Rosuvastatin repurposing for prophylaxis against ethanol-induced acute gastric ulceration in rats: a biochemical, histological, and ultrastructural perspective

Ethanol (EtOH) consumption is frequently associated with acute and chronic gastrointestinal disorders. Rosuvastatin (RSV), a third-generation statin, has demonstrated certain biological functions beyond its lipid-lowering properties. This study is designed to explore the gastroprotective impact of R...

Full description

Saved in:
Bibliographic Details
Published in:Inflammopharmacology 2024-10, Vol.32 (5), p.3475-3498
Main Authors: El-kerdasy, Hanan I., Faruk, Eman Mohamed, Hassan, Dina Allam Abdelmaksoud, Nafea, Ola Elsayed, Ibrahim, Fatma, Bagabir, Rania Abubaker, Anwer, Hala Magdy, Allam, Amany M.
Format: Article
Language:English
Subjects:
Allergology
Animals
Anti-Ulcer Agents - administration & dosage
Anti-Ulcer Agents - pharmacology
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Dermatology
Dinoprostone - metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Repositioning
Ethanol
Gastric Mucosa - drug effects
Gastric Mucosa - pathology
Gastroenterology
Immunology
Male
Original Article
Peroxidase - metabolism
Pharmacology/Toxicology
Rats
Rats, Wistar
Rheumatology
Rosuvastatin Calcium - pharmacology
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ethanol (EtOH) consumption is frequently associated with acute and chronic gastrointestinal disorders. Rosuvastatin (RSV), a third-generation statin, has demonstrated certain biological functions beyond its lipid-lowering properties. This study is designed to explore the gastroprotective impact of RSV in a rat model of EtOH-induced gastric ulceration in a dose-dependent manner through the evaluation of oxidant/antioxidant biomarkers, inflammatory myeloperoxidase (MPO) enzyme activity, and prostaglandin E2 (PGE 2 ) levels in gastric tissues, along with histopathological examination of the gastric tissues. Therefore, 40 adult male rats were randomly divided into five equal groups as control, EtOH (gastric ulcer), RSV-low dose plus EtOH and RSV-high dose plus EtOH. The EtOH rat model of gastric ulceration was achieved by intragastric administration of a single dose of EtOH. Seven days before EtOH administration, rats were orally administered either omeprazole (20 mg/kg/day) or RSV (10 mg/kg/day or 20 mg/kg/day). RSV administration enhanced the antioxidant glutathione reduced, countered oxidative malondialdehyde, augmented cytoprotective PGE 2 , suppressed inflammatory MPO enzyme activity in gastric tissues, decreased ulcer index scoring, increased the percentage of ulcer inhibition, and reversed the associated histological and ultrastructural abnormalities, additionally, RSV treatment resulted in weak positive nuclear staining for the inflammatory nuclear factor kappa B in a dose-dependent manner. It is concluded that RSV demonstrates gastroprotective potential, attributable at least in part, to its antioxidant and anti-inflammatory properties, as well as its ability to promote ulcer protection through the maintenance of mucosal content and PGE 2 levels. Thus, RSV therapy emerges as a safe option for patients with gastric ulcers.
ISSN:0925-4692
1568-5608
1568-5608
DOI:10.1007/s10787-024-01513-z