Patterns of recurrence in FIGO stage IB1-IB2 cervical cancer: Comparison between minimally invasive and abdominal radical hysterectomy

Aim of our study was to evaluate whether the different laparotomic (ARH) or minimally invasive (laparoscopic and robotic) approaches (MIS) in FIGO stage IB1-IB2 cervical cancer, present different patterns of recurrence of the disease. The secondary endpoint of the study was the evaluation of the var...

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Published in:European journal of surgical oncology 2023-11, Vol.49 (11), p.107047-107047, Article 107047
Main Authors: Corrado, Giacomo, Anchora, Luigi Pedone, Bruni, Simone, Sperduti, Isabella, Certelli, Camilla, Chiofalo, Benito, Giannini, Andrea, D'Oria, Ottavia, Bizzarri, Nicolò, Legge, Francesco, Cosentino, Francesco, Turco, Luigi Carlo, Vizza, Enrico, Scambia, Giovanni, Ferrandina, Gabriella
Format: Article
Language:English
Subjects:
Abdominal radical hysterectomy
Cervical cancer
Disease-Free Survival
Female
Humans
Hysterectomy
Laparoscopy
Minimally invasive surgery
Neoplasm Staging
Recurrence
Retrospective Studies
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - surgery
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Summary:Aim of our study was to evaluate whether the different laparotomic (ARH) or minimally invasive (laparoscopic and robotic) approaches (MIS) in FIGO stage IB1-IB2 cervical cancer, present different patterns of recurrence of the disease. The secondary endpoint of the study was the evaluation of the variables most involved with the risk of relapse and therefore lower DFS and OS. The study enrolled patients with definitive histological diagnosis of squamous or adenocarcinoma stage IB1-IB2 cervical cancer who underwent minimally invasive or abdominal radical hysterectomy from 2001 to 2018. The study enrolled 360 patients and 59 patients (16.4 %) reported a disease relapse. The data showed that ARH group was not associated with different recurrence patterns than MIS group (p = 0.14). Moreover, there was no statistically significant difference regarding DFS (p = 0.52) and OS (p = 0.29) between the ARH group and the MIS group. MIS, in FIGO stage IB1-IB2 cervical cancer, is not associated with different relapse patterns compared to ARH, nor with a higher risk of distance metastasis and finally, without significant difference in term of DFS and OS. More studies are needed to determine the factors that modify the site of relapse.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2023.107047