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Dynamic growth changes in fetal growth restriction using serial ultrasonographic biometry and umbilical artery doppler: The multicenter PORTO study
Objective To describe the growth dynamics of fetuses with initial fetal growth restriction (FGR) later outgrowing the 10th centile for estimated fetal weight with respect to perinatal outcomes and maternal factors. Methods A multicenter prospective study recruited 1116 patients for ultrasound survei...
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| Published in: | International journal of gynecology and obstetrics 2023-04, Vol.161 (1), p.198-203 |
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| Main Authors: | , , , , , , , , , , , , |
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| container_end_page | 203 |
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| container_title | International journal of gynecology and obstetrics |
| container_volume | 161 |
| creator | Cody, Fiona Unterscheider, Julia Daly, Sean Geary, Michael Kennelly, Mairead McAuliffe, Fionnuala Morrison, John O'Donoghue, Keelin Hunter, Alyson Dicker, Patrick Tully, Elizabeth Fhearaigh, Rachel Malone, Fergal |
| description | Objective
To describe the growth dynamics of fetuses with initial fetal growth restriction (FGR) later outgrowing the 10th centile for estimated fetal weight with respect to perinatal outcomes and maternal factors.
Methods
A multicenter prospective study recruited 1116 patients for ultrasound surveillance between 2010 and 2012. All pregnancies were growth‐restricted singleton gestations between 24 + 0 and 36 + 0 weeks. Biometry and Doppler analysis were carried out, and delivery and adverse perinatal outcomes were recorded.
Results
A total of 193 (17%) fetuses outgrew their diagnosis of initial FGR (surpassed the 10th centile) on their last sonogram before delivery. These fetuses were termed “growers,” to compare with the true FGR group. The mothers of “growers” were less likely to be smokers (14% vs 25%, P = 0.0001) or affected by hypertensive pregnancy complications (5.2% vs 15%, P = 0.001). Of the growers, 49 (25%) had an abnormal umbilical artery Doppler; however, in most cases (33/49, 67%), this was a single episode of raised umbilical artery pulsatility index, which subsequently normalized.
Conclusion
There were dynamic growth changes in FGR fetuses, with 17% outgrowing their original diagnosis. Positive growth spurts more commonly occurred in healthy mothers. Once a fetus had outgrown the 10th centile, antenatal surveillance could be decreased.
Synopsis
There are dynamic growth changes in fetuses with growth restriction, with recovery from growth restriction occurring most commonly in healthy mothers. |
| doi_str_mv | 10.1002/ijgo.14470 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2716523480</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2716523480</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3240-e1475615b9d2d3c7a2a045e2a5d7741e9468c05787c4bfe9a8db0257f0cefe033</originalsourceid><addsrcrecordid>eNp9kc1KxDAURoMozji68QEkSxGqSZpOWnfi74gwIuO6pOltJ9ImNWmRPocvbHRGl64u3O_kwM2H0DEl55QQdqHfantOORdkB01pKrIo5iLbRdMQkkiwjE3QgfdvhBAqKN1Hk3hOWRYLPkWfN6ORrVa4dvajX2O1lqYGj7XBFfSy-d078L3TqtfW4MFrU2MPTod8aHonvTW2drJbB1GhbQu9G7E0JR7aQjdaBU66HsKytF3XgLvEqzXgNjzWCkxI8PPyZbXEvh_K8RDtVbLxcLSdM_R6d7u6foielveL66unSMWMkwgoF8mcJkVWsjJWQjJJeAJMJqUQnELG56kiiUiF4kUFmUzLgrBEVERBBSSOZ-h04-2cfR_CgXmrvYKmkQbs4HMm6DxhMU9JQM82qHLWewdV3jndSjfmlOTfJeTfJeQ_JQT4ZOsdihbKP_T31wNAN8CHbmD8R5UvHu-XG-kXq-CVZg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2716523480</pqid></control><display><type>article</type><title>Dynamic growth changes in fetal growth restriction using serial ultrasonographic biometry and umbilical artery doppler: The multicenter PORTO study</title><source>Wiley</source><creator>Cody, Fiona ; Unterscheider, Julia ; Daly, Sean ; Geary, Michael ; Kennelly, Mairead ; McAuliffe, Fionnuala ; Morrison, John ; O'Donoghue, Keelin ; Hunter, Alyson ; Dicker, Patrick ; Tully, Elizabeth ; Fhearaigh, Rachel ; Malone, Fergal</creator><creatorcontrib>Cody, Fiona ; Unterscheider, Julia ; Daly, Sean ; Geary, Michael ; Kennelly, Mairead ; McAuliffe, Fionnuala ; Morrison, John ; O'Donoghue, Keelin ; Hunter, Alyson ; Dicker, Patrick ; Tully, Elizabeth ; Fhearaigh, Rachel ; Malone, Fergal ; Perinatal Ireland Research Consortium ; for the Perinatal Ireland Research Consortium</creatorcontrib><description>Objective
To describe the growth dynamics of fetuses with initial fetal growth restriction (FGR) later outgrowing the 10th centile for estimated fetal weight with respect to perinatal outcomes and maternal factors.
Methods
A multicenter prospective study recruited 1116 patients for ultrasound surveillance between 2010 and 2012. All pregnancies were growth‐restricted singleton gestations between 24 + 0 and 36 + 0 weeks. Biometry and Doppler analysis were carried out, and delivery and adverse perinatal outcomes were recorded.
Results
A total of 193 (17%) fetuses outgrew their diagnosis of initial FGR (surpassed the 10th centile) on their last sonogram before delivery. These fetuses were termed “growers,” to compare with the true FGR group. The mothers of “growers” were less likely to be smokers (14% vs 25%, P = 0.0001) or affected by hypertensive pregnancy complications (5.2% vs 15%, P = 0.001). Of the growers, 49 (25%) had an abnormal umbilical artery Doppler; however, in most cases (33/49, 67%), this was a single episode of raised umbilical artery pulsatility index, which subsequently normalized.
Conclusion
There were dynamic growth changes in FGR fetuses, with 17% outgrowing their original diagnosis. Positive growth spurts more commonly occurred in healthy mothers. Once a fetus had outgrown the 10th centile, antenatal surveillance could be decreased.
Synopsis
There are dynamic growth changes in fetuses with growth restriction, with recovery from growth restriction occurring most commonly in healthy mothers.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.14470</identifier><identifier>PMID: 36129374</identifier><language>eng</language><publisher>United States</publisher><subject>Biometry ; Female ; fetal growth restriction ; Fetal Growth Retardation - etiology ; Gestational Age ; growth trends ; Humans ; Pregnancy ; Prospective Studies ; Ultrasonography, Doppler - methods ; Ultrasonography, Prenatal - methods ; ultrasound ; Umbilical Arteries - diagnostic imaging ; umbilical artery Doppler</subject><ispartof>International journal of gynecology and obstetrics, 2023-04, Vol.161 (1), p.198-203</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.</rights><rights>2022 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3240-e1475615b9d2d3c7a2a045e2a5d7741e9468c05787c4bfe9a8db0257f0cefe033</cites><orcidid>0000-0002-3615-2618</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.14470$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.14470$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36129374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cody, Fiona</creatorcontrib><creatorcontrib>Unterscheider, Julia</creatorcontrib><creatorcontrib>Daly, Sean</creatorcontrib><creatorcontrib>Geary, Michael</creatorcontrib><creatorcontrib>Kennelly, Mairead</creatorcontrib><creatorcontrib>McAuliffe, Fionnuala</creatorcontrib><creatorcontrib>Morrison, John</creatorcontrib><creatorcontrib>O'Donoghue, Keelin</creatorcontrib><creatorcontrib>Hunter, Alyson</creatorcontrib><creatorcontrib>Dicker, Patrick</creatorcontrib><creatorcontrib>Tully, Elizabeth</creatorcontrib><creatorcontrib>Fhearaigh, Rachel</creatorcontrib><creatorcontrib>Malone, Fergal</creatorcontrib><creatorcontrib>Perinatal Ireland Research Consortium</creatorcontrib><creatorcontrib>for the Perinatal Ireland Research Consortium</creatorcontrib><title>Dynamic growth changes in fetal growth restriction using serial ultrasonographic biometry and umbilical artery doppler: The multicenter PORTO study</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To describe the growth dynamics of fetuses with initial fetal growth restriction (FGR) later outgrowing the 10th centile for estimated fetal weight with respect to perinatal outcomes and maternal factors.
Methods
A multicenter prospective study recruited 1116 patients for ultrasound surveillance between 2010 and 2012. All pregnancies were growth‐restricted singleton gestations between 24 + 0 and 36 + 0 weeks. Biometry and Doppler analysis were carried out, and delivery and adverse perinatal outcomes were recorded.
Results
A total of 193 (17%) fetuses outgrew their diagnosis of initial FGR (surpassed the 10th centile) on their last sonogram before delivery. These fetuses were termed “growers,” to compare with the true FGR group. The mothers of “growers” were less likely to be smokers (14% vs 25%, P = 0.0001) or affected by hypertensive pregnancy complications (5.2% vs 15%, P = 0.001). Of the growers, 49 (25%) had an abnormal umbilical artery Doppler; however, in most cases (33/49, 67%), this was a single episode of raised umbilical artery pulsatility index, which subsequently normalized.
Conclusion
There were dynamic growth changes in FGR fetuses, with 17% outgrowing their original diagnosis. Positive growth spurts more commonly occurred in healthy mothers. Once a fetus had outgrown the 10th centile, antenatal surveillance could be decreased.
Synopsis
There are dynamic growth changes in fetuses with growth restriction, with recovery from growth restriction occurring most commonly in healthy mothers.</description><subject>Biometry</subject><subject>Female</subject><subject>fetal growth restriction</subject><subject>Fetal Growth Retardation - etiology</subject><subject>Gestational Age</subject><subject>growth trends</subject><subject>Humans</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Ultrasonography, Doppler - methods</subject><subject>Ultrasonography, Prenatal - methods</subject><subject>ultrasound</subject><subject>Umbilical Arteries - diagnostic imaging</subject><subject>umbilical artery Doppler</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kc1KxDAURoMozji68QEkSxGqSZpOWnfi74gwIuO6pOltJ9ImNWmRPocvbHRGl64u3O_kwM2H0DEl55QQdqHfantOORdkB01pKrIo5iLbRdMQkkiwjE3QgfdvhBAqKN1Hk3hOWRYLPkWfN6ORrVa4dvajX2O1lqYGj7XBFfSy-d078L3TqtfW4MFrU2MPTod8aHonvTW2drJbB1GhbQu9G7E0JR7aQjdaBU66HsKytF3XgLvEqzXgNjzWCkxI8PPyZbXEvh_K8RDtVbLxcLSdM_R6d7u6foielveL66unSMWMkwgoF8mcJkVWsjJWQjJJeAJMJqUQnELG56kiiUiF4kUFmUzLgrBEVERBBSSOZ-h04-2cfR_CgXmrvYKmkQbs4HMm6DxhMU9JQM82qHLWewdV3jndSjfmlOTfJeTfJeQ_JQT4ZOsdihbKP_T31wNAN8CHbmD8R5UvHu-XG-kXq-CVZg</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Cody, Fiona</creator><creator>Unterscheider, Julia</creator><creator>Daly, Sean</creator><creator>Geary, Michael</creator><creator>Kennelly, Mairead</creator><creator>McAuliffe, Fionnuala</creator><creator>Morrison, John</creator><creator>O'Donoghue, Keelin</creator><creator>Hunter, Alyson</creator><creator>Dicker, Patrick</creator><creator>Tully, Elizabeth</creator><creator>Fhearaigh, Rachel</creator><creator>Malone, Fergal</creator><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3615-2618</orcidid></search><sort><creationdate>202304</creationdate><title>Dynamic growth changes in fetal growth restriction using serial ultrasonographic biometry and umbilical artery doppler: The multicenter PORTO study</title><author>Cody, Fiona ; Unterscheider, Julia ; Daly, Sean ; Geary, Michael ; Kennelly, Mairead ; McAuliffe, Fionnuala ; Morrison, John ; O'Donoghue, Keelin ; Hunter, Alyson ; Dicker, Patrick ; Tully, Elizabeth ; Fhearaigh, Rachel ; Malone, Fergal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3240-e1475615b9d2d3c7a2a045e2a5d7741e9468c05787c4bfe9a8db0257f0cefe033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biometry</topic><topic>Female</topic><topic>fetal growth restriction</topic><topic>Fetal Growth Retardation - etiology</topic><topic>Gestational Age</topic><topic>growth trends</topic><topic>Humans</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Ultrasonography, Doppler - methods</topic><topic>Ultrasonography, Prenatal - methods</topic><topic>ultrasound</topic><topic>Umbilical Arteries - diagnostic imaging</topic><topic>umbilical artery Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cody, Fiona</creatorcontrib><creatorcontrib>Unterscheider, Julia</creatorcontrib><creatorcontrib>Daly, Sean</creatorcontrib><creatorcontrib>Geary, Michael</creatorcontrib><creatorcontrib>Kennelly, Mairead</creatorcontrib><creatorcontrib>McAuliffe, Fionnuala</creatorcontrib><creatorcontrib>Morrison, John</creatorcontrib><creatorcontrib>O'Donoghue, Keelin</creatorcontrib><creatorcontrib>Hunter, Alyson</creatorcontrib><creatorcontrib>Dicker, Patrick</creatorcontrib><creatorcontrib>Tully, Elizabeth</creatorcontrib><creatorcontrib>Fhearaigh, Rachel</creatorcontrib><creatorcontrib>Malone, Fergal</creatorcontrib><creatorcontrib>Perinatal Ireland Research Consortium</creatorcontrib><creatorcontrib>for the Perinatal Ireland Research Consortium</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cody, Fiona</au><au>Unterscheider, Julia</au><au>Daly, Sean</au><au>Geary, Michael</au><au>Kennelly, Mairead</au><au>McAuliffe, Fionnuala</au><au>Morrison, John</au><au>O'Donoghue, Keelin</au><au>Hunter, Alyson</au><au>Dicker, Patrick</au><au>Tully, Elizabeth</au><au>Fhearaigh, Rachel</au><au>Malone, Fergal</au><aucorp>Perinatal Ireland Research Consortium</aucorp><aucorp>for the Perinatal Ireland Research Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic growth changes in fetal growth restriction using serial ultrasonographic biometry and umbilical artery doppler: The multicenter PORTO study</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2023-04</date><risdate>2023</risdate><volume>161</volume><issue>1</issue><spage>198</spage><epage>203</epage><pages>198-203</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective
To describe the growth dynamics of fetuses with initial fetal growth restriction (FGR) later outgrowing the 10th centile for estimated fetal weight with respect to perinatal outcomes and maternal factors.
Methods
A multicenter prospective study recruited 1116 patients for ultrasound surveillance between 2010 and 2012. All pregnancies were growth‐restricted singleton gestations between 24 + 0 and 36 + 0 weeks. Biometry and Doppler analysis were carried out, and delivery and adverse perinatal outcomes were recorded.
Results
A total of 193 (17%) fetuses outgrew their diagnosis of initial FGR (surpassed the 10th centile) on their last sonogram before delivery. These fetuses were termed “growers,” to compare with the true FGR group. The mothers of “growers” were less likely to be smokers (14% vs 25%, P = 0.0001) or affected by hypertensive pregnancy complications (5.2% vs 15%, P = 0.001). Of the growers, 49 (25%) had an abnormal umbilical artery Doppler; however, in most cases (33/49, 67%), this was a single episode of raised umbilical artery pulsatility index, which subsequently normalized.
Conclusion
There were dynamic growth changes in FGR fetuses, with 17% outgrowing their original diagnosis. Positive growth spurts more commonly occurred in healthy mothers. Once a fetus had outgrown the 10th centile, antenatal surveillance could be decreased.
Synopsis
There are dynamic growth changes in fetuses with growth restriction, with recovery from growth restriction occurring most commonly in healthy mothers.</abstract><cop>United States</cop><pmid>36129374</pmid><doi>10.1002/ijgo.14470</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3615-2618</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0020-7292 |
| ispartof | International journal of gynecology and obstetrics, 2023-04, Vol.161 (1), p.198-203 |
| issn | 0020-7292 1879-3479 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2716523480 |
| source | Wiley |
| subjects | Biometry Female fetal growth restriction Fetal Growth Retardation - etiology Gestational Age growth trends Humans Pregnancy Prospective Studies Ultrasonography, Doppler - methods Ultrasonography, Prenatal - methods ultrasound Umbilical Arteries - diagnostic imaging umbilical artery Doppler |
| title | Dynamic growth changes in fetal growth restriction using serial ultrasonographic biometry and umbilical artery doppler: The multicenter PORTO study |
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