Loading…
Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy
Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) has attracted great interest due to its high spatiotemporal controllability and noninvasiveness. Due to the trade‐off betwee...
Saved in:
Published in: | Angewandte Chemie International Edition 2024-03, Vol.63 (13), p.e202318539-n/a |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c3739-d4e1b8b5447ed686d36f86162be8823940e0cd2b1079a0b96c18509a1ed4f5b03 |
---|---|
cites | cdi_FETCH-LOGICAL-c3739-d4e1b8b5447ed686d36f86162be8823940e0cd2b1079a0b96c18509a1ed4f5b03 |
container_end_page | n/a |
container_issue | 13 |
container_start_page | e202318539 |
container_title | Angewandte Chemie International Edition |
container_volume | 63 |
creator | Yan, Xiao Li, Ke Xie, Tian‐Qiu Jin, Xiao‐Kang Zhang, Cheng Li, Qian‐Ru Feng, Jun Liu, Chuan‐Jun Zhang, Xian‐Zheng |
description | Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) has attracted great interest due to its high spatiotemporal controllability and noninvasiveness. Due to the trade‐off between particle size and photothermal efficiency of AuNPs, rational design is needed to realize aggregation of AuNPs into larger particles with desirable NIR adsorption in tumor site. Exploiting the bioorthogonal “Click and Release” (BCR) reaction between iminosydnone and cycloalkyne, aggregation of AuNPs can be achieved and attractively accompanied by the release of chemotherapeutic drug purposed to photothermal synergizing. We synthesize iminosydnone‐lonidamine (ImLND) as a prodrug and choose dibenzocyclooctyne (DBCO) as the trigger of BCR reaction. A PEGylated AuNPs‐based two‐component nanoplatform consisting of prodrug‐loaded AuNPs‐ImLND and tumor‐targeting peptide RGD‐conjugated AuNPs‐DBCO‐RGD is designed. In the therapeutic regimen, AuNPs‐DBCO‐RGD are intravenously injected first for tumor‐specific enrichment and retention. Once the arrival of AuNPs‐ImLND injected later at tumor site, highly photothermally active nanoaggregates of AuNPs are formed via the BCR reaction between ImLND and DBCO. The simultaneous release of lonidamine further enhanced the therapeutic performance by sensitizing cancer cells to PTT.
We reported the application of bioorthogonal “Click and Release” (BCR) reaction between prodrug iminosydnone‐lonidamine (ImLND) and dibenzocyclooctyne (DBCO) to form highly photothermal‐active nanoaggregates with synergistic drug release. The reactants of BCR reaction were grafted on surface of gold nanoparticles (AuNPs) and was proven both in vitro and in vivo to robustly enhance the therapeutic outcome of photothermal therapy. |
doi_str_mv | 10.1002/anie.202318539 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2928854486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2928854486</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3739-d4e1b8b5447ed686d36f86162be8823940e0cd2b1079a0b96c18509a1ed4f5b03</originalsourceid><addsrcrecordid>eNqFkcFu1DAURSMEoqWwZYkssekmgx0njrMcoqFUGhWEhnXk2C-Ji2MPdkbV7OYT-ABY81_zJTiatkhsWN2n5-Orp3uT5DXBC4Jx9k5YDYsMZ5TwglZPknNSZCSlZUmfxjmnNC15Qc6SFyHcRp5zzJ4nZ5RTTFlenie_32vn_DS43llh0PHwszZafkPCKvQFDIgAx8OvOAo5aWePhx8br_sePCi07HsPvZj3yHXoyhmFboR1W-EnLQ0EVLux1Taid3oaHvwUWjurlRjjC-qcRys7CCvjvp7Fo8-Dm9w0gB_jRZuoYrt_mTzrhAnw6l4vkq8fVpv6Y7r-dHVdL9eppCWtUpUDaXlb5HkJinGmKOs4IyxrgfOMVjkGLFXWElxWArcVkzE3XAkCKu-KFtOL5PLku_Xu-w7C1Iw6SDBGWHC70GRVzDDacxbRt_-gt27nY4ozVXDCaJGTSC1OlPQuBA9ds_V6FH7fENzMFTZzhc1jhfHDm3vbXTuCesQfOotAdQLutIH9f-ya5c316q_5H-aqrO8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2958163541</pqid></control><display><type>article</type><title>Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy</title><source>Wiley-Blackwell Journals</source><creator>Yan, Xiao ; Li, Ke ; Xie, Tian‐Qiu ; Jin, Xiao‐Kang ; Zhang, Cheng ; Li, Qian‐Ru ; Feng, Jun ; Liu, Chuan‐Jun ; Zhang, Xian‐Zheng</creator><creatorcontrib>Yan, Xiao ; Li, Ke ; Xie, Tian‐Qiu ; Jin, Xiao‐Kang ; Zhang, Cheng ; Li, Qian‐Ru ; Feng, Jun ; Liu, Chuan‐Jun ; Zhang, Xian‐Zheng</creatorcontrib><description>Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) has attracted great interest due to its high spatiotemporal controllability and noninvasiveness. Due to the trade‐off between particle size and photothermal efficiency of AuNPs, rational design is needed to realize aggregation of AuNPs into larger particles with desirable NIR adsorption in tumor site. Exploiting the bioorthogonal “Click and Release” (BCR) reaction between iminosydnone and cycloalkyne, aggregation of AuNPs can be achieved and attractively accompanied by the release of chemotherapeutic drug purposed to photothermal synergizing. We synthesize iminosydnone‐lonidamine (ImLND) as a prodrug and choose dibenzocyclooctyne (DBCO) as the trigger of BCR reaction. A PEGylated AuNPs‐based two‐component nanoplatform consisting of prodrug‐loaded AuNPs‐ImLND and tumor‐targeting peptide RGD‐conjugated AuNPs‐DBCO‐RGD is designed. In the therapeutic regimen, AuNPs‐DBCO‐RGD are intravenously injected first for tumor‐specific enrichment and retention. Once the arrival of AuNPs‐ImLND injected later at tumor site, highly photothermally active nanoaggregates of AuNPs are formed via the BCR reaction between ImLND and DBCO. The simultaneous release of lonidamine further enhanced the therapeutic performance by sensitizing cancer cells to PTT.
We reported the application of bioorthogonal “Click and Release” (BCR) reaction between prodrug iminosydnone‐lonidamine (ImLND) and dibenzocyclooctyne (DBCO) to form highly photothermal‐active nanoaggregates with synergistic drug release. The reactants of BCR reaction were grafted on surface of gold nanoparticles (AuNPs) and was proven both in vitro and in vivo to robustly enhance the therapeutic outcome of photothermal therapy.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>ISSN: 1521-3773</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.202318539</identifier><identifier>PMID: 38303647</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Aggregation ; Bioorthogonal chemistry ; Cancer ; Casualties ; Click chemistry ; Gold ; Gold nanoparticle ; Nanoparticles ; Neoplasms ; Photothermal therapy ; Prodrugs ; Sensitizing ; Synergistic therapy ; Tumors</subject><ispartof>Angewandte Chemie International Edition, 2024-03, Vol.63 (13), p.e202318539-n/a</ispartof><rights>2024 Wiley‐VCH GmbH</rights><rights>2024 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3739-d4e1b8b5447ed686d36f86162be8823940e0cd2b1079a0b96c18509a1ed4f5b03</citedby><cites>FETCH-LOGICAL-c3739-d4e1b8b5447ed686d36f86162be8823940e0cd2b1079a0b96c18509a1ed4f5b03</cites><orcidid>0000-0001-9543-7763</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.202318539$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.202318539$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38303647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Xiao</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Xie, Tian‐Qiu</creatorcontrib><creatorcontrib>Jin, Xiao‐Kang</creatorcontrib><creatorcontrib>Zhang, Cheng</creatorcontrib><creatorcontrib>Li, Qian‐Ru</creatorcontrib><creatorcontrib>Feng, Jun</creatorcontrib><creatorcontrib>Liu, Chuan‐Jun</creatorcontrib><creatorcontrib>Zhang, Xian‐Zheng</creatorcontrib><title>Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) has attracted great interest due to its high spatiotemporal controllability and noninvasiveness. Due to the trade‐off between particle size and photothermal efficiency of AuNPs, rational design is needed to realize aggregation of AuNPs into larger particles with desirable NIR adsorption in tumor site. Exploiting the bioorthogonal “Click and Release” (BCR) reaction between iminosydnone and cycloalkyne, aggregation of AuNPs can be achieved and attractively accompanied by the release of chemotherapeutic drug purposed to photothermal synergizing. We synthesize iminosydnone‐lonidamine (ImLND) as a prodrug and choose dibenzocyclooctyne (DBCO) as the trigger of BCR reaction. A PEGylated AuNPs‐based two‐component nanoplatform consisting of prodrug‐loaded AuNPs‐ImLND and tumor‐targeting peptide RGD‐conjugated AuNPs‐DBCO‐RGD is designed. In the therapeutic regimen, AuNPs‐DBCO‐RGD are intravenously injected first for tumor‐specific enrichment and retention. Once the arrival of AuNPs‐ImLND injected later at tumor site, highly photothermally active nanoaggregates of AuNPs are formed via the BCR reaction between ImLND and DBCO. The simultaneous release of lonidamine further enhanced the therapeutic performance by sensitizing cancer cells to PTT.
We reported the application of bioorthogonal “Click and Release” (BCR) reaction between prodrug iminosydnone‐lonidamine (ImLND) and dibenzocyclooctyne (DBCO) to form highly photothermal‐active nanoaggregates with synergistic drug release. The reactants of BCR reaction were grafted on surface of gold nanoparticles (AuNPs) and was proven both in vitro and in vivo to robustly enhance the therapeutic outcome of photothermal therapy.</description><subject>Aggregation</subject><subject>Bioorthogonal chemistry</subject><subject>Cancer</subject><subject>Casualties</subject><subject>Click chemistry</subject><subject>Gold</subject><subject>Gold nanoparticle</subject><subject>Nanoparticles</subject><subject>Neoplasms</subject><subject>Photothermal therapy</subject><subject>Prodrugs</subject><subject>Sensitizing</subject><subject>Synergistic therapy</subject><subject>Tumors</subject><issn>1433-7851</issn><issn>1521-3773</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkcFu1DAURSMEoqWwZYkssekmgx0njrMcoqFUGhWEhnXk2C-Ji2MPdkbV7OYT-ABY81_zJTiatkhsWN2n5-Orp3uT5DXBC4Jx9k5YDYsMZ5TwglZPknNSZCSlZUmfxjmnNC15Qc6SFyHcRp5zzJ4nZ5RTTFlenie_32vn_DS43llh0PHwszZafkPCKvQFDIgAx8OvOAo5aWePhx8br_sePCi07HsPvZj3yHXoyhmFboR1W-EnLQ0EVLux1Taid3oaHvwUWjurlRjjC-qcRys7CCvjvp7Fo8-Dm9w0gB_jRZuoYrt_mTzrhAnw6l4vkq8fVpv6Y7r-dHVdL9eppCWtUpUDaXlb5HkJinGmKOs4IyxrgfOMVjkGLFXWElxWArcVkzE3XAkCKu-KFtOL5PLku_Xu-w7C1Iw6SDBGWHC70GRVzDDacxbRt_-gt27nY4ozVXDCaJGTSC1OlPQuBA9ds_V6FH7fENzMFTZzhc1jhfHDm3vbXTuCesQfOotAdQLutIH9f-ya5c316q_5H-aqrO8</recordid><startdate>20240322</startdate><enddate>20240322</enddate><creator>Yan, Xiao</creator><creator>Li, Ke</creator><creator>Xie, Tian‐Qiu</creator><creator>Jin, Xiao‐Kang</creator><creator>Zhang, Cheng</creator><creator>Li, Qian‐Ru</creator><creator>Feng, Jun</creator><creator>Liu, Chuan‐Jun</creator><creator>Zhang, Xian‐Zheng</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9543-7763</orcidid></search><sort><creationdate>20240322</creationdate><title>Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy</title><author>Yan, Xiao ; Li, Ke ; Xie, Tian‐Qiu ; Jin, Xiao‐Kang ; Zhang, Cheng ; Li, Qian‐Ru ; Feng, Jun ; Liu, Chuan‐Jun ; Zhang, Xian‐Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3739-d4e1b8b5447ed686d36f86162be8823940e0cd2b1079a0b96c18509a1ed4f5b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aggregation</topic><topic>Bioorthogonal chemistry</topic><topic>Cancer</topic><topic>Casualties</topic><topic>Click chemistry</topic><topic>Gold</topic><topic>Gold nanoparticle</topic><topic>Nanoparticles</topic><topic>Neoplasms</topic><topic>Photothermal therapy</topic><topic>Prodrugs</topic><topic>Sensitizing</topic><topic>Synergistic therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Xiao</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Xie, Tian‐Qiu</creatorcontrib><creatorcontrib>Jin, Xiao‐Kang</creatorcontrib><creatorcontrib>Zhang, Cheng</creatorcontrib><creatorcontrib>Li, Qian‐Ru</creatorcontrib><creatorcontrib>Feng, Jun</creatorcontrib><creatorcontrib>Liu, Chuan‐Jun</creatorcontrib><creatorcontrib>Zhang, Xian‐Zheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Xiao</au><au>Li, Ke</au><au>Xie, Tian‐Qiu</au><au>Jin, Xiao‐Kang</au><au>Zhang, Cheng</au><au>Li, Qian‐Ru</au><au>Feng, Jun</au><au>Liu, Chuan‐Jun</au><au>Zhang, Xian‐Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2024-03-22</date><risdate>2024</risdate><volume>63</volume><issue>13</issue><spage>e202318539</spage><epage>n/a</epage><pages>e202318539-n/a</pages><issn>1433-7851</issn><issn>1521-3773</issn><eissn>1521-3773</eissn><notes>These authors contributed equally to this work.</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) has attracted great interest due to its high spatiotemporal controllability and noninvasiveness. Due to the trade‐off between particle size and photothermal efficiency of AuNPs, rational design is needed to realize aggregation of AuNPs into larger particles with desirable NIR adsorption in tumor site. Exploiting the bioorthogonal “Click and Release” (BCR) reaction between iminosydnone and cycloalkyne, aggregation of AuNPs can be achieved and attractively accompanied by the release of chemotherapeutic drug purposed to photothermal synergizing. We synthesize iminosydnone‐lonidamine (ImLND) as a prodrug and choose dibenzocyclooctyne (DBCO) as the trigger of BCR reaction. A PEGylated AuNPs‐based two‐component nanoplatform consisting of prodrug‐loaded AuNPs‐ImLND and tumor‐targeting peptide RGD‐conjugated AuNPs‐DBCO‐RGD is designed. In the therapeutic regimen, AuNPs‐DBCO‐RGD are intravenously injected first for tumor‐specific enrichment and retention. Once the arrival of AuNPs‐ImLND injected later at tumor site, highly photothermally active nanoaggregates of AuNPs are formed via the BCR reaction between ImLND and DBCO. The simultaneous release of lonidamine further enhanced the therapeutic performance by sensitizing cancer cells to PTT.
We reported the application of bioorthogonal “Click and Release” (BCR) reaction between prodrug iminosydnone‐lonidamine (ImLND) and dibenzocyclooctyne (DBCO) to form highly photothermal‐active nanoaggregates with synergistic drug release. The reactants of BCR reaction were grafted on surface of gold nanoparticles (AuNPs) and was proven both in vitro and in vivo to robustly enhance the therapeutic outcome of photothermal therapy.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38303647</pmid><doi>10.1002/anie.202318539</doi><tpages>10</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0001-9543-7763</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1433-7851 |
ispartof | Angewandte Chemie International Edition, 2024-03, Vol.63 (13), p.e202318539-n/a |
issn | 1433-7851 1521-3773 1521-3773 |
language | eng |
recordid | cdi_proquest_miscellaneous_2928854486 |
source | Wiley-Blackwell Journals |
subjects | Aggregation Bioorthogonal chemistry Cancer Casualties Click chemistry Gold Gold nanoparticle Nanoparticles Neoplasms Photothermal therapy Prodrugs Sensitizing Synergistic therapy Tumors |
title | Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T20%3A35%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioorthogonal%20%E2%80%9CClick%20and%20Release%E2%80%9D%20Reaction%E2%80%90Triggered%20Aggregation%20of%20Gold%20Nanoparticles%20Combined%20with%20Released%20Lonidamine%20for%20Enhanced%20Cancer%20Photothermal%20Therapy&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Yan,%20Xiao&rft.date=2024-03-22&rft.volume=63&rft.issue=13&rft.spage=e202318539&rft.epage=n/a&rft.pages=e202318539-n/a&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.202318539&rft_dat=%3Cproquest_cross%3E2928854486%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3739-d4e1b8b5447ed686d36f86162be8823940e0cd2b1079a0b96c18509a1ed4f5b03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2958163541&rft_id=info:pmid/38303647&rfr_iscdi=true |