Loading…
Assessing microplastics-antibiotics coexistence induced ciprofloxacin-resistant Pseudomonas aeruginosa at a water region scale
•MPs-niched CIP-resistant P. aeruginosa through water systems are assessed.•Enlarged CIP concentration around MPs poses resistance selectivity.•MPs provide media for P. aeruginosa propagation boosting bacteria number in waters.•MPs polymer type-related CIP level determines resistant fraction in wate...
Saved in:
| Published in: | Water research (Oxford) 2024-06, Vol.257, p.121721-121721, Article 121721 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c311t-b7d082c56b88eccf56ffbe9b7179b62b3da4b8b7e5ebe51b796e0e649b3d42e73 |
| container_end_page | 121721 |
| container_issue | |
| container_start_page | 121721 |
| container_title | Water research (Oxford) |
| container_volume | 257 |
| creator | Wang, Wei-Min Lu, Tien-Hsuan Chen, Chi-Yun Liao, Chung-Min |
| description | •MPs-niched CIP-resistant P. aeruginosa through water systems are assessed.•Enlarged CIP concentration around MPs poses resistance selectivity.•MPs provide media for P. aeruginosa propagation boosting bacteria number in waters.•MPs polymer type-related CIP level determines resistant fraction in waters.
Microplastics (MPs) waste is widespread globally in water systems. The opportunistic human pathogen Pseudomonas aeruginosa can cause serious acute and chronic infections that are notoriously difficult to treat. Ciprofloxacin (CIP) is broadly applied as an anti-P. aeruginosa drug. A growing evidence reveals that antibiotic-resistance genes-carrying Pseudomonas aeruginosa were detected on MPs forming plastisphere due to their adsorbability along with high occurrence of CIP in water environments. The MPs-niched CIP-resistant P. aeruginosa has been likely to emerge as an unignorable public health issue. Here, we offered a novel approach to assess the development of CIP-resistant P. aeruginosa under MPs-antibiotic coexistence at a water region scale. By combing the adsorption isotherm models used to estimate CIP condensation around MPs and a pharmacokinetic/pharmacodynamic-based microbial population dynamic model, we predicted the P. aeruginosa development on CIP-adsorbed MPs in waters. Our assessment revealed a high antibiotic resistance in the P. aeruginosa populations (∼50 %) with a wider range of waterborne total cell counts (∼10−2–104 cfu mL−1) among water regions in that the resistance proportion was primarily determined by CIP pollution level and relative abundance of various polymer type of MPs. We implicate that water region-specific MPs were highly likely to provide media for P. aeruginosa propagation. Our results highlight the importance of antibiotic-resistant pathogen colonization−emerging environmental medium interactions when addressing global threat from MPs pollution, in the context of MPs-antibiotics co-contamination assessment and for the continued provision of water system management.
[Display omitted] |
| doi_str_mv | 10.1016/j.watres.2024.121721 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3053975690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0043135424006225</els_id><sourcerecordid>3053975690</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-b7d082c56b88eccf56ffbe9b7179b62b3da4b8b7e5ebe51b796e0e649b3d42e73</originalsourceid><addsrcrecordid>eNp9kM1u1DAUhS0EokPhDRDykk0G_yV2NkhVxZ9UiS7atWU7NyOPEnvwTaDd8Ox4lMKSlS35O77nfoS85WzPGe8-HPe_3FIA94IJteeCa8GfkR03um-EUuY52TGmZMNlqy7IK8QjY0wI2b8kF9JoYbQRO_L7ChEQYzrQOYaST5PDJQZsXFqij_l8pyHDQ8QFUgAa07AGGGiIp5LHKT-4EFNTe1SgZugtwjrkOSeH1EFZDzFldNQt1NFaGAotcIg5UQxugtfkxegmhDdP5yW5__zp7vprc_P9y7frq5smSM6XxuuBGRHazhsDIYxtN44eeq-57n0nvByc8sZraMFDy73uO2DQqb6-KAFaXpL327-19I8VcLFzxADT5BLkFa1krex12_WsompDqw3EAqM9lTi78mg5s2fz9mg38_Zs3m7ma-zd04TVzzD8C_1VXYGPGwB1z58RisUQz0qHWCAsdsjx_xP-AD8Mm1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3053975690</pqid></control><display><type>article</type><title>Assessing microplastics-antibiotics coexistence induced ciprofloxacin-resistant Pseudomonas aeruginosa at a water region scale</title><source>ScienceDirect Freedom Collection</source><creator>Wang, Wei-Min ; Lu, Tien-Hsuan ; Chen, Chi-Yun ; Liao, Chung-Min</creator><creatorcontrib>Wang, Wei-Min ; Lu, Tien-Hsuan ; Chen, Chi-Yun ; Liao, Chung-Min</creatorcontrib><description>•MPs-niched CIP-resistant P. aeruginosa through water systems are assessed.•Enlarged CIP concentration around MPs poses resistance selectivity.•MPs provide media for P. aeruginosa propagation boosting bacteria number in waters.•MPs polymer type-related CIP level determines resistant fraction in waters.
Microplastics (MPs) waste is widespread globally in water systems. The opportunistic human pathogen Pseudomonas aeruginosa can cause serious acute and chronic infections that are notoriously difficult to treat. Ciprofloxacin (CIP) is broadly applied as an anti-P. aeruginosa drug. A growing evidence reveals that antibiotic-resistance genes-carrying Pseudomonas aeruginosa were detected on MPs forming plastisphere due to their adsorbability along with high occurrence of CIP in water environments. The MPs-niched CIP-resistant P. aeruginosa has been likely to emerge as an unignorable public health issue. Here, we offered a novel approach to assess the development of CIP-resistant P. aeruginosa under MPs-antibiotic coexistence at a water region scale. By combing the adsorption isotherm models used to estimate CIP condensation around MPs and a pharmacokinetic/pharmacodynamic-based microbial population dynamic model, we predicted the P. aeruginosa development on CIP-adsorbed MPs in waters. Our assessment revealed a high antibiotic resistance in the P. aeruginosa populations (∼50 %) with a wider range of waterborne total cell counts (∼10−2–104 cfu mL−1) among water regions in that the resistance proportion was primarily determined by CIP pollution level and relative abundance of various polymer type of MPs. We implicate that water region-specific MPs were highly likely to provide media for P. aeruginosa propagation. Our results highlight the importance of antibiotic-resistant pathogen colonization−emerging environmental medium interactions when addressing global threat from MPs pollution, in the context of MPs-antibiotics co-contamination assessment and for the continued provision of water system management.
[Display omitted]</description><identifier>ISSN: 0043-1354</identifier><identifier>EISSN: 1879-2448</identifier><identifier>DOI: 10.1016/j.watres.2024.121721</identifier><identifier>PMID: 38728782</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Ciprofloxacin ; Ciprofloxacin - pharmacology ; Drug Resistance, Bacterial ; Microplastics ; Pharmacokinetic/pharmacodynamic model ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Water Pollutants, Chemical ; Water region</subject><ispartof>Water research (Oxford), 2024-06, Vol.257, p.121721-121721, Article 121721</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-b7d082c56b88eccf56ffbe9b7179b62b3da4b8b7e5ebe51b796e0e649b3d42e73</cites><orcidid>0000-0002-5536-857X ; 0000-0001-7007-1371 ; 0000-0002-8360-7996</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38728782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Wei-Min</creatorcontrib><creatorcontrib>Lu, Tien-Hsuan</creatorcontrib><creatorcontrib>Chen, Chi-Yun</creatorcontrib><creatorcontrib>Liao, Chung-Min</creatorcontrib><title>Assessing microplastics-antibiotics coexistence induced ciprofloxacin-resistant Pseudomonas aeruginosa at a water region scale</title><title>Water research (Oxford)</title><addtitle>Water Res</addtitle><description>•MPs-niched CIP-resistant P. aeruginosa through water systems are assessed.•Enlarged CIP concentration around MPs poses resistance selectivity.•MPs provide media for P. aeruginosa propagation boosting bacteria number in waters.•MPs polymer type-related CIP level determines resistant fraction in waters.
Microplastics (MPs) waste is widespread globally in water systems. The opportunistic human pathogen Pseudomonas aeruginosa can cause serious acute and chronic infections that are notoriously difficult to treat. Ciprofloxacin (CIP) is broadly applied as an anti-P. aeruginosa drug. A growing evidence reveals that antibiotic-resistance genes-carrying Pseudomonas aeruginosa were detected on MPs forming plastisphere due to their adsorbability along with high occurrence of CIP in water environments. The MPs-niched CIP-resistant P. aeruginosa has been likely to emerge as an unignorable public health issue. Here, we offered a novel approach to assess the development of CIP-resistant P. aeruginosa under MPs-antibiotic coexistence at a water region scale. By combing the adsorption isotherm models used to estimate CIP condensation around MPs and a pharmacokinetic/pharmacodynamic-based microbial population dynamic model, we predicted the P. aeruginosa development on CIP-adsorbed MPs in waters. Our assessment revealed a high antibiotic resistance in the P. aeruginosa populations (∼50 %) with a wider range of waterborne total cell counts (∼10−2–104 cfu mL−1) among water regions in that the resistance proportion was primarily determined by CIP pollution level and relative abundance of various polymer type of MPs. We implicate that water region-specific MPs were highly likely to provide media for P. aeruginosa propagation. Our results highlight the importance of antibiotic-resistant pathogen colonization−emerging environmental medium interactions when addressing global threat from MPs pollution, in the context of MPs-antibiotics co-contamination assessment and for the continued provision of water system management.
[Display omitted]</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - pharmacology</subject><subject>Drug Resistance, Bacterial</subject><subject>Microplastics</subject><subject>Pharmacokinetic/pharmacodynamic model</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Water Pollutants, Chemical</subject><subject>Water region</subject><issn>0043-1354</issn><issn>1879-2448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kM1u1DAUhS0EokPhDRDykk0G_yV2NkhVxZ9UiS7atWU7NyOPEnvwTaDd8Ox4lMKSlS35O77nfoS85WzPGe8-HPe_3FIA94IJteeCa8GfkR03um-EUuY52TGmZMNlqy7IK8QjY0wI2b8kF9JoYbQRO_L7ChEQYzrQOYaST5PDJQZsXFqij_l8pyHDQ8QFUgAa07AGGGiIp5LHKT-4EFNTe1SgZugtwjrkOSeH1EFZDzFldNQt1NFaGAotcIg5UQxugtfkxegmhDdP5yW5__zp7vprc_P9y7frq5smSM6XxuuBGRHazhsDIYxtN44eeq-57n0nvByc8sZraMFDy73uO2DQqb6-KAFaXpL327-19I8VcLFzxADT5BLkFa1krex12_WsompDqw3EAqM9lTi78mg5s2fz9mg38_Zs3m7ma-zd04TVzzD8C_1VXYGPGwB1z58RisUQz0qHWCAsdsjx_xP-AD8Mm1g</recordid><startdate>20240615</startdate><enddate>20240615</enddate><creator>Wang, Wei-Min</creator><creator>Lu, Tien-Hsuan</creator><creator>Chen, Chi-Yun</creator><creator>Liao, Chung-Min</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5536-857X</orcidid><orcidid>https://orcid.org/0000-0001-7007-1371</orcidid><orcidid>https://orcid.org/0000-0002-8360-7996</orcidid></search><sort><creationdate>20240615</creationdate><title>Assessing microplastics-antibiotics coexistence induced ciprofloxacin-resistant Pseudomonas aeruginosa at a water region scale</title><author>Wang, Wei-Min ; Lu, Tien-Hsuan ; Chen, Chi-Yun ; Liao, Chung-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-b7d082c56b88eccf56ffbe9b7179b62b3da4b8b7e5ebe51b796e0e649b3d42e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Ciprofloxacin</topic><topic>Ciprofloxacin - pharmacology</topic><topic>Drug Resistance, Bacterial</topic><topic>Microplastics</topic><topic>Pharmacokinetic/pharmacodynamic model</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Water Pollutants, Chemical</topic><topic>Water region</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wei-Min</creatorcontrib><creatorcontrib>Lu, Tien-Hsuan</creatorcontrib><creatorcontrib>Chen, Chi-Yun</creatorcontrib><creatorcontrib>Liao, Chung-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Water research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Wei-Min</au><au>Lu, Tien-Hsuan</au><au>Chen, Chi-Yun</au><au>Liao, Chung-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing microplastics-antibiotics coexistence induced ciprofloxacin-resistant Pseudomonas aeruginosa at a water region scale</atitle><jtitle>Water research (Oxford)</jtitle><addtitle>Water Res</addtitle><date>2024-06-15</date><risdate>2024</risdate><volume>257</volume><spage>121721</spage><epage>121721</epage><pages>121721-121721</pages><artnum>121721</artnum><issn>0043-1354</issn><eissn>1879-2448</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>•MPs-niched CIP-resistant P. aeruginosa through water systems are assessed.•Enlarged CIP concentration around MPs poses resistance selectivity.•MPs provide media for P. aeruginosa propagation boosting bacteria number in waters.•MPs polymer type-related CIP level determines resistant fraction in waters.
Microplastics (MPs) waste is widespread globally in water systems. The opportunistic human pathogen Pseudomonas aeruginosa can cause serious acute and chronic infections that are notoriously difficult to treat. Ciprofloxacin (CIP) is broadly applied as an anti-P. aeruginosa drug. A growing evidence reveals that antibiotic-resistance genes-carrying Pseudomonas aeruginosa were detected on MPs forming plastisphere due to their adsorbability along with high occurrence of CIP in water environments. The MPs-niched CIP-resistant P. aeruginosa has been likely to emerge as an unignorable public health issue. Here, we offered a novel approach to assess the development of CIP-resistant P. aeruginosa under MPs-antibiotic coexistence at a water region scale. By combing the adsorption isotherm models used to estimate CIP condensation around MPs and a pharmacokinetic/pharmacodynamic-based microbial population dynamic model, we predicted the P. aeruginosa development on CIP-adsorbed MPs in waters. Our assessment revealed a high antibiotic resistance in the P. aeruginosa populations (∼50 %) with a wider range of waterborne total cell counts (∼10−2–104 cfu mL−1) among water regions in that the resistance proportion was primarily determined by CIP pollution level and relative abundance of various polymer type of MPs. We implicate that water region-specific MPs were highly likely to provide media for P. aeruginosa propagation. Our results highlight the importance of antibiotic-resistant pathogen colonization−emerging environmental medium interactions when addressing global threat from MPs pollution, in the context of MPs-antibiotics co-contamination assessment and for the continued provision of water system management.
[Display omitted]</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38728782</pmid><doi>10.1016/j.watres.2024.121721</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5536-857X</orcidid><orcidid>https://orcid.org/0000-0001-7007-1371</orcidid><orcidid>https://orcid.org/0000-0002-8360-7996</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0043-1354 |
| ispartof | Water research (Oxford), 2024-06, Vol.257, p.121721-121721, Article 121721 |
| issn | 0043-1354 1879-2448 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3053975690 |
| source | ScienceDirect Freedom Collection |
| subjects | Anti-Bacterial Agents - pharmacology Antibiotic resistance Ciprofloxacin Ciprofloxacin - pharmacology Drug Resistance, Bacterial Microplastics Pharmacokinetic/pharmacodynamic model Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Water Pollutants, Chemical Water region |
| title | Assessing microplastics-antibiotics coexistence induced ciprofloxacin-resistant Pseudomonas aeruginosa at a water region scale |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-30T14%3A29%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessing%20microplastics-antibiotics%20coexistence%20induced%20ciprofloxacin-resistant%20Pseudomonas%20aeruginosa%20at%20a%20water%20region%20scale&rft.jtitle=Water%20research%20(Oxford)&rft.au=Wang,%20Wei-Min&rft.date=2024-06-15&rft.volume=257&rft.spage=121721&rft.epage=121721&rft.pages=121721-121721&rft.artnum=121721&rft.issn=0043-1354&rft.eissn=1879-2448&rft_id=info:doi/10.1016/j.watres.2024.121721&rft_dat=%3Cproquest_cross%3E3053975690%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c311t-b7d082c56b88eccf56ffbe9b7179b62b3da4b8b7e5ebe51b796e0e649b3d42e73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3053975690&rft_id=info:pmid/38728782&rfr_iscdi=true |