Resting state network dynamic reconfiguration and neuropsychological functioning in temporal lobe epilepsy: An HD-EEG investigation

Temporal lobe epilepsy (TLE) is nowadays considered a network disorder impacting several cognitive domains. In this work we investigated dynamic network reconfiguration differences in patients with unilateral TLE compared to a healthy control group, focusing on two connectivity indices: flexibility...

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Published in:Cortex 2022-12, Vol.157, p.1-13
Main Authors: Duma, Gian Marco, Danieli, Alberto, Mattar, Marcelo G., Baggio, Martina, Vettorel, Airis, Bonanni, Paolo, Mento, Giovanni
Format: Article
Language:English
Subjects:
Brain
Brain Mapping - methods
Cognitive outcome
Dynamic functional connectivity
EEG source Reconstruction
Epilepsy, Temporal Lobe
Executive Function
Humans
Magnetic Resonance Imaging - methods
Network reconfiguration
Temporal lobe epilepsy
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container_title Cortex
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creator Duma, Gian Marco
Danieli, Alberto
Mattar, Marcelo G.
Baggio, Martina
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Mento, Giovanni
description Temporal lobe epilepsy (TLE) is nowadays considered a network disorder impacting several cognitive domains. In this work we investigated dynamic network reconfiguration differences in patients with unilateral TLE compared to a healthy control group, focusing on two connectivity indices: flexibility and integration. We apply these indices for the first time to high-density EEG source-based functional connectivity. We observed that patients with TLE exhibited significantly lower flexibility than healthy controls in the Control, Default Mode and Attentive Dorsal networks, expressed in the delta, theta and alpha bands. In addition, patients with TLE displayed greater integration values across the majority of the resting state networks, especially in the delta, theta and gamma bands. Relevantly, a higher integration index in the Control, Attentive Dorsal and Visual networks in the delta band was correlated with lower performance in visual attention and executive functions. Moreover, a greater integration index in the gamma band of the Control, Somatomotor and Temporoparietal networks was related to lower long-term memory performance. These results suggest that patients with TLE display dysregulated network reconfiguration, with lower flexibility in the brain areas related to cognitive control and attention, together with excessive inter-network communication (integration index). Finally, the correlation between network integration and the reduced cognitive performance suggests a potential mechanism underlying specific alterations in neuropsychological profile of patients with TLE.
doi_str_mv 10.1016/j.cortex.2022.08.010
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subjects Brain
Brain Mapping - methods
Cognitive outcome
Dynamic functional connectivity
EEG source Reconstruction
Epilepsy, Temporal Lobe
Executive Function
Humans
Magnetic Resonance Imaging - methods
Network reconfiguration
Temporal lobe epilepsy
title Resting state network dynamic reconfiguration and neuropsychological functioning in temporal lobe epilepsy: An HD-EEG investigation
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