Loading…
The possible protective role of pimpinella anisum oil versus selenium on aspartame induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscopic study
Aspartame (ASP) is an artificial sweeter. Chronic use of ASP has a harmful effect on cerebellar cortex. Anisum oil and selenium (SE) are antioxidant substances. Therefore, the present study was performed to study the possible protective role of anisum oil versus selenium on aspartame-induced changes...
Saved in:
Published in: | Ultrastructural pathology 2022-11, Vol.46 (6), p.497-510 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c314t-6ff74cc59549ab894ba0bbd18d6daeefbc2a328522b46df694782c651e4c4af03 |
container_end_page | 510 |
container_issue | 6 |
container_start_page | 497 |
container_title | Ultrastructural pathology |
container_volume | 46 |
creator | Shrief, Amira I. Abdel-Hamid, Ahmed A.M Moustafa, Am El-Mohandes, E. |
description | Aspartame (ASP) is an artificial sweeter. Chronic use of ASP has a harmful effect on cerebellar cortex. Anisum oil and selenium (SE) are antioxidant substances. Therefore, the present study was performed to study the possible protective role of anisum oil versus selenium on aspartame-induced changes in rat cerebellar cortex. Rats were divided into four main groups. Group I (Control group). Group II received 250 mg/kg/day aspartame once daily for 2 months. Group III received 0.5 ml/kg/day anisum 2 h before aspartame administration. Group IV received 0.5 mg/kg/day selenium 2 h before aspartame administration. The administration of Asp for 2 months (group II) resulted in cerebellar histopathological changes in the form of deformed Purkinje and granule cells. Ultrastructurally, Purkinje cells had irregular nuclei, dilated cisternae of rough endoplasmic reticulum, dilated saccules of Golgi apparatus, mitochondria with destroyed cristae. In addition, granule cells appeared shrunken with irregular nuclei. Aspartame and anisum oil treated group (group III) showed partial improvement. Examination of ASP and SE treated group (group IV) showed that cerebellar cortex was nearly similar to control. In conclusion, Anisum oil and selenium could protect against ASP-induced cerebellar damage. The protective effect of selenium is better than anisum oil. |
doi_str_mv | 10.1080/01913123.2022.2136809 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2727637657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2727637657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c314t-6ff74cc59549ab894ba0bbd18d6daeefbc2a328522b46df694782c651e4c4af03</originalsourceid><addsrcrecordid>eNp9kcuO1DAQRSMEYpqBTwB5yYI0fiROworRiJc0EpthbTl2edrIj2A7A_1x_BsO3cOSlV1Xp-qWfZvmJcF7gkf8FpOJMELZnmJK95QwPuLpUbMjPSUtHvrxcbPbmHaDLppnOX_HGPcMj0-bC8bpwGjHd83v2wOgJeZsZ1cvKRZQxd4DSrHW0aDF-sUGcE4iGWxePYrWoXtIec0og4NgNy0gmReZivSAbNCrAo3UQYY7yLVGSRakIMG8DUpIxVTg1zt0sLlEF--sku4Nst6vIf7V1AH8JlZPjaqJKqlaVCnFrOJiFcpl1cfnzRMjXYYX5_Oy-fbxw-315_bm66cv11c3rWKkKy03ZuiU6qe-m-Q8Tt0s8TxrMmquJYCZFZWMjj2lc8e14VM3jFTxnkCnOmkwu2xen-bWD_qxQi7C26y2twSIaxZ0oANnA--HivYndFs1JzBiSdbLdBQEiy058ZCc2JIT5-Rq36uzxTp70P-6HqKqwPsTYIOJycufMTktijy6mEySQdks2P89_gDGka5c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2727637657</pqid></control><display><type>article</type><title>The possible protective role of pimpinella anisum oil versus selenium on aspartame induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscopic study</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Shrief, Amira I. ; Abdel-Hamid, Ahmed A.M ; Moustafa, Am ; El-Mohandes, E.</creator><creatorcontrib>Shrief, Amira I. ; Abdel-Hamid, Ahmed A.M ; Moustafa, Am ; El-Mohandes, E.</creatorcontrib><description>Aspartame (ASP) is an artificial sweeter. Chronic use of ASP has a harmful effect on cerebellar cortex. Anisum oil and selenium (SE) are antioxidant substances. Therefore, the present study was performed to study the possible protective role of anisum oil versus selenium on aspartame-induced changes in rat cerebellar cortex. Rats were divided into four main groups. Group I (Control group). Group II received 250 mg/kg/day aspartame once daily for 2 months. Group III received 0.5 ml/kg/day anisum 2 h before aspartame administration. Group IV received 0.5 mg/kg/day selenium 2 h before aspartame administration. The administration of Asp for 2 months (group II) resulted in cerebellar histopathological changes in the form of deformed Purkinje and granule cells. Ultrastructurally, Purkinje cells had irregular nuclei, dilated cisternae of rough endoplasmic reticulum, dilated saccules of Golgi apparatus, mitochondria with destroyed cristae. In addition, granule cells appeared shrunken with irregular nuclei. Aspartame and anisum oil treated group (group III) showed partial improvement. Examination of ASP and SE treated group (group IV) showed that cerebellar cortex was nearly similar to control. In conclusion, Anisum oil and selenium could protect against ASP-induced cerebellar damage. The protective effect of selenium is better than anisum oil.</description><identifier>ISSN: 0191-3123</identifier><identifier>EISSN: 1521-0758</identifier><identifier>DOI: 10.1080/01913123.2022.2136809</identifier><identifier>PMID: 36273246</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; anisum oil ; aspartame ; Aspartame - toxicity ; Cerebellar Cortex ; Electrons ; Pimpinella - chemistry ; Rats ; selenium ; Selenium - pharmacology ; ultrastructural changes</subject><ispartof>Ultrastructural pathology, 2022-11, Vol.46 (6), p.497-510</ispartof><rights>2022 Taylor & Francis Group, LLC 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c314t-6ff74cc59549ab894ba0bbd18d6daeefbc2a328522b46df694782c651e4c4af03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36273246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shrief, Amira I.</creatorcontrib><creatorcontrib>Abdel-Hamid, Ahmed A.M</creatorcontrib><creatorcontrib>Moustafa, Am</creatorcontrib><creatorcontrib>El-Mohandes, E.</creatorcontrib><title>The possible protective role of pimpinella anisum oil versus selenium on aspartame induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscopic study</title><title>Ultrastructural pathology</title><addtitle>Ultrastruct Pathol</addtitle><description>Aspartame (ASP) is an artificial sweeter. Chronic use of ASP has a harmful effect on cerebellar cortex. Anisum oil and selenium (SE) are antioxidant substances. Therefore, the present study was performed to study the possible protective role of anisum oil versus selenium on aspartame-induced changes in rat cerebellar cortex. Rats were divided into four main groups. Group I (Control group). Group II received 250 mg/kg/day aspartame once daily for 2 months. Group III received 0.5 ml/kg/day anisum 2 h before aspartame administration. Group IV received 0.5 mg/kg/day selenium 2 h before aspartame administration. The administration of Asp for 2 months (group II) resulted in cerebellar histopathological changes in the form of deformed Purkinje and granule cells. Ultrastructurally, Purkinje cells had irregular nuclei, dilated cisternae of rough endoplasmic reticulum, dilated saccules of Golgi apparatus, mitochondria with destroyed cristae. In addition, granule cells appeared shrunken with irregular nuclei. Aspartame and anisum oil treated group (group III) showed partial improvement. Examination of ASP and SE treated group (group IV) showed that cerebellar cortex was nearly similar to control. In conclusion, Anisum oil and selenium could protect against ASP-induced cerebellar damage. The protective effect of selenium is better than anisum oil.</description><subject>Animals</subject><subject>anisum oil</subject><subject>aspartame</subject><subject>Aspartame - toxicity</subject><subject>Cerebellar Cortex</subject><subject>Electrons</subject><subject>Pimpinella - chemistry</subject><subject>Rats</subject><subject>selenium</subject><subject>Selenium - pharmacology</subject><subject>ultrastructural changes</subject><issn>0191-3123</issn><issn>1521-0758</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kcuO1DAQRSMEYpqBTwB5yYI0fiROworRiJc0EpthbTl2edrIj2A7A_1x_BsO3cOSlV1Xp-qWfZvmJcF7gkf8FpOJMELZnmJK95QwPuLpUbMjPSUtHvrxcbPbmHaDLppnOX_HGPcMj0-bC8bpwGjHd83v2wOgJeZsZ1cvKRZQxd4DSrHW0aDF-sUGcE4iGWxePYrWoXtIec0og4NgNy0gmReZivSAbNCrAo3UQYY7yLVGSRakIMG8DUpIxVTg1zt0sLlEF--sku4Nst6vIf7V1AH8JlZPjaqJKqlaVCnFrOJiFcpl1cfnzRMjXYYX5_Oy-fbxw-315_bm66cv11c3rWKkKy03ZuiU6qe-m-Q8Tt0s8TxrMmquJYCZFZWMjj2lc8e14VM3jFTxnkCnOmkwu2xen-bWD_qxQi7C26y2twSIaxZ0oANnA--HivYndFs1JzBiSdbLdBQEiy058ZCc2JIT5-Rq36uzxTp70P-6HqKqwPsTYIOJycufMTktijy6mEySQdks2P89_gDGka5c</recordid><startdate>20221102</startdate><enddate>20221102</enddate><creator>Shrief, Amira I.</creator><creator>Abdel-Hamid, Ahmed A.M</creator><creator>Moustafa, Am</creator><creator>El-Mohandes, E.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20221102</creationdate><title>The possible protective role of pimpinella anisum oil versus selenium on aspartame induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscopic study</title><author>Shrief, Amira I. ; Abdel-Hamid, Ahmed A.M ; Moustafa, Am ; El-Mohandes, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-6ff74cc59549ab894ba0bbd18d6daeefbc2a328522b46df694782c651e4c4af03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>anisum oil</topic><topic>aspartame</topic><topic>Aspartame - toxicity</topic><topic>Cerebellar Cortex</topic><topic>Electrons</topic><topic>Pimpinella - chemistry</topic><topic>Rats</topic><topic>selenium</topic><topic>Selenium - pharmacology</topic><topic>ultrastructural changes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shrief, Amira I.</creatorcontrib><creatorcontrib>Abdel-Hamid, Ahmed A.M</creatorcontrib><creatorcontrib>Moustafa, Am</creatorcontrib><creatorcontrib>El-Mohandes, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrastructural pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shrief, Amira I.</au><au>Abdel-Hamid, Ahmed A.M</au><au>Moustafa, Am</au><au>El-Mohandes, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The possible protective role of pimpinella anisum oil versus selenium on aspartame induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscopic study</atitle><jtitle>Ultrastructural pathology</jtitle><addtitle>Ultrastruct Pathol</addtitle><date>2022-11-02</date><risdate>2022</risdate><volume>46</volume><issue>6</issue><spage>497</spage><epage>510</epage><pages>497-510</pages><issn>0191-3123</issn><eissn>1521-0758</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Aspartame (ASP) is an artificial sweeter. Chronic use of ASP has a harmful effect on cerebellar cortex. Anisum oil and selenium (SE) are antioxidant substances. Therefore, the present study was performed to study the possible protective role of anisum oil versus selenium on aspartame-induced changes in rat cerebellar cortex. Rats were divided into four main groups. Group I (Control group). Group II received 250 mg/kg/day aspartame once daily for 2 months. Group III received 0.5 ml/kg/day anisum 2 h before aspartame administration. Group IV received 0.5 mg/kg/day selenium 2 h before aspartame administration. The administration of Asp for 2 months (group II) resulted in cerebellar histopathological changes in the form of deformed Purkinje and granule cells. Ultrastructurally, Purkinje cells had irregular nuclei, dilated cisternae of rough endoplasmic reticulum, dilated saccules of Golgi apparatus, mitochondria with destroyed cristae. In addition, granule cells appeared shrunken with irregular nuclei. Aspartame and anisum oil treated group (group III) showed partial improvement. Examination of ASP and SE treated group (group IV) showed that cerebellar cortex was nearly similar to control. In conclusion, Anisum oil and selenium could protect against ASP-induced cerebellar damage. The protective effect of selenium is better than anisum oil.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>36273246</pmid><doi>10.1080/01913123.2022.2136809</doi><tpages>14</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0191-3123 |
ispartof | Ultrastructural pathology, 2022-11, Vol.46 (6), p.497-510 |
issn | 0191-3123 1521-0758 |
language | eng |
recordid | cdi_proquest_miscellaneous_2727637657 |
source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
subjects | Animals anisum oil aspartame Aspartame - toxicity Cerebellar Cortex Electrons Pimpinella - chemistry Rats selenium Selenium - pharmacology ultrastructural changes |
title | The possible protective role of pimpinella anisum oil versus selenium on aspartame induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscopic study |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T22%3A25%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20possible%20protective%20role%20of%20pimpinella%20anisum%20oil%20versus%20selenium%20on%20aspartame%20induced%20changes%20in%20rat%20cerebellar%20cortex:%20histological,%20immunohistochemical%20and%20electron%20microscopic%20study&rft.jtitle=Ultrastructural%20pathology&rft.au=Shrief,%20Amira%20I.&rft.date=2022-11-02&rft.volume=46&rft.issue=6&rft.spage=497&rft.epage=510&rft.pages=497-510&rft.issn=0191-3123&rft.eissn=1521-0758&rft_id=info:doi/10.1080/01913123.2022.2136809&rft_dat=%3Cproquest_cross%3E2727637657%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c314t-6ff74cc59549ab894ba0bbd18d6daeefbc2a328522b46df694782c651e4c4af03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2727637657&rft_id=info:pmid/36273246&rfr_iscdi=true |