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Metabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice
Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined as morphofunctional changes in the liver. Studies have shown that Westernized eating patterns and environmental pollutants can directly induce the development of MASLD. This study evaluates the effect of co-exposure to inter...
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| Published in: | Food and chemical toxicology 2024-10, Vol.192, p.114965, Article 114965 |
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| creator | Teixeira, Ananda Vitoria Silva Quitete, Fernanda Torres Martins, Bruna Cadete Peixoto, Thamara Cherem Ribeiro, Mayara da Silva Velasco, Patricia Coelho de Miranda, Caroline Resende, Angela de Castro Costa, Daniela Caldeira Atella, Geórgia Correa Mucci, Daniela de Barros Souza-Mello, Vanessa Martins, Fabiane Ferreira Daleprane, Julio Beltrame |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined as morphofunctional changes in the liver. Studies have shown that Westernized eating patterns and environmental pollutants can directly induce the development of MASLD. This study evaluates the effect of co-exposure to interesterified palm oil (IPO) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126) on the progression of MASLD in an animal model. C57BL/6 mice were fed IPO and co-exposed to PCB-126 for ten weeks. The co-exposure led to an imbalance in carbohydrate metabolism, increased systemic inflammation markers, and morphofunctional changes in the liver. These liver changes included the presence of inflammatory cells, fibrosis, alterations in aspartate transaminase (AST) and alanine transaminase (ALT) enzymes, and imbalance in gene expression related to fatty acid β-oxidation, de novo lipogenesis, mitochondrial dynamics, and endoplasmic reticulum stress. Separate exposures to IPO and PCB-126 affected metabolism and MASLD progression. Nutritional and lifestyle factors may potentiate the onset and severity of MASLD.
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•Co-exposure to interesterified palm oil and PCB-126 worsens metabolic dysfunction and liver damage in C57BL/6 mice.•Co-exposure to interesterified palm oil and PCB-126 upregulates fibrotic gene expression.•Combined dietary and environmental factors can lead to health risks. |
| doi_str_mv | 10.1016/j.fct.2024.114965 |
| format | article |
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[Display omitted]
•Co-exposure to interesterified palm oil and PCB-126 worsens metabolic dysfunction and liver damage in C57BL/6 mice.•Co-exposure to interesterified palm oil and PCB-126 upregulates fibrotic gene expression.•Combined dietary and environmental factors can lead to health risks.</description><identifier>ISSN: 0278-6915</identifier><identifier>ISSN: 1873-6351</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2024.114965</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Endoplasmic reticulum stress ; Hepatic steatosis ; Inflammatory markers ; Metabolic dysfunction ; Mitochondrial dysfunction</subject><ispartof>Food and chemical toxicology, 2024-10, Vol.192, p.114965, Article 114965</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1274-275eac4444576247e8c7aa518abc9af283821c2236a4d17c2d31c7a395ad9ecb3</cites><orcidid>0009-0001-9400-4605 ; 0000-0002-0467-2109 ; 0000-0001-5488-0179 ; 0000-0001-8904-332X ; 0000-0002-3493-1386 ; 0000-0003-1747-9954</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Teixeira, Ananda Vitoria Silva</creatorcontrib><creatorcontrib>Quitete, Fernanda Torres</creatorcontrib><creatorcontrib>Martins, Bruna Cadete</creatorcontrib><creatorcontrib>Peixoto, Thamara Cherem</creatorcontrib><creatorcontrib>Ribeiro, Mayara da Silva</creatorcontrib><creatorcontrib>Velasco, Patricia Coelho de</creatorcontrib><creatorcontrib>Miranda, Caroline</creatorcontrib><creatorcontrib>Resende, Angela de Castro</creatorcontrib><creatorcontrib>Costa, Daniela Caldeira</creatorcontrib><creatorcontrib>Atella, Geórgia Correa</creatorcontrib><creatorcontrib>Mucci, Daniela de Barros</creatorcontrib><creatorcontrib>Souza-Mello, Vanessa</creatorcontrib><creatorcontrib>Martins, Fabiane Ferreira</creatorcontrib><creatorcontrib>Daleprane, Julio Beltrame</creatorcontrib><title>Metabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice</title><title>Food and chemical toxicology</title><description>Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined as morphofunctional changes in the liver. Studies have shown that Westernized eating patterns and environmental pollutants can directly induce the development of MASLD. This study evaluates the effect of co-exposure to interesterified palm oil (IPO) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126) on the progression of MASLD in an animal model. C57BL/6 mice were fed IPO and co-exposed to PCB-126 for ten weeks. The co-exposure led to an imbalance in carbohydrate metabolism, increased systemic inflammation markers, and morphofunctional changes in the liver. These liver changes included the presence of inflammatory cells, fibrosis, alterations in aspartate transaminase (AST) and alanine transaminase (ALT) enzymes, and imbalance in gene expression related to fatty acid β-oxidation, de novo lipogenesis, mitochondrial dynamics, and endoplasmic reticulum stress. Separate exposures to IPO and PCB-126 affected metabolism and MASLD progression. Nutritional and lifestyle factors may potentiate the onset and severity of MASLD.
[Display omitted]
•Co-exposure to interesterified palm oil and PCB-126 worsens metabolic dysfunction and liver damage in C57BL/6 mice.•Co-exposure to interesterified palm oil and PCB-126 upregulates fibrotic gene expression.•Combined dietary and environmental factors can lead to health risks.</description><subject>Endoplasmic reticulum stress</subject><subject>Hepatic steatosis</subject><subject>Inflammatory markers</subject><subject>Metabolic dysfunction</subject><subject>Mitochondrial dysfunction</subject><issn>0278-6915</issn><issn>1873-6351</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EEqXwA9g8sqT12YmdiAkivqQiGGBhsVznIrlK4mCnCP49rsLMDXfL-5zuHkIuga2AgVzvVq2dVpzxfAWQV7I4IgsolcikKOCYLBhXZSYrKE7JWYw7xpgCJRfk4xkns_Wds9T6IeLnHgeLkfqWumHCgDE11zps6Gi6nnrXUTM09LW-zYDLBGX4Pfq4D5gAWhfqdrOWtHcWz8lJa7qIF39zSd7v797qx2zz8vBU32wyC1zlGVcFGpunKpTkucLSKmMKKM3WVqblpSg5WM6FNHkDyvJGQEqIqjBNhXYrluRq3jsGn86Pk-5dtNh1ZkC_j1qwqgJR5TxPUZijNvgYA7Z6DK434UcD0wePeqeTR33wqGePibmeGUw_fDkMOlp3kNS4gCnbePcP_QusKHjl</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Teixeira, Ananda Vitoria Silva</creator><creator>Quitete, Fernanda Torres</creator><creator>Martins, Bruna Cadete</creator><creator>Peixoto, Thamara Cherem</creator><creator>Ribeiro, Mayara da Silva</creator><creator>Velasco, Patricia Coelho de</creator><creator>Miranda, Caroline</creator><creator>Resende, Angela de Castro</creator><creator>Costa, Daniela Caldeira</creator><creator>Atella, Geórgia Correa</creator><creator>Mucci, Daniela de Barros</creator><creator>Souza-Mello, Vanessa</creator><creator>Martins, Fabiane Ferreira</creator><creator>Daleprane, Julio Beltrame</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0001-9400-4605</orcidid><orcidid>https://orcid.org/0000-0002-0467-2109</orcidid><orcidid>https://orcid.org/0000-0001-5488-0179</orcidid><orcidid>https://orcid.org/0000-0001-8904-332X</orcidid><orcidid>https://orcid.org/0000-0002-3493-1386</orcidid><orcidid>https://orcid.org/0000-0003-1747-9954</orcidid></search><sort><creationdate>202410</creationdate><title>Metabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice</title><author>Teixeira, Ananda Vitoria Silva ; Quitete, Fernanda Torres ; Martins, Bruna Cadete ; Peixoto, Thamara Cherem ; Ribeiro, Mayara da Silva ; Velasco, Patricia Coelho de ; Miranda, Caroline ; Resende, Angela de Castro ; Costa, Daniela Caldeira ; Atella, Geórgia Correa ; Mucci, Daniela de Barros ; Souza-Mello, Vanessa ; Martins, Fabiane Ferreira ; Daleprane, Julio Beltrame</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1274-275eac4444576247e8c7aa518abc9af283821c2236a4d17c2d31c7a395ad9ecb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Endoplasmic reticulum stress</topic><topic>Hepatic steatosis</topic><topic>Inflammatory markers</topic><topic>Metabolic dysfunction</topic><topic>Mitochondrial dysfunction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teixeira, Ananda Vitoria Silva</creatorcontrib><creatorcontrib>Quitete, Fernanda Torres</creatorcontrib><creatorcontrib>Martins, Bruna Cadete</creatorcontrib><creatorcontrib>Peixoto, Thamara Cherem</creatorcontrib><creatorcontrib>Ribeiro, Mayara da Silva</creatorcontrib><creatorcontrib>Velasco, Patricia Coelho de</creatorcontrib><creatorcontrib>Miranda, Caroline</creatorcontrib><creatorcontrib>Resende, Angela de Castro</creatorcontrib><creatorcontrib>Costa, Daniela Caldeira</creatorcontrib><creatorcontrib>Atella, Geórgia Correa</creatorcontrib><creatorcontrib>Mucci, Daniela de Barros</creatorcontrib><creatorcontrib>Souza-Mello, Vanessa</creatorcontrib><creatorcontrib>Martins, Fabiane Ferreira</creatorcontrib><creatorcontrib>Daleprane, Julio Beltrame</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teixeira, Ananda Vitoria Silva</au><au>Quitete, Fernanda Torres</au><au>Martins, Bruna Cadete</au><au>Peixoto, Thamara Cherem</au><au>Ribeiro, Mayara da Silva</au><au>Velasco, Patricia Coelho de</au><au>Miranda, Caroline</au><au>Resende, Angela de Castro</au><au>Costa, Daniela Caldeira</au><au>Atella, Geórgia Correa</au><au>Mucci, Daniela de Barros</au><au>Souza-Mello, Vanessa</au><au>Martins, Fabiane Ferreira</au><au>Daleprane, Julio Beltrame</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice</atitle><jtitle>Food and chemical toxicology</jtitle><date>2024-10</date><risdate>2024</risdate><volume>192</volume><spage>114965</spage><pages>114965-</pages><artnum>114965</artnum><issn>0278-6915</issn><issn>1873-6351</issn><eissn>1873-6351</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined as morphofunctional changes in the liver. Studies have shown that Westernized eating patterns and environmental pollutants can directly induce the development of MASLD. This study evaluates the effect of co-exposure to interesterified palm oil (IPO) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126) on the progression of MASLD in an animal model. C57BL/6 mice were fed IPO and co-exposed to PCB-126 for ten weeks. The co-exposure led to an imbalance in carbohydrate metabolism, increased systemic inflammation markers, and morphofunctional changes in the liver. These liver changes included the presence of inflammatory cells, fibrosis, alterations in aspartate transaminase (AST) and alanine transaminase (ALT) enzymes, and imbalance in gene expression related to fatty acid β-oxidation, de novo lipogenesis, mitochondrial dynamics, and endoplasmic reticulum stress. Separate exposures to IPO and PCB-126 affected metabolism and MASLD progression. Nutritional and lifestyle factors may potentiate the onset and severity of MASLD.
[Display omitted]
•Co-exposure to interesterified palm oil and PCB-126 worsens metabolic dysfunction and liver damage in C57BL/6 mice.•Co-exposure to interesterified palm oil and PCB-126 upregulates fibrotic gene expression.•Combined dietary and environmental factors can lead to health risks.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.fct.2024.114965</doi><orcidid>https://orcid.org/0009-0001-9400-4605</orcidid><orcidid>https://orcid.org/0000-0002-0467-2109</orcidid><orcidid>https://orcid.org/0000-0001-5488-0179</orcidid><orcidid>https://orcid.org/0000-0001-8904-332X</orcidid><orcidid>https://orcid.org/0000-0002-3493-1386</orcidid><orcidid>https://orcid.org/0000-0003-1747-9954</orcidid></addata></record> |
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| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2024-10, Vol.192, p.114965, Article 114965 |
| issn | 0278-6915 1873-6351 1873-6351 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Endoplasmic reticulum stress Hepatic steatosis Inflammatory markers Metabolic dysfunction Mitochondrial dysfunction |
| title | Metabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice |
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