Targeting ferroptosis in cardio‐metabolic‐diseases: Mechanisms and therapeutic prospects

Cardio‐metabolic‐diseases (cardio‐metabolic‐diseases) are leading causes of death and disability worldwide and impose a tremendous burden on whole society as well as individuals. As a new type of regulated cell death (RCD), ferroptosis is distinct from several classical types of RCDs such as apoptos...

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Published in:Medicinal research reviews 2023-05, Vol.43 (3), p.683-712
Main Authors: Zhang, Jia‐Bao, Tong, Jie, Sun, Di‐Yang, Fu, Jiang‐Tao, Li, Dong‐Jie, Wang, Pei
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
cardio‐metabolic‐diseases
Ferroptosis
Humans
lipid peroxide
Lipid Peroxides
Metabolic Diseases - drug therapy
Metabolism
potential druggable molecules
therapeutic target
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Summary:Cardio‐metabolic‐diseases (cardio‐metabolic‐diseases) are leading causes of death and disability worldwide and impose a tremendous burden on whole society as well as individuals. As a new type of regulated cell death (RCD), ferroptosis is distinct from several classical types of RCDs such as apoptosis and necroptosis in cell morphology, biochemistry, and genetics. The main molecular mechanisms of ferroptosis involve iron metabolism dysregulation, mitochondrial malfunction, impaired antioxidant capacity, accumulation of lipid‐related peroxides and membrane disruption. Within the past few years, mounting evidence has shown that ferroptosis contributes to the pathophysiological process in cardio‐metabolic‐diseases. However, the exact roles and underlying molecular mechanisms have not been fully elucidated. This review comprehensively summarizes the mechanism of ferroptosis in the development and progression of cardio‐metabolic‐diseases, so as to provide new insights for cardio‐metabolic‐diseases pathophysiology. Moreover, we highlight potential druggable molecules in ferroptosis signaling pathway, and discuss recent advances in management strategies by targeting ferroptosis for prevention and treatment of cardio‐metabolic‐diseases.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21934