Hyaluronic acid coated spinel ferrite for combination of chemo and photodynamic therapy: Green synthesis, characterization, and in vitro and in vivo biocompatibility study

In this project, different photosensitizers were prepared using different ratios of nickel, manganese, and iron. Then, multiple analysis were performed to evaluate their efficiency, and the most suitable one was used to be coated by hyaluronic acid to improve the nano-platform's biocompatibilit...

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Published in:International journal of biological macromolecules 2022-10, Vol.219, p.709-720
Main Authors: Zamani, Mostafa, Aghajanzadeh, Mozhgan, Jashnani, Setare, Shahangian, S. Shirin, Shirini, Farhad
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Language:English
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Chemo therapy
Curcumin
Photodynamic therapy
Spinel ferrite, hyaluronic acid
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container_title International journal of biological macromolecules
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creator Zamani, Mostafa
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Shirini, Farhad
description In this project, different photosensitizers were prepared using different ratios of nickel, manganese, and iron. Then, multiple analysis were performed to evaluate their efficiency, and the most suitable one was used to be coated by hyaluronic acid to improve the nano-platform's biocompatibility and target ability. Moreover, another chemical targeting agent (riboflavin) was used to further improve the target ability of the prepared nano-platform. Different spectroscopies and thermal analysis were used to determine the physical and chemical characteristics of the prepared nano-platform. Also, in order to determine the biocompatibility of the nano-platform, in vitro and in vivo tests such as blood hemolysis, blood aggregation and lethal dose were performed. Then, an anti-cancer agent (curcumin) was loaded on the selected nano-platform to makes us able utilizing the synergistic effect of chemotherapy and photodynamic therapy simultaneously. Finally, the cell cytotoxicity results showed that the prepared nano-platform had a great anti-cancer potential which can make it a great candidate as a dual photo and chemo therapy agent for treatment of breast cancers. •Nix Mn1-X Fe2O4 based nano-platforms was synthesized using co-precipitation method.•Presence of Mn could reduce the activity of GSH in tumor microenvironment.•The photosensitizers showed a great potential in PDT under visible light.•HA and Rb were used as targeting agent and improved the biocompatibility of PSs.•Great potential of Cur stablished a synergistic effect of chemo therapy and PDT.
doi_str_mv 10.1016/j.ijbiomac.2022.08.036
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subjects Chemo therapy
Curcumin
Photodynamic therapy
Spinel ferrite, hyaluronic acid
title Hyaluronic acid coated spinel ferrite for combination of chemo and photodynamic therapy: Green synthesis, characterization, and in vitro and in vivo biocompatibility study
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