point.</description><subject>Agnatha. Pisces</subject><subject>Alcohol</subject><subject>Alcohol Dehydrogenase - biosynthesis</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biotransformation</subject><subject>Cytochrome</subject><subject>Cytochrome P-450 CYP1A1 - biosynthesis</subject><subject>Dehydrogenases</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Endangered & extinct species</subject><subject>Endangered Species</subject><subject>Enrichment</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Health</subject><subject>Enzyme Induction</subject><subject>Enzymes</subject><subject>Exposure</subject><subject>Female</subject><subject>Fish</subject><subject>Fresh Water - analysis</subject><subject>Freshwater</subject><subject>Freshwater ecology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Hazardous materials</subject><subject>Killifishes - metabolism</subject><subject>Lakes</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Males</subject><subject>Medical laboratories</subject><subject>Metabolic Detoxication, Phase I</subject><subject>Metabolites</subject><subject>Mexico</subject><subject>Mixed Function Oxygenases - biosynthesis</subject><subject>Monitoring/Environmental Analysis</subject><subject>PCB</subject><subject>Pollution</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - analysis</subject><subject>Polychlorinated Biphenyls - pharmacokinetics</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Soil Science & Conservation</subject><subject>Studies</subject><subject>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - pharmacokinetics</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water pollution</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNqFks1uEzEUhUcIREvhAdiAhQRi0YHrv7G9hCoNlSKoBBVLyxl7Oq4mdmrPBMLj8KQ4SkQlFmVly_c75_rqnqp6juEdBhDvMwBhrAZQtSJS1fJBdYwZJTUIoA-r41KAmlGGj6onOd8AYCIle1wdYYWVFBwfV78ve5MdukCz8Gu7Kpdgp3b0MSAf0Nwnk6wPvu3HfpvRxm_82qQpnyITisKacO2Ss2geo3XeonOf-1M0-7mOubyOEX03o0uoS3GFPpvRbxxaxNYMfvQuF4NUnAv4w489uozDtu2HmHwoIos--nXvwnbIT6tHnRmye3Y4T6qr89m3s0_14sv84uzDom45VmPtlpR3gC3vlpYqImxDFCsTg2yFYUYtGUgquoZLxpztSNctiSO4bUAIbiinJ9Wbve86xdvJ5VGvfG7dMJjg4pQ15UAoEPxfkGAQCvOmgG_vBbEQonC4gYK--ge9iVMKZV5NQHEqlZQFwnuoTTHn5Dq9Tn5l0lZj0LtE6H0idFm83iVC7zQvDsbTcuXsneIQgQK8PgAml9V0yYTW578cKRhmbGdE9lwupd3e7354X_eXe1FnojbXqRhffSWAKeBGghKc_gE0btef</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Vega-López, Armando</creator><creator>Jiménez-Orozco, F. 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Alejandro ; Jiménez-Zamudio, Luís A ; García-Latorre, Ethel ; Domínguez-López, M. Lilia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-eb35f01d5fbd3927d629401208c7a4a9b40837f65844edf2ffb2e21c60775a353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Agnatha. Pisces</topic><topic>Alcohol</topic><topic>Alcohol Dehydrogenase - biosynthesis</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Biotransformation</topic><topic>Cytochrome</topic><topic>Cytochrome P-450 CYP1A1 - biosynthesis</topic><topic>Dehydrogenases</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Endangered & extinct species</topic><topic>Endangered Species</topic><topic>Enrichment</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Health</topic><topic>Enzyme Induction</topic><topic>Enzymes</topic><topic>Exposure</topic><topic>Female</topic><topic>Fish</topic><topic>Fresh Water - analysis</topic><topic>Freshwater</topic><topic>Freshwater ecology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Hazardous materials</topic><topic>Killifishes - metabolism</topic><topic>Lakes</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Males</topic><topic>Medical laboratories</topic><topic>Metabolic Detoxication, Phase I</topic><topic>Metabolites</topic><topic>Mexico</topic><topic>Mixed Function Oxygenases - biosynthesis</topic><topic>Monitoring/Environmental Analysis</topic><topic>PCB</topic><topic>Pollution</topic><topic>Polychlorinated biphenyls</topic><topic>Polychlorinated Biphenyls - analysis</topic><topic>Polychlorinated Biphenyls - pharmacokinetics</topic><topic>Polychlorinated Biphenyls - toxicity</topic><topic>Soil Science & Conservation</topic><topic>Studies</topic><topic>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - pharmacokinetics</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Water pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vega-López, Armando</creatorcontrib><creatorcontrib>Jiménez-Orozco, F. 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Alejandro</au><au>Jiménez-Zamudio, Luís A</au><au>García-Latorre, Ethel</au><au>Domínguez-López, M. Lilia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase I Enzyme Induction in Girardinichthys viviparus, an Endangered Goodeid Fish, Exposed to Water from Native Localities Enriched with Polychlorinated Biphenyls</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><stitle>Arch Environ Contam Toxicol</stitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>57</volume><issue>3</issue><spage>561</spage><epage>570</epage><pages>561-570</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><notes>http://dx.doi.org/10.1007/s00244-009-9289-8</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>The present study examines the induction of mixed-function oxidase (MFO) enzymes, including CYP content CYP1A (EROD) activity and alcohol dehydrogenase activity (ADH), in an endemic Mexican fish species, the black-fin goodeid Girardinichthys viviparus, exposed to the water of two localities, Lake Texcoco (LTX) and Lake Zumpango, and to the same matrices enriched in polychlorinated biphenyls (PCBs) to simulate the potential toxic effects of sublethal increases in these xenobiotics. Fishes of both sexes born in the laboratory were exposed for 1, 2, 4, 8, and 16 days. Water from the two types of localities of the black-fin goodeid contains MFO inducers. Of the two, the most contaminated is LTX water, which also contains PCBs. EROD activity was higher in all treatments with female compared with male fish. This suggests greater metabolic compromise in female fish as a response to damage caused by these xenobiotics. In this species, CYP induction displayed two patterns that were not always concurrent with higher CYP1A activity. In the enriched matrix system, biotransformation processes were notably altered. Increased ADH may indicate that this enzyme is involved in the biotransformation of PCBs and their metabolites, particularly in male fish, and provides at least a part of reductive power required by the MFO enzymes; however, specific studies are needed to clarify this point.</abstract><cop>New York</cop><pub>New York : Springer-Verlag</pub><pmid>19198751</pmid><doi>10.1007/s00244-009-9289-8</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-4341 |
| ispartof | Archives of environmental contamination and toxicology, 2009-10, Vol.57 (3), p.561-570 |
| issn | 0090-4341 1432-0703 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_35023021 |
| source | ABI/INFORM Global (ProQuest); Springer Link |
| subjects | Agnatha. Pisces Alcohol Alcohol Dehydrogenase - biosynthesis Animal, plant and microbial ecology Animals Applied ecology Biochemistry Biological and medical sciences Biomarkers Biomarkers - analysis Biotransformation Cytochrome Cytochrome P-450 CYP1A1 - biosynthesis Dehydrogenases Earth and Environmental Science Ecotoxicology Ecotoxicology, biological effects of pollution Endangered & extinct species Endangered Species Enrichment Environment Environmental Chemistry Environmental Exposure - analysis Environmental Health Enzyme Induction Enzymes Exposure Female Fish Fresh Water - analysis Freshwater Freshwater ecology Fundamental and applied biological sciences. Psychology General aspects Hazardous materials Killifishes - metabolism Lakes Liver - drug effects Liver - enzymology Male Males Medical laboratories Metabolic Detoxication, Phase I Metabolites Mexico Mixed Function Oxygenases - biosynthesis Monitoring/Environmental Analysis PCB Pollution Polychlorinated biphenyls Polychlorinated Biphenyls - analysis Polychlorinated Biphenyls - pharmacokinetics Polychlorinated Biphenyls - toxicity Soil Science & Conservation Studies Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution Water Pollutants, Chemical - analysis Water Pollutants, Chemical - pharmacokinetics Water Pollutants, Chemical - toxicity Water pollution |
| title | Phase I Enzyme Induction in Girardinichthys viviparus, an Endangered Goodeid Fish, Exposed to Water from Native Localities Enriched with Polychlorinated Biphenyls |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T01%3A29%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phase%20I%20Enzyme%20Induction%20in%20Girardinichthys%20viviparus,%20an%20Endangered%20Goodeid%20Fish,%20Exposed%20to%20Water%20from%20Native%20Localities%20Enriched%20with%20Polychlorinated%20Biphenyls&rft.jtitle=Archives%20of%20environmental%20contamination%20and%20toxicology&rft.au=Vega-L%C3%B3pez,%20Armando&rft.date=2009-10-01&rft.volume=57&rft.issue=3&rft.spage=561&rft.epage=570&rft.pages=561-570&rft.issn=0090-4341&rft.eissn=1432-0703&rft.coden=AECTCV&rft_id=info:doi/10.1007/s00244-009-9289-8&rft_dat=%3Cproquest_cross%3E1777156160%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c519t-eb35f01d5fbd3927d629401208c7a4a9b40837f65844edf2ffb2e21c60775a353%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=209538988&rft_id=info:pmid/19198751&rfr_iscdi=true |