Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin

Thirteen previously undescribed iridoids (1–13), together with five known iridoids (14–18) were isolated from the roots and rhizomes of Valeriana jatamansi Jones. Their structures with absolute configurations were elucidated by analysis of MS, NMR, optical rotation and their experimental and calcula...

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Published in:Phytochemistry (Oxford) 2024-03, Vol.219, p.113962-113962, Article 113962
Main Authors: Zhu, Yao, Guo, Peng-Ju, Ding, Ao-Xue, Zheng, Liu, Du, Gao-Xiang, Chen, Tong, Qin, Guo-Qing, Hu, Xiang-Gang, Wang, Wen-Qiong, Xuan, Li-Jiang
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Language:English
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Iridoids
Protective effects
Valeriana jatamansi Jones
α-hemolysin
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cited_by cdi_FETCH-LOGICAL-c371t-7a0b5a949c287ec596e5b305808e0cb63f7247f297f5e91dd7a7133ad5b3809c3
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container_title Phytochemistry (Oxford)
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creator Zhu, Yao
Guo, Peng-Ju
Ding, Ao-Xue
Zheng, Liu
Du, Gao-Xiang
Chen, Tong
Qin, Guo-Qing
Hu, Xiang-Gang
Wang, Wen-Qiong
Xuan, Li-Jiang
description Thirteen previously undescribed iridoids (1–13), together with five known iridoids (14–18) were isolated from the roots and rhizomes of Valeriana jatamansi Jones. Their structures with absolute configurations were elucidated by analysis of MS, NMR, optical rotation and their experimental and calculated electronic circular dichroism spectra. All of the isolated compounds were tested for their protective effects against α-hemolysin-induced cell death in A549 cells. Compounds 14, 16 and 17 showed moderate protective effects, and compounds 15 and 18 showed weak protective effects. Eighteen iridoids including thirteen previously undescribed ones were isolated from Valeriana jatamansi Jones and some of them exhibited protective effects against α-hemolysin-induced cell death in A549 cells. [Display omitted] •Thirteen previously undescribed iridoids were isolated from Valeriana jatamansi.•Compounds 1 and 2 were unique iridoids with isovaleroxy at C-1 and C-3.•Compounds 14, 16 and 17 showed moderate protective effects against α-hemolysin.
doi_str_mv 10.1016/j.phytochem.2023.113962
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subjects Iridoids
Protective effects
Valeriana jatamansi Jones
α-hemolysin
title Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin
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