Incidence of invasive fungal diseases in inflammatory bowel disease patients: A nationwide study in South Korea

Background Limited reports exist regarding invasive fungal diseases (IFDs) in inflammatory bowel disease (IBD) patients. Objectives This study aims to investigate the incidence and risk factors of IFDs, specifically invasive candidiasis, aspergillosis and pneumocystosis, in IBD patients in South Kor...

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Bibliographic Details
Published in:Mycoses 2024-01, Vol.67 (1), p.e13689-n/a
Main Authors: Na, Ji Eun, Jung, Sung Hoon, Choi, Arum, Kim, Sukil, Kim, Tae‐Oh
Format: Article
Language:English
Subjects:
Aspergillosis
Aspergillosis - complications
Candidiasis
Candidiasis, Invasive - complications
Colitis, Ulcerative - complications
Colitis, Ulcerative - epidemiology
Comorbidity
Crohn Disease - complications
Crohn Disease - epidemiology
Crohn's disease
Fungal diseases
Humans
Incidence
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - epidemiology
Intestine
invasive fungal diseases
Invasive Fungal Infections - complications
Invasive Fungal Infections - epidemiology
Pneumocystosis
Pneumonia, Pneumocystis
Republic of Korea - epidemiology
Retrospective Studies
Risk factors
Ulcerative colitis
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Summary:Background Limited reports exist regarding invasive fungal diseases (IFDs) in inflammatory bowel disease (IBD) patients. Objectives This study aims to investigate the incidence and risk factors of IFDs, specifically invasive candidiasis, aspergillosis and pneumocystosis, in IBD patients in South Korea using nationwide data. Patients/Methods A population‐based retrospective cohort of 42,913 IBD patients between January 2010 and December 2018 was evaluated using the Health Insurance Review and Assessment database. The primary outcome was the incidence of IFDs, including invasive candidiasis, aspergillosis and pneumocystosis, while the secondary outcome involved analysing the risk factors associated with each specific infection. Results The study included a total of 42,913 IBD patients, with 29,909 (69.7%) diagnosed with ulcerative colitis (UC) and 13,004 (30.3%) diagnosed with Crohn's disease (CD). IFDs occurred in 166 IBD patients (0.4%), with 93 cases in UC patients and 73 cases in CD patients. The incidence rates of invasive candidiasis, aspergillosis and pneumocystosis in IBD patients were 0.71 per 1000 person‐years (PYs), 0.15 per 1000 PYs and 0.12 per 1000 PYs, respectively. The cumulative incidence of invasive candidiasis (adjusted p‐value
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.13689