Trans‐synaptic mechanisms orchestrated by mammalian synaptic cell adhesion molecules

Bidirectional trans‐synaptic signaling is essential for the formation, maturation, and plasticity of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in shaping the identities of trans‐synaptic signaling pathways. A series of recent studies provide evidence that divers...

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Bibliographic Details
Published in:BioEssays 2022-11, Vol.44 (11), p.e2200134-n/a
Main Authors: Kim, Jinhu, Wulschner, Luis E. Gomez, Oh, Won Chan, Ko, Jaewon
Format: Article
Language:English
Subjects:
Adhesion
amyloid precursor protein
Cell adhesion
Cell adhesion molecules
Circuits
latrophilin
LRRTM
Mammals
MDGA
neurexin
Signal transduction
Signaling
Synapses
synaptic adhesion
Synaptic plasticity
trans‐synaptic signaling
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Summary:Bidirectional trans‐synaptic signaling is essential for the formation, maturation, and plasticity of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in shaping the identities of trans‐synaptic signaling pathways. A series of recent studies provide evidence that diverse presynaptic cell adhesion proteins dictate the regulation of specific synaptic properties in postsynaptic neurons. Focusing on mammalian synaptic CAMs, this article outlines several exemplary cases supporting this notion and highlights how these trans‐synaptic signaling pathways collectively contribute to the specificity and diversity of neural circuit architecture. Synaptic cell adhesion molecules (CAMs) are essential for shaping neural circuit architecture. Evidence shows that various presynaptic CAMs define specific postsynaptic properties. In addition, a subset of synaptic CAMs confers the specificity of neural circuit properties across diverse brain regions.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.202200134