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Composite PCL Scaffold With 70% β-TCP as Suitable Structure for Bone Replacement
The purpose of this work was to optimise printable polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) biomaterials with high percentages of β-TCP endowed with balanced mechanical characteristics to resemble human cancellous bone, presumably improving osteogenesis. PCL/β-TCP scaffolds were obtaine...
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| Published in: | International dental journal 2024-04 |
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| container_title | International dental journal |
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| creator | Ghezzi, Benedetta Matera, Biagio Meglioli, Matteo Rossi, Francesca Duraccio, Donatella Faga, Maria Giulia Zappettini, Andrea Macaluso, Guido Maria Lumetti, Simone |
| description | The purpose of this work was to optimise printable polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) biomaterials with high percentages of β-TCP endowed with balanced mechanical characteristics to resemble human cancellous bone, presumably improving osteogenesis.
PCL/β-TCP scaffolds were obtained from customised filaments for fused deposition modelling (FDM) 3D printing with increasing amounts of β-TCP. Samples mechanical features, surface topography and wettability were evaluated as well as cytocompatibility assays, cell adhesion and differentiation.
The parameters of the newly fabricated materila were optimal for PCL/β-TCP scaffold fabrication. Composite surfaces showed higher hydrophilicity compared with the controls, and their surface roughness sharply was higher, possibly due to the presence of β-TCP. The Young's modulus of the composites was significantly higher than that of pristine PCL, indicating that the intrinsic strength of β-TCP is beneficial for enhancing the elastic modulus of the composite biomaterials. All novel composite biomaterials supported greater cellular growth and stronger osteoblastic differentiation compared with the PCL control.
This project highlights the possibility to fabricat, through an FDM solvent-free approach, PCL/β-TCP scaffolds of up to 70 % concentrations of β-TCP. overcoming the current lmit of 60 % stated in the literature. The combination of 3D printing and customised biomaterials allowed production of highly personalised scaffolds with optimal mechanical and biological features resembling the natural structure and the composition of bone. This underlines the promise of such structures for innovative approaches for bone and periodontal regeneration. |
| doi_str_mv | 10.1016/j.identj.2024.02.013 |
| format | article |
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PCL/β-TCP scaffolds were obtained from customised filaments for fused deposition modelling (FDM) 3D printing with increasing amounts of β-TCP. Samples mechanical features, surface topography and wettability were evaluated as well as cytocompatibility assays, cell adhesion and differentiation.
The parameters of the newly fabricated materila were optimal for PCL/β-TCP scaffold fabrication. Composite surfaces showed higher hydrophilicity compared with the controls, and their surface roughness sharply was higher, possibly due to the presence of β-TCP. The Young's modulus of the composites was significantly higher than that of pristine PCL, indicating that the intrinsic strength of β-TCP is beneficial for enhancing the elastic modulus of the composite biomaterials. All novel composite biomaterials supported greater cellular growth and stronger osteoblastic differentiation compared with the PCL control.
This project highlights the possibility to fabricat, through an FDM solvent-free approach, PCL/β-TCP scaffolds of up to 70 % concentrations of β-TCP. overcoming the current lmit of 60 % stated in the literature. The combination of 3D printing and customised biomaterials allowed production of highly personalised scaffolds with optimal mechanical and biological features resembling the natural structure and the composition of bone. This underlines the promise of such structures for innovative approaches for bone and periodontal regeneration.</description><identifier>ISSN: 0020-6539</identifier><identifier>EISSN: 1875-595X</identifier><identifier>DOI: 10.1016/j.identj.2024.02.013</identifier><identifier>PMID: 38614878</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>3D printing ; Bone regeneration ; PCL ; Solvent-free ; Tissue engineering ; β-TCP</subject><ispartof>International dental journal, 2024-04</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2723-8720865e27c244bf6f1be2570a94d8951667a03951b3e7fd2fc6c06289263c0a3</cites><orcidid>0000-0002-5289-3360 ; 0000-0002-8922-2915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0020653924000674$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,786,790,3568,27957,27958,45815</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38614878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghezzi, Benedetta</creatorcontrib><creatorcontrib>Matera, Biagio</creatorcontrib><creatorcontrib>Meglioli, Matteo</creatorcontrib><creatorcontrib>Rossi, Francesca</creatorcontrib><creatorcontrib>Duraccio, Donatella</creatorcontrib><creatorcontrib>Faga, Maria Giulia</creatorcontrib><creatorcontrib>Zappettini, Andrea</creatorcontrib><creatorcontrib>Macaluso, Guido Maria</creatorcontrib><creatorcontrib>Lumetti, Simone</creatorcontrib><title>Composite PCL Scaffold With 70% β-TCP as Suitable Structure for Bone Replacement</title><title>International dental journal</title><addtitle>Int Dent J</addtitle><description>The purpose of this work was to optimise printable polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) biomaterials with high percentages of β-TCP endowed with balanced mechanical characteristics to resemble human cancellous bone, presumably improving osteogenesis.
PCL/β-TCP scaffolds were obtained from customised filaments for fused deposition modelling (FDM) 3D printing with increasing amounts of β-TCP. Samples mechanical features, surface topography and wettability were evaluated as well as cytocompatibility assays, cell adhesion and differentiation.
The parameters of the newly fabricated materila were optimal for PCL/β-TCP scaffold fabrication. Composite surfaces showed higher hydrophilicity compared with the controls, and their surface roughness sharply was higher, possibly due to the presence of β-TCP. The Young's modulus of the composites was significantly higher than that of pristine PCL, indicating that the intrinsic strength of β-TCP is beneficial for enhancing the elastic modulus of the composite biomaterials. All novel composite biomaterials supported greater cellular growth and stronger osteoblastic differentiation compared with the PCL control.
This project highlights the possibility to fabricat, through an FDM solvent-free approach, PCL/β-TCP scaffolds of up to 70 % concentrations of β-TCP. overcoming the current lmit of 60 % stated in the literature. The combination of 3D printing and customised biomaterials allowed production of highly personalised scaffolds with optimal mechanical and biological features resembling the natural structure and the composition of bone. This underlines the promise of such structures for innovative approaches for bone and periodontal regeneration.</description><subject>3D printing</subject><subject>Bone regeneration</subject><subject>PCL</subject><subject>Solvent-free</subject><subject>Tissue engineering</subject><subject>β-TCP</subject><issn>0020-6539</issn><issn>1875-595X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMtu1DAUhi0EokPhDRDyBolNwrEdX7JBgoibNFILUwQ7y3GOhUfJeLATJF6LB-GZSDVtl12ds_j-c_kIec6gZsDU630dBzzM-5oDb2rgNTDxgGyY0bKSrfzxkGwAOFRKivaMPCllD9AYAeoxORNGscZosyFfujQdU4kz0stuS3fehZDGgX6P80-q4SX997e66i6pK3S3xNn1I9LdnBc_LxlpSJm-SwekX_E4Oo_TetBT8ii4seCzm3pOvn14f9V9qrYXHz93b7eV55qLymgORknk2vOm6YMKrEcuNbi2GUwrmVLagVibXqAOAw9eeVDctFwJD06ck1enucecfi1YZjvF4nEc3QHTUqwAYZpGSKlXtDmhPqdSMgZ7zHFy-Y9lYK9l2r09ybTXMi1wu8pcYy9uNiz9hMNd6NbeCrw5Abj--TtitsVHPHgcYkY_2yHF-zf8Bw0IhSk</recordid><startdate>20240413</startdate><enddate>20240413</enddate><creator>Ghezzi, Benedetta</creator><creator>Matera, Biagio</creator><creator>Meglioli, Matteo</creator><creator>Rossi, Francesca</creator><creator>Duraccio, Donatella</creator><creator>Faga, Maria Giulia</creator><creator>Zappettini, Andrea</creator><creator>Macaluso, Guido Maria</creator><creator>Lumetti, Simone</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5289-3360</orcidid><orcidid>https://orcid.org/0000-0002-8922-2915</orcidid></search><sort><creationdate>20240413</creationdate><title>Composite PCL Scaffold With 70% β-TCP as Suitable Structure for Bone Replacement</title><author>Ghezzi, Benedetta ; Matera, Biagio ; Meglioli, Matteo ; Rossi, Francesca ; Duraccio, Donatella ; Faga, Maria Giulia ; Zappettini, Andrea ; Macaluso, Guido Maria ; Lumetti, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2723-8720865e27c244bf6f1be2570a94d8951667a03951b3e7fd2fc6c06289263c0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3D printing</topic><topic>Bone regeneration</topic><topic>PCL</topic><topic>Solvent-free</topic><topic>Tissue engineering</topic><topic>β-TCP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghezzi, Benedetta</creatorcontrib><creatorcontrib>Matera, Biagio</creatorcontrib><creatorcontrib>Meglioli, Matteo</creatorcontrib><creatorcontrib>Rossi, Francesca</creatorcontrib><creatorcontrib>Duraccio, Donatella</creatorcontrib><creatorcontrib>Faga, Maria Giulia</creatorcontrib><creatorcontrib>Zappettini, Andrea</creatorcontrib><creatorcontrib>Macaluso, Guido Maria</creatorcontrib><creatorcontrib>Lumetti, Simone</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International dental journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghezzi, Benedetta</au><au>Matera, Biagio</au><au>Meglioli, Matteo</au><au>Rossi, Francesca</au><au>Duraccio, Donatella</au><au>Faga, Maria Giulia</au><au>Zappettini, Andrea</au><au>Macaluso, Guido Maria</au><au>Lumetti, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Composite PCL Scaffold With 70% β-TCP as Suitable Structure for Bone Replacement</atitle><jtitle>International dental journal</jtitle><addtitle>Int Dent J</addtitle><date>2024-04-13</date><risdate>2024</risdate><issn>0020-6539</issn><eissn>1875-595X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The purpose of this work was to optimise printable polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) biomaterials with high percentages of β-TCP endowed with balanced mechanical characteristics to resemble human cancellous bone, presumably improving osteogenesis.
PCL/β-TCP scaffolds were obtained from customised filaments for fused deposition modelling (FDM) 3D printing with increasing amounts of β-TCP. Samples mechanical features, surface topography and wettability were evaluated as well as cytocompatibility assays, cell adhesion and differentiation.
The parameters of the newly fabricated materila were optimal for PCL/β-TCP scaffold fabrication. Composite surfaces showed higher hydrophilicity compared with the controls, and their surface roughness sharply was higher, possibly due to the presence of β-TCP. The Young's modulus of the composites was significantly higher than that of pristine PCL, indicating that the intrinsic strength of β-TCP is beneficial for enhancing the elastic modulus of the composite biomaterials. All novel composite biomaterials supported greater cellular growth and stronger osteoblastic differentiation compared with the PCL control.
This project highlights the possibility to fabricat, through an FDM solvent-free approach, PCL/β-TCP scaffolds of up to 70 % concentrations of β-TCP. overcoming the current lmit of 60 % stated in the literature. The combination of 3D printing and customised biomaterials allowed production of highly personalised scaffolds with optimal mechanical and biological features resembling the natural structure and the composition of bone. This underlines the promise of such structures for innovative approaches for bone and periodontal regeneration.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>38614878</pmid><doi>10.1016/j.identj.2024.02.013</doi><orcidid>https://orcid.org/0000-0002-5289-3360</orcidid><orcidid>https://orcid.org/0000-0002-8922-2915</orcidid><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals; PubMed Central |
| subjects | 3D printing Bone regeneration PCL Solvent-free Tissue engineering β-TCP |
| title | Composite PCL Scaffold With 70% β-TCP as Suitable Structure for Bone Replacement |
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