Nrf2 improves hippocampal synaptic plasticity, learning and memory through the circ-Vps41/miR-26a-5p/CaMKIV regulatory network

Antioxidant response transcription factor nuclear factor erythroid-2-related factor 2 (Nrf2/Nfe2l2) is a neuroprotective agent in learning and memory impairment. This study provides a new perspective to explore the regulatory mechanisms of Nrf2. Here, we found that Nrf2 regulated circular RNA circ-V...

Full description

Saved in:
Bibliographic Details
Published in:Experimental neurology 2022-05, Vol.351, p.113998-113998, Article 113998
Main Authors: Zhang, Runjiao, Gao, Yanjing, Li, Yibo, Geng, Dandan, Liang, Yuxiang, He, Qingwen, Wang, Lei, Cui, Huixian
Format: Article
Language:English
Subjects:
CaMKIV
Cell Proliferation
Circ-Vps41
Hippocampus - metabolism
Learning and memory
MicroRNAs - genetics
MicroRNAs - metabolism
miR-26a-5p
Neuronal Plasticity - genetics
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
Nrf2
RNA, Circular - genetics
Synaptic plasticity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antioxidant response transcription factor nuclear factor erythroid-2-related factor 2 (Nrf2/Nfe2l2) is a neuroprotective agent in learning and memory impairment. This study provides a new perspective to explore the regulatory mechanisms of Nrf2. Here, we found that Nrf2 regulated circular RNA circ-Vps41 to increase hippocampal synaptic plasticity; Nrf2 bound the Vps41 promoter to activate transcription of the Vps41 gene and promote expression of circ-Vps41; circ-Vps41 positively correlated with Nrf2, synaptic plasticity, and learning and memory but negatively correlated with reactive oxygen species; and Nrf2 promoted CaMKIV expression by increasing levels of circ-Vps41, which can absorb miR-26a-5p that targets CaMKIV. Our findings revealed a new circRNA-based regulatory network regulated by Nrf2 and provided novel insights into the potential mechanism involved in the improvement of learning and memory impairment. [Display omitted]
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2022.113998