Loading…
The application of lag times in cancer pharmacoepidemiology: a narrative review
With the increasing utilization of medications worldwide, coupled with the increasing availability of long-term data, there is a growing opportunity and need for robust studies evaluating drug–cancer associations. One methodology of importance in such studies is the application of lag times. In this...
Saved in:
Published in: | Annals of epidemiology 2023-08, Vol.84, p.25-32 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c486t-11b3a0340c51a49484738d88ad1ee34561db235f71e55a77b2a1993c404e92ab3 |
---|---|
cites | cdi_FETCH-LOGICAL-c486t-11b3a0340c51a49484738d88ad1ee34561db235f71e55a77b2a1993c404e92ab3 |
container_end_page | 32 |
container_issue | |
container_start_page | 25 |
container_title | Annals of epidemiology |
container_volume | 84 |
creator | Hicks, Blánaid Kaye, James A. Azoulay, Laurent Kristensen, Kasper Bruun Habel, Laurel A. Pottegård, Anton |
description | With the increasing utilization of medications worldwide, coupled with the increasing availability of long-term data, there is a growing opportunity and need for robust studies evaluating drug–cancer associations. One methodology of importance in such studies is the application of lag times.
In this narrative review, we discuss the main reasons for using lag times.
Namely, we discuss the typically long latency period of cancer concerning both tumor promoter and initiator effects and outline why cancer latency is a key consideration when choosing a lag time. We also discuss how the use of lag times can help reduce protopathic and detection bias. Finally, we present practical advice for implementing lag periods.
In general, we recommend that researchers consider the information that generated the hypothesis as well as clinical and biological knowledge to inform lag period selection. In addition, given that latency periods are usually unknown, we also advocate that researchers examine multiple lag periods in sensitivity analyses as well as duration analyses and flexible modeling approaches. |
doi_str_mv | 10.1016/j.annepidem.2023.05.004 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2813560015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S104727972300090X</els_id><sourcerecordid>2813560015</sourcerecordid><originalsourceid>FETCH-LOGICAL-c486t-11b3a0340c51a49484738d88ad1ee34561db235f71e55a77b2a1993c404e92ab3</originalsourceid><addsrcrecordid>eNqFkMtu1TAQhi0EoqXwCuAlm4TxLXbYVRU3qRIsytqaOHNaHyVxsHNa9W14Fp4MV6d0y2pm8f3zaz7G3gloBYjuw77FZaE1jjS3EqRqwbQA-hk7Fc6qRhpnntcdtG2k7e0Je1XKHgCss_IlO1FWdD1oOGU_rm7oz29c1ykG3GJaeNrxCa_5FmcqPC484BIo8_UG84whHUtjmtL1_UeOfMGca_CWeKbbSHev2YsdToXePM4z9vPzp6uLr83l9y_fLs4vm6BdtzVCDApBaQhGoO6101a50TkcBZHSphPjIJXZWUHGoLWDRNH3KmjQ1Esc1Bl7f7y75vTrQGXzcyyBpgkXSofipRPKdADCVNQe0ZBTKZl2fs1xxnzvBfgHnX7vn3T6B50ejK86a_LtY8lhmGl8yv3zV4HzI0D11fp-9iVEqsLGmClsfkzxvyV_AWH7ivE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2813560015</pqid></control><display><type>article</type><title>The application of lag times in cancer pharmacoepidemiology: a narrative review</title><source>Elsevier</source><creator>Hicks, Blánaid ; Kaye, James A. ; Azoulay, Laurent ; Kristensen, Kasper Bruun ; Habel, Laurel A. ; Pottegård, Anton</creator><creatorcontrib>Hicks, Blánaid ; Kaye, James A. ; Azoulay, Laurent ; Kristensen, Kasper Bruun ; Habel, Laurel A. ; Pottegård, Anton</creatorcontrib><description>With the increasing utilization of medications worldwide, coupled with the increasing availability of long-term data, there is a growing opportunity and need for robust studies evaluating drug–cancer associations. One methodology of importance in such studies is the application of lag times.
In this narrative review, we discuss the main reasons for using lag times.
Namely, we discuss the typically long latency period of cancer concerning both tumor promoter and initiator effects and outline why cancer latency is a key consideration when choosing a lag time. We also discuss how the use of lag times can help reduce protopathic and detection bias. Finally, we present practical advice for implementing lag periods.
In general, we recommend that researchers consider the information that generated the hypothesis as well as clinical and biological knowledge to inform lag period selection. In addition, given that latency periods are usually unknown, we also advocate that researchers examine multiple lag periods in sensitivity analyses as well as duration analyses and flexible modeling approaches.</description><identifier>ISSN: 1047-2797</identifier><identifier>EISSN: 1873-2585</identifier><identifier>DOI: 10.1016/j.annepidem.2023.05.004</identifier><identifier>PMID: 37169040</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bias ; Cancer ; Humans ; Induction period ; Lag time ; Latency ; Neoplasms ; Neoplasms - diagnosis ; Neoplasms - drug therapy ; Neoplasms - epidemiology ; Pharmacoepidemiology ; Pharmacoepidemiology - methods ; Time Factors</subject><ispartof>Annals of epidemiology, 2023-08, Vol.84, p.25-32</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-11b3a0340c51a49484738d88ad1ee34561db235f71e55a77b2a1993c404e92ab3</citedby><cites>FETCH-LOGICAL-c486t-11b3a0340c51a49484738d88ad1ee34561db235f71e55a77b2a1993c404e92ab3</cites><orcidid>0000-0002-5730-9469</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37169040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hicks, Blánaid</creatorcontrib><creatorcontrib>Kaye, James A.</creatorcontrib><creatorcontrib>Azoulay, Laurent</creatorcontrib><creatorcontrib>Kristensen, Kasper Bruun</creatorcontrib><creatorcontrib>Habel, Laurel A.</creatorcontrib><creatorcontrib>Pottegård, Anton</creatorcontrib><title>The application of lag times in cancer pharmacoepidemiology: a narrative review</title><title>Annals of epidemiology</title><addtitle>Ann Epidemiol</addtitle><description>With the increasing utilization of medications worldwide, coupled with the increasing availability of long-term data, there is a growing opportunity and need for robust studies evaluating drug–cancer associations. One methodology of importance in such studies is the application of lag times.
In this narrative review, we discuss the main reasons for using lag times.
Namely, we discuss the typically long latency period of cancer concerning both tumor promoter and initiator effects and outline why cancer latency is a key consideration when choosing a lag time. We also discuss how the use of lag times can help reduce protopathic and detection bias. Finally, we present practical advice for implementing lag periods.
In general, we recommend that researchers consider the information that generated the hypothesis as well as clinical and biological knowledge to inform lag period selection. In addition, given that latency periods are usually unknown, we also advocate that researchers examine multiple lag periods in sensitivity analyses as well as duration analyses and flexible modeling approaches.</description><subject>Bias</subject><subject>Cancer</subject><subject>Humans</subject><subject>Induction period</subject><subject>Lag time</subject><subject>Latency</subject><subject>Neoplasms</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - epidemiology</subject><subject>Pharmacoepidemiology</subject><subject>Pharmacoepidemiology - methods</subject><subject>Time Factors</subject><issn>1047-2797</issn><issn>1873-2585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkMtu1TAQhi0EoqXwCuAlm4TxLXbYVRU3qRIsytqaOHNaHyVxsHNa9W14Fp4MV6d0y2pm8f3zaz7G3gloBYjuw77FZaE1jjS3EqRqwbQA-hk7Fc6qRhpnntcdtG2k7e0Je1XKHgCss_IlO1FWdD1oOGU_rm7oz29c1ykG3GJaeNrxCa_5FmcqPC484BIo8_UG84whHUtjmtL1_UeOfMGca_CWeKbbSHev2YsdToXePM4z9vPzp6uLr83l9y_fLs4vm6BdtzVCDApBaQhGoO6101a50TkcBZHSphPjIJXZWUHGoLWDRNH3KmjQ1Esc1Bl7f7y75vTrQGXzcyyBpgkXSofipRPKdADCVNQe0ZBTKZl2fs1xxnzvBfgHnX7vn3T6B50ejK86a_LtY8lhmGl8yv3zV4HzI0D11fp-9iVEqsLGmClsfkzxvyV_AWH7ivE</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Hicks, Blánaid</creator><creator>Kaye, James A.</creator><creator>Azoulay, Laurent</creator><creator>Kristensen, Kasper Bruun</creator><creator>Habel, Laurel A.</creator><creator>Pottegård, Anton</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5730-9469</orcidid></search><sort><creationdate>202308</creationdate><title>The application of lag times in cancer pharmacoepidemiology: a narrative review</title><author>Hicks, Blánaid ; Kaye, James A. ; Azoulay, Laurent ; Kristensen, Kasper Bruun ; Habel, Laurel A. ; Pottegård, Anton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-11b3a0340c51a49484738d88ad1ee34561db235f71e55a77b2a1993c404e92ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bias</topic><topic>Cancer</topic><topic>Humans</topic><topic>Induction period</topic><topic>Lag time</topic><topic>Latency</topic><topic>Neoplasms</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - epidemiology</topic><topic>Pharmacoepidemiology</topic><topic>Pharmacoepidemiology - methods</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hicks, Blánaid</creatorcontrib><creatorcontrib>Kaye, James A.</creatorcontrib><creatorcontrib>Azoulay, Laurent</creatorcontrib><creatorcontrib>Kristensen, Kasper Bruun</creatorcontrib><creatorcontrib>Habel, Laurel A.</creatorcontrib><creatorcontrib>Pottegård, Anton</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hicks, Blánaid</au><au>Kaye, James A.</au><au>Azoulay, Laurent</au><au>Kristensen, Kasper Bruun</au><au>Habel, Laurel A.</au><au>Pottegård, Anton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The application of lag times in cancer pharmacoepidemiology: a narrative review</atitle><jtitle>Annals of epidemiology</jtitle><addtitle>Ann Epidemiol</addtitle><date>2023-08</date><risdate>2023</risdate><volume>84</volume><spage>25</spage><epage>32</epage><pages>25-32</pages><issn>1047-2797</issn><eissn>1873-2585</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>With the increasing utilization of medications worldwide, coupled with the increasing availability of long-term data, there is a growing opportunity and need for robust studies evaluating drug–cancer associations. One methodology of importance in such studies is the application of lag times.
In this narrative review, we discuss the main reasons for using lag times.
Namely, we discuss the typically long latency period of cancer concerning both tumor promoter and initiator effects and outline why cancer latency is a key consideration when choosing a lag time. We also discuss how the use of lag times can help reduce protopathic and detection bias. Finally, we present practical advice for implementing lag periods.
In general, we recommend that researchers consider the information that generated the hypothesis as well as clinical and biological knowledge to inform lag period selection. In addition, given that latency periods are usually unknown, we also advocate that researchers examine multiple lag periods in sensitivity analyses as well as duration analyses and flexible modeling approaches.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37169040</pmid><doi>10.1016/j.annepidem.2023.05.004</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5730-9469</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1047-2797 |
ispartof | Annals of epidemiology, 2023-08, Vol.84, p.25-32 |
issn | 1047-2797 1873-2585 |
language | eng |
recordid | cdi_proquest_miscellaneous_2813560015 |
source | Elsevier |
subjects | Bias Cancer Humans Induction period Lag time Latency Neoplasms Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - epidemiology Pharmacoepidemiology Pharmacoepidemiology - methods Time Factors |
title | The application of lag times in cancer pharmacoepidemiology: a narrative review |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T12%3A51%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%C2%A0application%20of%20lag%20times%20in%20cancer%20pharmacoepidemiology:%20a%20narrative%20review&rft.jtitle=Annals%20of%20epidemiology&rft.au=Hicks,%20Bl%C3%A1naid&rft.date=2023-08&rft.volume=84&rft.spage=25&rft.epage=32&rft.pages=25-32&rft.issn=1047-2797&rft.eissn=1873-2585&rft_id=info:doi/10.1016/j.annepidem.2023.05.004&rft_dat=%3Cproquest_cross%3E2813560015%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c486t-11b3a0340c51a49484738d88ad1ee34561db235f71e55a77b2a1993c404e92ab3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2813560015&rft_id=info:pmid/37169040&rfr_iscdi=true |