Blood group O is associated with post-COVID-19 syndrome in outpatients with a low comorbidity index

ABO blood group system modulates the inflammatory response and has been implicated in COVID-19. Group O protects against SARS-CoV-2 infection, but there are no data regarding post-COVID-19 syndrome (PCS). Our aim was to assess this possible association. Case-control study in a community setting, wit...

Full description

Saved in:
Bibliographic Details
Published in:Infectious diseases (London, England) England), 2022-12, Vol.54 (12), p.897-908
Main Authors: Díaz-Salazar, Sara, Navas, Raquel, Sainz-Maza, Laura, Fierro, Patricia, Maamar, Meryam, Artime, Arancha, Basterrechea, Héctor, Petitta, Benedetta, Pini, Stefanie, Olmos, José Manuel, Ramos, Carmen, Pariente, Emilio, Hernández, José Luis
Format: Article
Language:English
Subjects:
ABO blood group
Blood group O
COVID-19
inflammatory markers
post-COVID-19 syndrome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c390t-a1cf7aa9de3f3fdbfd9f38f16edcfb02726b49e4fd373eea6a09463b89555f013
cites cdi_FETCH-LOGICAL-c390t-a1cf7aa9de3f3fdbfd9f38f16edcfb02726b49e4fd373eea6a09463b89555f013
container_end_page 908
container_issue 12
container_start_page 897
container_title Infectious diseases (London, England)
container_volume 54
creator Díaz-Salazar, Sara
Navas, Raquel
Sainz-Maza, Laura
Fierro, Patricia
Maamar, Meryam
Artime, Arancha
Basterrechea, Héctor
Petitta, Benedetta
Pini, Stefanie
Olmos, José Manuel
Ramos, Carmen
Pariente, Emilio
Hernández, José Luis
description ABO blood group system modulates the inflammatory response and has been implicated in COVID-19. Group O protects against SARS-CoV-2 infection, but there are no data regarding post-COVID-19 syndrome (PCS). Our aim was to assess this possible association. Case-control study in a community setting, with subjects who had experienced mild COVID-19. Cases were PCS+, controls were PCS-, and the exposure variable, group O. We collected age, sex, BMI, smoking, comorbidities, inflammatory markers, anti-SARS-CoV-2 IgG antibodies, blood type and clinical data. Five composite inflammatory indices were developed. Multivariate analyses were performed. We analysed 121 subjects (56.2% women), mean age 45.7 ± 16 years. Blood group frequencies were 41.5%, 7.9%, 5.9%, and 44.5% for A, B, AB and O, respectively. Thirty-six patients were PCS+, without significant differences between cases and controls. Compared to non-O, a higher prevalence of PCS (p = .036), and number of symptoms of PCS (p = .017) were noted in group O. Concerning biomarkers, PCS + and PCS- showed no differences in A, B, and AB groups. In contrast, group O PCS + patients had significantly lower albumin-to-globulin ratio and higher lymphocyte count, fibrinogen, CRP levels, and higher percentages of 3 composite indices, than PCS- subjects. Group O showed a 6-fold increased risk of PCS, compared to non-O (adjusted OR = 6.25 [95%CI, 1.6-23]; p = .007). Group O has shown a consistent relationship with PCS, characterised by a more intense inflammatory burden than the other blood groups. Blood group O could be part of the immunological link between acute COVID-19 and PCS.
doi_str_mv 10.1080/23744235.2022.2115548
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2707877611</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2707877611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-a1cf7aa9de3f3fdbfd9f38f16edcfb02726b49e4fd373eea6a09463b89555f013</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMoOIzzCEKWbjrm0lt26ngbGJiNug1pLhppm5qkjH17Wzq6dHUOh-__4XwAXGK0xqhE14QWaUpotiaIkDXBOMvS8gQspnuSkpSe_u00OwerED4RQpgyNrILIO9q5xR8967v4B7aAEUITloRtYIHGz9g50JMNvu37X2CGQxDq7xrNLQtdH3sRLS6jWFGBazdAUrXOF9ZZeMwUkp_X4AzI-qgV8e5BK-PDy-b52S3f9pubneJpAzFRGBpCiGY0tRQoyqjmKGlwblW0lSIFCSvUqZTo2hBtRa5QCzNaVWyLMvM-NISXM29nXdfvQ6RNzZIXdei1a4PnBSoKIsixxOazaj0LgSvDe-8bYQfOEZ88sp_vfLJKz96HXM3c862xvlGHJyvFY9iqJ03XrTSBk7_r_gBSu1_sw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2707877611</pqid></control><display><type>article</type><title>Blood group O is associated with post-COVID-19 syndrome in outpatients with a low comorbidity index</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Díaz-Salazar, Sara ; Navas, Raquel ; Sainz-Maza, Laura ; Fierro, Patricia ; Maamar, Meryam ; Artime, Arancha ; Basterrechea, Héctor ; Petitta, Benedetta ; Pini, Stefanie ; Olmos, José Manuel ; Ramos, Carmen ; Pariente, Emilio ; Hernández, José Luis</creator><creatorcontrib>Díaz-Salazar, Sara ; Navas, Raquel ; Sainz-Maza, Laura ; Fierro, Patricia ; Maamar, Meryam ; Artime, Arancha ; Basterrechea, Héctor ; Petitta, Benedetta ; Pini, Stefanie ; Olmos, José Manuel ; Ramos, Carmen ; Pariente, Emilio ; Hernández, José Luis</creatorcontrib><description>ABO blood group system modulates the inflammatory response and has been implicated in COVID-19. Group O protects against SARS-CoV-2 infection, but there are no data regarding post-COVID-19 syndrome (PCS). Our aim was to assess this possible association. Case-control study in a community setting, with subjects who had experienced mild COVID-19. Cases were PCS+, controls were PCS-, and the exposure variable, group O. We collected age, sex, BMI, smoking, comorbidities, inflammatory markers, anti-SARS-CoV-2 IgG antibodies, blood type and clinical data. Five composite inflammatory indices were developed. Multivariate analyses were performed. We analysed 121 subjects (56.2% women), mean age 45.7 ± 16 years. Blood group frequencies were 41.5%, 7.9%, 5.9%, and 44.5% for A, B, AB and O, respectively. Thirty-six patients were PCS+, without significant differences between cases and controls. Compared to non-O, a higher prevalence of PCS (p = .036), and number of symptoms of PCS (p = .017) were noted in group O. Concerning biomarkers, PCS + and PCS- showed no differences in A, B, and AB groups. In contrast, group O PCS + patients had significantly lower albumin-to-globulin ratio and higher lymphocyte count, fibrinogen, CRP levels, and higher percentages of 3 composite indices, than PCS- subjects. Group O showed a 6-fold increased risk of PCS, compared to non-O (adjusted OR = 6.25 [95%CI, 1.6-23]; p = .007). Group O has shown a consistent relationship with PCS, characterised by a more intense inflammatory burden than the other blood groups. Blood group O could be part of the immunological link between acute COVID-19 and PCS.</description><identifier>ISSN: 2374-4235</identifier><identifier>EISSN: 2374-4243</identifier><identifier>DOI: 10.1080/23744235.2022.2115548</identifier><language>eng</language><publisher>Taylor &amp; Francis</publisher><subject>ABO blood group ; Blood group O ; COVID-19 ; inflammatory markers ; post-COVID-19 syndrome</subject><ispartof>Infectious diseases (London, England), 2022-12, Vol.54 (12), p.897-908</ispartof><rights>2022 Society for Scandinavian Journal of Infectious Diseases 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-a1cf7aa9de3f3fdbfd9f38f16edcfb02726b49e4fd373eea6a09463b89555f013</citedby><cites>FETCH-LOGICAL-c390t-a1cf7aa9de3f3fdbfd9f38f16edcfb02726b49e4fd373eea6a09463b89555f013</cites><orcidid>0000-0002-7765-0891 ; 0000-0003-0035-3298 ; 0000-0002-6585-8847 ; 0000-0003-1970-1627</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Díaz-Salazar, Sara</creatorcontrib><creatorcontrib>Navas, Raquel</creatorcontrib><creatorcontrib>Sainz-Maza, Laura</creatorcontrib><creatorcontrib>Fierro, Patricia</creatorcontrib><creatorcontrib>Maamar, Meryam</creatorcontrib><creatorcontrib>Artime, Arancha</creatorcontrib><creatorcontrib>Basterrechea, Héctor</creatorcontrib><creatorcontrib>Petitta, Benedetta</creatorcontrib><creatorcontrib>Pini, Stefanie</creatorcontrib><creatorcontrib>Olmos, José Manuel</creatorcontrib><creatorcontrib>Ramos, Carmen</creatorcontrib><creatorcontrib>Pariente, Emilio</creatorcontrib><creatorcontrib>Hernández, José Luis</creatorcontrib><title>Blood group O is associated with post-COVID-19 syndrome in outpatients with a low comorbidity index</title><title>Infectious diseases (London, England)</title><description>ABO blood group system modulates the inflammatory response and has been implicated in COVID-19. Group O protects against SARS-CoV-2 infection, but there are no data regarding post-COVID-19 syndrome (PCS). Our aim was to assess this possible association. Case-control study in a community setting, with subjects who had experienced mild COVID-19. Cases were PCS+, controls were PCS-, and the exposure variable, group O. We collected age, sex, BMI, smoking, comorbidities, inflammatory markers, anti-SARS-CoV-2 IgG antibodies, blood type and clinical data. Five composite inflammatory indices were developed. Multivariate analyses were performed. We analysed 121 subjects (56.2% women), mean age 45.7 ± 16 years. Blood group frequencies were 41.5%, 7.9%, 5.9%, and 44.5% for A, B, AB and O, respectively. Thirty-six patients were PCS+, without significant differences between cases and controls. Compared to non-O, a higher prevalence of PCS (p = .036), and number of symptoms of PCS (p = .017) were noted in group O. Concerning biomarkers, PCS + and PCS- showed no differences in A, B, and AB groups. In contrast, group O PCS + patients had significantly lower albumin-to-globulin ratio and higher lymphocyte count, fibrinogen, CRP levels, and higher percentages of 3 composite indices, than PCS- subjects. Group O showed a 6-fold increased risk of PCS, compared to non-O (adjusted OR = 6.25 [95%CI, 1.6-23]; p = .007). Group O has shown a consistent relationship with PCS, characterised by a more intense inflammatory burden than the other blood groups. Blood group O could be part of the immunological link between acute COVID-19 and PCS.</description><subject>ABO blood group</subject><subject>Blood group O</subject><subject>COVID-19</subject><subject>inflammatory markers</subject><subject>post-COVID-19 syndrome</subject><issn>2374-4235</issn><issn>2374-4243</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMoOIzzCEKWbjrm0lt26ngbGJiNug1pLhppm5qkjH17Wzq6dHUOh-__4XwAXGK0xqhE14QWaUpotiaIkDXBOMvS8gQspnuSkpSe_u00OwerED4RQpgyNrILIO9q5xR8967v4B7aAEUITloRtYIHGz9g50JMNvu37X2CGQxDq7xrNLQtdH3sRLS6jWFGBazdAUrXOF9ZZeMwUkp_X4AzI-qgV8e5BK-PDy-b52S3f9pubneJpAzFRGBpCiGY0tRQoyqjmKGlwblW0lSIFCSvUqZTo2hBtRa5QCzNaVWyLMvM-NISXM29nXdfvQ6RNzZIXdei1a4PnBSoKIsixxOazaj0LgSvDe-8bYQfOEZ88sp_vfLJKz96HXM3c862xvlGHJyvFY9iqJ03XrTSBk7_r_gBSu1_sw</recordid><startdate>20221202</startdate><enddate>20221202</enddate><creator>Díaz-Salazar, Sara</creator><creator>Navas, Raquel</creator><creator>Sainz-Maza, Laura</creator><creator>Fierro, Patricia</creator><creator>Maamar, Meryam</creator><creator>Artime, Arancha</creator><creator>Basterrechea, Héctor</creator><creator>Petitta, Benedetta</creator><creator>Pini, Stefanie</creator><creator>Olmos, José Manuel</creator><creator>Ramos, Carmen</creator><creator>Pariente, Emilio</creator><creator>Hernández, José Luis</creator><general>Taylor &amp; Francis</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7765-0891</orcidid><orcidid>https://orcid.org/0000-0003-0035-3298</orcidid><orcidid>https://orcid.org/0000-0002-6585-8847</orcidid><orcidid>https://orcid.org/0000-0003-1970-1627</orcidid></search><sort><creationdate>20221202</creationdate><title>Blood group O is associated with post-COVID-19 syndrome in outpatients with a low comorbidity index</title><author>Díaz-Salazar, Sara ; Navas, Raquel ; Sainz-Maza, Laura ; Fierro, Patricia ; Maamar, Meryam ; Artime, Arancha ; Basterrechea, Héctor ; Petitta, Benedetta ; Pini, Stefanie ; Olmos, José Manuel ; Ramos, Carmen ; Pariente, Emilio ; Hernández, José Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-a1cf7aa9de3f3fdbfd9f38f16edcfb02726b49e4fd373eea6a09463b89555f013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>ABO blood group</topic><topic>Blood group O</topic><topic>COVID-19</topic><topic>inflammatory markers</topic><topic>post-COVID-19 syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Díaz-Salazar, Sara</creatorcontrib><creatorcontrib>Navas, Raquel</creatorcontrib><creatorcontrib>Sainz-Maza, Laura</creatorcontrib><creatorcontrib>Fierro, Patricia</creatorcontrib><creatorcontrib>Maamar, Meryam</creatorcontrib><creatorcontrib>Artime, Arancha</creatorcontrib><creatorcontrib>Basterrechea, Héctor</creatorcontrib><creatorcontrib>Petitta, Benedetta</creatorcontrib><creatorcontrib>Pini, Stefanie</creatorcontrib><creatorcontrib>Olmos, José Manuel</creatorcontrib><creatorcontrib>Ramos, Carmen</creatorcontrib><creatorcontrib>Pariente, Emilio</creatorcontrib><creatorcontrib>Hernández, José Luis</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Infectious diseases (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Díaz-Salazar, Sara</au><au>Navas, Raquel</au><au>Sainz-Maza, Laura</au><au>Fierro, Patricia</au><au>Maamar, Meryam</au><au>Artime, Arancha</au><au>Basterrechea, Héctor</au><au>Petitta, Benedetta</au><au>Pini, Stefanie</au><au>Olmos, José Manuel</au><au>Ramos, Carmen</au><au>Pariente, Emilio</au><au>Hernández, José Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood group O is associated with post-COVID-19 syndrome in outpatients with a low comorbidity index</atitle><jtitle>Infectious diseases (London, England)</jtitle><date>2022-12-02</date><risdate>2022</risdate><volume>54</volume><issue>12</issue><spage>897</spage><epage>908</epage><pages>897-908</pages><issn>2374-4235</issn><eissn>2374-4243</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>ABO blood group system modulates the inflammatory response and has been implicated in COVID-19. Group O protects against SARS-CoV-2 infection, but there are no data regarding post-COVID-19 syndrome (PCS). Our aim was to assess this possible association. Case-control study in a community setting, with subjects who had experienced mild COVID-19. Cases were PCS+, controls were PCS-, and the exposure variable, group O. We collected age, sex, BMI, smoking, comorbidities, inflammatory markers, anti-SARS-CoV-2 IgG antibodies, blood type and clinical data. Five composite inflammatory indices were developed. Multivariate analyses were performed. We analysed 121 subjects (56.2% women), mean age 45.7 ± 16 years. Blood group frequencies were 41.5%, 7.9%, 5.9%, and 44.5% for A, B, AB and O, respectively. Thirty-six patients were PCS+, without significant differences between cases and controls. Compared to non-O, a higher prevalence of PCS (p = .036), and number of symptoms of PCS (p = .017) were noted in group O. Concerning biomarkers, PCS + and PCS- showed no differences in A, B, and AB groups. In contrast, group O PCS + patients had significantly lower albumin-to-globulin ratio and higher lymphocyte count, fibrinogen, CRP levels, and higher percentages of 3 composite indices, than PCS- subjects. Group O showed a 6-fold increased risk of PCS, compared to non-O (adjusted OR = 6.25 [95%CI, 1.6-23]; p = .007). Group O has shown a consistent relationship with PCS, characterised by a more intense inflammatory burden than the other blood groups. Blood group O could be part of the immunological link between acute COVID-19 and PCS.</abstract><pub>Taylor &amp; Francis</pub><doi>10.1080/23744235.2022.2115548</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7765-0891</orcidid><orcidid>https://orcid.org/0000-0003-0035-3298</orcidid><orcidid>https://orcid.org/0000-0002-6585-8847</orcidid><orcidid>https://orcid.org/0000-0003-1970-1627</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2374-4235
ispartof Infectious diseases (London, England), 2022-12, Vol.54 (12), p.897-908
issn 2374-4235
2374-4243
language eng
recordid cdi_proquest_miscellaneous_2707877611
source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects ABO blood group
Blood group O
COVID-19
inflammatory markers
post-COVID-19 syndrome
title Blood group O is associated with post-COVID-19 syndrome in outpatients with a low comorbidity index
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T04%3A58%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Blood%20group%20O%20is%20associated%20with%20post-COVID-19%20syndrome%20in%20outpatients%20with%20a%20low%20comorbidity%20index&rft.jtitle=Infectious%20diseases%20(London,%20England)&rft.au=D%C3%ADaz-Salazar,%20Sara&rft.date=2022-12-02&rft.volume=54&rft.issue=12&rft.spage=897&rft.epage=908&rft.pages=897-908&rft.issn=2374-4235&rft.eissn=2374-4243&rft_id=info:doi/10.1080/23744235.2022.2115548&rft_dat=%3Cproquest_cross%3E2707877611%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c390t-a1cf7aa9de3f3fdbfd9f38f16edcfb02726b49e4fd373eea6a09463b89555f013%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2707877611&rft_id=info:pmid/&rfr_iscdi=true