Loading…
A new look at cognitive functioning in pediatric MS
Objective: Cognitive involvement in pediatric multiple sclerosis (MS) relative to adult MS is less defined. This study advances our understanding by measuring cognitive performances in pediatric MS, adult MS, and pediatric healthy controls. Methods: Consecutive relapsing pediatric MS participants fr...
Saved in:
| Published in: | Multiple sclerosis 2023-01, Vol.29 (1), p.140-149 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c368t-ea1195b3d41f2fc083fd647da981abef543a2cb1ae89425e69b21be7aa4ec1ff3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c368t-ea1195b3d41f2fc083fd647da981abef543a2cb1ae89425e69b21be7aa4ec1ff3 |
| container_end_page | 149 |
| container_issue | 1 |
| container_start_page | 140 |
| container_title | Multiple sclerosis |
| container_volume | 29 |
| creator | Krupp, Lauren B Waubant, Emmanuelle Waltz, Michael Casper, T Charles Belman, Anita Wheeler, Yolanda Ness, Jayne Graves, Jennifer Gorman, Mark Benson, Leslie Mar, Soe Goyal, Manu Schreiner, Teri Weinstock-Guttman, Bianca Rodriguez, Moses Tillema, Jan-Mendelt Lotze, Timothy Aaen, Greg Rensel, Mary Rose, John Chitinis, Tanuja George, Allan Charvet, Leigh E |
| description | Objective:
Cognitive involvement in pediatric multiple sclerosis (MS) relative to adult MS is less defined. This study advances our understanding by measuring cognitive performances in pediatric MS, adult MS, and pediatric healthy controls.
Methods:
Consecutive relapsing pediatric MS participants from the United States Network of Pediatric MS Centers were compared with pediatric healthy controls and adults with relapsing MS. Participants were compared on two screening batteries: the Brief International Cognitive Assessment for MS and the Cogstate Brief Battery. Results were transformed to age-normative z scores.
Results:
The pediatric groups (MS vs. Healthy Controls) did not differ on either battery’s composite mean score or individual test scores (ps > 0.32), nor in the proportions impaired on either battery, Brief International Cognitive Assessment for MS (26% vs. 24%, p = 0.83); Cogstate Brief Battery (26% vs. 32%, p = 0.41). The pediatric versus adult MS group even after controlling for differences in disease duration performed better on the Brief International Cognition Assessment for MS composite (p = 0.03), Symbol Digit Modalities Test (p = 0.02), Rey Auditory Verbal Learning Test (p = 0.01), and Cogstate choice reaction time (p |
| doi_str_mv | 10.1177/13524585221123978 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2720932307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_13524585221123978</sage_id><sourcerecordid>2720932307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-ea1195b3d41f2fc083fd647da981abef543a2cb1ae89425e69b21be7aa4ec1ff3</originalsourceid><addsrcrecordid>eNp10E9LwzAYBvAgipvTD-BFCl68dOZN2qY5juE_mHhQzyVN34zMLZlNq_jtzdhUUDwlkN_75OUh5BToGECIS-A5y_IyZwyAcSnKPTKETIiUSkH34z2-pxswIEchLCilQvD8kAx4AaUUAEPCJ4nD92Tp_UuiukT7ubOdfcPE9E531jvr5ol1yRobq7rW6uT-8ZgcGLUMeLI7R-T5-uppepvOHm7uppNZqnlRdikqAJnXvMnAMKNpyU1TZKJRsgRVo8kzrpiuQWEpM5ZjIWsGNQqlMtRgDB-Ri23uuvWvPYauWtmgcblUDn0fKiYYlZxxKiI9_0UXvm9d3C4qAZxKABoVbJVufQgtmmrd2pVqPyqg1abR6k-jceZsl9zXK2y-J74qjGC8BUHN8efb_xM_AUcCe_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2771309110</pqid></control><display><type>article</type><title>A new look at cognitive functioning in pediatric MS</title><source>SAGE</source><creator>Krupp, Lauren B ; Waubant, Emmanuelle ; Waltz, Michael ; Casper, T Charles ; Belman, Anita ; Wheeler, Yolanda ; Ness, Jayne ; Graves, Jennifer ; Gorman, Mark ; Benson, Leslie ; Mar, Soe ; Goyal, Manu ; Schreiner, Teri ; Weinstock-Guttman, Bianca ; Rodriguez, Moses ; Tillema, Jan-Mendelt ; Lotze, Timothy ; Aaen, Greg ; Rensel, Mary ; Rose, John ; Chitinis, Tanuja ; George, Allan ; Charvet, Leigh E</creator><creatorcontrib>Krupp, Lauren B ; Waubant, Emmanuelle ; Waltz, Michael ; Casper, T Charles ; Belman, Anita ; Wheeler, Yolanda ; Ness, Jayne ; Graves, Jennifer ; Gorman, Mark ; Benson, Leslie ; Mar, Soe ; Goyal, Manu ; Schreiner, Teri ; Weinstock-Guttman, Bianca ; Rodriguez, Moses ; Tillema, Jan-Mendelt ; Lotze, Timothy ; Aaen, Greg ; Rensel, Mary ; Rose, John ; Chitinis, Tanuja ; George, Allan ; Charvet, Leigh E ; US Network of Pediatric MS Centers ; and the US Network of Pediatric MS Centers</creatorcontrib><description>Objective:
Cognitive involvement in pediatric multiple sclerosis (MS) relative to adult MS is less defined. This study advances our understanding by measuring cognitive performances in pediatric MS, adult MS, and pediatric healthy controls.
Methods:
Consecutive relapsing pediatric MS participants from the United States Network of Pediatric MS Centers were compared with pediatric healthy controls and adults with relapsing MS. Participants were compared on two screening batteries: the Brief International Cognitive Assessment for MS and the Cogstate Brief Battery. Results were transformed to age-normative z scores.
Results:
The pediatric groups (MS vs. Healthy Controls) did not differ on either battery’s composite mean score or individual test scores (ps > 0.32), nor in the proportions impaired on either battery, Brief International Cognitive Assessment for MS (26% vs. 24%, p = 0.83); Cogstate Brief Battery (26% vs. 32%, p = 0.41). The pediatric versus adult MS group even after controlling for differences in disease duration performed better on the Brief International Cognition Assessment for MS composite (p = 0.03), Symbol Digit Modalities Test (p = 0.02), Rey Auditory Verbal Learning Test (p = 0.01), and Cogstate choice reaction time (p < 0.001).
Conclusion:
Pediatric MS patients do not differ from healthy pediatric controls on cognitive screens but perform better than adults with MS.</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/13524585221123978</identifier><identifier>PMID: 36189711</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Adults ; Auditory discrimination learning ; Child ; Cognition ; Cognition Disorders - psychology ; Cognitive ability ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - etiology ; Humans ; Memory and Learning Tests ; Multiple sclerosis ; Multiple Sclerosis - diagnosis ; Neuropsychological Tests ; Pediatrics</subject><ispartof>Multiple sclerosis, 2023-01, Vol.29 (1), p.140-149</ispartof><rights>The Author(s), 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-ea1195b3d41f2fc083fd647da981abef543a2cb1ae89425e69b21be7aa4ec1ff3</citedby><cites>FETCH-LOGICAL-c368t-ea1195b3d41f2fc083fd647da981abef543a2cb1ae89425e69b21be7aa4ec1ff3</cites><orcidid>0000-0001-9613-8394 ; 0000-0001-7003-807X ; 0000-0001-6732-151X ; 0000-0003-4429-9713 ; 0000-0002-9897-4422</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36189711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krupp, Lauren B</creatorcontrib><creatorcontrib>Waubant, Emmanuelle</creatorcontrib><creatorcontrib>Waltz, Michael</creatorcontrib><creatorcontrib>Casper, T Charles</creatorcontrib><creatorcontrib>Belman, Anita</creatorcontrib><creatorcontrib>Wheeler, Yolanda</creatorcontrib><creatorcontrib>Ness, Jayne</creatorcontrib><creatorcontrib>Graves, Jennifer</creatorcontrib><creatorcontrib>Gorman, Mark</creatorcontrib><creatorcontrib>Benson, Leslie</creatorcontrib><creatorcontrib>Mar, Soe</creatorcontrib><creatorcontrib>Goyal, Manu</creatorcontrib><creatorcontrib>Schreiner, Teri</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><creatorcontrib>Rodriguez, Moses</creatorcontrib><creatorcontrib>Tillema, Jan-Mendelt</creatorcontrib><creatorcontrib>Lotze, Timothy</creatorcontrib><creatorcontrib>Aaen, Greg</creatorcontrib><creatorcontrib>Rensel, Mary</creatorcontrib><creatorcontrib>Rose, John</creatorcontrib><creatorcontrib>Chitinis, Tanuja</creatorcontrib><creatorcontrib>George, Allan</creatorcontrib><creatorcontrib>Charvet, Leigh E</creatorcontrib><creatorcontrib>US Network of Pediatric MS Centers</creatorcontrib><creatorcontrib>and the US Network of Pediatric MS Centers</creatorcontrib><title>A new look at cognitive functioning in pediatric MS</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Objective:
Cognitive involvement in pediatric multiple sclerosis (MS) relative to adult MS is less defined. This study advances our understanding by measuring cognitive performances in pediatric MS, adult MS, and pediatric healthy controls.
Methods:
Consecutive relapsing pediatric MS participants from the United States Network of Pediatric MS Centers were compared with pediatric healthy controls and adults with relapsing MS. Participants were compared on two screening batteries: the Brief International Cognitive Assessment for MS and the Cogstate Brief Battery. Results were transformed to age-normative z scores.
Results:
The pediatric groups (MS vs. Healthy Controls) did not differ on either battery’s composite mean score or individual test scores (ps > 0.32), nor in the proportions impaired on either battery, Brief International Cognitive Assessment for MS (26% vs. 24%, p = 0.83); Cogstate Brief Battery (26% vs. 32%, p = 0.41). The pediatric versus adult MS group even after controlling for differences in disease duration performed better on the Brief International Cognition Assessment for MS composite (p = 0.03), Symbol Digit Modalities Test (p = 0.02), Rey Auditory Verbal Learning Test (p = 0.01), and Cogstate choice reaction time (p < 0.001).
Conclusion:
Pediatric MS patients do not differ from healthy pediatric controls on cognitive screens but perform better than adults with MS.</description><subject>Adult</subject><subject>Adults</subject><subject>Auditory discrimination learning</subject><subject>Child</subject><subject>Cognition</subject><subject>Cognition Disorders - psychology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Humans</subject><subject>Memory and Learning Tests</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Neuropsychological Tests</subject><subject>Pediatrics</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp10E9LwzAYBvAgipvTD-BFCl68dOZN2qY5juE_mHhQzyVN34zMLZlNq_jtzdhUUDwlkN_75OUh5BToGECIS-A5y_IyZwyAcSnKPTKETIiUSkH34z2-pxswIEchLCilQvD8kAx4AaUUAEPCJ4nD92Tp_UuiukT7ubOdfcPE9E531jvr5ol1yRobq7rW6uT-8ZgcGLUMeLI7R-T5-uppepvOHm7uppNZqnlRdikqAJnXvMnAMKNpyU1TZKJRsgRVo8kzrpiuQWEpM5ZjIWsGNQqlMtRgDB-Ri23uuvWvPYauWtmgcblUDn0fKiYYlZxxKiI9_0UXvm9d3C4qAZxKABoVbJVufQgtmmrd2pVqPyqg1abR6k-jceZsl9zXK2y-J74qjGC8BUHN8efb_xM_AUcCe_Q</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Krupp, Lauren B</creator><creator>Waubant, Emmanuelle</creator><creator>Waltz, Michael</creator><creator>Casper, T Charles</creator><creator>Belman, Anita</creator><creator>Wheeler, Yolanda</creator><creator>Ness, Jayne</creator><creator>Graves, Jennifer</creator><creator>Gorman, Mark</creator><creator>Benson, Leslie</creator><creator>Mar, Soe</creator><creator>Goyal, Manu</creator><creator>Schreiner, Teri</creator><creator>Weinstock-Guttman, Bianca</creator><creator>Rodriguez, Moses</creator><creator>Tillema, Jan-Mendelt</creator><creator>Lotze, Timothy</creator><creator>Aaen, Greg</creator><creator>Rensel, Mary</creator><creator>Rose, John</creator><creator>Chitinis, Tanuja</creator><creator>George, Allan</creator><creator>Charvet, Leigh E</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9613-8394</orcidid><orcidid>https://orcid.org/0000-0001-7003-807X</orcidid><orcidid>https://orcid.org/0000-0001-6732-151X</orcidid><orcidid>https://orcid.org/0000-0003-4429-9713</orcidid><orcidid>https://orcid.org/0000-0002-9897-4422</orcidid></search><sort><creationdate>202301</creationdate><title>A new look at cognitive functioning in pediatric MS</title><author>Krupp, Lauren B ; Waubant, Emmanuelle ; Waltz, Michael ; Casper, T Charles ; Belman, Anita ; Wheeler, Yolanda ; Ness, Jayne ; Graves, Jennifer ; Gorman, Mark ; Benson, Leslie ; Mar, Soe ; Goyal, Manu ; Schreiner, Teri ; Weinstock-Guttman, Bianca ; Rodriguez, Moses ; Tillema, Jan-Mendelt ; Lotze, Timothy ; Aaen, Greg ; Rensel, Mary ; Rose, John ; Chitinis, Tanuja ; George, Allan ; Charvet, Leigh E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-ea1195b3d41f2fc083fd647da981abef543a2cb1ae89425e69b21be7aa4ec1ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Auditory discrimination learning</topic><topic>Child</topic><topic>Cognition</topic><topic>Cognition Disorders - psychology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Humans</topic><topic>Memory and Learning Tests</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Neuropsychological Tests</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krupp, Lauren B</creatorcontrib><creatorcontrib>Waubant, Emmanuelle</creatorcontrib><creatorcontrib>Waltz, Michael</creatorcontrib><creatorcontrib>Casper, T Charles</creatorcontrib><creatorcontrib>Belman, Anita</creatorcontrib><creatorcontrib>Wheeler, Yolanda</creatorcontrib><creatorcontrib>Ness, Jayne</creatorcontrib><creatorcontrib>Graves, Jennifer</creatorcontrib><creatorcontrib>Gorman, Mark</creatorcontrib><creatorcontrib>Benson, Leslie</creatorcontrib><creatorcontrib>Mar, Soe</creatorcontrib><creatorcontrib>Goyal, Manu</creatorcontrib><creatorcontrib>Schreiner, Teri</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><creatorcontrib>Rodriguez, Moses</creatorcontrib><creatorcontrib>Tillema, Jan-Mendelt</creatorcontrib><creatorcontrib>Lotze, Timothy</creatorcontrib><creatorcontrib>Aaen, Greg</creatorcontrib><creatorcontrib>Rensel, Mary</creatorcontrib><creatorcontrib>Rose, John</creatorcontrib><creatorcontrib>Chitinis, Tanuja</creatorcontrib><creatorcontrib>George, Allan</creatorcontrib><creatorcontrib>Charvet, Leigh E</creatorcontrib><creatorcontrib>US Network of Pediatric MS Centers</creatorcontrib><creatorcontrib>and the US Network of Pediatric MS Centers</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krupp, Lauren B</au><au>Waubant, Emmanuelle</au><au>Waltz, Michael</au><au>Casper, T Charles</au><au>Belman, Anita</au><au>Wheeler, Yolanda</au><au>Ness, Jayne</au><au>Graves, Jennifer</au><au>Gorman, Mark</au><au>Benson, Leslie</au><au>Mar, Soe</au><au>Goyal, Manu</au><au>Schreiner, Teri</au><au>Weinstock-Guttman, Bianca</au><au>Rodriguez, Moses</au><au>Tillema, Jan-Mendelt</au><au>Lotze, Timothy</au><au>Aaen, Greg</au><au>Rensel, Mary</au><au>Rose, John</au><au>Chitinis, Tanuja</au><au>George, Allan</au><au>Charvet, Leigh E</au><aucorp>US Network of Pediatric MS Centers</aucorp><aucorp>and the US Network of Pediatric MS Centers</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new look at cognitive functioning in pediatric MS</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2023-01</date><risdate>2023</risdate><volume>29</volume><issue>1</issue><spage>140</spage><epage>149</epage><pages>140-149</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective:
Cognitive involvement in pediatric multiple sclerosis (MS) relative to adult MS is less defined. This study advances our understanding by measuring cognitive performances in pediatric MS, adult MS, and pediatric healthy controls.
Methods:
Consecutive relapsing pediatric MS participants from the United States Network of Pediatric MS Centers were compared with pediatric healthy controls and adults with relapsing MS. Participants were compared on two screening batteries: the Brief International Cognitive Assessment for MS and the Cogstate Brief Battery. Results were transformed to age-normative z scores.
Results:
The pediatric groups (MS vs. Healthy Controls) did not differ on either battery’s composite mean score or individual test scores (ps > 0.32), nor in the proportions impaired on either battery, Brief International Cognitive Assessment for MS (26% vs. 24%, p = 0.83); Cogstate Brief Battery (26% vs. 32%, p = 0.41). The pediatric versus adult MS group even after controlling for differences in disease duration performed better on the Brief International Cognition Assessment for MS composite (p = 0.03), Symbol Digit Modalities Test (p = 0.02), Rey Auditory Verbal Learning Test (p = 0.01), and Cogstate choice reaction time (p < 0.001).
Conclusion:
Pediatric MS patients do not differ from healthy pediatric controls on cognitive screens but perform better than adults with MS.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36189711</pmid><doi>10.1177/13524585221123978</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9613-8394</orcidid><orcidid>https://orcid.org/0000-0001-7003-807X</orcidid><orcidid>https://orcid.org/0000-0001-6732-151X</orcidid><orcidid>https://orcid.org/0000-0003-4429-9713</orcidid><orcidid>https://orcid.org/0000-0002-9897-4422</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1352-4585 |
| ispartof | Multiple sclerosis, 2023-01, Vol.29 (1), p.140-149 |
| issn | 1352-4585 1477-0970 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2720932307 |
| source | SAGE |
| subjects | Adult Adults Auditory discrimination learning Child Cognition Cognition Disorders - psychology Cognitive ability Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Humans Memory and Learning Tests Multiple sclerosis Multiple Sclerosis - diagnosis Neuropsychological Tests Pediatrics |
| title | A new look at cognitive functioning in pediatric MS |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T09%3A49%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20look%20at%20cognitive%20functioning%20in%20pediatric%20MS&rft.jtitle=Multiple%20sclerosis&rft.au=Krupp,%20Lauren%20B&rft.aucorp=US%20Network%20of%20Pediatric%20MS%20Centers&rft.date=2023-01&rft.volume=29&rft.issue=1&rft.spage=140&rft.epage=149&rft.pages=140-149&rft.issn=1352-4585&rft.eissn=1477-0970&rft_id=info:doi/10.1177/13524585221123978&rft_dat=%3Cproquest_cross%3E2720932307%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c368t-ea1195b3d41f2fc083fd647da981abef543a2cb1ae89425e69b21be7aa4ec1ff3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2771309110&rft_id=info:pmid/36189711&rft_sage_id=10.1177_13524585221123978&rfr_iscdi=true |