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Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence
Objective To compare pre‐eclampsia risk factors identified by clinical practice guidelines (CPGs) with risk factors from hierarchical evidence review, to guide pre‐eclampsia prevention. Design Our search strategy provided hierarchical evidence of relationships between risk factors and pre‐eclampsia...
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| Published in: | BJOG : an international journal of obstetrics and gynaecology 2024-01, Vol.131 (1), p.46-62 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Elawad, Terteel Scott, Georgia Bone, Jeffrey N. Elwell, Helen Lopez, Cristina Escalona Filippi, Veronique Green, Marcus Khalil, Asma Kinshella, Mai‐Lei W. Mistry, Hiten D. Pickerill, Kelly Shanmugam, Reshma Singer, Joel Townsend, Rosemarie Tsigas, Eleni Z. Vidler, Marianne Volvert, Marie‐Laure Dadelszen, Peter Magee, Laura A. |
| description | Objective
To compare pre‐eclampsia risk factors identified by clinical practice guidelines (CPGs) with risk factors from hierarchical evidence review, to guide pre‐eclampsia prevention.
Design
Our search strategy provided hierarchical evidence of relationships between risk factors and pre‐eclampsia using Medline (Ovid), searched from January 2010 to January 2021.
Setting
Published studies and CPGs.
Population
Pregnant women.
Methods
We evaluated the strength of association and quality of evidence (GRADE). CPGs (n = 15) were taken from a previous systematic review.
Main outcome measure
Pre‐eclampsia.
Results
Of 78 pre‐eclampsia risk factors, 13 (16.5%) arise only during pregnancy. Strength of association was usually ‘probable’ (n = 40, 51.3%) and the quality of evidence was low (n = 35, 44.9%). The ‘major’ and ‘moderate’ risk factors proposed by 8/15 CPGs were not well aligned with the evidence; of the ten ‘major’ risk factors (alone warranting aspirin prophylaxis), associations with pre‐eclampsia were definite (n = 4), probable (n = 5) or possible (n = 1), based on moderate (n = 4), low (n = 5) or very low (n = 1) quality evidence. Obesity (‘moderate’ risk factor) was definitely associated with pre‐eclampsia (high‐quality evidence). The other ten ‘moderate’ risk factors had probable (n = 8), possible (n = 1) or no (n = 1) association with pre‐eclampsia, based on evidence of moderate (n = 1), low (n = 5) or very low (n = 4) quality. Three risk factors not identified by the CPGs had probable associations (high quality): being overweight; ‘prehypertension’ at booking; and blood pressure of 130–139/80–89 mmHg in early pregnancy.
Conclusions
Pre‐eclampsia risk factors in CPGs are poorly aligned with evidence, particularly for the strongest risk factor of obesity. There is a lack of distinction between risk factors identifiable in early pregnancy and those arising later. A refresh of the strategies advocated by CPGs is needed.
Linked article: This article is commented on by Stefan C. Kane et al., pp. 63 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17311. |
| doi_str_mv | 10.1111/1471-0528.17320 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2723160430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2896516184</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4120-1db67556e02e4d007610591e9fa064fd17cf9abe5395754c24f20d8317b14c1c3</originalsourceid><addsrcrecordid>eNqFkLtOHTEQhi0UxL2miyyloVmY8WUvdOEohERISIi0sXy8s8Gwt9hnQXR5hDwjT4IPByhocDPWzDe_Rh9j-wiHmN4RqgIz0KI8xEIKWGNbb51Pz3_IQIpyk23HeAOAuQC5wTZlqpUGtcV-X_p4yxvrFkOIvBkCHwM9_vtPrrXdGL3lvueu9b13tk2zBHpH_M_ka0pdisd8NnSjDT4OPb_3i2u-uCZOd2neO9pl641tI-291B326_Tb1ewsO7_4_mP29TxzCgVkWM_zQuucQJCqAYocQVdIVWMhV02NhWsqOyctK11o5YRqBNSlxGKOyqGTO-xglTuG4e9EcWE6Hx21re1pmKIRhZCYg5KQ0C_v0JthCn26zoiyyjXmWKpEHa0oF4YYAzVmDL6z4cEgmKV6sxRtlqLNs_q08fkld5p3VL_xr64ToFfAvW_p4aM8c_LzYhX8BFq4jRE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2896516184</pqid></control><display><type>article</type><title>Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Elawad, Terteel ; Scott, Georgia ; Bone, Jeffrey N. ; Elwell, Helen ; Lopez, Cristina Escalona ; Filippi, Veronique ; Green, Marcus ; Khalil, Asma ; Kinshella, Mai‐Lei W. ; Mistry, Hiten D. ; Pickerill, Kelly ; Shanmugam, Reshma ; Singer, Joel ; Townsend, Rosemarie ; Tsigas, Eleni Z. ; Vidler, Marianne ; Volvert, Marie‐Laure ; Dadelszen, Peter ; Magee, Laura A.</creator><creatorcontrib>Elawad, Terteel ; Scott, Georgia ; Bone, Jeffrey N. ; Elwell, Helen ; Lopez, Cristina Escalona ; Filippi, Veronique ; Green, Marcus ; Khalil, Asma ; Kinshella, Mai‐Lei W. ; Mistry, Hiten D. ; Pickerill, Kelly ; Shanmugam, Reshma ; Singer, Joel ; Townsend, Rosemarie ; Tsigas, Eleni Z. ; Vidler, Marianne ; Volvert, Marie‐Laure ; Dadelszen, Peter ; Magee, Laura A. ; PRECISE Network ; the PRECISE Network</creatorcontrib><description>Objective
To compare pre‐eclampsia risk factors identified by clinical practice guidelines (CPGs) with risk factors from hierarchical evidence review, to guide pre‐eclampsia prevention.
Design
Our search strategy provided hierarchical evidence of relationships between risk factors and pre‐eclampsia using Medline (Ovid), searched from January 2010 to January 2021.
Setting
Published studies and CPGs.
Population
Pregnant women.
Methods
We evaluated the strength of association and quality of evidence (GRADE). CPGs (n = 15) were taken from a previous systematic review.
Main outcome measure
Pre‐eclampsia.
Results
Of 78 pre‐eclampsia risk factors, 13 (16.5%) arise only during pregnancy. Strength of association was usually ‘probable’ (n = 40, 51.3%) and the quality of evidence was low (n = 35, 44.9%). The ‘major’ and ‘moderate’ risk factors proposed by 8/15 CPGs were not well aligned with the evidence; of the ten ‘major’ risk factors (alone warranting aspirin prophylaxis), associations with pre‐eclampsia were definite (n = 4), probable (n = 5) or possible (n = 1), based on moderate (n = 4), low (n = 5) or very low (n = 1) quality evidence. Obesity (‘moderate’ risk factor) was definitely associated with pre‐eclampsia (high‐quality evidence). The other ten ‘moderate’ risk factors had probable (n = 8), possible (n = 1) or no (n = 1) association with pre‐eclampsia, based on evidence of moderate (n = 1), low (n = 5) or very low (n = 4) quality. Three risk factors not identified by the CPGs had probable associations (high quality): being overweight; ‘prehypertension’ at booking; and blood pressure of 130–139/80–89 mmHg in early pregnancy.
Conclusions
Pre‐eclampsia risk factors in CPGs are poorly aligned with evidence, particularly for the strongest risk factor of obesity. There is a lack of distinction between risk factors identifiable in early pregnancy and those arising later. A refresh of the strategies advocated by CPGs is needed.
Linked article: This article is commented on by Stefan C. Kane et al., pp. 63 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17311.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.17320</identifier><identifier>PMID: 36209504</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aspirin ; Blood Pressure ; Clinical medicine ; Clinical practice guidelines ; determinants ; Eclampsia ; Female ; Humans ; Obesity ; outcomes ; Population studies ; Pre-Eclampsia - epidemiology ; Pre-Eclampsia - etiology ; Pre-Eclampsia - prevention & control ; Pregnancy ; prevention ; pre‐eclampsia ; Prophylaxis ; Risk Factors</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2024-01, Vol.131 (1), p.46-62</ispartof><rights>2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4120-1db67556e02e4d007610591e9fa064fd17cf9abe5395754c24f20d8317b14c1c3</citedby><cites>FETCH-LOGICAL-c4120-1db67556e02e4d007610591e9fa064fd17cf9abe5395754c24f20d8317b14c1c3</cites><orcidid>0000-0003-2802-7670 ; 0000-0001-5846-3014 ; 0000-0003-4136-3070 ; 0000-0002-1355-610X ; 0000-0002-4561-8256 ; 0000-0003-2564-7348 ; 0000-0002-0527-4145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,783,787,27936,27937</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36209504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elawad, Terteel</creatorcontrib><creatorcontrib>Scott, Georgia</creatorcontrib><creatorcontrib>Bone, Jeffrey N.</creatorcontrib><creatorcontrib>Elwell, Helen</creatorcontrib><creatorcontrib>Lopez, Cristina Escalona</creatorcontrib><creatorcontrib>Filippi, Veronique</creatorcontrib><creatorcontrib>Green, Marcus</creatorcontrib><creatorcontrib>Khalil, Asma</creatorcontrib><creatorcontrib>Kinshella, Mai‐Lei W.</creatorcontrib><creatorcontrib>Mistry, Hiten D.</creatorcontrib><creatorcontrib>Pickerill, Kelly</creatorcontrib><creatorcontrib>Shanmugam, Reshma</creatorcontrib><creatorcontrib>Singer, Joel</creatorcontrib><creatorcontrib>Townsend, Rosemarie</creatorcontrib><creatorcontrib>Tsigas, Eleni Z.</creatorcontrib><creatorcontrib>Vidler, Marianne</creatorcontrib><creatorcontrib>Volvert, Marie‐Laure</creatorcontrib><creatorcontrib>Dadelszen, Peter</creatorcontrib><creatorcontrib>Magee, Laura A.</creatorcontrib><creatorcontrib>PRECISE Network</creatorcontrib><creatorcontrib>the PRECISE Network</creatorcontrib><title>Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective
To compare pre‐eclampsia risk factors identified by clinical practice guidelines (CPGs) with risk factors from hierarchical evidence review, to guide pre‐eclampsia prevention.
Design
Our search strategy provided hierarchical evidence of relationships between risk factors and pre‐eclampsia using Medline (Ovid), searched from January 2010 to January 2021.
Setting
Published studies and CPGs.
Population
Pregnant women.
Methods
We evaluated the strength of association and quality of evidence (GRADE). CPGs (n = 15) were taken from a previous systematic review.
Main outcome measure
Pre‐eclampsia.
Results
Of 78 pre‐eclampsia risk factors, 13 (16.5%) arise only during pregnancy. Strength of association was usually ‘probable’ (n = 40, 51.3%) and the quality of evidence was low (n = 35, 44.9%). The ‘major’ and ‘moderate’ risk factors proposed by 8/15 CPGs were not well aligned with the evidence; of the ten ‘major’ risk factors (alone warranting aspirin prophylaxis), associations with pre‐eclampsia were definite (n = 4), probable (n = 5) or possible (n = 1), based on moderate (n = 4), low (n = 5) or very low (n = 1) quality evidence. Obesity (‘moderate’ risk factor) was definitely associated with pre‐eclampsia (high‐quality evidence). The other ten ‘moderate’ risk factors had probable (n = 8), possible (n = 1) or no (n = 1) association with pre‐eclampsia, based on evidence of moderate (n = 1), low (n = 5) or very low (n = 4) quality. Three risk factors not identified by the CPGs had probable associations (high quality): being overweight; ‘prehypertension’ at booking; and blood pressure of 130–139/80–89 mmHg in early pregnancy.
Conclusions
Pre‐eclampsia risk factors in CPGs are poorly aligned with evidence, particularly for the strongest risk factor of obesity. There is a lack of distinction between risk factors identifiable in early pregnancy and those arising later. A refresh of the strategies advocated by CPGs is needed.
Linked article: This article is commented on by Stefan C. Kane et al., pp. 63 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17311.</description><subject>Aspirin</subject><subject>Blood Pressure</subject><subject>Clinical medicine</subject><subject>Clinical practice guidelines</subject><subject>determinants</subject><subject>Eclampsia</subject><subject>Female</subject><subject>Humans</subject><subject>Obesity</subject><subject>outcomes</subject><subject>Population studies</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Pre-Eclampsia - etiology</subject><subject>Pre-Eclampsia - prevention & control</subject><subject>Pregnancy</subject><subject>prevention</subject><subject>pre‐eclampsia</subject><subject>Prophylaxis</subject><subject>Risk Factors</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkLtOHTEQhi0UxL2miyyloVmY8WUvdOEohERISIi0sXy8s8Gwt9hnQXR5hDwjT4IPByhocDPWzDe_Rh9j-wiHmN4RqgIz0KI8xEIKWGNbb51Pz3_IQIpyk23HeAOAuQC5wTZlqpUGtcV-X_p4yxvrFkOIvBkCHwM9_vtPrrXdGL3lvueu9b13tk2zBHpH_M_ka0pdisd8NnSjDT4OPb_3i2u-uCZOd2neO9pl641tI-291B326_Tb1ewsO7_4_mP29TxzCgVkWM_zQuucQJCqAYocQVdIVWMhV02NhWsqOyctK11o5YRqBNSlxGKOyqGTO-xglTuG4e9EcWE6Hx21re1pmKIRhZCYg5KQ0C_v0JthCn26zoiyyjXmWKpEHa0oF4YYAzVmDL6z4cEgmKV6sxRtlqLNs_q08fkld5p3VL_xr64ToFfAvW_p4aM8c_LzYhX8BFq4jRE</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Elawad, Terteel</creator><creator>Scott, Georgia</creator><creator>Bone, Jeffrey N.</creator><creator>Elwell, Helen</creator><creator>Lopez, Cristina Escalona</creator><creator>Filippi, Veronique</creator><creator>Green, Marcus</creator><creator>Khalil, Asma</creator><creator>Kinshella, Mai‐Lei W.</creator><creator>Mistry, Hiten D.</creator><creator>Pickerill, Kelly</creator><creator>Shanmugam, Reshma</creator><creator>Singer, Joel</creator><creator>Townsend, Rosemarie</creator><creator>Tsigas, Eleni Z.</creator><creator>Vidler, Marianne</creator><creator>Volvert, Marie‐Laure</creator><creator>Dadelszen, Peter</creator><creator>Magee, Laura A.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2802-7670</orcidid><orcidid>https://orcid.org/0000-0001-5846-3014</orcidid><orcidid>https://orcid.org/0000-0003-4136-3070</orcidid><orcidid>https://orcid.org/0000-0002-1355-610X</orcidid><orcidid>https://orcid.org/0000-0002-4561-8256</orcidid><orcidid>https://orcid.org/0000-0003-2564-7348</orcidid><orcidid>https://orcid.org/0000-0002-0527-4145</orcidid></search><sort><creationdate>202401</creationdate><title>Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence</title><author>Elawad, Terteel ; Scott, Georgia ; Bone, Jeffrey N. ; Elwell, Helen ; Lopez, Cristina Escalona ; Filippi, Veronique ; Green, Marcus ; Khalil, Asma ; Kinshella, Mai‐Lei W. ; Mistry, Hiten D. ; Pickerill, Kelly ; Shanmugam, Reshma ; Singer, Joel ; Townsend, Rosemarie ; Tsigas, Eleni Z. ; Vidler, Marianne ; Volvert, Marie‐Laure ; Dadelszen, Peter ; Magee, Laura A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4120-1db67556e02e4d007610591e9fa064fd17cf9abe5395754c24f20d8317b14c1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aspirin</topic><topic>Blood Pressure</topic><topic>Clinical medicine</topic><topic>Clinical practice guidelines</topic><topic>determinants</topic><topic>Eclampsia</topic><topic>Female</topic><topic>Humans</topic><topic>Obesity</topic><topic>outcomes</topic><topic>Population studies</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>Pre-Eclampsia - etiology</topic><topic>Pre-Eclampsia - prevention & control</topic><topic>Pregnancy</topic><topic>prevention</topic><topic>pre‐eclampsia</topic><topic>Prophylaxis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elawad, Terteel</creatorcontrib><creatorcontrib>Scott, Georgia</creatorcontrib><creatorcontrib>Bone, Jeffrey N.</creatorcontrib><creatorcontrib>Elwell, Helen</creatorcontrib><creatorcontrib>Lopez, Cristina Escalona</creatorcontrib><creatorcontrib>Filippi, Veronique</creatorcontrib><creatorcontrib>Green, Marcus</creatorcontrib><creatorcontrib>Khalil, Asma</creatorcontrib><creatorcontrib>Kinshella, Mai‐Lei W.</creatorcontrib><creatorcontrib>Mistry, Hiten D.</creatorcontrib><creatorcontrib>Pickerill, Kelly</creatorcontrib><creatorcontrib>Shanmugam, Reshma</creatorcontrib><creatorcontrib>Singer, Joel</creatorcontrib><creatorcontrib>Townsend, Rosemarie</creatorcontrib><creatorcontrib>Tsigas, Eleni Z.</creatorcontrib><creatorcontrib>Vidler, Marianne</creatorcontrib><creatorcontrib>Volvert, Marie‐Laure</creatorcontrib><creatorcontrib>Dadelszen, Peter</creatorcontrib><creatorcontrib>Magee, Laura A.</creatorcontrib><creatorcontrib>PRECISE Network</creatorcontrib><creatorcontrib>the PRECISE Network</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elawad, Terteel</au><au>Scott, Georgia</au><au>Bone, Jeffrey N.</au><au>Elwell, Helen</au><au>Lopez, Cristina Escalona</au><au>Filippi, Veronique</au><au>Green, Marcus</au><au>Khalil, Asma</au><au>Kinshella, Mai‐Lei W.</au><au>Mistry, Hiten D.</au><au>Pickerill, Kelly</au><au>Shanmugam, Reshma</au><au>Singer, Joel</au><au>Townsend, Rosemarie</au><au>Tsigas, Eleni Z.</au><au>Vidler, Marianne</au><au>Volvert, Marie‐Laure</au><au>Dadelszen, Peter</au><au>Magee, Laura A.</au><aucorp>PRECISE Network</aucorp><aucorp>the PRECISE Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2024-01</date><risdate>2024</risdate><volume>131</volume><issue>1</issue><spage>46</spage><epage>62</epage><pages>46-62</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Objective
To compare pre‐eclampsia risk factors identified by clinical practice guidelines (CPGs) with risk factors from hierarchical evidence review, to guide pre‐eclampsia prevention.
Design
Our search strategy provided hierarchical evidence of relationships between risk factors and pre‐eclampsia using Medline (Ovid), searched from January 2010 to January 2021.
Setting
Published studies and CPGs.
Population
Pregnant women.
Methods
We evaluated the strength of association and quality of evidence (GRADE). CPGs (n = 15) were taken from a previous systematic review.
Main outcome measure
Pre‐eclampsia.
Results
Of 78 pre‐eclampsia risk factors, 13 (16.5%) arise only during pregnancy. Strength of association was usually ‘probable’ (n = 40, 51.3%) and the quality of evidence was low (n = 35, 44.9%). The ‘major’ and ‘moderate’ risk factors proposed by 8/15 CPGs were not well aligned with the evidence; of the ten ‘major’ risk factors (alone warranting aspirin prophylaxis), associations with pre‐eclampsia were definite (n = 4), probable (n = 5) or possible (n = 1), based on moderate (n = 4), low (n = 5) or very low (n = 1) quality evidence. Obesity (‘moderate’ risk factor) was definitely associated with pre‐eclampsia (high‐quality evidence). The other ten ‘moderate’ risk factors had probable (n = 8), possible (n = 1) or no (n = 1) association with pre‐eclampsia, based on evidence of moderate (n = 1), low (n = 5) or very low (n = 4) quality. Three risk factors not identified by the CPGs had probable associations (high quality): being overweight; ‘prehypertension’ at booking; and blood pressure of 130–139/80–89 mmHg in early pregnancy.
Conclusions
Pre‐eclampsia risk factors in CPGs are poorly aligned with evidence, particularly for the strongest risk factor of obesity. There is a lack of distinction between risk factors identifiable in early pregnancy and those arising later. A refresh of the strategies advocated by CPGs is needed.
Linked article: This article is commented on by Stefan C. Kane et al., pp. 63 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17311.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36209504</pmid><doi>10.1111/1471-0528.17320</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-2802-7670</orcidid><orcidid>https://orcid.org/0000-0001-5846-3014</orcidid><orcidid>https://orcid.org/0000-0003-4136-3070</orcidid><orcidid>https://orcid.org/0000-0002-1355-610X</orcidid><orcidid>https://orcid.org/0000-0002-4561-8256</orcidid><orcidid>https://orcid.org/0000-0003-2564-7348</orcidid><orcidid>https://orcid.org/0000-0002-0527-4145</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2024-01, Vol.131 (1), p.46-62 |
| issn | 1470-0328 1471-0528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2723160430 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Aspirin Blood Pressure Clinical medicine Clinical practice guidelines determinants Eclampsia Female Humans Obesity outcomes Population studies Pre-Eclampsia - epidemiology Pre-Eclampsia - etiology Pre-Eclampsia - prevention & control Pregnancy prevention pre‐eclampsia Prophylaxis Risk Factors |
| title | Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence |
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